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Biospecies capture and detection at low concentration

Micro and Nanosystems 2012年第4期4卷 254-272页

作者： Liu, Yaling Wang, Shunqiang Song, Yu Yang, Jie Department of Mechanical Engineering and Mechanics Lehigh University Bethlehem PA 18015 United States Bioengineering Program Lehigh University Bethlehem PA 18015 United States

For the past century, capture and detection of biospecies such as cells, DNA, and biomarkers at low concentration has been extensively studied by chemists, physicists, and engineers. Various methods including computational modeling, microfluidics, electrical, magnetic, and optical manipulation, have been proposed. In this review, we discuss recent advances in biospecies capture and detection at low concentration. Techniques applied in detection and capture of cells, DNA and biomarkers at low concentration are introduced first. Furthermore, concentrating of microparticles at low concentration is reviewed as a pre-concentration step and enhancement process for biospecies capture and detection. Finally, the applications of biospecies capture and detection in biochemistry analysis and medical diagnosis are discussed. © 2012 Bentham Science Publishers.

关键词： Biomarkers

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Microchannels: In Situ Realization of Asymmetric Ratchet Structures within Microchannels by Directionally Guided Light Transmission and Their Directional Flow Behavior (Adv. Mater. 17/2014)

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Advanced Materials 2014年第17期26卷

作者： Won‐Gyu Bae Sang Moon Kim Se‐Jin Choi Sang Geun Oh Hyunsik Yoon Kookheon Char Kahp Y. Suh School of Mechanical & Aerospace Engineering Seoul National University Seoul 151‐742 Republic of Korea Interdisciplinary Program of Bioengineering Seoul National University Seoul 151‐742 Republic of Korea MCNet Co. Ltd. Room 307‐1 Building 103 SK Ventium Dangjeong‐dong Gunpo‐si Gyeonggi‐do 435‐833 Korea Department of Chemical & Biomolecular Engineering Seoul National University of Science & Technology Seoul 139‐743 Republic of Korea The National Initiative Creative Research Center for Intelligent Hybrids & the World Class University Program for Chemical Convergence for Energy & Environment School of Chemical & Biological Engineering Seoul National University Seoul 151‐744 Republic of Korea

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Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins

Distinct mechanisms of FAK mechanoactivation by different ex...

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第五届中美生物医学工程暨海内外生物力学学术研讨会

作者： Jihye Seong Arash Tajik Jie Sun Jun-Lin Guan Martin J.Humphries Susan E.Craig Asha Shekaran Andres J.Garcia Ning Wang Yingxiao Wang Neuroscience Program University of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Mechanical Science and Engineering University of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Bioengineering & Beckman Institute for Advanced Science and Technology University of IllinoisUrbana-ChampaignUrbanaIL61801USA Division of Molecular Medicine and Genetics Departments of Internal Medicine and Cell & Developmental BiologyUniversity of Michigan Medical SchoolAnn ArborMI48109USA Wellcome Trust Centre for Cell-Matrix Research Faculty of Life SciencesUniversity of ManchesterManchesterUK Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGA30332USA Department of Biomedical Engineering School of Life Science and TechnologyHuazhong University of Science and Technology Department of Integrative and Molecular Physiology Center for Biophysics and Computational BiologyInstitute for Genomic BiologyUniversity of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Bioengineering University of CaliforniaSan DiegoCA92093USA

Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,*** adhesions are the major sites of interaction between a cell and its extracellular matrix(ECM) microenvironment, thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor *** particular,it has been shown that matrix elasticity can control the cell fate

关键词： FAK Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins ECM

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Active manipulation of ECM stiffness and its effect on endothelial cell migration during angiogenesis

Active manipulation of ECM stiffness and its effect on endot...

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2012 World Congress on engineering, WCE 2012

作者： Chen, Peter C.Y. Herath, Sahan C.B. Wang, Dong-An Asada, Harry Department of Mechanical Engineering National University of Singapore Singapore Singapore Biosystem and Micromechanics Interdisciplinary Research Group Singapore-MIT Alliance for Research and Technology Program Singapore Singapore Division of Bioengineering Nanyang Technological University Singapore Singapore Department of Mechanical Engineering Massachusetts Institute of Technology United States

ISBN: (纸本)9789881925138

We have developed an engineering approach for actively manipulating the local stiffness of the extracellular matrix (ECM) and studied its effect on the migration of endothelial cells (ECs). In this approach, magnetic beads are embedded in an ECM through bio-conjugation between the Streptavidin-coated beads and the collagen fibers in order to alter the local stiffness of the ECM with the application of an external magnetic field. Our experimental results show that the magnetic forces acting on the embedded beads influence the behaviour of ECs during angiogenesis. These results suggest the possibility of creating desired stiffness gradients in an ECM for manipulating cell behavior in vitro. © 2012 Newswood Limited. All rights reserved.

关键词： Stiffness matrix

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Microstructures: Structure and Energetics of Dislocations at Micro‐Structured Complementary Interfaces Govern Adhesion (Adv. Funct. Mater. 27/2013)

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Advanced Functional Materials 2013年第27期23卷

作者： Congrui Jin Anand Jagota Chung‐Yuen Hui Field of Theoretical and Applied Mechanics Sibley School of Mechanical and Aerospace Engineering Cornell University Ithaca NY 14850 USA Department of Chemical Engineering and Bioengineering Program Lehigh University Bethlehem PA 18015 USA

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Assemble single stranded DNA and gold nanoparticle complexes onto the surface of RBC

Assemble single stranded DNA and gold nanoparticle complexes...

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Annual Northeast bioengineering Conference

作者： Jia Hu Antony Thomas Kyle Selditch Yaling Liu Department of Mechanical Engineering and Mechanics Bioengineering Program Lehigh University Bethlehem PA USA

This work aims to assemble single stranded DNA(ssDNA) and gold nanoparticles(AuNPs) into microstructures. The building units of the microstructure first consist of two AuNPs each with one of two sequences of ssDNA attached to their surfaces each with a fluorophore at the free end. A larger piece of hairpin loop ssDNA will then be added with each of its ends complimentary to one of the two ssDNA strands already on the AuNPs. A red blood cell is used as a template for DNA and gold nanoparticles to assemble around. ssDNA-AuNPs binding was confirmed using confocal laser scanning microscope which shows fluorescence in samples after binding.

关键词： Fluorescence DNA Gold Nanoparticles Shape Assembly Materials

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A multiphase model for Nanoparticle delivery in microcirculation

A multiphase model for Nanoparticle delivery in microcircula...

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Annual Northeast bioengineering Conference

作者： Jifu Tan Antony Thomas Yaling Liu Department of Mechanical Engineering and Mechanics Lehigh University Bethlehem PA USA Department of Mechanical Engineering and Mechanics Bioengineering Program Lehigh University Bethlehem PA USA

In this paper, a particle-cell multiphase model is developed to model Nanoparticle (NP) transport, dispersion, and binding dynamics in blood suspension under the influence of Red blood cells (RBCs). The motion and deformation of RBCs is captured through the Immersed Finite Element Method. The motion and adhesion of individual NPs are tracked through Brownian adhesion dynamics. A mapping algorithm and an interaction potential function are introduced to consider the cell-particle collision. NP dispersion and binding rates are derived from the developed model under various rheology conditions. The influence of RBCs, vascular flow rate, and particle size on NP distribution and delivery efficacy is characterized. A non-uniform NP distribution profile with higher particle concentration near the vessel wall is observed. Such distribution leads to over 50% higher particle binding rate compared to the case without RBC considered. The tumbling motion of RBCs in the core region of the capillary is found to enhance NP dispersion, with dispersion rate increases as shear rate increases. Results from this study contribute to the fundamental understanding and knowledge on how the particulate nature of blood influences NP delivery, which will provide mechanistic insights on the nanomedicine design for targeted drug delivery.

关键词： Dispersion Dynamics Blood Finite element methods Adhesives Mathematical model Nanobioscience

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Towards a terramechanics for bio-inspired locomotion in granular environments

Towards a terramechanics for bio-inspired locomotion in gran...

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13th Biennial ASCE Aerospace Division International Conference on engineering, Science, Construction, and Operations in Challenging Environments, Earth and Space 2012 and the 5th NASA/ASCE Workshop on Granular Materials in Space Exploration

作者： Li, Chen Ding, Yang Gravish, Nick Maladen, Ryan D. Masse, Andrew Umbanhowar, Paul B. Komsuoglu, Haldun Koditschek, Daniel E. Goldman, Daniel I. School of Physics Georgia Institute of Technology Atlanta GA 30332 United States Interdisciplinary Bioengineering Program Georgia Institute of Technology Atlanta GA 30332 United States Department of Mechanical Engineering Northwestern University Evanston IL 60208 United States Department of Electrical and Systems Engineering University of Pennsylvania Philadelphia PA 19104 United States

ISBN: (纸本)9780784412190

Granular media (GM) present locomotor challenges for terrestrial and extraterrestrial devices because they can flow and solidify in response to localized intrusion of wheels, limbs, and bodies. While the development of airplanes and submarines is aided by understanding of hydrodynamics, fundamental theory does not yet exist to describe the complex interactions of locomotors with GM. In this paper, we use experimental, computational, and theoretical approaches to develop a terramechanics for bio-inspired locomotion in granular environments. We use a fluidized bed to prepare GM with a desired global packing fraction, and use empirical force measurements and the Discrete Element Method (DEM) to elucidate interaction mechanics during locomotion-relevant intrusions in GM such as vertical penetration and horizontal drag. We develop a resistive force theory (RFT) to account for more complex intrusions. We use these force models to understand the locomotor performance of two bio-inspired robots moving on and within GM. © ASCE 2012.

关键词： Finite difference method

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Self-assembled rosette nanotube composites improve chondrocyte functions

Self-assembled rosette nanotube composites improve chondrocy...

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2012 AIChE Annual Meeting, AIChE 2012

作者： Sun, Linlin Zhang, Lijie Hemraz, Usha D. Fenniri, Hicham Webster, Thomas J. Bioengineering Program College of Engineering Northeastern University 360 Huntington Avenue Boston MA 02115 United States Department of Mechanical and Aerospace Engineering George Washington University Washington DC 20052 United States National Institute for Nanotechnology Department of Chemistry and Biomedical Engineering University of Alberta 11421 Saskatchewan Drive Edmonton AB T6G 2M9 Canada

ISBN: (纸本)9780816910731

Even with intensive studies over the past several decades, cartilage injuries are still some of the most difficult challenges in medicine. The main reason is that cartilage has a limited regenerative capacity due to it non-vascular structure and small number of chondrocytes (or cartilage producing cells) able to heal cartilage damage. Novel materials for cartilage injury treatment and regeneration require biocompatibility and bioactivity to enhance chondrocyte functions as well as mechanical properties similar to natural cartilage [1]. With unique biological and mechanical properties, rosette nanotubes [2-6], which are selfassembled structures composed of DNA bases guanine and cytosine, have a strong potential to regenerate cartilage implants. In this study, one type of rosette nanotubes (termed TBL or twin base linkers) and poly(2-hydroxyethyl methacrylate) (pHEMA) were used to generate biocompatible, bioactive, and injectable composites for cartilage applications.

关键词： Cartilage

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ct Mechanism of FAK Mechanoactivation by Different Extracellular Matrix Proteins

ct Mechanism of FAK Mechanoactivation by Different Extracell...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Jihye Seong Arash Tajik Ning Wang Ying-xiao Wang Neuroscience Program University of Illinois Urbana-Champaign Urbana IL USA Department of Mechanical Science and EngineeringUniversity of Illinois Urbana-Champaign Urbana IL USA Neuroscience Program University of Illinois Urbana-Champaign Urbana IL USA Department of Bioengineering & Beckman Institute for Advanced Science and Te

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