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Picrasidine I Regulates Apoptosis in Melanoma Cell Lines by Activating ERK and JNK Pathways and Suppressing AKT Signaling

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Environmental Toxicology 2024年第12期39卷 5309-5320页

作者： Shieu, Mu-Kuei Lin, Chia-Chieh Ho, Hsin-Yu Lo, Yu-Sheng Chuang, Yi-Ching Hsieh, Ming-Ju Department of Dermatology Changhua Christian Hospital Changhua Taiwan Oral Cancer Research Center Changhua Christian Hospital Changhua Taiwan Graduate Institute of Clinical Medicine College of Medicine National Chung Hsing University Taichung Taiwan Doctoral Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan

World Health Organization data indicate a continuous increase in melanoma incidence, with metastatic melanoma characterized by poor prognosis and drug resistance. The exploration of therapeutics derived from natural products remains an active area of in vitro research. The aim of this study was to determine the antitumor effects of picrasidine I, a natural compound extracted from Picrasma quassioides, against two melanoma cell lines. We selected two metastatic melanoma cell lines, HMY-1 and A2058, for molecular studies, including Western blotting, 4′,6-diamidino-2-phenylindole staining, and flow cytometry. Picrasidine I demonstrated cytotoxic effects against the HMY-1 and A2058 melanoma cell lines. It induced cell cycle arrest in the sub-G1 phase and downregulated cell cycle–related proteins (e.g., cyclin A2, D1, cyclin-dependent kinases 4, and 6). In the intrinsic apoptosis pathway, picrasidine I activated proapoptotic proteins (e.g., Bax, Bak, t-Bid, BimL/S) and suppressed the expression of antiapoptotic proteins (e.g., Bcl-2, Bcl-xL), with an observed increase in the quantity of depolarized cells. In addition, the apoptotic effects of picrasidine I were linked to the activation of the c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways and the inhibition of the protein kinase B signaling pathway. A human apoptosis array indicated claspin inhibition upon picrasidine I treatment, suggesting the potential involvement of picrasidine I in apoptosis and cell cycle regulation. Our findings suggest that picrasidine I has potential as a candidate for treating advanced melanoma, and thus these findings warrant further investigation. The modulation of claspin expression by picrasidine I could be investigated further as a potential biomarker to predict its efficacy in related to advanced stages of melanoma. © 2024 The Author(s). Environmental Toxicology published by Wiley Periodicals LLC.

关键词： Dermatology

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Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

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Journal of Magnesium and Alloys 2023年第6期11卷 2106-2124页

作者： Xiaosong Liu Guoqiang Chen Xiongxiong Zhong Tianfang Wang Xiaohong He Weipeng Yuan Pingping Zhang Ying Liu Dongming Cao Shu Chen Ken-ichi Manabe Zhengyi Jiang Tsuyoshi Furushima Damon Kent Yang Chen Guoying Ni Mingyong Gao Hejie Li Cancer Research Institute First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Rheumatology First People’s Hospital of FoshanFoshanGuangdong 528000China The Second Clinical Medical College of Jinan University Shenzhen People’s HospitalShenzhenGuangdong 510632China Genecology Research Centre University of the Sunshine CoastMaroochydore BCQLD 4558Australia Department of Medical Imaging First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Surgery First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Mechanical Engineering Graduate School of Science and EngineeringTokyo Metropolitan University1-1 Minami-osawaHachiojiTokyo 192-0397Japan School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AveWollongong NSW 2522Australia Institute of Industrial Science Department of Mechanical and Biofunctional Systemsthe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan School of Science Technology and EngineeringUniversity of the Sunshine CoastMaroochydore BCQLD 4558Australia

Mg alloys have mechanical properties compatible with human ***,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human *** this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat *** three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital *** analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array ***,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured ***,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,*** is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in *** conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

关键词： Toxicity test Proteomics analysis Signaling pathway Biocompatibility and corrosion resistance First-order pyramidal slip system Recovery and recrystallization Foreign body reactions(FBRs)

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Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses

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Journal of Asian Ceramic Societies 2024年第1期12卷 104-116页

作者： Ningsih, Henni Setia Vietanti, Frizka Wong, Chin-Chean Chou, Yu-Jen Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Orthopedics Taipei Medical University Shuang Ho Hospital New Taipei Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Research Center of Biomedical Devices Taipei Medical University Taipei Taiwan International PhD Program for Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei Taiwan

Owing to the advancement of bioactive materials, bioactive glasses (BGs) are progressively being recognized as promising choices in fields of bone and tissue engineering with their superior properties such as bioactivity and biocompatibility. However, their applications are limited by the fact that the material itself does not possess antibacterial properties. To address this limitation, antibacterial BGs with silver-zinc co-dopant were proposed and successfully synthesized via the one-step spray pyrolysis technique in this work. The phase composition, chemical composition, surface morphology, and nanoscale structures of the obtained BG specimens were characterized using X-ray diffraction, energy dispersive spectroscopy, scanning electron microscopy, and transmission electron microscopy. Moreover, in-vitro bioactivity was assessed through immersion of the SBF solution, while the in-vitro antibacterial property was examined using Escherichia coli bacteria. Meanwhile, the viability of MC3T3-E1 osteoblast cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Finally, the results showed positive effects of zinc addition, and the influence of silver and zinc dopants on the in-vitro bioactivity, antibacterial property, and cell viability were discussed. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The Korean Ceramic Society and The Ceramic Society of Japan.

关键词： Spray pyrolysis

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The benefits of long-duration energy storage for New England's energy system decarbonization goals

Next Energy

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Next Energy 2024年 5卷

作者： Freeman, Sergio Agar, Ertan Department of Mechanical Engineering Energy Engineering Graduate Program University of Massachusetts Lowell Lowell 01854 MA United States

Utilizing a macro-scale energy model alongside 44 years of New England's hourly weather data from MERRA-2, this study investigates the benefits of various combinations of renewable energy technologies, particularly wind and solar, and their integration with long-duration energy storage (LDES) systems. The potential of these renewable energy sources to enhance both the reliability and affordability of New England's power system is evaluated. The findings demonstrate that incorporating LDES into the technology mix leads to a remarkable 55% reduction in overall system costs compared to relying solely on short-duration energy storage (SDES), such as lithium-ion batteries. Additionally, the cost reductions of LDES lead to approximately a 35% increase in the utilization of solar generation. The results suggest that total system costs for LDES are more responsive to relative decreases in power-capacity costs than decreases in energy-capacity costs. Furthermore, the analysis indicates that a combination of different LDES storage technologies can offer the most cost-effective solution for wind-solar power systems. Overall, by examining the interplay between different storage technologies and their impact on system costs, this research contributes significantly to the discourse on sustainable energy solutions. © 2024 The Author(s)

关键词： Energy reliability Long-duration energy storage (LDES) New England Power-to-gas-to-power (P2G2P) Redox flow battery (RFB) Renewable energy

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3D Simulation Combustion Characteristics Of EFB Biomass Co-Firing With Low Rank Coal In Pulverized Coal Boiler

3D Simulation Combustion Characteristics Of EFB Biomass Co-F...

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International Conference on Advanced Mechatronics, Intelligent Manufacture, and Industrial Automation (ICAMIMIA)

作者： I Nyoman Agus Adi Saputra Prabowo Atok Setiyawan I Gusti Bagus Wijaya Kusuma Sobar Ihsan Hariana Graduate Program of Mechanical Engineering Department Institut Teknologi Sepuluh Nopember Surabaya Indonesia Mechanical Engineering Department Institut Teknologi Sepuluh Nopember Surabaya Indonesia Mechanical Engineering Department Udayana University Indonesia

Climate change has received a lot of attention due to high emissions in the energy sector from coal-dependent generators, but the solution that can be done to overcome this is the co-firing method through CFD simulation with a discrete phase model (DPM) carried out by adding EFB biomass in a ratio 5% and 95% LRC coal are injected into the boiler combustion furnace. The research was carried out on a PC boiler with a generation capacity of 315Mwe. The research results show that the addition of EFB biomass to coal combustion causes changes in the calorific value which has an impact on the high temperature of the combustion process. However, it has a good impact from the operational side of burning coal particles.

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Injectable Platelet-Rich Fibrin in Contact with Bone Substitutes, Porous Zirconia, or Laser-Textured Implant Surfaces: A Detailed Morphological Analysis

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biomedical Materials and Devices 2024年第1期2卷 415-426页

作者： Oliveira, Miguel Noronha Varela, Hugo Almeida Nascimento, Rubens M. Sahoo, Narayan Carvalho, Oscar Henriques, Bruno Souza, Júlio C. M. Ceramic and Composite Materials Research Group (CERMAT) Department of Mechanical Engineering (EMC) Federal University of Santa Catarina (UFSC) Post-graduate Program in Materials Science and Engineering Federal University of Rio Grande Norte (UFRN) Center for MicroElectroMechanical Systems (CMEMS-UMINHO) Universidade do Minho LABBELS - Associate Laboratory University of Minho University Institute of Health Sciences (IUCS) CESPU

The aim of the present study was to perform a detailed morphological analysis of an injectable platelet rich fibrin after combination with two different particulate hydroxyapatite-based granules, a porous zirconia block, and laser-textured zirconia or titanium surfaces. Blood samples were harvested from three participants to prepare the flowable injectable PRF in contact or not with particulate hydroxyapatite (Hap), bone mineral granules (DBBM), porous zirconia blocks, laser-textured titanium or zirconia surfaces. Optical and scanning electron microscopy (SEM) were used to evaluate the fibrin network density, fibrin fibers’ diameter, blood cells, and the interaction of PRF with the biomaterials. Histomorphometry of the flowable PRF was also performed using the hematoxylin–eosin staining protocol. Specimens were independently evaluated by two blinded and well-trained researchers in histomorphometry and microscopy. Particulate Hap and DBBM shown different morphological aspects by SEM analyses since DBBM revealed macro- and micro-scale pores while Hap revealed a dense structure. Hydroxyapatite and DBBM granules were entirely embedded by the fibrin-network in the presence of leukocytes and blood platelets. The zirconia porous structured was filled with PRF and its components. Also, the laser-structured zirconia or implant surfaces were entirely coated with the PRF fibrin network embedding leukocytes and blood platelets. Laser-textured titanium surfaces revealed macro- and micro-scale irregularities that increase the surface area and retention of the injectable PRF. Histomorphometric analyses revealed complementary details on the distribution of lymphocytes, red blood cells, and fibrin associated with platelet aggregation. The flowing and viscosity of an injectable platelet rich fibrin provided an agglomeration of synthetic or xenogeneic particulate bone substitutes and the coating of porous zirconia and textured implant surfaces as inspected by scanning electron microsc

关键词： Bone healing Bone substitutes Histology Morphology Platelet-rich fibrin

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Cidade Inteligente: análise da evolução dos indicadores de uma Cidade Universitária da região norte a partir da ISO 37122:2020

Cidade Inteligente: análise da evolução dos indicadores d...

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IEEE/IAS International Conference on Industry Applications (INDUSCON)

作者： Lucas Henrique Brito Santos Kaylane de Sousa Silva Elen Priscila Lobato Jhennifer Freitas dos Santos Allan R. A. Manito Wellington da Silva Fonseca Marcelo de Oliveira e Silva Faculty of Electrical and Biomedical Engineering Federal University of Pará Belém Brazil Electrical Engineering Graduate Program Federal University of Pará Belém Brazil Mechanical Engineering Graduate Program Federal University of Pará Belém Brazil

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Monitoring Industrial Systems Using ESP-NOW Protocol with Mesh and Ad Hoc Network

Monitoring Industrial Systems Using ESP-NOW Protocol with Me...

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IEEE/IAS International Conference on Industry Applications (INDUSCON)

作者： Lucas Henrique Brito Santos Eduardo José Monteiro Da Silva Aleqssandro Alexandre De Oliveira Farias Jhennifer Freitas Dos Santos Iago Ranieri Miranda Rodrigues Morais Wellington Da Silva Fonseca Marcelo De Oliveira e Silva Faculty of Electrical and Biomedical Engineering Federal University of Pará Belém Brazil Electrical Engineering Graduate Program Federal University of Pará Belém Brazil Mechanical Engineering Graduate Program Federal University of Pará Belém Brazil

Nowadays, industrial processes are creating increasing demands for optimized and efficient sensing systems and require high reliability and a short time interval for information delivery. This paper presents an embedded sensor system that uses the ESP-NOW protocol with a Mesh and Ad Hoc network, in order to provide an auto mesh configuration upon failure at some point in the network. This system was implemented to monitor the variables of an induction motor, after which, before sending the data to the cloud, local processing is performed to reduce the volume of data. Finally, a computer simulation of the WROOM-32 module is performed for a thermal analysis during its operation, where the heating points of the plate are identified and analyzed, in order to validate that the system, even processing a large amount of data, maintains a high reliability during its operation.

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High Order of Accuracy for Poisson Equation Obtained by Grouping of Repeated Richardson Extrapolation with Fourth Order Schemes

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Computer Modeling in engineering & Sciences 2021年第8期128卷 699-715页

作者： Luciano Pereira da Silva Bruno Benato Rutyna Aline Roberta Santos Righi Marcio Augusto Villela Pinto Graduate Program in Numerical Methods in Engineering Federal University of ParanaCuritiba81531-980Brazil Graduate Program in Space Sciences and Technologies Aeronautics Institute of TechnologySao Jose dos Campos12228-900Brazil Department of Mechanical Engineering Federal University of ParanaCuritiba81531-980Brazil

In this article,we improve the order of precision of the two-dimensional Poisson equation by combining extrapolation techniques with high order *** high order solutions obtained traditionally generate non-sparse matrices and the calculation time is very *** can obtain sparse matrices by applying compact *** this article,we compare compact and exponential finite difference schemes of fourth *** numerical solutions are calculated in quadruple precision(Real*16 or extended precision)in FORTRAN language,and iteratively obtained until reaching the round-off error magnitude around 1.0E−*** procedure is performed to ensure that there is no iteration *** Repeated Richardson Extrapolation(RRE)method combines numerical solutions in different grids,determining higher orders of *** main contribution of this work is based on a process that initializes with fourth order solutions combining with RRE in order to find solutions of sixth,eighth,and tenth order of *** multigrid Full Approximation Scheme(FAS)is also applied to accelerate the convergence and obtain the numerical solutions on the fine grids.

关键词： Tenth order accuracy RRE compact scheme exponential scheme multigrid finite difference

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The Effect of Rotational Speed on the Thermal Characteristics of a Wheel Hub Motor on an Electric Scooter

The Effect of Rotational Speed on the Thermal Characteristic...

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International Seminar on Intelligent Technology and Its Applications (ISITIA)

作者： Muhammad Hasan Albana Harus Laksana Guntur Ary Bachtiar Khrisna Putra Graduate Program of Mechanical Engineering Department Institut Teknologi Sepuluh Nopember Surabaya Indonesia Mechanical Engineering Department Institut Teknologi Sepuluh Nopember Surabaya Indonesia

When using an electric scooter, there is a problem with the electric motor overheating. Temperatures that are too high will damage motor performance and reduce reliability. As a result, heat transfer from electric motors needs to be carefully considered. This study aims to determine the thermal characteristics of an electric motor by varying the rotational speed. The rotational speeds varied were 250 rpm, 500 rpm, and 750 rpm. Using finite element analysis to answer research questions, the software used is Ansys Motor-CAD. The type of electric motor used is a wheel hub motor with a power of 1.5 kW. The findings indicate that the rotating speed influenced the thermal properties of a wheel hub motor. Wheel hub motor components, including the winding, stator, rotor, cover, and axle, exhibit a drop in temperature with increasing rotational speed. The winding is the component that experiences the highest temperature, and the cover is the component that experiences the lowest temperature. The winding loss value is much higher than the stator, magnet, and rotor loss. Compared to other rotational speeds, the winding temperature at 750 rpm rotational speed achieved a stable temperature the quickest, at 519 minutes, while the temperatures at 250 rpm and 500 rpm reached stable temperatures, respectively, at 592.2 and 550.5 minutes.

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