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113th Annual ASEE Conference and Exposition, 2006

作者： Gassert, John Enderle, John Denis Lerner, Amy Richerson, Samantha Katona, Peter Milwaukee School of Engineering United States Biomedical Engineering Program BMES China Accreditation Activities Committee BMES China IEEE ABET EAC Program Evaluator for Biomedical Engineering NSPE University of Connecticut United States Biomedical Engineering University of Connecticut United States AIMBE United States UConn. ABET Engineering Commission Biomedical Engineering Society United Kingdom University of Rochester United States Department of Biomedical and Mechanical Engineering University of Rochester United States ASME Orthopaedic Research Society United States University of Rochester Senior Design Program United States Bucknell University United States ASEE Society for Neuroscience Whitaker Foundation United States American Association for the Advancement of Science American Institute for Medical and Biological Engineering United States Cardiovascular Section American Physiological Society United States

The ABET Criteria for Accrediting engineering programs specifically requires design in criterion three and criterion four. These requirements stem from a fundamental need for engineers to understand and carry out the design process and the requirements are unlikely to change in the foreseeable future. ABET criteria do not allow substitution of research for design in an engineering program. What is the difference between research projects and design projects and why doesn't ABET allow the substitution? The objective of this paper is to review the rationale for the design requirement in the ABET criteria;review the differences between design and research;and to propose questions that can be used to differentiate between a research project and a design project in an engineering curriculum. © American Society for engineering Education, 2006.

关键词： Requirements engineering

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Properties of the surface-modified layer of plasma-oxidized poly(dimethylsiloxane)

Properties of the surface-modified layer of plasma-oxidized ...

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2006 MRS Spring Meeting

作者： Mills, Kristen L. Zhu, Xiaoyue Lee, Donghee Takayama, Shuichi Thouless, M.D. Department of Mechanical Engineering University of Michigan Ann Arbor MI 48109 United States Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 United States Macromolecular Science and Engineering Program University of Michigan Ann Arbor MI 48109 United States Department of Materials Science and Engineering University of Michigan Ann Arbor MI 48109 United States

ISBN: (纸本)1558998810

Exposure of poly(dimethylsiloxane) (PDMS) to oxygen plasma creates a thin, stiff surface-modified layer that reaches a submicron depth. Due to a significant modulus mismatch between the stiff surface-modified layer and the compliant bulk PDMS the surface-modified layer forms intricate patterns of surface buckles when under compressive stress and nano-cracks when under tensile stress. It is desirable to be able to design patterns of nano-cracks, or at least to have an understanding of them. Among the properties necessary to do this are the thickness and elastic modulus of the surface-modified layer. Due to the very small length scale of the surface-modified layer, it is a significant challenge to measure these properties. In this proceedings paper, a two-step method is described for determining the thickness and elastic modulus of the surface-modified layer using the atomic force microscope (AFM). First, nanoindentation is performed from which the bending stiffness of the surface-modified layer is calculated. Second, the surface-modified layer thickness is determined by using phase imaging on the cross-section of oxidized PDMS to map the region of the relatively stiffer surface-modified layer. © 2006 Materials Research Society.

关键词： Silicones

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Corrigendum to “Perceptual learning improves contrast sensitivity and visual acuity in adults with anisometropic amblyopia” [Vis. Res. 46 (2006) 739–750]

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Vision Research 2007年第15期47卷 2113-2113页

作者： Yifeng Zhou Changbing Huang Pengjing Xu Liming Tao Zhuping Qiu Xiangrui Li Zhong-Lin Lu Vision Research Lab School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 PR China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 PR China Department of Ophthalmology First Affiliated Hospital Anhui Medical University Hefei Anhui 230022 PR China Laboratory of Brain Processes (LOBES) Department of Psychology Neuroscience Graduate Program University of Southern California Los Angeles CA 90089-1061 USA Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los Angeles CA 90089-1061 USA

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Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats

Tumour oxygen dynamics measured simultaneously by near-infra...

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作者： Xia, Mengna Kodibagkar, Vikram Liu, Hanli Mason, Ralph P. Joint Biomedical Engineering Graduate Program University of Texas at Arlington University of Texas Southwestern Medical Center Dallas TX 76019 United States Cancer Imaging Program Department of Radiology University of Texas Southwestern Medical Center Dallas TX 75390 United States

Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature. © 2006 IOP Publishing Ltd.

关键词： Tumors

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Properties of the surface-modified layer of plasma-oxidized poly(dimethylsiloxane)

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MRS Online Proceedings Library 2006年第1期924卷 1-6页

作者： Kristen L. Mills Xiaoyue Zhu Donghee Lee Shuichi Takayama M. D. Thouless Department of Mechanical Engineering University of Michigan Ann Arbor USA Department of Biomedical Engineering University of Michigan Ann Arbor USA Macromolecular Science and Engineering Program University of Michigan Ann Arbor USA Department of Materials Science and Engineering University of Michigan Ann Arbor USA

关键词： nanoscale elastic properties film

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Calculation of Wall Shear Stress in Left Coronary Artery Bifurcation for Pulsatile Flow Using Two-Dimensional Computational Fluid Dynamics

Calculation of Wall Shear Stress in Left Coronary Artery Bif...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Sahid Smith Shawn Austin G. Dale Wesson Carl A. Moore Department of Chemical Engineering and Biomedical Engineering Florida Agricultural and Mechanical University Tallahassee FL USA Biological and Agricultural Systems Engineering Program Florida Agricultural and Mechanical University Tallahassee FL USA Department of Mechanical Engineering Florida Agricultural and Mechanical University Tallahassee FL USA

The onset of coronary heart disease may be governed by distribution and magnitude of hemodynamic shear stress in the coronary arteries. This study numerically examines pulsatile blood flow through the left coronary artery system. A triphasic waveform is employed to simulate pulsating flow. Five non-Newtonian models, as well as the usual Newtonian model, are used to describe the viscous shear-thinning behavior of blood. It is concluded that when using computational fluid dynamics (CFD) to numerically investigate blood velocity profiles within small arteries, such the coronary artery system examined in this work, great care should be taken in choosing a blood viscosity model. It is suggested that the generalized power law model be the viscous shear thinning model of choice. When using CFD to investigate only patterns of wall shear stresses, the model selection is not as crucial and the simple Newtonian model will suffice but when the magnitude of WSS is of great importance, as in the case of the determining the development of coronary artery disease, the model selection is key

关键词： Stress Arteries Bifurcation Computational fluid dynamics Power system modeling Cardiac disease Hemodynamics Blood flow Computational modeling Viscosity

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Project based active learning involving freshman and sophomore engineering majors at university of Maryland Eastern Shore

Project based active learning involving freshman and sophomo...

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113th Annual ASEE Conference and Exposition, 2006

作者： Nagchaudhuri, Abhijit Smith, Whitney Poddalgoda, Uditha Jarrett, Amy Omar, Omar A. Redden, Aaron Seaton, Daniel Johnson, Robert University of Maryland Eastern Shore United States Department of Engineering and Aviation Sciences University of Maryland Eastern Shore United States UMES/Rutgers University United States Rutgers University Biomedical Engineering Department United States United States University of Minnesota Mechanical Engineering Program United States United States Department of Mathematics and Computer Science University of Maryland Eastern Shore United States UMES France Department of Mathematics and Computer Sciences

With support from HBCU-UP (Historically Black College and University - Undergraduate program) at National Science Foundation (NSF), the ACTION (Advanced Curriculum and Technology-Based Instructional Opportunities Network) program at University of Maryland Eastern Shore (UMES) is promoting inquiry based active learning and research projects among undergraduate STEM (Science, Technology, engineering and Mathematics) majors. This paper highlights efforts of selected freshman and sophomore engineering majors while performing ACTION projects at UMES. Integration of Lego-Mindstorm Robotic Invention System as well as ProEngineer and ProMechanica software for solid modeling and analysis are the focus of the reported endeavors. Involvement in ACTION projects have not only reinforced concepts introduced in classroom setting but have inspired students to be engaged in the process of learning and discovery well beyond expectations of the course syllabi, format, and structure. © American Society for engineering Education, 2006.

关键词： engineering education

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Generalization of Motor Adaptation Skills from Bimanual-Grasp to Individual Limbs

Generalization of Motor Adaptation Skills from Bimanual-Gras...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jamie Hitchens James Patton Sensory Motor Performance Program Rehabilitation Institute of Chicago Physical Medicine & Rehabilitation Mechanical and Biomedical Engineering Northwestern University Chicago IL USA Sensory Motor Performance Program Rehabilitation Institute of Chicago and Biomedical Engineering graduate program Northwestern University Chicago IL USA

We reported previously that the skills transferred from practicing using a bimanual grasp to skills in right hand are small but significant. In this study on healthy right-handed people we compared how well skills learned while training using a bimanual grasp transferred to the left and right hands performance individually. As before, the task was to make target-directed reaching movements while grasping a planar robotic device that systematically disturbed movements at the handle. Results showed that skills learned while practicing with a bimanual grasp generalized (transferred) to both the dominant and the non-dominant arm equally well, with the right limb benefiting the most because it began with less error

关键词： USA Councils Robots Grasping Rehabilitation robotics biomedical engineering Cities and towns DC motors Force control Motion control Torque control

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Effect of porous oxide films on characterization and bioactivity of titanium niobium alloy by electrochemical treatments

Effect of porous oxide films on characterization and bioacti...

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Biological Nanostructures, Materials, and Applications - 210th ECS Meeting

作者： Peng, Pei-Wen Pan, Yung-Ning Shyng, Yih-Chuen Chen, Chin-Sung Ou, Keng-Liang Department of Mechanical Engineering College of Engineering National Taiwan University Taipei 110 Taiwan Division of Oral and Maxillofacial Surgery Kaohsiung Military General Hospital Kaohsiung 807 Taiwan Department of Dentistry Cathay General Hospital Taipei 110 Taiwan Department of Dentistry Cathay General Hospital Sijhih Taipei 110 Taiwan Graduate Institute of Oral Sciences College of Oral Medicine Taipei Medical University Taipei 110 Taiwan Graduate Institute of Biomedical Materials and Engineering College of Oral Medicine Taipei Medical University Taipei 110 Taiwan

ISBN: (纸本)9781604233728

In the present investigation, the mechanical properties of TiNb alloys were modified by electrochemical treatment. The properties of the TiNb alloy specimens were determined by electrochemical measurement and material analyses. The effects of titanium hydride compounds on the formation of porous structural oxide film during electrochemical surface treatment are examined by XPS, TF-XRD and SEM. Oxide films are formed during anodization following cathodic pretreatments, TiH1.971 is formed by cathodic pretreatment. The TiH1.971is directly dissolved following anodic treatment. Additionally, the porous TiNb that was formed by the dissolution of TiH 1.971 were modified to porous oxide films. Hydrogen charging is important in forming porous oxide films. Anodization following cathodic pretreatment not only yields a thick oxide film, but also produces porous structures, Implanting bioactive TiNb into a porous oxidation film promotes bone-interface contact, improving osseo/osetointegration. copyright The Electrochemical Society.

关键词： Oxide films

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A novel biodegradable system based on BSA/PCL core-shell structured nanofibers for controlled drug delivery

A novel biodegradable system based on BSA/PCL core-shell str...

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2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

作者： Feng, Y. Zhang, Y.Z. Yong, T. Ramakrishna, S. Graduate Program in Bioengineering National University of Singapore Singapore Singapore Department of Mechanical Engineering National University of Singapore Singapore Singapore Division of Bioengineering National University of Singapore Singapore Singapore NUS Nanoscience and Nanotechnology Initiative National University of Singapore Singapore Singapore

ISBN: (纸本)0976798573

Electrospun core-shell structured nanofibers encapsulating BSA were evaluated as a potential drug delivery model in a biological system in the present study. These nanofibers were prepared by coaxial electrospinning method with PCL as the shell and BSA as the core. During electrospinning, graded and constant feed rates were set for the core and shell components, respectively. These fibers were characterized for their structure, in vitro release, and interactions with human dermal fibroblasts (HDFs). The core-shell structure was confirmed by TEM and ATR-FTIR spectroscopy. Release kinetic studies of these nanofibers without HDFs showed a gradual release of BSA instead of a burst release profile. Faster release was observed when HDFs were cultured on these fibers. These results suggest that the core-shell structured nanofibers could possibly have great potentials as a novel controlled drug delivery system, as well as tissue engineering scaffolds encapsulating bioactive molecules for tissue repair and regeneration.

关键词： Nanostructured materials

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