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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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Takeoff Parameter Estimation for a Subscale Flight Test of an Amphibious Floatplane

Takeoff Parameter Estimation for a Subscale Flight Test of a...

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AIAA Science and Technology Forum and Exposition, AIAA SciTech Forum 2025

作者： Rocha, Ana C. S. Medeiros, Eduardo Bauzer Magalhães, Tarcisio Faustino Tofaneli, Luzia Aparecida Oliveira, Turan Dias Sieves, Guilherme Benaci Guimarães, Tamara Graduate Program of Mechanical Engineering Federal University of Minas Gerais MG Belo Horizonte31270-901 Brazil Department of Energy Senai CIMATEC University Center BA Salvador41650-010 Brazil Department of Mechanical Engineering The Pennsylvania State University University ParkPA16802 United States

ISBN: (数字)9781624107238

ISBN: (纸本)9781624107238

The recent renewed interest in amphibious seaplane operation has stimulated the research related to this class of airplane. In fact, modern techniques previously developed for conventional land planes are now being modified to suit the development of these aircraft. Even though computer simulation presently offers highly efficient design tools there is still the need for experimental testing. Modern development of micro electric motors and actuators, together with the development of compact power electronics have laid the conditions for the development of Subscale Flight Testing (SFT), a very efficient tool for the improvement of the aircraft modeling process. The present research addresses the problem of conceptual design of reduced scale f loatplanes. Takeoff performance, one of the most complex flight phases of an amphibious airplane, is considered a modeling process considerably more difficult than the corresponding conventional land estimation. A typical floatplane, now being designed by the authors, is used to illustrate this development. The dynamic scaling process is described, and the expected performance of a reduced scale is shown. The authors expect to use in the near future the acquired insight to carry their own SFT flight test, and also improve modeling also providing improvements applicable to computer simulation. © 2025, American Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Amphibious aircraft

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Synthesis of amorphous silica from rice husk ash using the sol-gel method: Effect of alkaline and alkaline concentration

Synthesis of amorphous silica from rice husk ash using the s...

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3rd International Conference on Chemical engineering and Applied Sciences, ICChEAS 2022

作者： Aprilia, Sri Rosnelly, Cut Meurah Zuhra Fitriani, Fitriani Haffiz Akbar, Emir Raqib, Muhammad Rahmah, Khairul Amin, Amri Baity, Rima Aidi Department of Chemical Engineering Engineering Faculty Universitas Syiah Kuala Banda Aceh23111 Indonesia Doctoral Program School of Engineering Post Graduate Program Universitas Syiah Kuala Banda Aceh23111 Indonesia Mechanical Engineering Department Engineering Faculty University of Abulyatama Lampoh Keude-Aceh Besar Indonesia

In this study, silica extraction from RHA (rice husk ash) has been successfully performed by alkaline using KOH and NaOH with sol-gel precipitation. The silica gel was characterized for the functional group by FTIR, crystallinity with XRD, structure silica with SEM and particle size with PSA. The results show the higher concentration of solvent led to higher silica. The FTIR analysis revealed vibrations of Si-O and Si-O-Si on the product. Additionally, observed to be amorphous and aggregated, the silica extracted from RHA also exhibited a decrease in all samples. © 2023 Elsevier Ltd. All rights reserved.

关键词： Sodium hydroxide

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Multiplexed Nanoscopy via Buffer Exchange

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ACS Nano 2024年第34期18卷 23445-23456页

作者： Chang, Ting-Jui Ben Yang, T. Tony Department of Electrical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei10617 Taiwan

Understanding cellular functions, particularly in their intricate complexity, can greatly benefit from the spatial mapping of diverse molecules through multitarget single-molecule localization microscopy (SMLM). Existing methodologies, primarily restricting the encoding dimensions to color and lifetime or requiring cyclic staining, often involve broad chromatic detection, specialized optical configurations, or sophisticated labeling techniques. Here, we propose a simple approach called buffer-exchange stochastic optical reconstruction microscopy (beSTORM), which introduces an additional dimension to differentiate between single molecules irrespective of their spectral properties. This method leverages the distinguishable photoblinking responses to distinct buffer conditions, offering a straightforward yet effective means of fluorophore discrimination. Through buffer exchanges, beSTORM achieves multitarget SMLM imaging with minimal crosstalk. Direct integration with expansion microscopy (ExM) demonstrates its capability to resolve up to six proteins at the molecular level within a single emission color without chromatic aberration. Overall, beSTORM presents a highly compatible imaging platform, promising significant advancements in highly multiplexed nanoscopy for exploring multiple targets in biological systems with nanoscale precision. © 2024 The Authors. Published by American Chemical Society.

关键词： Stochastic systems

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Effect of Sn addition on electrochemical activity of ribbons of Mg-Al-Ca anode material for rechargeable magnesium batteries fabricated by rapid solidification

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Keikinzoku/Journal of Japan Institute of Light Metals 2025年第1期75卷 9-13页

作者： Fukuta, Yoshitaka Kikura, Kensei Tsukeda, Tadayoshi Aida, Tetsuo Tabata, Hironobu Kurihara, Hideki Suzuki, Mayumi Program of Materials Science and Engineering Studies in Science and Engineering Graduate School of Science and Engineering University of Toyama 3190 Gofuku Toyama-shi Toyama930-8555 Japan Graduate School of Science and Engineering University of Toyama Toyama-shi Toyama Japan Faculty of Sustainable Design Academic Assembly University of Toyama Toyama-shi Toyama Japan CHUETSU METAL WORKS CO. LTD. Nakaniikawagun Toyama Japan Saitama Industrial technology Center Kawaguchi-shi Saitama Japan Department of Mechanical Systems Engineering Faculty of Engineering Toyama Prefectural University Imizu-shi Toyama Japan

Magnesium-based batteries are potential candidates for next-generation rechargeable batteries due to the divalent nature of magnesium cations and the natural abundance of magnesium resources. In this study, the electrochemical activity of Mg-6mass%Al-3mass%Ca anodes combined with Sn was investigated. Thin ribbons of the anode specimens were prepared by a single-roll rapid solidification method. The results showed that the electrochemical activity increased upon adding 1 mass% Sn, while it decreased for 3 mass% Sn. Based on the results of an X-ray diffraction analysis, the addition of Sn led to the formation of Mg2Sn and Ca2Sn phases, which increased the lattice distortion. Scanning electron microscopy observations indicated that these secondary phases were homogeneously distributed for 1 mass% Sn addition, while they were coarsely distributed for 3 mass% Sn. © 2025 The Japan Institute of Light Metals.

关键词： X ray diffraction analysis

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Design and Feasibility Test of In-House Indirect Perfusion Bioreactor for 3-D Cell Culture 15

Design and Feasibility Test of In-House Indirect Perfusion B...

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15th biomedical engineering International Conference, BMEiCON 2023

作者： Suwannaphan, T. Tharasanit, T. Wongpakham, T. Pimpin, A. Chessadangkul, K. King Mongkut's University of Technology North Bangkok Department of Mechanical Engineering Technology Bangkok Thailand Faculty of Veterinary Science Chulalongkorn University Department of Obstetrics Gynaecology and Reproduction Bangkok Thailand Chulalongkorn University Faculty of Engineering Department of Mechanical Engineering Bangkok Thailand Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand

ISBN: (纸本)9798350345247

Selection of bioreactor system depends on many factors such as type of products, process of culture, and product density. No standard for development methodology is available nowadays. This work demonstrated the development of multi mini-chamber indirect perfusion bioreactor to support 3-D cell culture. The systems consisted of scaffolds, cell/scaffold retainers, culture tanks with a single peristaltic pump. Flow simulation was conducted to investigate the effects of flow rate and inlets/outlets' position on the distribution of shear stresses on the cell/scaffold cassettes installed inside the bioreactor. The prototype with 4 culture tanks connected in series was tested for long period operation. Lastly, preliminary experiments to culture and differentiate pig muscle stem cells were conducted. The results showed that muscle cells were successfully differentiated both on glass slides and aloe vera scaffolds inside the developed bioreactor. © 2023 IEEE.

关键词： Flow simulation

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Interfering with sleep apnea

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Bioelectronic Medicine 2024年第1期10卷 1-3页

作者： Pedersen, Nigel Paul Astorga, Raul Castillo Department of Neurology School of Medicine and Center for Neuroscience University of California Davis 1515 Newton Court DavisCA95618 United States Graduate Program in Biomedical Engineering University of California DavisCA95618 United States

The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect of non-invasive stimulation of the hypoglossal nerve by an interference envelope of interfering carrier waves is examined in mice and participants with sleep apnea. This stimulation is capable of activating the nerve and reducing apnea-hypopnea events. Temporally interfering electric fields have potential applications far beyond hypoglossal stimulation and may represent a revolutionary new approach to treating illness and understanding the functional organization of the nervous system. © 2024, The Author(s).

关键词： Electric fields

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A Comprehensive Technique Based on Machine Learning for Device and Circuit Modeling of Gate-All-Around Nanosheet Transistors

IEEE Open Journal of Nanotechnology

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IEEE Open Journal of Nanotechnology 2023年 4卷 181-194页

作者： Butola, Rajat Li, Yiming Kola, Sekhar Reddy National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Institute of Communications Engineering the Institute of Biomedical Engineering the Department of Electronics and Electrical Engineering the Institute of Pioneer Semiconductor Innovation and the Institute of Artificial Intelligence Innovation Hsinchu300093 Taiwan

Machine learning (ML) is poised to play an important part in advancing the predicting capability in semiconductor device compact modeling domain. One major advantage of ML-based compact modeling is its ability to capture complex relationships and patterns in large datasets. Therefore, in this paper a novel design scheme based on dynamically adaptive neural network (DANN) is proposed to develop fast and accurate compact model (CM). This framework constitutes a powerful yet computationally efficient methodology and exhibits emergent dynamic behaviors. This paper demonstrates that the compact model based on ML can be designed to replicate the performance of conventional compact model for nanodevices. For this work, gate-all-around (GAA) nanosheet (NS) device characteristics are comprehensively analyzed for process variability sources using the proposed model. The device geometry parameters such as channel length, nanosheet width and nanosheet thickness are fed as input features to the DANN model. The adaptive neural network learns dynamically by updating weights of the model in accordance with the input features and achieves accurate neural weight convergence. The proposed model predicted the electrical characteristics of NS devices with less than 1% error rate. The model is also implemented and validated for the simulations of digital circuit designs such as inverter, and logic gates. ©;2023 The Authors.

关键词： Circuit simulation

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Label-Free Classification of L-Histidine Vs Artificial Human Sweat Using Laser Scribed Electrodes and a Multi-Layer Perceptron Neural Network 46

Label-Free Classification of L-Histidine Vs Artificial Human...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： García-Rodríguez, William Saavedra-Ruiz, Andrés Resto-Irizarry, Pedro J. University of Puerto Rico Department of Mechanical Engineering Mayagüez00680 Puerto Rico University of Puerto Rico Bioengineering Graduate Program Mayagüez00680 Puerto Rico

ISBN: (纸本)9798350371499

A challenge in wearable technology lies in the realtime monitoring of molecular biomarkers associated with human health. Electrochemical sensors are one of the most useful tools for this purpose and are commonly used in health monitoring devices. Electrochemical biosensing is particularly convenient when used in user-friendly, low-cost devices for testing noninvasive body fluids such as sweat and saliva. However, achieving high selectivity and specificity in measurements depends on the complexity of the biomarker and the stability of the biomarker capture molecule. In this study, laser-scribed electrodes (LSEs) were manufactured using a CO2 laser cutter on Polyimide for the label-free classification of sweat components. Cyclic voltammetry experiments were performed on artificial human sweat and the sweat component L-Histidine. The resulting voltammogram data served as input to train a Multi-Layer Perceptron Neural Network (MLP-NN) algorithm capable of classifying L-Histidine and artificial sweat. © 2024 IEEE.

关键词： Carbon dioxide lasers

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Design considerations for piezocomposite materials for electrical stimulation in medical implants

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Journal of Medical engineering and Technology 2022年第5期46卷 402-414页

作者： Krech, Ember Haas, Evan Tideman, Grace Reinsch, Bonnie Friis, Elizabeth Bioengineering Graduate Program University of Kansas LawrenceKS United States Department of Mechanical Engineering University of Kansas LawrenceKS United States Department of Chemical Engineering University of Kansas LawrenceKS United States

Incidence of non-union following long bone fracture fixation and spinal fusion procedures is increasing, and very costly for patients and the medical system. Direct current (DC) electrical stimulation has shown success as an adjunct therapy to stimulate bone healing and increase surgery success rates, though drawbacks of current devices and implantable battery packs have limited widespread use. Energy harvesting utilising piezoelectric materials has been widely studied for powering devices without a battery, and a preclinical animal study has shown efficacy of a piezocomposite spinal fusion implant resulting in faster, more robust fusion. Most piezoelectric energy harvesters operate most effectively at high frequencies, limiting power generation from loads experienced by orthopaedic implants during human motion. This work characterises the efficient power generation capability of a novel composite piezoelectric material under simulated walking loads. Building on compliant layer adaptive composite stacks (CLACS), the power generation of mixed-mode CLACS (MMCLACS) is defined. Utilising poling direction to capitalise on in-plane strain generation due to compliant layer expansion, MMCLACS significantly increased power output compared to a standard piezo stack. The combination of radial and through-thickness poled piezoelectric elements within a stack to create MMCLACS significantly increases power generation under low-frequency dynamic loads. This technology can be adapted to a variety of architectures and assembled as a load-bearing energy harvester within current implants. MMCLACS integrated with implants would provide enough power to deliver bone healing electrical stimulation directly to the fusion site, decreasing non-union rates, and also could provide quantitative assessment of healing progression through load sensing. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Energy harvesting

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