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1st IEEE Colombian Caribbean Conference, C3 2023

作者： Ulhoa, Pedro Fiorezi, Guilherme Filho, Teodiano Andrade, Rafhael Universidade Federal Do Espírito Santo Department of Electrical Engineering Vitória Brazil Universidade Federal Do Espírito Santo Department of Mechanical Engineering Vitória Brazil Universidade Federal Do Espírito Santo Graduate Program in Electrical Engineering Vitória Brazil Universidade Federal Do Espírito Santo Graduate Program in Mechanical Engineering Vitória Brazil

ISBN: (纸本)9798350341799

Rehabilitation of amputees is still mostly limited to passive technology that cannot provide energy to the gait and contribute to a better experience and comfort of walking. To address this shortcoming, active prostheses have been introduced with actuators capable of generating and dissipating energy in a controlled way. However, proposed designs of powered leg prosthesis still present heavy and bulky structure or low backdrivable actuators, which reduce the volitional control and comfort of the user. This work presents the development and control of a lightweight and highly backdrivable powered knee prosthesis. The designed actuator is composed by a coaxial motor-reducer with a 200 W brushless DC motor in series with a harmonic drive with a 51:1 ratio. After assembled the leg prosthesis weights just 3.64 kg. Bench tests were performed to validate the model and tune a position-based controller. Then, a custom force sensor was implemented to measure ground reaction force and identify gait phases so an impedance controller can regulate joint torque. The powered prosthesis was experimented in three able-bodied subjects walking on a treadmill using both the position and impedance controller. The prosthesis presented high backdrivability in bench tests and the treadmill results shown that the proposed impedance controller was more effective to follow the healthy knee trajectory compared to the position controller. In future works we plan to evaluate the prosthesis in amputee subjects. © 2023 IEEE.

关键词： Controllers

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3D-printed porous titanium suture anchor: a rabbit lateral femoral condyle model

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BMC Musculoskeletal Disorders 2024年第1期25卷 1页

作者： Wu, Lien-Chen Hsieh, Yueh-Ying Hsu, Ting-Shuo Liu, Po-Yi Tsuang, Fon-Yih Kuo, Yi-Jie Chen, Chia-Hsien Van Huynh, T.I.N. Chiang, Chang-Jung Department of Orthopaedics Shuang Ho Hospital Taipei Medical University Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Division of Neurosurgery Department of Surgery National Taiwan University Hospital Spine Tumor Center National Taiwan University Hospital Department of Orthopedic Surgery Wan Fang Hospital Taipei Medical University School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Department of Interventional Cardiology Thong Nhat Hospital International Ph.D program in medicine college of medicine Taipei medical university

Background: The inclusion of a connecting path in a porous implant can promote nutrient diffusion to cells and enhance bone ingrowth. Consequently, this study aimed to evaluate the biomechanical, radiographic, and histopathological performance of a novel 3D-printed porous suture anchor in a rabbit femur model. Methods: Three test groups were formed based on the type of suture anchor (SA): Commercial SA (CSA, Group A, n = 20), custom solid SA (CSSA, Group B, n = 20), and custom porous SA (CPSA, Group C, n = 20). The SAs were implanted in the lateral femoral condyle of the right leg in each rabbit. The rabbits (New Zealand white rabbits, male, mean body weight of 2.8 ± 0.5 kg, age 8 months) underwent identical treatment and were randomized into experimental and control groups via computer-generated randomization. Five rabbits (10 femoral condyles) were euthanized at 0, 4, 8, and 12 weeks post-implantation for micro-CT, histological analysis, and biomechanical testing. Results: At 12 weeks, the CPSA showed a higher BV/TV (median 0.7301, IQR 0.7276–0.7315) than the CSSA and CSA. The histological analysis showed mineralized osteocytes near the SA. At 4 weeks, new bone was observed around the CPSA and had penetrated its porous structure. By 12 weeks, there was no significant difference in ultimate failure load between the CSA and CPSA. Conclusions: We demonstrated that the innovative 3D-printed porous suture anchor exhibited comparable pullout strength to conventional threaded suture anchors at the 12-week postoperative time-point period. Furthermore, our porous anchor design enhanced new bone formation and facilitated bone growth into the implant structure, resulting in improved biomechanical stability. © The Author(s) 2024.

关键词： 3D-printed porous anchor Bone formation Bone ingrowth Suture anchor

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High sound pressure piezoelectric micromachined ultrasonic transducers using sputtered potassium sodium niobate

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Microsystems & Nanoengineering 2024年第6期10卷 311-323页

作者： Fan Xia Yande Peng Wei Yue Mingze Luo Megan Teng Chun-Ming Chen Sedat Pala Xiaoyang Yu Yuanzheng Ma Megha Acharya Ryuichi Arakawa Lane W.Martin Liwei Lin Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA School of Electronic Science and Engineering Southeast UniversityNanjingJiangsu 210096China Bioengineering and Biomedical Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Scientific Research Laboratory Div. Niterra Co.LtdNagoya 461-0005Japan Departments of Materials Science and NanoEngineering Chemistryand Physics and Astronomy and the Rice Advanced Materials InstituteRice UniversityHoustonTX 77005USA

This work presents air-coupled piezoelectric micromachined ultrasonic transducers(pMUTs)with high sound pressure level(SPL)under low-driving voltages by utilizing sputtered potassium sodium niobate K0.34Na0.66NbO3(KNN)films.A prototype single KNN pMUT has been tested to show a resonant frequency at 106.3 kHz under 4 Vp-p with outstanding characteristics:(1)a large vibration amplitude of 3.74μm/V,and(2)a high acoustic root mean square(RMS)sound pressure level of 105.5 dB/V at 10 cm,which is 5–10 times higher than those of AlN-based pMUTs at a similar *** are various potential sensing and actuating applications,such as fingerprint sensing,touch point,and gesture *** this work,we present demonstrations in three fields:haptics,loudspeakers,and *** haptics,an array of 15×15 KNN pMUTs is used as a non-contact actuator to provide a focal pressure of around 160.3 dB RMS SPL at a distance of 15 *** represents the highest output pressure achieved by an airborne pMUT for haptic sensation on human *** used as a loudspeaker,a single pMUT element with a resonant frequency close to the audible range at 22.8 kHz is *** is shown to be able to generate a uniform acoustic output with an amplitude modulation *** the rangefinder application,pulse-echo measurements using a single pMUT element demonstrate good transceiving results,capable of detecting objects up to 2.82 m *** such,this new class of high-SPL and low-driving-voltage pMUTs could be further extended to other applications requiring high acoustic pressure and a small form factor.

关键词： potassium piezoelectric sound

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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

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Removal of As(V)in the presence of Cr(VI)in contaminated water from the Bajio region of Mexico using ferrihydrite-functionalized graphene oxide(GOFH):A case study

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Emerging Contaminants 2024年第3期10卷 134-144页

作者： D.R.Joya-Cardenas J.P.Rodríguez-Caicedo M.A.Corona-Rivera N.Saldana-Robles C.E.Damian-Ascencio A.Saldana-Robles Graduate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad de Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico Department of Agricultural Engineering University of GuanajuatoIrapuato36500Mexico Department of Mechanical Engineering University of GuanajuatoSalamanca36800Mexico Mechanical Engineering Department Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and chromium(Cr)can be considered one of the most toxic heavy *** study aims to develop and evaluate a graphene oxide(GO)based material functionalized with ferrihydrite for the removal of As(V)in the presence of Cr(VI).The adsorbent ferrihydrite-functionalized graphene oxide(GOFH)was characterized by SEM,FTIR,XRD,XPS,surface charge,BET and *** adsorption capacities for As(V)and Cr(VI)were 160 and 66 mg g^(-1)respectively at pH 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(V)with an adsorption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(VI)at room *** analysis revealed an exothermic and spontaneous ***,GOFH effectively removed several coexisting anions from groundwater,including SO_(4)^(2-),CO_(3)^(2-)and Cl^(-).This work evidences the potential of GOFH for competitive adsorption of priority pollutants from complex *** GOFH material represents a technically and economically viable technology for application in groundwater decontamination,as it requires inexpensive precursors and ambient conditions during synthesis and operation.

关键词： Competition Ions Contamination Groundwater Adsorption capacity

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A novel label-free electrochemical immunosensor for the detection of heat shock protein 70 of lung adenocarcinoma cell line following paclitaxel treatment using l-cysteine-functionalized Au@MnO2/MoO3 nanocomposites

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RSC Advances 2023年第43期13卷 29847-29861页

作者： Chen, Yi-An Shie, Ming-You Ho, Chia-Che Ye, Sheng-Wen Chen, I.-Wen Peter Shih, Yu-Yin Shen, Yu-Fang Chen, Yi-Wen x-Dimension Center for Medical Research and Translation China Medical University Hospital Taichung City404332 Taiwan The Master Program for Biomedical Engineering China Medical University Taichung City406040 Taiwan Department of Biomedical Engineering China Medical University Taichung City40447 Taiwan Department of Bioinformatics and Medical Engineering Asia University Taichung City41354 Taiwan Department of Chemistry National Cheng Kung University Tainan70101 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung City40447 Taiwan

The future trend in achieving precision medicine involves the development of non-invasive cancer biomarker sensors that offer high accuracy, low cost, and time-saving benefits for risk clarification, early detection, disease detection, and therapeutic monitoring. A facile approach for the synthesis of MoO3 nanosheets was developed by thermally oxidizing MoS2 nanosheets in air followed by thermal annealing. Subsequently, Au@MnO2 nanocomposites were prepared using a combined hydrothermal process and in situ chemical synthesis. In this study, we present a novel immunosensor design strategy involving the immobilization of antiHSP70 antibodies on Au@MnO2/MoO3 nanocomposites modified on a screen-printed electrode (SPE) using EDC/NHS chemistry. This study establishes HSP70 as a potential biomarker for monitoring therapeutic response during anticancer therapy. Impedance measurements of HSP70 on the Au@MnO2/MoO3/SPE immunosensor using EIS showed an increase in impedance with an increase in HSP70 concentration. The electrochemical immunosensor demonstrated a good linear response in the range of 0.001 to 1000 ng mL−1 with a detection limit of 0.17 pg mL−1 under optimal conditions. Moreover, the immunosensor was effective in detecting HSP70 at low concentrations in a lung adenocarcinoma cell line following Paclitaxel treatment, indicating its potential for early detection of the HSP70 biomarker in organ-on-a-chip and clinical applications. © 2023 The Royal Society of Chemistry.

关键词： Nanosheets

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Helical swimming motion driven by coordinated rotation of flagellar apparatus in marine bacterial cells

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Journal of Biomechanical Science and engineering 2025年第1期20卷 1-11页

作者： SHIMOGONYA, Yuji RUAN, Juanfang KATO, Takayuki ISHIKAWA, Takuji NAMBA, Keiichi WU, Long-Fei NISHIYAMA, Masayoshi Department of Mechanical Engineering College of Engineering Nihon University 1 Nakagawara Tokusada Tamuramachi Koriyama Fukushima963-8642 Japan Graduate School of Frontier Biosciences Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Institute for Protein Research Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Department of Biomedical Engineering Graduate School of Biomedical Engineering Tohoku University 6-6-01 Aoba Sendai Miyagi980-8579 Japan Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aoba Sendai Miyagi980-8579 Japan JEOL YOKOGUSHI Research Alliance Laboratories Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Aix Marseille Université CNRS Laboratoire de Chimie Bactérienne Marseille CedexF-13402 France Department of Science Faculty of Science and Engineering KINDAI University 3-4-1 Kowakae Higashiosaka Osaka577-8502 Japan

The magnetotactic bacterium MO-1 possesses a pair of unique flagellar apparatuses. Each apparatus comprises seven flagella and 24 thin fibrils enclosed in a sheath. Using these apparatuses, the cells swim at high speed through solutions, tracing helical trajectories. The mechanism by which MO-1 cells utilize their two flagellar apparatuses to propel the cell body remains unclear. Due to the short length of the flagellar apparatus, direct observation of individual movements under a microscope is technically challenging. In this study, we performed numerical simulations based on the boundary element method to investigate the swimming motility of MO-1 cells. Our cell models successfully reproduced the helical trajectories of active MO-1 cells. The two flagellar apparatuses were positioned at the front and back of the cell body relative to the direction of movement. The cell body was pulled by the anterior flagellar apparatus and pushed by the posterior apparatus. The swimming motion of the cell model exhibited minimal changes near a wall. This unique swimming behavior of MO-1 cells could only be achieved through the rotation of both flagellar apparatuses. Based on the revolution rate of active MO-1 cells, we estimated the rotational speed of the flagellar apparatus to be approximately 1200 s-1. This rapid rotation may result from the tight packing of flagellar filaments within the sheath. Our study elucidates the mechanism by which active MO-1 cells swim in helical trajectories. © 2025 The Japan Society of mechanical Engineers.

关键词： Rotation

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Identification of benefits, challenges, and pathways in E-commerce industries: An integrated two-phase decision-making model

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Sustainable Operations and Computers 2023年第1期4卷 200-218页

作者： Gupta, Srikant Kushwaha, Pooja.S. Badhera, Usha Chatterjee, Prasenjit Gonzalez, Ernesto D.R. Santibanez Department of Operations and Decision Sciences Jaipuria Institute of Management Jaipur India Department of Business Analytics Jaipuria Institute of Management Indore India Department of Business Analytics Jaipuria Institute of Management Jaipur India Department of Mechanical Engineering MCKV Institute of Engineering West Bengal 711204 India Post-Doctoral Fellow Management Graduate Program Universidade Paulista Indianópolis Campus Brazil Department of Industrial Engineering and CES 4.0 Faculty of Engineering University of Talca Curico Chile

The e-commerce industry has seen significant growth over the past decade as it focuses on convenience and accessibility, leading to a surge in online shopping with more and more consumers opting for it. At the same time, the e-commerce industry faces various challenges. In order to fully harness the potential of this industry, it is important to identify its benefits and challenges and focus on pathways to mitigate the challenges and harness its growth. This study utilizes the Delphi approach and involves experts from the e-commerce domain to get their opinions to identify the top ten benefits, challenges, and pathways for the e-commerce industry. Analytic Hierarchy Process (AHP) and Criteria Importance Through Intercriteria Correlation (CRITIC) methods are subsequently, employed to prioritize the identified factors. Results of the study revealed that factors such as affordable advertising & marketing;availability and product variety;and Global reachability are the most important benefits, while technological upgradation;returns or refunds;and counterfeit products posed the greatest challenges for the industry. Government compliance check;better relationship with delivery partners;and strong data privacy and online security policies emerged as the best pathways. This study also provides valuable insights to businesses, policymakers, and researchers in the e-commerce industry on how to navigate the benefits, challenges, and pathways of this rapidly growing sector. © 2023

关键词： Electronic commerce

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Plasma-Enabled Graphene Quantum Dot Hydrogel-Magnesium Composites as Bioactive Scaffolds for In Vivo Bone Defect Repair

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ACS Applied Materials and Interfaces 2023年第38期15卷 44607-44620页

作者： Wong, Pei-Chun Kurniawan, Darwin Wu, Jia-Lin Wang, Wei-Ru Chen, Kuan-Hao Chen, Chieh-Ying Chen, Ying-Chun Veeramuthu, Loganathan Kuo, Chi-Ching Ostrikov, Kostya Ken Chiang, Wei-Hung Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Orthopedics Research Center Taipei Medical University Hospital Taipei110 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei110 Taiwan Centers for Regional Anesthesia and Pain Medicine Wan Fang Hospital Taipei Medical University Taipei110 Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei235 Taiwan Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Molecular Science and Engineering Institute of Organic and Polymeric Materials National Taipei University of Technology Taipei106 Taiwan BrisbaneQLD4000 Australia

Bioactive and mechanically stable metal-based scaffolds are commonly used for bone defect repair. However, conventional metal-based scaffolds induce nonuniform cell growth, limiting damaged tissue restoration. Here, we develop a plasma nanotechnology-enhanced graphene quantum dot (GQD) hydrogel-magnesium (Mg) composite scaffold for functional bone defect repair by integrating a bioresource-derived nitrogen-doped GQD (NGQD) hydrogel into the Mg ZK60 alloy. Each scaffold component brings major synergistic advantages over the current alloy-based state of the art, including (1) mechanical support of the cortical bone and calcium deposition by the released Mg2+ during degradation;(2) enhanced uptake, migration, and distribution of osteoblasts by the porous hydrogel;and (3) improved osteoblast adhesion and proliferation, osteogenesis, and mineralization by the NGQDs in the hydrogel. Through an in vivo study, the hybrid scaffold with the much enhanced osteogenic ability induced by the above synergy promotes a more rapid, uniform, and directional bone growth across the hydrogel channel, compared with the control Mg-based scaffold. This work provides insights into the design of multifunctional hybrid scaffolds, which can be applied in other areas well beyond the demonstrated bone defect repair. © 2023 American Chemical Society.

关键词： Semiconductor quantum dots

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A Novel Approach to Breast Tumor Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Imaging

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Computers, Materials & Continua 2024年第5期79卷 1875-1901页

作者： K.Umapathi S.Shobana Anand Nayyar Judith Justin R.Vanithamani Miguel Villagómez Galindo Mushtaq Ahmad Ansari Hitesh Panchal Department of Biomedical Engineering KIT-Kalaignarkarunanidhi Institute of TechnologyCoimbatore641402India Graduate School Faculty of Information TechnologyDuy Tan UniversityDa Nang550000Viet Nam Department of Biomedical and Instrumentation Engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatore641043India UniversidadMichoacana de SanNicolás de HidalgoAvenida Francisco J.Múgica S/N Ciudad Universitaria MoreliaCP58030Mexico Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Mechanical Engineering Gujarat Technological UniveristyNigam NagarChandkhedaAhmedabadGujarat382424India

Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effectivetreatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breastcancer fromultrasound images. The primary challenge is accurately distinguishing between malignant and benigntumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentationand classification. The main objective of the research paper is to develop an advanced methodology for breastultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, andmachine learning-based classification. A unique approach is introduced that combines Enhanced Speckle ReducedAnisotropic Diffusion (SRAD) filters for speckle noise reduction, U-NET-based segmentation, Genetic Algorithm(GA)-based feature selection, and Random Forest and Bagging Tree classifiers, resulting in a novel and efficientmodel. To test and validate the hybrid model, rigorous experimentations were performed and results state thatthe proposed hybrid model achieved accuracy rate of 99.9%, outperforming other existing techniques, and alsosignificantly reducing computational time. This enhanced accuracy, along with improved sensitivity and specificity,makes the proposed hybrid model a valuable addition to CAD systems in breast cancer diagnosis, ultimatelyenhancing diagnostic accuracy in clinical applications.

关键词： Ultrasound images breast cancer tumor classification segmentation deep learning lesion detection

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