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A handheld HIV detection platform using paper-based sample preparation and real-time isothermal amplification

Microsystems & Nanoengineering 2024年第6期10卷 213-223页

作者： George Adedokun Gurjit Sidhu Morteza Alipanah Gary P.Wang Z.Hugh Fan Interdisciplinary Microsystems Group Department of Mechanical&Aerospace EngineeringUniversity of FloridaGainesvilleFL 32611USA Division of Infectious Diseases and Global Medicine Department of MedicineCollege of MedicineUniversity of FloridaGainesvilleFL 32610USA Medical Service North Florida/South Georgia Veterans Health SystemGainesvilleFL 32608USA Purrit Family Department of Biomedical Engineering University of FloridaGainesvilleFL 32611USA

Early and accurate diagnosis of human immunodeficiency virus(HIV)infection is essential for timely initiation of antiretroviral therapy(ART)and prevention of new ***,conventional nucleic-acid-based tests for HIV detection require sophisticated laboratory equipment and trained personnel,which are often unavailable at the point-of-care(POC)or unaffordable in resource-limited *** report our development of a low-cost,integrated platform for POC testing of *** platform integrates viral nucleic acid extraction on a paper substrate and reverse transcription loop-mediated isothermal amplification(RT-LAMP)in a portable,battery-powered heating device with real-time *** platform does not require laboratory infrastructure such as power *** assay showed a detection limit of 30 copies/mL of HIV RNA in 140μL human serum or 4 copies/reaction using 50μL human serum,with no cross-reactivity with hepatitis C virus(HCV).We validated the platform using both plasma samples spiked with HIV and clinical samples from HIV-positive individuals,and compared it with standard laboratory assays based on polymerase chain reaction(PCR).These results demonstrate the feasibility of our platform for HIV testing at the POC.

关键词： prevention testing isothermal

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LOW-COST NEAR-INFRARED SENSING FOR ENHANCED IN-SITU MONITORING IN LASER-POWDER BED FUSION 11

LOW-COST NEAR-INFRARED SENSING FOR ENHANCED IN-SITU MONITORI...

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11th ASPE-euspen Summer Topical Meeting on Advancing Precision in Additive Manufacturing

作者： Campbell, Caleb T. Brady, Brett E. Miramontes, Eduardo Khurana, Shuchi Jared, Bradley H. University of Tennessee Knoxville Department of Mechanical Aerospace and Biomedical Engineering KnoxvilleTN United States Addiguru HoustonTX United States

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Concentric Tube Robot Redundancy Resolution via Velocity/Compliance Manipulability Optimization

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IEEE Robotics and Automation Letters 2023年第11期8卷 7495-7502页

作者： Shen, Jia Wang, Yifan Azizkhani, Milad Qiu, Deqiang Chen, Yue Georgia Institute of Technology Department of Mechanical Engineering AtlantaGA30332 United States Emory University Department of Radiology and Imaging Sciences AtlantaGA30338 United States Georgia Institute of Technology/Emory Department of Biomedical Engineering AtlantaGA30332 United States

Concentric Tube Robots (CTR) have the potential to enable effective minimally invasive surgeries. While extensive modeling and control work have been proposed in the past decade, limited efforts have been made to improve the path tracking performance from the perspective of manipulability, which can be critical to generate safe motion and feasible actuator commands. In this letter, we propose a gradient-based redundancy resolution framework that optimizes velocity/compliance manipulability-based performance indices during path tracking for a kinematically redundant CTR. We efficiently calculate the gradients of manipulabilities by propagating the first- and second-order derivatives of state variables of the Cosserat rod model along the CTR arc length, reducing the gradient computation time by 68% compared to the finite difference method. Task-specific performance indices are optimized by projecting the gradient into the null-space of path tracking. Simulation results show that the proposed method is able to accomplish the required tasks while commonly used redundancy resolution approaches underperform or even fail. © 2016 IEEE.

关键词： Redundancy

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Spectral Analysis and Validation of Parietal Signals for Different Arm Movements

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Intelligent Automation & Soft Computing 2023年第6期36卷 2849-2863页

作者： Umashankar Ganesan A.Vimala Juliet R.Amala Jenith Joshi School of Electrical and Electronics Engineering Sathyabama Institute of Science and TechnologyChennai600119India School of Electronics and Instrumentation Engineering SRM Institute of Science and TechnologyChennai630203India Department of Biomedical and Mechanical Engineering School of EngineeringNational University of IrelandGalwayH91 CF50Ireland

Brain signal analysis plays a significant role in attaining data related to motor *** parietal region of the brain plays a vital role in muscular *** approach aims to demonstrate a unique technique to identify an ideal region of the human brain that generates signals responsible for muscular movements;perform statistical analysis to provide an absolute characterization of the signal and validate the obtained results using a prototype *** can enhance the practical implementation of these frequency extractions for future neuro-prosthetic applications and the characterization of neurological diseases like Parkinson’s disease(PD).To play out this handling method,electroencepha-logram(EEG)signals are gained while the subject is performing different wrist and elbow ***,the frontal brain signals and just the parietal signals are separated from the obtained EEG signal by utilizing a band pass ***,feature extraction is carried out using Fast Fourier Transform(FFT).Subse-quently,the extraction process is done by Daubechies(db4)and Haar wavelet(db1)in MATLAB and classified using the Levenberg-Marquardt *** results of the frequency changes that occurred during various wrist move-ments in the parietal region are compared with the frequency changes that occurred in frontal EEG *** proposed algorithm also uses the deep learn-ing pattern analysis network to evaluate the matching sequence for each action that takes *** accuracy of 97.2%and maximum error range of 0.6684%are achieved during the *** of this research confirm that the Levenberg-Marquardt algorithm,along with the newly developed deep learn-ing hybrid PatternNet,provides a more accurate range of frequency changes than any other classifier used in previous works of *** on the analysis,the peak-to-peak value is used to define the threshold for the prototype arm,which performs all the intended degrees of freedom(DOF),verifying

关键词： Parietal EEG signals fast fourier transform Levenberg-Marquardt algorithm haar wavelet daubechies wavelet statistical analysis

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Design and development of an integrated enset processing machine suitable for central highland farmers of west shewa zone Ethiopia

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Discover Agriculture 2025年第1期3卷 1-26页

作者： Jima, Beka Adugna Kolhe, Kishor Purushottam Jiru, Moera Gutu Agricultural Machinery Engineering Program Department of Mechanical Engineering School of Mechanical Chemical and Materials Engineering at Adama Science and Technology University Adama Ethiopia Department of Mechanical Engineering School of Mechanical Chemical and Materials Engineering at Adama Science and Technology University Adama Ethiopia

The development of Integrated Enset processing technology is significant for the easy availability of stable food in the current condition for fulfilling the pangs of hunger in Ethiopia, currently; individual manual technologies such as decortication, corm granting, bulla extraction, and fermenting techniques eventually contribute to utilizing food security such as Kocho, which is not affordable for the marginal farmers of Ethiopia. However, there is a lack of integrated compromise of the all-function process of corm granting, decortication, and pulverization in one machine wholesome of the product such as Kocho, and bulla within consuming time and labor. Therefore, it is decided to design and develop an integrated enset processing machine for central high land of Ethiopian farmers with high-quality production. The physical and mechanical properties of the enset is studied to get an efficient and robust design of the various components. The overall design and development of proposed machine components were carried out at Adama Science and Technology University, Ethiopia by using ANSYS 2023 R1 software by considering the engineering economics and material specifications as per ASTM standards. The process parameters of the proposed machine are identified as feed rate, drum speed, concave to drum clearance, power requirement, etc. Also, the enset characteristics were considered as decorticating and granting, fiber cutting resistance, fiber length, dimension, shape, and weight. The overall developed enset integrated machine assembles are analyzed for granting and decorticating with drum clearance and bulla extraction throughput capacity, reliability, simplicity, safety, and overall cost. The machine's safety from a Design Perspective is checked and validated by a simulation study on the critical parts subjected to higher stresses. The cost of available individual decorticators, granting, pulverized, and bulla squeezer machines is costly to the farmer’s community. Theref

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Multidisciplinary Learning for Multifaceted Thinking in Globalized Society 13

Multidisciplinary Learning for Multifaceted Thinking in Glob...

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13th International Multi-Conference on Complexity, Informatics and Cybernetics, IMCIC 2022

作者： Hashimoto, Shigehiro Biomedical Engineering Department of Mechanical Engineering Kogakuin University Tokyo163-8677 Japan

ISBN: (纸本)9781950492602

Multifaceted thinking is essential to address global proposal. Learning experience in multidisciplinary fields is useful. Following steps are important: multifaceted understanding the purpose of instructions to society, considering advantages and disadvantages, considering options, and considering relationship between individual behavior and society. As a multidisciplinary field, biomedical engineering has been applied to the present study. As a topic of case study, COVID-19 has been selected. While answering the questions, the students (in Japan, and in Thailand) noticed the multifaceted problem and the diversity of related disciplines. The education system provided the experience of linking biomedical engineering learning (statistics, biomeasurement, cellular mechanics, micromachining, designing, immunology, artificial organs) to the proposal of the solution to the global problem. © 2022 IMCIC 2022 - 13th International Multi-Conference on Complexity, Informatics and Cybernetics, Proceedings. All rights reserved.

关键词： COVID-19

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Beyond the Bin: An Extensive Analysis of the Waste Stream at UCSI University, Malaysia and Its Impact on Greenhouse Gas Emissions 1

Beyond the Bin: An Extensive Analysis of the Waste Stream at...

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1st International Conference on Innovative engineering Sciences and Technological Research, ICIESTR 2024

作者： Malik, Johar Abbas Ahmed, Hein Htet Aung Hussain, Tanweer Ucsi University Faculty Of Engineering Technology & Built Environment Kuala Lumpur Malaysia The University of Dublin Trinity College Dublin Department of Mechanical Manufacturing & Biomedical Engineering Dublin02 Ireland

ISBN: (纸本)9798350348637

Around 50 billion tons of CO2-eq emit each year and municipal solid waste is the fourth biggest supplier of greenhouse gas emission globally due to which atmospheric temperature has increased vastly also human health and environment is at stake. Universities are trying to limit their waste generation and carbon emission. A study has been done on UCSI university municipal solid waste. Data for the campus waste is gathered and classified, and brief analysis of the waste is done in terms of components, recyclability, and greenhouse gas emissions. Each waste is classified into categories on behalf of their nature and capacity to be recycled, the data from this classified waste was used to perform life cycle analysis with the help of Open-LCA software to calculate carbon footprint of campus waste. Life cycle analysis was carried out in order to analyze the environmental impact of campus waste in detail and compute the daily and annual carbon footprint of campus-classified solid waste on behalf of these results, future trends in greenhouse gas emissions were forecasted, and solutions to reduce carbon footprint were suggested. These efforts will enable UCSI University to participate in the global sustainable race to reduce greenhouse gas emissions, which must reach zero by 2050. © 2024 IEEE.

关键词： Greenhouse gas emissions

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Synthesis, characterization, and interfacial adhesion of titania iodine-doped nanotubes architectures on additively manufactured Ti-6Al-4 V implant

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Materialwissenschaft und Werkstofftechnik 2025年第3期56卷 438-454页

作者： Taweekitikul, P. Aliyu, A.A. Decha-Umphai, D. Tantavisut, S. Khamwannah, J. Puncreobutr, C. Lohwongwatana, B. Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Trauma Unit Department of Orthopaedic Queen Savang Vadhana Memorial Hospital Chonburi20110 Thailand Biomedical Engineering Research Center Chulalongkorn University Bangkok10330 Thailand M3D Laboratory Advanced Materials Analysis Research Unit Department of Metallurgical Engineering Faculty of Engineering Chulalongkorn University Phayathai Road Wangmai Pathumwan District Bangkok10330 Thailand Biomechanics Research Center Meticuly Co. Ltd. Chulalongkorn University Bangkok10330 Thailand Hip Fracture Research Unit Department of Orthopaedic Faculty of Medicine Chulalongkorn University Bangkok10330 Thailand Department of Metallurgical Engineering Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand CambridgeMA02139 United States

This study aimed to synthesize, characterize, and evaluate the adhesion strength of titania nanotubes (titania nanotubes) and iodine-doped titania nanotubes (I-titania nanotubes) architectures on the additively manufactured Ti-6Al-4 V (Ti64) implant surface. The titania nanotubes and I-titania nanotubes were synthesized through two stages of electrochemical anodization, whereby titania nanotubes are anodically fabricated through a conventional approach and then modified by replacing the ethylene glycol electrolyte with potassium iodide solution. The characterization results revealed the formation of α-Ti, β-Ti, and titanium iodide (TiI2) phases on the titania nanotubes and I-titania nanotubes surfaces. The morphology of titania nanotubes exhibits a consistent diameter, evenly distributed, well-ordered array, and densely packed nanotubular structures. Formation of a water-soluble fluoride-rich [TiF6]2 complexes in the inner titania nanotubes surface and incessant nanotube′s sidewall etching resulted in poor interfacial titania nanotubes adhesion to the titanium-substrate surface. Iodine doping on the titania nanotubes is believed to reduce the [TiF6]2 complexes accumulation and the titania nanotubes sidewall etching. This facilitates the adhesion and interfacial mechanical anchorage between the titania nanotubes and the surface of the Ti64 implant. The hardness and adhesion strength of the titania nanotubes increased by more than 50 %, due to the formation of a hard titanium iodide film at the titania nanotubes/I-titania nanotubes surfaces and interfaces. © 2025 The Author(s). Materialwissenschaft und Werkstofftechnik published by Wiley-VCH GmbH.

关键词： Potassium iodide

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Quantitative Droplets for DNA Sequence Printing with a Low-voltage Logic Circuit, High-power Driver, and Micro-electromechanical Technology

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Sensors and Materials 2023年第7(2)期35卷 2265-2279页

作者： Peng, Chih-Wei Chou, Chen-Chia Chen, Zhen-Xi Liou, Jian-Chiun School of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei Taiwan Institute of Biophotonics National Yang Ming Chiao Tung University Taipei Taiwan

In this study, inkjet printing was used to produce quantitative droplets of a DNA sequence using a novel, high-density, high-resolution nano-ink inkjet chip. It contains thousands of tiny orifices like very tiny volcano-shaped nozzles. This technology was used to design high-speed, high-voltage drive circuit systems. This chip integrates digital circuits, an optoelectronic thin-film process, and micro-electromechanical process technology on a single monolithic chip. The entire chip is a very large digital circuit that controls more than 1000 nano-ink nozzles. The circuit design simulates and uses a 0.18 µm line width high-voltage process to drive an array of micro-electromechanical elements. It can drive 432 nozzles very quickly within 85 µs. According to this specification, the high-precision nano-inkjet print head was extended to drive 1296 nozzles in a sequential manner. It can complete dynamic tracking measurements and analyze a low trajectory of inkjet liquid. In research and development in the field of DNA detection and medical electronics, the developed DNA spray array can be quantitatively distributed on a glass slide. This technology can be extended to high-speed, high-density nozzles and micro-liquid spray applications. © MYU K.K.

关键词： DNA sequences

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