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The development of video laryngoscope via additive manufacturing for use in a pre-hospital environment

Research on biomedical engineering 2024年第1期40卷 15-23页

作者： Alves, Marcio Allan Foggiatto, Jose Aguiomar Berti, Lucas Freitas Ulbricht, Leandra Graduate Program in Biomedical Engineering Universidade Federal Tecnológica do Paraná Curitiba Brazil Graduate Program in Mechanical and Materials Engineering Universidade Federal Tecnológica do Paraná Curitiba Brazil

Purpose: Due to failures that occur during intubation, some authors advocate that intubation should always be done with a video laryngoscope. What makes the implementation of this recommendation difficult, especially in developing countries, is the high price of the device. Thus, the objective of this study is to present a low-cost video laryngoscope developed via additive manufacturing, being the first device to have the safety parameters duly tested according to the ISO 7673:2020 standard. Methods: A video laryngoscope with a Macintosh-type rigid blade was developed. After modeling it in the CAD-3D SolidWorks® program, the prototype was printed in PLA (polylactic acid), and load and fatigue tests were carried out with the MTS 810/793 testing machine. Results: The main results were an improvement in ergonomics (with a better fixation of the camera wire and camera positioning). Load and fatigue tests showed compliance with the requirements of the ISO 7673:2020 standard. The first is that when subjected to a traction force of 65 N, the center of illumination must not move more than 10 mm (the average movement was only 3.95 mm). The second is that when subjected to a traction force of 150 N, the laryngoscope blade must not break (348 N of load was applied and the piece resisted without breaking). Conclusion: It was shown that the Macintosh-type PLA video laryngoscope has the potential to become a safe and low-cost tool in the emergency intubation arsenal. © The Author(s), under exclusive licence to The Brazilian Society of biomedical engineering 2023.

关键词： 3D printing

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A possible solution for noise attenuation material for urban buses: The downtown São Paulo case study

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Noise and Vibration Worldwide 2025年第3期56卷 137-147页

作者： Monteiro, Elvis C Avila, Antonio F Division Stellantis Betim Brazil Mechanical Engineering Graduate Studies Program Universidade Federal de Minas Gerais Belo Horizonte Brazil Department of Mechanical Engineering and Mechanical Engineering Graduate Studies Program Universidade Federal de Minas Gerais Belo Horizonte Brazil

Urban buses, particularly in large cities, are exposed to significant noise pollution. This paper presents a new family of materials at the micro/nano level designed for urban noise attenuation, specifically for application in urban buses. Melamine foam is combined in series with nanomembranes, creating a composite material that functions as a Helmholtz resonator. As sound waves pass over the nanomembranes, they are disturbed, and the sound resonates within the melamine foam. This interaction reduces the energy of the sound waves and enhances the noise absorption coefficient. In ten cases studied, the average sound absorption coefficient was approximately 89%, with peak frequencies ranging from 2400 Hz to 4300 Hz. The average thickness of the nanomembranes was around 5.0 µm, while the melamine foam had a thickness of 13 mm. The mean noise reduction achieved was about 11 dB, which depends on factors such as the morphology, thickness, and pore size of the nanomembranes. A case study conducted in downtown São Paulo demonstrated that applying these materials to urban buses can significantly reduce interior noise levels. Finally, the proposed system is fully scalable and adaptable for various applications where acoustic insulation is required. © The Author(s) 2025.

关键词： Noise pollution

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A Novel SERS Substrate Containing Silver Nanoparticle-Deposited Photoresist Microcone Array for Sensitive Biosensing

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IEEE Sensors Journal 2024年第2期24卷 1398-1404页

作者： Lin, Ying-Ting Wang, Sheng-Hsiang Tseng, Yu-Hsin Lin, Ze-Cheng Chen, Jyun-Tu Chang, Cheng-Chung Wang, Gou-Jen National Chung Hsing University Program in Tissue Engineering and Regenerative Medicine Taichung40227 Taiwan National Chung Hsing University Department of Mechanical Engineering Taichung40227 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan

In this study, we developed a novel surface-enhanced Raman scattering (SERS) substrate formed by depositing silver nanoparticles (AgNPs) on a silver thin film-coated photoresist (PR) microcone array. The semiconductor photolithographic process was adopted for fabricating the PR microcone array. The hotspot enhancement effect of the SERS substrates was optimized by adjusting the concentration of the trisodium citrate, which was used as a reducing agent and a stabilizing agent for the synthesis of AgNPs. Experimental results showed that the proposed SERS substrate could detect the indicating peaks of Rhodamine 6G (R6G) at a relatively low concentration of 10-12 M. A standard detection curve for HbA1c detection with a linear detection range of 5000-20000 ng/mL with good linearity of 0.994 and a limit of detection (LOD) of 850.2 ng/mL was further established by adding HbA1c agent to artificial blood to simulate a real environmental condition. Recovery rate detection experiments confirmed the reproducibility of the established standard detection curve. © 2001-2012 IEEE.

关键词： Silver nanoparticles

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An Electrochemical HbA1c Immunosensor With a Simple Electrode of Gold Nanoparticle Monolayer

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IEEE Sensors Journal 2023年第15期23卷 16579-16584页

作者： Tseng, Chun-Chiang Lin, Ying-Ting Wang, Gou-Jen National Chung-Hsing University Department of Mechanical Engineering Taichung40227 Taiwan National Chung-Hsing University Program in Tissue Engineering and Regenerative Medicine Taichung40227 Taiwan National Chung-Hsing University Department of Mechanical Engineering The Graduate Institute of Biomedical Engineering Taichung40227 Taiwan

This study developed a novel electrochemical glycosylated hemoglobin (HbA1c) immunosensor. Polyethylene terephthalate (PET) was used as a substrate. After gold (Au) film sputtering on the PET surface, 1,6-hexanedithol with thiol groups on both terminals was used as an intermediary to attach a monolayer of uniformly distributed Au nanoparticles (AuNPs) to the Au thin film to form a nanostructured electrode. HbA1c antibodies were successfully immobilized on the AuNP monolayer via the self-assembled monolayer (SAM) approach. To mimic a real clinical detection environment, a calibration curve for HbA1c detection was performed in a mixture solution containing heparin sodium, red blood cell (RBC) lysis buffer, artificial human serum, and hemoglobin. The experimental results revealed that the proposed HbA1c immunosensor detected HbA1c in a linear range from 2500 to 10 000 ng/mL with a limit of detection of 2253 ng/mL. The developed HbA1c-sensing chip offers the advantages of simple operation, low cost, short detection time, and provides high feasibility for clinical application. © 2001-2012 IEEE.

关键词： Gold nanoparticles

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Feasibility Study of Finger Interface for Miniature Surgical Instruments 1

Feasibility Study of Finger Interface for Miniature Surgical...

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1st IEEE Conference on Telepresence, Telepresence 2024

作者： Cha, Serin Kim, Sebin Ryu, Seok Chang Ewha Womans University Graduate Program in Smart Factory BioRobotics Laboratory Department of Mechanical and Biomedical Engineering Seoul03760 Korea Republic of Ewha Womans University BioRobotics Laboratory Department of Mechanical and Biomedical Engineering Korea Republic of

ISBN: (纸本)9798331528249

This paper presents a study on the design of a finger interface to improve the teleoperation of a miniaturized surgical instrument with a bendable distal section. A unique design principle employing the kinematic similarity between the human motion and the follower robot has been proposed for such instruments, which may result in embodied teleoperation, enhancing the overall telepresence experience. According to the principle, a design for an index finger interface was proposed, consisting of a sub-unit measuring finger motion and a handle. When the interface is connected to a robotic platform, it can control the entire tool motion in two separate ways: distal bending by the sub-unit and overall tool motion by the handle. A human subject test was conducted for trajectory-following tasks in a virtual environment, and their performance score was quantified for analysis of the learning curve. Based on the satisfactory learning rate of 75.78% for all nine subjects, the proposed finger interface could be a promising interface for a miniature surgical instrument with a long bendable section at the distal end. © 2024 IEEE.

关键词： Machine design

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Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

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China Ocean engineering 2024年第4期38卷 689-700页

作者： Sunny Kumar POGULURI Dongeun KIM Yoon Hyeok BAE Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

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Influence of Biomimetic Apatite Coating on the Biobehavior of TiO_(2)Scaffolds

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Journal of Bionic engineering 2024年第4期21卷 1975-1986页

作者： Shima Mahtabian Seyed Mehdi Mirhadi Nahid Hassanzadeh Nemati Melika Sharifi Fariborz Tavangarian Department of Biomedical Engineering University of DelawareNewarkDE19716USA Department of Ceramic Engineering Islamic Azad University(Shahreza Branch)ShahrezaIsfahan86145-311Iran Department of Biomedical Engineering Islamic Azad University(Science and Research Branch)TehranIran Mechanical Engineering Program School of ScienceEngineering and TechnologyPennsylvania State UniversityHarrisburgMiddletownPA17057USA Department of Materials Science&Engineering Islamic Azad University(Najaf Abad Branch)Najaf AbadIsfahan***Iran Biomedical Engineering Department Pennsylvania State UniversityState CollegeUniversity ParkPennsylvania16802USA

Immersion of scaffolds in Simulated Body Fluid(10SBF)is a standardized method for evaluating their bioactivity,simulating in vivo conditions where apatite deposits can be formed on the surface of scaffold,facilitating bone integration and ensuring their suitability for bone implant purposes,ultimately contributing to long-term implant *** effect of apatite deposition on bioactivity and cell behavior of TiO_(2)scaffolds was *** were soaked in 10SBF for different durations to form HAP layer on their *** results proved the development of a hydroxyapatite film resembling the mineral composition of bone Extracellular Matrix(ECM)on the TiO_(2)*** XRD test findings showed the presence of hydroxyapatite layer similar to bone at the depth of 10 nm.A decrease in the specific surface area(18.913 m^(2)g^(−1)),the total pore volume(0.045172 cm^(3)g^(−1)(at p/p0=0.990)),and the mean pore diameter(9.5537 nm),were observed by BET analysis which confirmed the formation of the apatite *** was found that titania scaffolds with HAP coating promoted human osteosarcoma bone cell(MG63)cell attachment and *** seems that immersing the scaffolds in 10SBF to form HAP coating before utilizing them for bone tissue engineering applications might be a good strategy to promote bioactivity,cell attachment,and implant fixation.

关键词： Titania Hierarchical meso/macro porous 10SBF Biomimetic apatite Coating

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Enhancing the Versatility and Performance of Soft Robotic Grippers, Hands, and Crawling Robots Through Three-Dimensional-Printed Multifunctional Buckling Joints

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Soft Robotics 2024年第5期11卷 741-754页

作者： Yang, Chih-Wen Ou Yu, Shao-Yi Chan, Che-Wei Tseng, Chien-Yao Cai, Jing-Fang Huang, Han-Pang Juang, Jia-Yang Department of Mechanical Engineering National Taiwan University Taipei Taiwan Department of Mechanical Engineering University of California at Berkeley BerkeleyCA United States Program in Nanoengineering and Nanoscience Graduate School of Advanced Technology National Taiwan University Taipei Taiwan

Soft robotic grippers and hands offer adaptability, lightweight construction, and enhanced safety in human–robot interactions. In this study, we introduce vacuum-actuated soft robotic finger joints to overcome their limitations in stiffness, response, and load-carrying capability. Our design—optimized through parametric design and three-dimensional (3D) printing—achieves high stiffness using vacuum pressure and a buckling mechanism for large bending angles (>90◦) and rapid response times (0.24 s). We develop a theoretical model and nonlinear finite-element simulations to validate the experimental results and provide valuable insights into the underlying mechanics and visualization of the deformation and stress field. We showcase versatile applications of the buckling joints: a three-finger gripper with a large lifting ratio (*96), a five-finger robotic hand capable of replicating human gestures and adeptly grasping objects of various characteristics in static and dynamic scenarios, and a planar-crawling robot carrying loads 30 times its weight at 0.89 body length per second (BL/s). In addition, a jellyfish-inspired robot crawls in circular pipes at 0.47 BL/s. By enhancing soft robotic grippers’ functionality and performance, our study expands their applications and paves the way for innovation through 3D-printed multifunctional buckling joints. © Mary Ann Liebert, Inc.

关键词： Grippers

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Recent development in multizonal scaffolds for osteochondral regeneration

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Bioactive Materials 2023年第7期25卷 122-159页

作者： Le Yu Sacha Cavelier Brett Hannon Mei Wei Department of Chemical and Biomolecular Engineering Ohio UniversityAthensOH45701USA Biomedical Engineering Program Ohio UniversityAthensOH45701USA Department of Mechanical Engineering Ohio UniversityAthensOH45701USA

Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral *** contrast to the current surgical approaches which yield only short-term relief of symptoms,tissue engineering strategy has been shown more promising outcomes in treating OC defects since its emergence in the *** particular,the use of multizonal scaffolds(MZSs)that mimic the gradient transitions,from cartilage surface to the subchondral bone with either continuous or discontinuous compositions,structures,and properties of natural OC tissue,has been gaining momentum in recent *** the latest developments in the field,this review offers a comprehensive summary of recent advances,current hurdles,and future perspectives of OC repair,particularly the use of MZSs including bilayered,trilayered,multilayered,and gradient scaffolds,by bringing together onerous demands of architecture designs,material selections,manufacturing techniques as well as the choices of growth factors and cells,each of which possesses its unique challenges and opportunities.

关键词： Multizonal scaffolds Osteochondral regeneration Fabrication Cells Growth factors

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CHITOSAN-COLLAGEN COMPOSITE SCAFFOLDS FOR GROWTH DIRECTION GUIDANCE OF PC12 AXONS

CHITOSAN-COLLAGEN COMPOSITE SCAFFOLDS FOR GROWTH DIRECTION G...

引用

ASME 2024 International Design engineering Technical Conferences and Computers and Information in engineering Conference, IDETC-CIE 2024

作者： Tsai, Po-Yu Lin, Ying-Ting Wang, Gou-Jen Graduate Institute of Biomedical Engineering National Chung-Hsing University Taichung Taiwan PhD Program in Tissue Engineering and Regenerative Medicine National Chung-Hsing University Taichung Taiwan Department of Mechanical Engineering Graduate Institute of Biomedical Engineering National Chung-Hsing University Taichung Taiwan

ISBN: (纸本)9780791888421

In this study, nerve conduits of chitosan and collagen composites with biocompatibility and biodegradability were fabricated. The effects of material composition and surface morphology on the axonal growth and directionality of rat epinephric pheochromocytoma PC12 were investigated. The cells were separated by a PDMS structure to simulate nerve injury, and the growth of axons of PC12 cells was observed under the separation of large gaps. At the same time, mitochondria extracted from osteosarcoma cybrid cells (C2-GFP) were added to the culture to investigate the effect of healthy mitochondria on axon differentiation and growth. The experimental results showed that the chitosan-collagen composite film can promote the growth of PC12 axons more effectively than the pure chitosan film. Cell culture results at different groove widths also showed that smaller grooves resulted in more axon numbers and longer axon lengths. Nerve injury simulation experiments showed that the nerve repair could be almost completed after 12 days of culture. Copyright © 2024 by ASME.

关键词： Mitochondria

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