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Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient

Microsystems & Nanoengineering 2023年第1期9卷 191-202页

作者： Kai Duan Mengyang Zhou Yong Wang Jose Oberholzer Joe F.Lo Department of Mechanical Engineering Bioengineering ProgramUniversity of Michigan at DearbornDearbornMI48128USA Department of Surgery/Transplant University of VirginiaCharlottesvilleVA22908USA

One distinct advantage of microfluidic-based cell assays is their scalability for multiple concentrations or *** scaling can be extremely powerful when combining multiple parameters and ***,in situ stimulation and detection eliminates variability between individual ***,conventional microfluidics must combat diffusion,which limits the spatial distance and time for molecules traveling through ***,we leveraged a multilayered microfluidic approach to integrate a novel oxygen gradient(0–20%)with an enhanced hydrogel sensor to study pancreatic beta *** enabled our microfluidics to achieve spatiotemporal detection that is difficult to achieve with traditional *** this device,we demonstrated the in situ detection of calcium,insulin,and ATP(adenosine triphosphate)in response to glucose and oxygen ***,insulin was quantified at levels as low as 25 pg/mL using our imaging ***,by analyzing the spatial detection data dynamically over time,we uncovered a new relationship between oxygen and beta cell *** observed an optimum oxygen level between 10 and 12%,which is neither hypoxic nor normoxic in the conventional cell culture *** results provide evidence to support the current islet oscillator *** future applications,this spatial microfluidic technique can be adapted for discrete protein detection in a robust platform to study numerous oxygen-dependent tissue dysfunctions.

关键词： hypoxic stimulation gradient

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Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

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Mechanobiology in Medicine 2025年第1期3卷 57-67页

作者： Alexander M.Regner Maximilien DeLeon Kalin D.Gibbons Sean Howard Derek Q.Nesbitt Seyedeh F.Darghiasi Anamaria G.Zavala Trevor J.Lujan Clare K.Fitzpatrick Mary C.Farach-Carson Danielle Wu Gunes Uzer Mechanical and Biomedical Engineering Department Boise State UniversityUSA Department of Diagnostic and Biomedical Sciences UTHealth Houston School of DentistryUSA Department of Bioengineering Rice UniversityUSA Department of Biosciences Rice UniversityUSA Biomedical Engineering Program Boise State UniversityUSA

Aged individuals and astronauts experience bone loss despite rigorous physical *** mechanoresponse is in-part regulated by mesenchymal stem cells(MSCs)that respond to mechanical *** delivery of low intensity vibration(LIV)recovers MSC proliferation in senescence and simulated microgravity models,indicating that age-related reductions in mechanical signal delivery within bone marrow may contribute to declining bone *** answer this question,we developed a 3D bone marrow analog that controls trabecular geometry,marrow mechanics and external *** finite element(FE)models were developed to quantify strain environment within hydrogels during *** marrow analogs with gyroid-based trabeculae of scaffold volume fractions(SV/TV)corresponding to adult(25%)and aged(13%)mice were printed using polylactic acid(PLA).MSCs encapsulated in migration-permissive hydrogels within printed trabeculae showed robust cell populations on both PLA surface and hydrogel within a *** 14 days of LIV treatment(1 g,100 Hz,1 h/day),cell proliferation,type-I collagen(Collagen-I)and filamentous actin(F-actin)were quantified for the cells in the hydrogel *** LIV increased all measured outcomes,FE models predicted higher von Mises strains for the 13%SV/TV groups(0.2%)when compared to the 25%SV/TV group(0.1%).While LIV increased collagen-I volume 34%more in 13%SV/TV groups when compared to 25%SV/TV groups,collagen-I and F-actin measures remained lower in the 13%SV/TV groups when compared to 25%SV/TV counterparts,indicating that both LIV-induced strains and scaffold volume fraction(*** scaffold surface)affect cell behavior in the hydrogel ***,bone marrow analogs offer a robust and repeatable platform to study bone mechanobiology.

关键词： mechanical signals Low-intensity vibration Mesenchymal stem cells 3D printing mechanical modeling Tissue modeling

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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AllWeather-UsableWearable Dual Energy Harvester for Outdoor Sustainable Operation

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SusMat 2025年第1期5卷 159-170页

作者： Yeongju Jung Jiyong Ahn Ji-Seok Kim Junhyuk Bang Minwoo Kim Seongmin Jeong Jinwoo Lee Seonggeun Han Il-Kwon Oh Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulRepublic of Korea National Creative Research Initiative for Functionally Antagonistic Nano-Engineering Department of Mechanical EngineeringSchool of Mechanical and Aerospace EngineeringKorea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Mechanical Roboticsand Energy EngineeringDongguk UniversitySeoulRepublic of Korea Device Solutions Research Samsung ElectronicsHwaseong-siRepublic of Korea Institute of Engineering Research/Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoulRepublic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoulRepublic of Korea

Sustainable power sources for outdoor wearable electronics are essential for the continuous operation of wearable ***,the current lack of engineering design that can harvest energy regardless of weather conditions presents a significant *** this regard,this study introduces a wearable,breathable all-weather usable dual energy harvester(AWuDEH)that can seamlessly generate electrical energy regardless of weather *** this study,the AWuDEH integrated with the thermoelectric generator and the droplet-based electricity generator is *** AWuDEH,especially engineered with a bi-functional top substrate for radiative cooling and electrification,achieves sustainable energy harvesting outdoors,thereby addressing the conventional challenge associated with the necessity for separate energy harvesters tailored to outdoor usage contingent on weather *** device reaches a maximum power output of 14.6μW cm^(-2)under simulated sunny conditions and generates a much more enhanced thermoelectric power of 74.78μW cm^(-2)and a droplet-based electric power of 256.25 mW m^(-2)in rainy *** proof,this study developed self-powered wearable electronics capable of acquiring physiological signals in simulated outdoor *** study presents a promising advancement in wearable technology,offering a potent solution for sustainable energy harvesting independent of weather conditions.

关键词： all-weather usable droplet-based electricity generator hybrid architecture outdoor sustainable operation thermoelectric generator

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Label-Free Classification of L-Histidine Vs Artificial Human Sweat Using Laser Scribed Electrodes and a Multi-Layer Perceptron Neural Network 46

Label-Free Classification of L-Histidine Vs Artificial Human...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： García-Rodríguez, William Saavedra-Ruiz, Andrés Resto-Irizarry, Pedro J. University of Puerto Rico Department of Mechanical Engineering Mayagüez00680 Puerto Rico University of Puerto Rico Bioengineering Graduate Program Mayagüez00680 Puerto Rico

ISBN: (纸本)9798350371499

A challenge in wearable technology lies in the realtime monitoring of molecular biomarkers associated with human health. Electrochemical sensors are one of the most useful tools for this purpose and are commonly used in health monitoring devices. Electrochemical biosensing is particularly convenient when used in user-friendly, low-cost devices for testing noninvasive body fluids such as sweat and saliva. However, achieving high selectivity and specificity in measurements depends on the complexity of the biomarker and the stability of the biomarker capture molecule. In this study, laser-scribed electrodes (LSEs) were manufactured using a CO2 laser cutter on Polyimide for the label-free classification of sweat components. Cyclic voltammetry experiments were performed on artificial human sweat and the sweat component L-Histidine. The resulting voltammogram data served as input to train a Multi-Layer Perceptron Neural Network (MLP-NN) algorithm capable of classifying L-Histidine and artificial sweat. © 2024 IEEE.

关键词： Carbon dioxide lasers

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Design considerations for piezocomposite materials for electrical stimulation in medical implants

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Journal of Medical engineering and Technology 2022年第5期46卷 402-414页

作者： Krech, Ember Haas, Evan Tideman, Grace Reinsch, Bonnie Friis, Elizabeth Bioengineering Graduate Program University of Kansas LawrenceKS United States Department of Mechanical Engineering University of Kansas LawrenceKS United States Department of Chemical Engineering University of Kansas LawrenceKS United States

Incidence of non-union following long bone fracture fixation and spinal fusion procedures is increasing, and very costly for patients and the medical system. Direct current (DC) electrical stimulation has shown success as an adjunct therapy to stimulate bone healing and increase surgery success rates, though drawbacks of current devices and implantable battery packs have limited widespread use. Energy harvesting utilising piezoelectric materials has been widely studied for powering devices without a battery, and a preclinical animal study has shown efficacy of a piezocomposite spinal fusion implant resulting in faster, more robust fusion. Most piezoelectric energy harvesters operate most effectively at high frequencies, limiting power generation from loads experienced by orthopaedic implants during human motion. This work characterises the efficient power generation capability of a novel composite piezoelectric material under simulated walking loads. Building on compliant layer adaptive composite stacks (CLACS), the power generation of mixed-mode CLACS (MMCLACS) is defined. Utilising poling direction to capitalise on in-plane strain generation due to compliant layer expansion, MMCLACS significantly increased power output compared to a standard piezo stack. The combination of radial and through-thickness poled piezoelectric elements within a stack to create MMCLACS significantly increases power generation under low-frequency dynamic loads. This technology can be adapted to a variety of architectures and assembled as a load-bearing energy harvester within current implants. MMCLACS integrated with implants would provide enough power to deliver bone healing electrical stimulation directly to the fusion site, decreasing non-union rates, and also could provide quantitative assessment of healing progression through load sensing. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Energy harvesting

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Transferrin-Mediated Nanophotosensitizer to Enhance Phototherapy with Photoacoustic Imaging Under Hypoxia

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CCS Chemistry 2025年第4期7卷 1127-1141页

作者： Mengyao Yang Yunyoung Nah Donghyeon Oh Xingshu Li Heejeong Kim Sinyoung Park Junha Lim Aibing Chen Chulhong Kim Won Jong Kim Juyoung Yoon College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018 Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03760 Department of Chemistry POSTECH-Catholic Biomedical Engineering InstitutePOSTECHPohang 37673 Department of Electrical Engineering Convergence IT EngineeringMechanical Engineeringand Medical Science and EngineeringMedical Device Innovation CenterPOSTECHPohang 37673 Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350108 School of Interdisciplinary Bioscience and Bioengineering POSTECHPohang 37673 Graduate Program in Innovative Biomaterials Convergence Ewha Womans UniversitySeoul 03760

Various obstacles[poor tissue penetration,hypoxic tumor microenvironment,and reactive oxygen species(ROS)production quenching due to aggregation]obstruct imaging-guided high-efficiency phototherapy targeting ***,nanophthalocyanine(ZnPcN4-TF)is elaborately designed based on a synthetic phthalocyanine derivative(ZnPcN4)and nonimmunogenic transferrin(TF)through multiple noncovalent interactions for photoacoustic(PA)imaging-guided *** conjugating electron-rich amino groups effectively suppressed fluorescence and ROS generation due to the strong photoinduced electron transfer effect,ZnPcN4 became an ideal photothermal and PA imaging ***4-TF not only effectively targeted tumor sites and accumulated there,but also,surprisingly,facilitated the enhancement of ROS production via a type I process in an aggregate compared to ZnPcN4 itself,potentially due to accelerated electron ***,ZnPcN4-TF had a substantially more powerful photothermal effect than ZnPcN4 ***,this design effectively overcomes the obstacles to photodynamic therapy(aggregation-related ROS generation quenching in a hypoxic environment).Furthermore,PA imaging solves the tissue penetration challenge in optical *** study provides a broader base for designing novel photosensitizers to improve phototherapy under hypoxia.

关键词： photoacoustic imaging type I reactive oxygen species photothermal effect tumor accumulation self-assembly

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DEVELOPING A DIGITAL TWIN FOR SINGLE-CELL mechanical PHENOTYPING MICROFLUIDIC DEVICES 26

DEVELOPING A DIGITAL TWIN FOR SINGLE-CELL MECHANICAL PHENOTY...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Roychowdhury, Sayan Mahmud, Samreen T. Puleri, Daniel F. Lai, Andre Rex, Rachel Li, Brian Sohn, Lydia L. Randles, Amanda Department of Biomedical Engineering Duke University United States UC Berkeley-UC San Francisco Graduate Program in Bioengineering University of California Berkeley United States Department of Mechanical Engineering University of California Berkeley United States

ISBN: (纸本)9781733419048

Microfluidics can be used to characterize individual cells in a population based on their mechanical traits. In this work, we digitally replicate the microfluidic device developed by Li et al. [1] and perform simulations of a representative AP-1060 cell. We show that the numerical model is able to recover whole-cell deformability index, a metric used to quantify the resistance of cells to compressive deformation, within 3% of the experimental average. These results pave the way for future studies which utilize experimental and computational approaches to optimize geometric design parameters, complement signal analysis, and enhance the acquisition of mechanical information. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Fluid structure interaction

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Tactile Displays Driven by Projected Light

arXiv

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arXiv 2024年

作者： Linnander, Max Goetz, Dustin Reardon, Gregory Kumar, Vijay Hawkes, Elliot Visell, Yon Department of Mechanical Engineering United States Department of Bioengineering United States Media Arts & Technology Program United States Department of Electrical and Computer Engineering University of California Santa Barbara United States

Tactile displays that lend tangible form to digital content could transform computing interactions. However, achieving the resolution, speed, and dynamic range needed for perceptual fidelity remains challenging. We present a tactile display that directly converts projected light into visible tactile patterns via a photomechanical surface populated with millimeter-scale optotactile pixels. The pixels transduce incident light into mechanical displacements through photostimulated thermal gas expansion, yielding millimeter scale displacements with response times of 2 to 100 milliseconds. Employing projected light for power transmission and addressing renders these displays highly scalable. We demonstrate optically driven displays with up to 1,511 addressable pixels – several times more pixels than any prior tactile display attaining comparable performance. Perceptual studies confirm that these displays can reproduce diverse spatiotemporal tactile patterns with high fidelity. This research establishes a foundation for practical, versatile high-resolution tactile displays driven by light. Copyright © 2024, The Authors. All rights reserved.

关键词： Light transmission

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Label-Free Classification of L-Histidine Vs Artificial Human Sweat Using Laser Scribed Electrodes and a Multi-Layer Perceptron Neural Network

Label-Free Classification of L-Histidine Vs Artificial Human...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： William García-Rodríguez Andrés Saavedra-Ruiz Pedro J. Resto-Irizarry Department of Mechanical Engineering University of Puerto Rico Mayagüez PR USA Bioengineering Graduate Program University of Puerto Rico Mayagüez PR USA

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

关键词： Electrodes Neural networks Measurement by laser beam Polyimides Laser stability Sensors Molecular biomarkers Laser beam cutting Monitoring Testing

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