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MRS Advances

作者： Castagnola, Elisa Winchester Vahidi, Nasim Nimbalkar, Surabhi Rudraraju, Srihita Thielk, Marvin Zucchini, Elena Cea, Claudia Carli, Stefano Gentner, Timothy Q. Ricci, Davide Fadiga, Luciano Kassegne, Sam MEMS Research Lab. Department of Mechanical Engineering College of Engineering San Diego State University 5500 Campanile Drive San DiegoCA92182-1323 United States Center for Sensorimotor Neural Engineering Box 37 1414 NE 42nd St SeattleWA98105-6271 United States Dept. of Electrical Engineering University of California San Diego San DiegoCA92093 United States Neurosciences Graduate Program University of California San Diego 9500 Gilman Dr San DiegoCA United States Department of Bioengineering University of California San Diego San DiegoCA United States Center for Translational Neurophysiology of Speech and Communication Istituto Italiano di Tecnologia Via Fossato di Mortara 17/19 Ferrara44121 Italy Department of Human Physiology University of Ferrara Via Fossato di Mortara 17/19 Ferrara44121 Italy

In this study, we present a 4-channel intracortical glassy carbon (GC) microelectrode array on a flexible substrate for the simultaneous in vivo neural activity recording and dopamine (DA) concentration measurement at four different brain locations (220m vertical spacing). The ability of GC microelectrodes to detect DA was firstly assessed in vitro in phosphate-buffered saline solution and then validated in vivo measuring spontaneous DA concentration in the Striatum of European Starling songbird through fast scan cyclic voltammetry(FSCV). The capability of GC microelectrode arrays and commercial penetrating metal microelectrode arrays to record neural activity from the Caudomedial Neostriatum of European starling songbird was compared. Preliminary results demonstrated the ability of GC microelectrodes in detecting neurotransmitters release and recording neural activity in vivo. GC microelectrodes array may, therefore, offer a new opportunity to understand the intimate relations linking electrophysiological parameters with neurotransmitters release. © 2018 Materials Research Society.

关键词： Microelectrodes Amines Birds Brain Carbon Cyclic voltammetry Electrophysiology Glass Glassy carbon Microelectronics Neurons Sensors Carbon microelectrodes Concentration Measurement devices Fast scan cyclic voltammetry Microelectrode array Microelectrodes arrays Phosphate buffered saline solutions Single unit recordings

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Erratum to: Anisotropic Permeability of Trabecular Bone and Its Relationship to Fabric and Architecture: A Computational Study

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Annals of biomedical engineering 2017年第6期45卷 1555-1559页

作者： T C Kreipke G L Niebur Tissue Mechanics Laboratory Bioengineering Graduate Program and Department of Aerospace and Mechanical Engineering University of Notre Dame Notre Dame IN USA. Tissue Mechanics Laboratory Bioengineering Graduate Program and Department of Aerospace and Mechanical Engineering University of Notre Dame Notre Dame IN USA. gniebur@nd.edu. 147 Multidisciplinary Research Building Notre Dame IN 46556 USA. gniebur@nd.edu.

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High-Throughput Screening: One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening (Adv. Sci. 3/2019)

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Advanced Science 2019年第3期6卷 1970014-1970014页

作者： Seo Woo Song Su Deok Kim Dong Yoon Oh Yongju Lee Amos Chungwon Lee Yunjin Jeong Hyung Jong Bae Daewon Lee Sumin Lee Jiyun Kim Sunghoon Kwon Department of Electrical and Computer Engineering Seoul National University Seoul 08826 South Korea Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 08826 South Korea Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA Nano Systems Institute Seoul National University Seoul 08826 South Korea Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 South Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology Ulsan 44919 South Korea

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A tissue engineered model of aging: Interdependence and cooperative effects in failing tissues

arXiv

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arXiv 2017年

作者： Acun, A. Vural, D.C. Zorlutuna, P. Bioengineering Graduate Program University of Notre Dame IN United States Department of Physics University of Notre Dame IN United States Aerospace and Mechanical Engineering University of Notre Dame IN United States

Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs and ultimately the organism. The goal of this work is to bridge microscopic cell failure to macroscopic manifestations of aging. We use tissue engineered constructs to control the cellular-level damage and cell-cell distance in individual tissues to establish the role of complex interdependence and interactions between cells in aging tissues. We found that while microscopic mechanisms drive aging, the interdependency between cells plays a major role in tissue death, providing evidence on how cellular aging is connected to its higher systemic consequences. Copyright © 2017, The Authors. All rights reserved.

关键词： Tissue engineering

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Dark-Exciton-Mediated Fano Resonance from a Single Gold Nanostructure Deposited on Monolayer WS2 at Room Temperature

arXiv

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arXiv 2018年

作者： Wang, Mingsong Wu, Zilong Krasnok, Alex Zhang, Tianyi Liu, Mingzu Liu, He Scarabelli, Leonardo Fang, Jie Liz-Marzán, Luis M. Terrones, Mauricio Alù, Andrea Zheng, Yuebing Department of Mechanical Engineering Materials Science and Engineering Program Texas Materials Institute University of Texas at Austin AustinTX78712 United States Photonics Initiative Advanced Science Research Center Physics Program Graduate Center Department of Electrical Engineering City College of The City University of New York NY10031 United States Department of Materials Science and Engineering Department of Physics Center for 2-Dimensional and Layered Materials Department of Chemistry Pennsylvania State University Pennsylvania State University University ParkPA16802 United States Department of Chemistry and Biochemistry California NanoSystems Institute University of California Los Angeles Los AngelesCA90095 United States Bionanoplasmonics Laboratory CIC biomaGUNE Paseo de Miramón 182 Donostia-San Sebastián20014 Spain Ikerbasque Basque Foundation for Science Bilbao48013 Spain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine CIBER-BBN Donostia- San Sebastián20014 Spain

Strong spatial confinement and highly reduced dielectric screening provide monolayer transition metal dichalcogenides (TMDCs) with strong many-body effects, thereby possessing optically forbidden excitonic states (i.e., dark excitons) at room temperature. Herein, we explore the interaction of surface plasmons with dark excitons in hybrid systems consisting of stacked gold nanotriangles (AuNTs) and monolayer WS2. We observe a narrow Fano resonance when the hybrid system is surrounded by water, and we attribute the narrowing of the spectral Fano linewidth to the plasmon-enhanced decay of dark K-K excitons. Our results reveal that dark excitons in monolayer WS2 can strongly modify Fano resonances in hybrid plasmon-exciton systems and can be harnessed for novel optical sensors and active nanophotonic devices. Copyright © 2018, The Authors. All rights reserved.

关键词： Gold nanoparticles

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Influence of Sequential Ponte Osteotomies on the Human Thoracic Spine With a Rib Cage

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Spine Deformity 2017年第2期5卷 91-96页

作者： Mannen, Erin M. Arnold, Paul M. Anderson, John T. Friis, Elizabeth A. Department of Mechanical Engineering University of Kansas 1530 W 15th St. Learned Hall Room 3138 Lawrence 66045 KS United States Department of Neurosurgery University of Kansas Medical Center 3901 Rainbow Blvd Kansas City 66160 KS United States Department of Orthopaedic Surgery Children's Mercy Hospital and Clinics of Kansas City 2401 Gillham Rd Kansas City 64108 MO United States Bioengineering Graduate Program University of Kansas 1450 Jayhawk Blvd Lawrence 66045 KS United States

Study Design Biomechanical cadaveric study. Objectives The purpose of this study was to determine the change in range of motion (ROM) of the human thoracic spine and rib cage due to sequential Ponte osteotomies (POs). Summary of Background Data POs are often performed in deformity correction surgeries to provide flexibility in the sagittal plane at an estimated correction potential of 5° per PO, but no studies have evaluated the biomechanical impact of the procedure on a cadaveric model with an intact rib cage. Methods Seven human thoracic cadavers with intact rib cages were loaded with pure moments in flexion, extension, axial rotation, and lateral bending for five conditions: intact, PO at T9–T10, PO at T8–T9, PO at T7–T8, and PO at T6–T7. Motion of T1, T6, and T10 were measured, and overall (T1–T12) and regional (T6–T10) ROMs were reported for each mode of bending at each condition. Results POs increased ROM in flexion both overall (T1–T12) and regionally (T6–T10), although the magnitude of the increase was marginal (<1°/PO). No significant differences were found in axial rotation or lateral bending. Conclusions POs may increase sagittal correction potential before fusion in patients with hyperkyphosis, though more work should be done to determine the magnitude of the changes. Level of Evidence Level V. © 2016 Scoliosis Research Society

关键词： Biomechanics Ponte Release Smith-Petersen Thoracic spine

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Microfluidic Devices for Nanoparticle Targeted Delivery and Permeability Evaluation

Microfluidic Devices for Nanoparticle Targeted Delivery and ...

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2016年大连国际微流控和芯片实验室大会

作者： Yaling Liu Antony Thomas Chris Uhl Department of Mechanical Engineering and Mechanics Bioengineering ProgramLehigh University

This talk covers characterization and evaluation of nanoparticle targeted delivery and permeability *** systems have been widely used in diagnostic imaging and targeted therapeutic applications in recent *** of the major challenges in nanomedicine is to improve particle selectivity and adhesion efficiency under complex vascular flow *** developed an integrated microvascular mimetic microfluidic testing platform to evaluate nanoparticle targeted delivery under vascular flow.A monolayer of endothelium cell is formed in the channel and activated locally through TNF-α to mimic the physiological diseased *** binding dynamics and permeability under a range of shear rates are characterized to evaluate the targeting *** aim to provide a systematic design and evaluation tool toward a virtual vascular platform for nanomedicine testing.

关键词： Microfluidic Devices for Nanoparticle Targeted Delivery and Permeability Evaluation

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Patterned Microfluidic Devices for Efficient and Selective Capture of Circulating Tumor Cells

Patterned Microfluidic Devices for Efficient and Selective C...

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2016年大连国际微流控和芯片实验室大会

作者： Yaling Liu Shunqiang Wang Shu Yang Xuanhong Chen Department of Mechanical Engineering and Mechanics Bioengineering ProgramLehigh University

Circulating tumor cells(CTCs) hold great promise for cancer diagnosis and prognosis,especially for early-stage cancer *** the significant progress in development of cell capture techniques,the capture efficiency is still limited and often accompanied with drawbacks such as low throughput,low selectivity,and cell viability *** designed a surface with both micro and nano features which significantly enhance capture efficiency and selectivity of cancer cells.A systematic study on the effects of micro pattern and nano feature design on adhesion is performed on antibody functionalized ***-ripples of different wavelengths/amplitudes and nano feature coating with different sizes and densities are *** results show signficantly improved cell capture yield and selectivity over a wide range of shear rates.

关键词： Patterned Microfluidic Devices for Efficient and Selective Capture of Circulating Tumor Cells

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Multi-modality in gene regulatory networks with slow promoter kinetics

arXiv

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arXiv 2017年

作者： Al-Radhawi, M. Ali Vecchio, Domitilla Del Sontag, Eduardo D. Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139-4307 United States Departments of Bioengineering and of Electrical and Computer Engineering Northeastern University BostonMA02115 United States Harvard Program in Therapeutic Science Harvard Medical School BostonMA02115 United States

Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, different phenotypes are associated with alternative states of complex nonlinear systems: stable attractors in deterministic models or modes of stationary distributions in stochastic descriptions. We provide theoretical and practical characterizations of these landscapes, specifically focusing on stochastic slow promoter kinetics, a time scale relevant when transcription factor binding and unbinding are affected by epigenetic processes like DNA methylation and chromatin remodeling. In this case, largely unexplored except for numerical simulations, adiabatic approximations of promoter kinetics are not appropriate. In contrast to the existing literature, we provide rigorous analytic characterizations of multiple modes. A general formal approach gives insight into the influence of parameters and the prediction of how changes in GRN wiring, for example through mutations or artificial interventions, impact the possible number, location, and likelihood of alternative states. We adapt tools from the mathematical field of singular perturbation theory to represent stationary distributions of Chemical Master Equations for GRNs as mixtures of Poisson distributions and obtain explicit formulas for the locations and probabilities of metastable states as a function of the parameters describing the system. As illustrations, the theory is used to tease out the role of cooperative binding in stochastic models in comparison to deterministic models, and applications are given to various model systems, such as toggle switches in isolation or in communicating populations, a synthetic oscillator and a trans-differentiation network. Copyright © 2017, The Authors. All rights reserved.

关键词： Stochastic systems

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A Full Eulerian Method for Fluid-structure Interaction Problems

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Procedia IUTAM 2017年 20卷 159-166页

作者： Kazuyasu Sugiyama Satoshi Ii Kazuya Shimizu Shigeho Noda Shu Takagi Department of Mechanical Science and Bioengineering Osaka University 1-1 Machikaneyama Toyonaka Osaka 560-0043 Japan School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Computational Science Research Program RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

An efficient and scalable numerical method for massively parallel computing of fluid-structure interaction systems has been developed for biomedical applications. To facilitate the treatment of complex geometry, a full Eulerian method is employed to couple the incompressible motions of fluid and hyperelastic materials. Instead of implicitly solving the pressure Poisson equation, a novel artificial compressibility method with adaptive parameters, which are determined to guarantee the computed field to be nearly incompressible, is proposed. In both weak and strong scaling tests, the developed solver attains excellent scalability on the K computer. A sustained performance of 4.54 Pflops (42.7% of peak) has been achieved for a microchannel flow involving more than 5 million deformable bodies using 6.96 × 10 11 grid points with 663,552 compute cores. We study arteriole blood flows in a brain to gain insight into dynamic interactions among motions of plasma and blood cells, which are relevant to initial thrombus formations.

关键词： Eulerian method artificial compressibility method fluid-structure interaction blood flow

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