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Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels

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Journal of Nanobiotechnology 2023年第1期21卷 1-17页

作者： Hao, Ping-Chien Burnouf, Thierry Chiang, Chih-Wei Jheng, Pei-Ru Szunerits, Sabine Yang, Jen-Chang Chuang, Er-Yuan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Univ. Lille CNRS Centrale Lille Univ. Polytechnique Hauts-de-France UMR 8520 IEMN LilleF- 59000 France Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei110-52 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Impaired wound healing is a significant complication of diabetes. Platelet-derived extracellular vesicles (pEVs), rich in growth factors and cytokines, show promise as a powerful biotherapy to modulate cellular proliferation, angiogenesis, immunomodulation, and inflammation. For practical home-based wound therapy, however, pEVs should be incorporated into wound bandages with careful attention to delivery strategies. In this work, a gelatin-alginate hydrogel (GelAlg) loaded with reduced graphene oxide (rGO) was fabricated, and its potential as a diabetic wound dressing was investigated. The GelAlg@rGO-pEV gel exhibited excellent mechanical stability and biocompatibility in vitro, with promising macrophage polarization and reactive oxygen species (ROS)-scavenging capability. In vitro cell migration experiments were complemented by in vivo investigations using a streptozotocin-induced diabetic rat wound model. When exposed to near-infrared light at 2 W cm− 2, the GelAlg@rGO-pEV hydrogel effectively decreased the expression of inflammatory biomarkers, regulated immune response, promoted angiogenesis, and enhanced diabetic wound healing. Interestingly, the GelAlg@rGO-pEV hydrogel also increased the expression of heat shock proteins involved in cellular protective pathways. These findings suggest that the engineered GelAlg@rGO-pEV hydrogel has the potential to serve as a wound dressing that can modulate immune responses, inflammation, angiogenesis, and follicle regeneration in diabetic wounds, potentially leading to accelerated healing of chronic wounds. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Platelets

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Implementation of a PID Controller using Online Tuning Applied to a Mobile Robot Obstacle Following/Avoidance

Implementation of a PID Controller using Online Tuning Appli...

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Argentine Conference on Electronics (CAE)

作者： M. A. Pastrana L. H. Oliveira D. A. Mendes Douglas. L. Silva Jose Mendoza-Peñaloza Daniel M. Muñoz Department of Mechanical Engineering Mechatronics Graduate Program Faculty of Gama Electronics Engineering Undergraduate Program University of Brasilia Brasilia DF Brazil

The implementation of a bioinspired PID-based controller with online tuning capabilities is developed for obstacle following/avoidance of a nonholonomic mobile robot. An innovative mixture of the conventional PID controller and particle swarm optimization (PSO), which has a strong capability of adaptation across unknown scenarios, reduced objective error, brings us a novel online tuning methodology that can derive optimal controller parameters for a given scenario. It is appropriate for a kind of plant without prior knowledge or established mobile robot model. Computer simulation for obstacle following/avoidance is carried out in four different scenarios using the CoppeliaSim software and the EVA mobile robot platform. The effectiveness of the proposed control algorithm is demonstrated trough the simulation experiment, which shows its superior performance in the training scenario, including an overshoot of 20.1 %, a settling time of 10 seconds, and a steady-state error of 0.76%.

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Development of a 7-DOF Electric Shoulder Prosthesis Using a Return-routing Coupled Tendondriven Mechanism 4

Development of a 7-DOF Electric Shoulder Prosthesis Using a ...

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4th IEEE Global Conference on Life Sciences and Technologies, LifeTech 2022

作者： Nakamura, Yuko Jiang, Yinlai Yokoi, Hiroshi Togo, Shunta The University of Electro-Communications Graduate School of Informatics and Engineering Department of Mechanical and Intelligent System Engineering Tokyo Japan The University of Electro-Communications Center for Neuroscience and Biomedical Engineering Tokyo Japan

ISBN: (纸本)9781665419048

An electric shoulder disarticulation prosthesis is effective in reconstructing upper limb function in a shoulder disarticulation amputee. Our research group has been developing a lightweight, high-power, and 7-DOF (Degrees of Freedom) humanoid robot arm with a modularized coupled tendon-driven mechanism. The shoulder module of the arm is supposed to be fixed to the base. Therefore, when the arm is applied as an electric shoulder disarticulation prosthesis, the shoulder width becomes about twice as wide as that of an ablebodied person, which makes it difficult to reconstruct the appearance and to wear. In this study, we proposed and fabricated a return-routing coupled tendon-driven mechanism and applied it to a 7-DOF electric shoulder disarticulation prosthesis. By using a return-routing tendon-driven mechanism, the shoulder width of the arm was successfully reduced by 53 mm compared to the previous model. A comparison experiment was also conducted with a bilateral shoulder disarticulation amputee. The proposed shoulder module reduced the shoulder width and well reconstructed the appearance. In addition, the moment around the shoulder was reduced, resulting in less shoulder socket slip. These results indicate that the proposed return-routing coupled tendon-driven mechanism can reduce the shoulder width of the arm, thereby enabling the design of a 7-DOF arm that can reconstruct the appearance and improve the wearing problem. © 2022 IEEE.

关键词： Degrees of freedom (mechanics)

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VR-Based Implicit Authentication Using Electromyogram and Inertial Measurement Unit 23

VR-Based Implicit Authentication Using Electromyogram and In...

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23rd International Conference on Cyberworlds, CW 2024

作者： Yu, Da-Young Lee, Hyung-Tak Kim, Youngsam Roh, Jong-Hyuk Kim, Soohyung Ku, Jeonghun Hwang, Han-Jeong Korea University Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Dept. Electronics and Information Engineering Sejong Korea Republic of Korea University Dept. Electronics and Information Engineering Sejong Korea Republic of Daejeon Korea Republic of Keimyung University College of Medicine Department of Biomedical Engineering Daegu Korea Republic of

ISBN: (纸本)9798331527174

Biometrics based on electromyogram (EMG) and inertial measurement unit (IMU) signals has received significant attention due to its resistance to forgery and tampering, as well as its relatively higher convenience and security compared to other biometric modalities. However, most EMG and IMU signal-based authentication methods require explicit authentication using unnatural gestures, which is not userfriendly. To address this, we collected EMG and IMU data during virtual reality (VR) rhythm game play, which does not require explicit gestures, and performed implicit authentication. Using a linear discriminant analysis (LDA) classifier, we achieved classification accuracies of 91.71% for human identification and 87.91% for human authentication. The result demonstrated the feasibility of a seamless and implicit authentication in VR environments. © 2024 IEEE.

关键词： Electromyography

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Design and Performance Comparison of Current References for a 32-bit Microcontroller Using 22nm Technology

Design and Performance Comparison of Current References for ...

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IEEE Latin American Symposium on Circuits and Systems (LASCAS)

作者： Eduardo A. Barcelos Pâmela R. A. N. Campagnucci Daniel M. Muñoz Wellington A. Amaral Sandro A. P. Haddad Department of Mechanical Engineering Faculty of Technology Mechatronics Graduate Program Faculty of Gama Electronics Engineering Undergraduate Program University of Brasilia Brasilia DF Brazil

ISBN: (数字)9798331522124

ISBN: (纸本)9798331522131

With the advancement of semiconductor technologies, the need for efficient power management solutions in integrated systems, such as RISC-V architecture-based microcontrollers, becomes increasingly critical. However, there is a lack of studies comparing current reference architectures in terms of performance and robustness, particularly in 22nm technologies. In this paper, we present a comparative analysis of two current reference designs implemented in the same technology-referred to as Reference Design A and Reference Design B. We focus on their approaches to thermal compensation, supply stability, and layout optimizations. Through simulations and experimental tests, we evaluate the performance of each design within a power management system that includes DC-DC converters and LDO regulators. Our results indicate that Design A exhibits superior power supply rejection with a PSRR of -85 dB, while Design B demonstrates enhanced energy efficiency and thermal stability, achieving a nominal current of 5.14 μA and a temperature coefficient of 16.21 ppm. These findings underscore the importance of balancing energy efficiency, thermal stability, and power supply variation rejection when selecting current references for low-power, high-reliability applications, such as those in the Internet of Things (IoT).

关键词： Resistance Microcontrollers Power system management Stability criteria Energy efficiency Robustness Circuit stability Thermal analysis Internet of Things Thermal stability

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A 22nm CMOS PFM Buck Converter Used in a 32-Bit RISC-V Microcontroller for IoT Applications

A 22nm CMOS PFM Buck Converter Used in a 32-Bit RISC-V Micro...

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IEEE Latin American Symposium on Circuits and Systems (LASCAS)

作者： Luiz H. N. Oliveira Wellington A. Amaral Sandro A. P. Haddad Daniel M. Muñoz Eduardo A. Barcelos Vinícius V. M. Sotero Emmanuel K. M. Jonhson Pâmela R. A. N. Campagnucci Luis V. N. Lima Department of Mechanical Engineering Faculty of Technology Mechatronics Graduate Program University of Brasilia Brasilia DF Brazil Faculty of Gama Electronics Engineering Undergraduate Program

ISBN: (数字)9798331522124

ISBN: (纸本)9798331522131

The demand for efficient power management solutions in electronic devices has increased significantly, especially for microcontrollers operating in low-power modes. This article presents the design and implementation of a Pulse Frequency Modulation (PFM)-based buck converter for applications in 32-bit microcontrollers using 22nm CMOS technology. The methodology involves the development of a Constant On Time (COT) architecture that maintains a fixed duration for the activation of the high-side MOSFET, using a monostable multivibrator to generate the necessary timing signals. The converter's performance was simulated under various load conditions and process corners to evaluate its efficiency and output characteristics. The results show that the proposed buck converter achieves high efficiency, with peak values above 95%, while maintaining a low output ripple. Specifically, the converter exhibits an efficiency of 93.4% at a load of 1mA, with output ripple voltages as low as 2.20 mV under ideal conditions. The contributions of this work lie in the advancement of PFM converter technology for modern microcontroller applications, demonstrating the potential of 22nm CMOS processes to improve power efficiency and performance.

关键词： Semiconductor device modeling Performance evaluation MOSFET Buck converters Microcontrollers Power system management Multivibrators Timing Internet of Things Load modeling

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The Impact of Total Quality Management and Perceived Service Quality on Patient Satisfaction in Healthcare: A Systematic Review

The Impact of Total Quality Management and Perceived Service...

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2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Alshrbaji, Mohammad Mohammed, Maryam Shamayleh, Abdulrahim American University of Sharjah Biomedical Engineering Graduate program College of Engineering Sharjah United Arab Emirates University of Sharjah College of Engineering American Industrial Engineering Department Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

The main goal of Total Quality Management (TQM) and Perceived Service Quality (PSQ) in the healthcare sector is to provide high-quality care to patients to meet their needs and expectation. Even in very unique circumstances like the COVID-19 outbreak, there is a need to evaluate how much the prementioned approaches affect patient satisfaction. However, patient satisfaction requires a proper synchronization between what the patient value and what the management perceives. In addition, there should be a focus on what impact the dimensions of TQM and PCQ have on patient satisfaction. As a result, studies have been conducted to identify what the patients value the most related to PSQ and TQM by designing and distributing questionnaires to a sample of patients and analyzing their responses. In this study, a review is conducted of empirical studies from various databases covering the period between 2008 and 2021. The objective is to analyze the influence of TQM and PSQ dimensions on patient satisfaction in healthcare organizations. © 2022 IEEE.

关键词： Health care

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Thermomechanical Characterization of Hot Surface Ignition Device Using Phenomenological Heat Flux Model

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JOURNAL OF PROPULSION AND POWER 2022年第4期38卷 656-670页

作者： Kang, Sang-Guk Ryu, Je Ir Motily, Austen H. Numkiatsakul, Prapassorn Lee, Tonghun Kriven, Waltraud M. Kim, Kenneth S. Kweon, Chol-Bum M. U.S. Army Research Laboratory Aberdeen Proving Ground MD 21005 Aerospace Engineer Weapons and Materials Research Directorate Postdoctoral Fellow Computational and Information Sciences Directorate University of Illinois at Urbana-Champaign Urbana IL 61801 Graduate Student Department of Mechanical Science and Engineering. Student Member AIAA Graduate Student Department of Materials Science and Engineering Professor Department of Mechanical Science and Engineering. Associate Fellow AIAA Professor Department of Materials Science and Engineering Mechanical Engineer Computational and Information Sciences Directorate. Member AIAA Program Manager Computational and Information Sciences Directorate. Member AIAA.

Modern aircraft compression ignition engines that seek to achieve fuel-flexible operation require ignition-assisting devices to perform reliably. Many military propulsion systems, and unmanned aircraft in particular, can use hot surface energy addition to improve engine performance. An analysis of the thermomechanical stress behavior of hot surface ignition devices is therefore critical to ensure that they can satisfy new operational requirements. In this paper, a phenomenological heat-flux model is proposed to simulate heat generation inside a heating element. Two finite element analysis models are established using the proposed heat-flux model in order to characterize the transient thermomechanical behavior of an ignition assistant: a two-dimensional (2-D) axisymmetric model with an equivalent cylindrical heating element and a three-dimensional (3-D) solid model with realistic heating element geometry. The transient behavior of the ignition assistant is investigated at standard conditions by characterizing the temperature and thermal stress inside the device for various input voltages. The effect of the nonaxisymmetric heating element geometry on the temperature and thermal stress distribution is assessed. Furthermore, the 3-D ignition assistant model is used to analyze the thermomechanical behavior of an ignition device subjected to a combustion event inside a rapid compression machine. Multiple circumferential orientations of the heating element plane relative to the spray axis are investigated. Results demonstrate that the observed maximum principal stress depends significantly on heating element orientation.

关键词： Heat Flux Stress Distribution Heat Generation Unmanned Aerial Vehicle Propulsion System Surface Energy Adaptive Mesh Refinement Fuel Injection CFD Simulation Fracture Toughness

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Plant Maintenance Budgeting Prioritization Based on Reliability Prediction of Repairable System 5th

Plant Maintenance Budgeting Prioritization Based on Reliabil...

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5th International Conference on mechanical engineering, ICOME 2021

作者： Setia, Fandi Wibawa, Agus Yuniarto, Muhammad Nur Graduate Program of Mechanical Engineering Institut Teknologi Sepuluh Nopember Surabaya Indonesia PT Pembangkitan Jawa Bali Jl. Ketintang Baru No. 11 Surabaya60231 Indonesia Department of Mechanical Engineering Institut Teknologi Sepuluh Nopember Surabaya60111 Indonesia

ISBN: (纸本)9789811908668

A reliability prediction study has been carried out using failure data from the gas turbine system at a combined cycle power plant in Indonesia. From this study, the prediction value of the equipment reliability of the gas turbine subsystem was obtained along with the value of Failure Cost (FC), Component Risk (CR), and Maintenance Cost (MC) which is then processed further to produce a Benefit to Cost Ratio (BCR) which is useful for preparing priority rankings for the allocation of very limited maintenance budgets. This research also leads to a conclusion that the more the failures experienced by the equipment in one observation period, the lower the predictive value of its reliability. In addition, it is also discovered the fact that subsystems with the same number of failures but with different times of failure will produce different reliability values. And lastly, the subsystem risk rating obtained from Component Risk (CR) does not necessarily become a budget priority rating;this rating can change when the risk rating is combined with Maintenance Cost (MC) to produce a more objective budget priority rating with broader considerations. The methodology that combines the prediction of equipment reliability with budget prioritization in this research can also be used in other power generation plants that predominantly manage physical assets in order to obtain optimal asset life cycle management without compromising the performance of the equipment in the power plant due to limited maintenance budgets. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Gas turbines

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Learning from failure - Development of a Culture of Failure Scale for Higher Education

Learning from failure - Development of a Culture of Failure ...

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2022 IEEE IFEES World engineering Education Forum - Global engineering Deans Council, WEEF-GEDC 2022

作者： Malschutzky, Michael M. Gurganus, Jamie R. Department of Management Sciences Germany Mechanical Engineering and Graduate School University of Maryland Baltimore County Engineering and Computing Education Program Baltimore United States

ISBN: (纸本)9781665475280

Benefits of a failure friendly culture, e.g., learning from failure, are widely known in occupational settings. Validated scales have been developed to measure organizational failure culture and individuals' mind-sets on failure. While research on learning from failure exists in secondary education, scales for higher education are lacking. To support both higher education engineering instructors and students, this contribution aims to develop a Culture of Failure Scale to assess students' and lecturers' handling of failures in engineering higher education settings. This data-driven approach helps inform instructors about aspects of educational settings that are safe and conducive to learning and supports their students to develop a mind-set where failures are seen as a source for improvements and learning. Exemplary application of the developed scale is shown by assessing the failure culture in different groupings, e.g., gender, between two participating German and US institutions. © 2022 IEEE.

关键词： Failure (mechanical)

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