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2024 Transactions of the American Nuclear Society on Winter Conference and Expo, ANS 2024

作者： Sanches, David Zilllinger, James Hamilton, Sarah Idaho National Laboratory Idaho FallsID United States Nuclear Engineering Program Mechanical Engineering Department Virginia Tech BlacksburgVA United States

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A Proposed Model for Calculate the Number of Mammography Machines for the South-West Area of Mexico 9th

A Proposed Model for Calculate the Number of Mammography Mac...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Martinez-Licona, Fabiola M. Martinez-Vazquez, Cipactli M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Breast cancer is a global health problem. Mexican statistics show that 28.2% of new cancer cases in women come from the breast, so efforts must be made to control the burden of the disease. Early detection is an essential part of the social programs aimed at female populations at potential risk, and mammography machines are the technology used to perform screening methods. The possible coverage of a region is mainly affected by the available technological resources. This paper presents a proposal model to determine the number of mammography machines required to meet the State’s requirements of Guerrero, Oaxaca and Chiapas, as those in which there are municipalities with the highest social backwardness. The socioeconomic and demographic determinants, as well as the screening mammography demand data, were extracted from official Mexican agencies. The model variables were selected from the categories of target population, epidemiological indicators and infrastructure. Under the author’s heuristic assumptions, the analytic hierarchy process produced the weight that led to selecting the final set of variables. The resource allocation principles were used to adapt the Resource Allocation Working Party (RAWP) focus formula from population to equipment to calculate the State Weighted Machines using the mentioned category adjustments. Model results with 2017 and 2020 data showed that, on average, 50% more mammography machines are needed to cover around 46% of the female population 50–64 years old in the studied States. Further study and analysis of the determinants of access to the service and the equipment proposals are necessary. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Resource allocation

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Analysis of Failure Causes in the Mammography Machines 9th

Analysis of Failure Causes in the Mammography Machines

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Hernandez-Contreras, Indira Martinez-Licona, Fabiola M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Patient safety arises from the need to prevent and protect patients from avoidable mistakes. Two fundamental concepts that shape patient safety are error and adverse events, the consequences may range from potentially dangerous complications, slow recoveries, high medical costs, or unnecessary deaths. Breast cancer has become a global health problem with one of the most expensive burdens among non-communicative diseases. Since screening mammography is the most used method for tumor identification, patient safety applied to this technology is focused on delivering safe and effective service that results in an accurate and reliable diagnosis. This paper presents the analysis of the causes that can induce a potential failure in the mammography machine, and the actions to correct them. We used a risk analysis approach to identify the failures that may occur while using a mammography machine in screening programs. We extracted the information about the failures from specialized consultation and discussion forums and technical and operation manuals. We adapted the concepts of severity, occurrence, and detection involved in calculating the risk priority number according to the Failure Mode and Effects Analysis method, assigning them one of three levels (low, medium, and high). The adapted risk priority level was calculated from the averaged product of levels from the mentioned components. The results were mapped into an Ishikawa diagram, and an action procedure proposal was shown. The causes found are defined mainly concerning the handling of the equipment components, although causes related to the acquisition technique, patient handling, and availability of support information. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Risk assessment

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Implementation and calibration of spectroscopic single-molecule localization microscopy

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BMC Methods 2025年第1期2卷 1-20页

作者： Brenner, Benjamin Yeo, Wei-Hong Lee, Youngseop Kweon, Junghun Sun, Cheng Zhang, Hao F. Department of Biomedical Engineering Northwestern University Evanston USA Department of Mechanical Engineering Northwestern University Evanston USA

Spectroscopic single-molecule localization microscopy allows multi-color super-resolution images with high spectral sensitivity. While its profile has been steadily growing, it is still under-utilized in biology labs, and the complexity of adoption for existing is prohibitive. In this protocol, we provide essential information for researchers to implement sSMLM in a laboratory setting. We describe how to assemble and optically align the illumination and detection paths of a 3D dual-wedge prism-based sSMLM instrument. We provide detailed step-by-step instructions on performing spectral and axial calibration using fluorescent beads and a nanohole array, respectively. We also discuss using sSMLM to image fluorescently labeled cells and report a new MATLAB package RainbowSTORM v2 to reconstruct super-resolution 3D images. Further, we present representative images as typical anticipated results. By demonstrating an implementation of spectroscopic single-molecule localization microscopy that is simple to implement with commercial microscope systems using freely distributed hardware and by introducing new calibration and image processing user interfaces, we hope to remove some of the barriers to entry that biological labs face when entering the spectroscopic super-resolution field. Ultimately, this protocol will allow users to achieve multi-color super-resolution imaging using a single excitation wavelength.

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Feature-oriented vibrations in LCD-based vat photopolymerization

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Journal of Manufacturing Processes 2025年 148卷 224-236页

作者： Xu, Han Li, Qizhou Zhang, Shangxiong Pu, Changyuan Chen, Yizhu Chen, Yong Center for Advanced Manufacturing University of Southern California Los AngelesCA90007 United States Department of Aerospace and Mechanical Engineering University of Southern California Los AngelesCA90089 United States Department of Industrial and Systems Engineering University of Southern California Los AngelesCA90089 United States Department of Biomedical Engineering University of Southern California Los AngelesCA90089 United States

Liquid crystal display (LCD)-based vat photopolymerization (VPP) is a versatile and accessible 3D printing technology due to its low cost and fast printing speed. It is ideal for applications requiring rapid fabrication of high-resolution intricate geometry. However, as the feature size approaches the resolution limit (a single pixel) of the LCD mask, undesirable pixelated aliasing emerges, resulting in increased roughness and dimensional inaccuracies. This study introduces a new feature-oriented vibration method in LCD-based VPP to enhance linear feature fabrication precision. Coupled with grayscale mask images, it can significantly reduce pixelated aliasing and improve dimensional accuracy in printing linear features. In this method, the mask images are vibrated along the direction of a linear feature to enhance its feature smoothness while maintaining dimensional accuracy. The vibration amplitude is optimized based on the simulation of the printing results derived from the light energy model of the LCD mask. This method achieves up to a 4× improvement in line roughness (0.6 μm–1.5 μm) compared to conventional vat photopolymerization (1.2 μm–5.9 μm) and demonstrates precise dimensional control with subpixel-level (10 μm) accuracy for an LCD with 50 μm pixel size. The advantages of the feature-oriented vibration method are further highlighted through the fabrication of honeycomb metamaterials with enhanced strength and micro-filters with customizable shapes and mesh sizes. The study demonstrates that controlled vibrations provide an effective path for future VPP development in microstructure fabrication. © 2025 The Society of Manufacturing Engineers

关键词： Masks

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Design of a Control System on the HVAC Damper to Regulate Temperature and Humidity in the Isolation Room 4th

Design of a Control System on the HVAC Damper to Regulate Te...

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4th International Conference on Experimental and Computational Mechanics in engineering, ICECME 2022

作者： Salamul Fajar Sabri, M. Rizal, Samsul Kurniawan, Rudi Putra, Rachmad Almi Suheri, Suheri Master of Mechanical Engineering Program Faculty of Engineering Universitas Syiah Kuala Banda Aceh23111 Indonesia Department of Mechanical and Industrial Engineering FacultyofEngineering Universitas Syiah Kuala Banda Aceh23111 Indonesia Doktoral Program Faculty ofEngineering Universitas Syiah Kuala Banda Aceh23111 Indonesia

ISBN: (纸本)9789819974948

Most infectious diseases are caused by viruses that are spread from one person to another through the air. Isolation room is a room that keeps virus in infected people from spreading to other people by maintaining temperature and humidity. Therefore, a system is needed that regulates the isolation room to remain sterile, where this system must control and maintain the stability of air circulation in the room. For this purpose, this study proposes the design of an automated control system to regulate the temperature and humidity in an isolated room by controlling the supply air with damper. The method that is used in making this control system is experimental and analysis from sensor readings that will be used as a sign of decision-making for the damper output that will control the air flow to the isolation room with closed loop algorithm for the system control, the controller will send digital signal to the damper relay based on sensor reading, so that the data results of the experiment and analysis can see whether the control system can work well or not. The successful performance of the control system is seen from results of sensor readings;when the system changed the damper position it can maintain the isolation room situation around 22 °C to 24 °C for temperature and 50% until 60% for the humidity. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Viruses

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programmable Modular Acoustic Microrobots 6

Programmable Modular Acoustic Microrobots

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6th International Conference on Manipulation, Automation, and Robotics at Small Scales, MARSS 2023

作者： Cherukumilli, Subrahmanyam Kirmizitas, Fatma Ceren Sokolich, Max Valencia, Alejandra Karakan, M. Cagatay White, Alice E. Malikopoulos, Andreas A. Das, Sambeeta University of Delaware Department of Mechanical Engineering NewarkDE19716 United States University of Delaware Department of Animal and Food Sciences NewarkDE19716 United States Boston University Department of Biomedical Engineering BostonMA02215 United States Boston University Department of Mechanical Engineering Departments of Biomedical Engineering and Materials Science and Engineering BostonMA02215 United States

ISBN: (纸本)9798350330397

Microrobots have emerged as promising tools for biomedical and in vivo applications, leveraging their untethered actuation capabilities and miniature size. Despite extensive research on diversifying multi-actuation modes for single types of robots, these tiny machines tend to have limited versatility while navigating different environments or performing specific tasks. To overcome such limitations, self-assembled microstructures with on-demand reconfiguration capabilities have gained recent attention as the future of biocompatible microrobotics, since they can address drug delivery, microsurgery, and organoid development processes. Reversible modular reconfiguration structures require specific arrangements of particles that can assume several shapes when external fields are applied. We show how magnetic interaction can be used to assemble cylindrical microrobots into modular microstructures with different shapes. The motion of the formed microstructure is actuated via an external acoustic field, which generates responsive forces in the air bubbles trapped in the inner cavity of the robots. An external magnetic field can also steer these structures. We illustrate these capabilities by assembling the robots into different shapes that can swim and be steered, showing the potential to perform biomedical applications. Furthermore, we confirm the biocompatibility of the cylindrical microrobots used as the building blocks of our microstructure. Exposing Chinese Hamster Ovary cells to our microrobots for 24 hours demonstrates cell viability when in contact with the microrobot. © 2023 IEEE.

关键词： Microstructure

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Rolling Helical Microrobots for Cell Patterning 6

Rolling Helical Microrobots for Cell Patterning

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6th International Conference on Manipulation, Automation, and Robotics at Small Scales, MARSS 2023

作者： Yang, Yanda Kirmizitas, Fatma Ceren Sokolich, Max Valencia, Alejandra Rivas, David Karakan, M. Cagatay White, Alice E. Malikopoulos, Andreas A. Das, Sambeeta University of Delaware Department of Mechanical Engineering NewarkDE19716 United States University of Delaware Department of Animal and Food Sciences NewarkDE19716 United States Boston University Department of Biomedical Engineering BostonMA02215 United States Boston University Department of Mechanical Engineering Departments of Biomedical Engineering and Materials Science and Engineering BostonMA02215 United States

ISBN: (纸本)9798350330397

Microrobots, untethered miniature devices capable of performing tasks at the microscale, have gained significant attention in the fields of robotics and biomedicine. These devices hold immense potential for various industrial and scientific applications, including targeted drug delivery and cell manipulation. In this study, we present a novel magnetic rolling helical microrobot specifically designed for bio-compatible cell patterning. Our microrobot incorporates both open-loop and closed-loop control mechanisms, providing flexible, precise, and rapid control for various applications. Through experiments, we demonstrate the microrobot's ability to manipulate cells by pushing them while rolling and arranging cells into desired patterns. This result is particularly significant as it has implications for diverse biological applications such as tissue engineering and organoid development. Moreover, we showcase the effectiveness of our microrobot in a closed-loop control system, where it successfully follows a predetermined path from an origin to a destination. The combination of cellular manipulation capabilities and trajectory-tracking performance underlines the versatility and potential of our magnetic rolling helical microrobot. The ability to control and navigate the microrobot with high precision opens up new possibilities for advanced biomedical applications. These findings contribute to the growing body of knowledge in microbotics and pave the way for further research and development in the field. © 2023 IEEE.

关键词： Cells

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In-vitro analysis of neo-sinus flow dynamics after transcatheter aortic valve replacement using particle image velocimetry technique

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Journal of Biorheology 2023年第2期37卷 162-169页

作者： Xu, Xuetong Hattori, Kaoru Ai, Ryusuke Iwasaki, Kiyotaka Department of Integrative Bioscience and Biomedical Engineering Graduate School and Advanced Science of Engineering Waseda University Tokyo1628480 Japan Waseda Research Institute for Science and Engineering Waseda University Tokyo1698555 Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University Tokyo1628480 Japan Cooperative Major in Advanced Biomedical Sciences Joint Graduate School of Tokyo Women’s Medical University and Waseda University Waseda University Tokyo1628480 Japan

Particle imaging velocimetry (PIV) is an effective methodology for investigating flow in the neo-sinus after transcatheter aortic valve replacement. However, understanding fluid dynamics in the lower part of the neo-sinus has been challenging due to limited optical access. In this study, we developed a novel PIV technique to extensively visualize the neo-sinus and to assess the potential risk of transcatheter heart valve (THV) leaflet thrombosis with the intra-annular valve. This technique involved shooting in the sinus and neo-sinus via the ventral wall of the aortic silicone model to visualize a larger region of the neo-sinus, including the lower portions (overlooking-view shooting). In the neo-sinus, stagnated flow was observed throughout the entire region in middle and late diastole. By contrast, in the native sinus, low-velocity vortical flow that inflows into the coronary artery was developed exclusively in the upper region. The present results suggest that the lower portion of the native sinus, as well as the neo-sinus, may be at high risk for leaflet thrombosis. The novel PIV technique holds promise for revealing influences of fluid dynamics on THV leaflet thrombosis with various stent flame designs. © 2023, Japanese Society of Biorheology. All rights reserved.

关键词： Velocity measurement

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Soft,full Wheatstone bridge 3D pressure sensors for cardiovascular monitoring

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npj Flexible Electronics 2024年第1期8卷 910-917页

作者： Yoonseok Park Haiwen Luan Kyeongha Kwon Ted S.Chung Seyong Oh Jae-Young Yoo Gooyoon Chung Junha Kim Suhyeon Kim Sung Soo Kwak Junhwan Choi Hoang-Phuong Phan Seonggwang Yoo Hyoyoung Jeong Jaeho Shin Sang Min Won Hong-Joon Yoon Yei Hwan Jung John A.Rogers Department of Advanced Materials Engineering for Information and Electronics Integrated Education Institute for Frontier Science&Technology(BK21 Four)Kyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea Department of Mechanical and Aerospace Engineering University of California San DiegoLa JollaCA 92093USA School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Columbia UniversityNew YorkNYUSA Division of Electrical Engineering Hanyang University ERICAAnsan 15588Republic of Korea Department of Semiconductor Convergence Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Biomedical Research Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Chemical Engineering Dankook UniversityYonginGyeonggi-do 16890Republic of Korea School of Mechanical and Manufacturing Engineering Tyree Institute of Health EngineeringUniversity of New South WalesSydneyNSW 2052Australia Querrey Simpson Institute for Bioelectronics Northwestern University EvanstonEvanstonIL 60208USA Department of Electrical and Computer Engineering University of California DavisDavisCA 95616USA Department of Electrical and Computer Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Electronic Engineering Gachon UniversitySeongnamsiGyeonggi-do 13120Republic of Korea Department of Electronic Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Biomedical EngineeringNeurological SurgeryChemistryMechanical EngineeringElectrical Engineering and Computer Science Simpson Querrey Institute and Feinberg Medical SchoolCenter for Bio-Integrated ElectronicsNorthwestern University EvanstonEvanstonIL 60208USA

Variations in parameters associated with the ambient environment can introduce noise in soft,body-worn *** example,many piezoresistive pressure sensors exhibit a high degree of sensitivity to fluctuations in temperature,thereby requiring active compensation *** research presented here addresses this challenge with a multilayered 3D microsystem design that integrates four piezoresistive sensors in a full-Wheatstone bridge *** optimized layout of the sensors relative to the neutral mechanical plane leads to both an insensitivity to temperature and an increased sensitivity to pressure,relative to previously reported devices that rely on similar operating *** this 3D pressure sensor into a soft,flexible electronics platform yields a system capable of real-time,wireless measurements from the surface of the *** above the radial and carotid arteries yields high-quality waveforms associated with pulsatile blood flow,with quantitative correlations to blood *** results establish the materials and engineering aspects of a technology with broad potential in remote health monitoring.

关键词： Wheat bridge thereby

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