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Corrigendum to “Stiffness and stability of bamboo stem- A optimal design perspective” [Heliyon Volume 10, Issue 16, August 2024, Article e35403]

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Heliyon 2025年第9期11卷

作者： Mannan Sayyad Bhanudas Bachchhav Sachin Salunkhe Lenka Cepova Jiri Struz Emad Abouel Nasr Khaled M.S. Gad El Mola Department of Mechanical Engineering AISSMS College of Engineering Pune India Department of Biosciences Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences Chennai India Gazi University Faculty of Engineering Department of Mechanical Engineering Maltepe Ankara Turkey Department of Machining Assembly and Engineering Metrology Faculty of Mechanical Engineering VSB—Technical University of Ostrava 70800 Ostrava Czech Republic Faculty of Mechanical Engineering Department of Machine Parts and Mechanism VSB – Technical University of Ostrava 17. Listopadu 15/2172 CZ 708 33 Ostrava Czech Republic Department of Industrial Engineering College of Engineering King Saud University P.O. Box 800 Riyadh 11421 Saudi Arabia Department of Mechanical Engineering Industrial Engineering Program Helwan University Helwan Cairo Egypt

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Anomaly Detection in Pediatric and Adults Brain MRI with Generative Model

Anomaly Detection in Pediatric and Adults Brain MRI with Gen...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Chaojun Chen Khashayar Namdar Matthias W. Wagner Birgit B. Ertl-Wagner Farzad Khalvati Department of Mechanical and Industrial Engineering University of Toronto Institute of Medical Science University of Toronto Neurosciences & Mental Health Research Program SickKids Research Institute Toronto Canada Department of Diagnostic & Interventional Radiology The Hospital for Sick Children Toronto Canada Department of Diagnostic and Interventional Neuroradiology University Hospital Augsburg Germany Department of Medical Imaging University of Toronto Department of Computer Science University of Toronto Vector Institute Toronto Canada

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Magnetic Resonance Imaging (MRI) serves as a valuable tool for detecting abnormalities in brain structures. However, a notable 5-10% of pathologies remain unnoticed in MRI scans. To address this challenge and reduce the burden on radiologists, machine learning methods have been used to automate anomaly detection. In this work, we propose to use Denoising Diffusion Probabilistic Model (DDPM) for anomaly detection in MRI. DDPM learns to reconstruct healthy brain MRI and generates anomaly maps to facilitate the classification of the input MRI as healthy or unhealthy. The proposed model correctly differentiated all healthy or unhealthy test patients. Additionally, localized regions of interest in the generated anomaly maps, and the diffusion model achieved a Dice coefficient of 0.376, outperforming other generative models such as generative adversarial network (GAN).

关键词： Location awareness Pathology Magnetic resonance imaging Noise reduction Medical services Brain modeling Diffusion models Generative adversarial networks Anomaly detection Monitoring

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A DIRECT METHOD OF GENERATING QUADRATIC CURVILINEAR TETRAHEDRAL MESHES USING AN ADVANCING FRONT APPROACH 29

A DIRECT METHOD OF GENERATING QUADRATIC CURVILINEAR TETRAHED...

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29th International Meshing Roundtable, IMR 2021

作者： Mohammadi, Fariba Shontz, Suzanne M. Department of Mechanical Engineering Information and Telecommunication Technology Center The University of Kansas 1520 W. 15th Street LawrenceKS66045 United States Department of Electrical Engineering and Computer Science Bioengineering Program Information and Telecommunication Technology Center University of Kansas 1520 W. 15th Street LawrenceKS66045 United States

ISBN: (纸本)9781733489010

Computational modeling and simulation of real-world problems, e.g., various applications in the automotive, aerospace, and biomedical industries, often involve geometric objects which are bounded by curved surfaces. The geometric modeling of such objects can be performed via high-order meshes. Such a mesh, when paired with a high-order partial differential equation (PDE) solver, can realize more accurate solution results with a decreased number of mesh elements (in comparison to a low-order mesh). There are several types of high-order mesh generation approaches, such as direct methods, a posteriori methods, and isogeometric analysis (IGA)-based spline modeling approaches. In this paper, we propose a direct, high-order, curvilinear tetrahedral mesh generation method using an advancing front technique. After generating the mesh, we apply mesh optimization to improve the quality and to take advantage of the degrees of freedom available in the initially straight-sided quadratic elements. Our method aims to generate high-quality tetrahedral mesh elements from various types of boundary representations including the cases where no computer-aided design files are available. Such a method is essential, for example, for generating meshes for various biomedical models where the boundary representation is obtained from medical images instead of CAD files. We present several numerical examples of second-order tetrahedral meshes generated using our method based on input triangular surface meshes. © 2021 held by the authors of the individual papers.

关键词： Mesh generation

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Article surface modification of pdms-based microfluidic devices with collagen using polydopamine as a spacer to enhance primary human bronchial epithelial cell adhesion

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Micromachines 2021年第2期12卷 1-11页

作者： Dabaghi, Mohammadhossein Shahriari, Shadi Saraei, Neda Da, Kevin Chandiramohan, Abiram Selvaganapathy, Ponnambalam Ravi Hirota, Jeremy A. Firestone Institute for Respiratory Health–Division of Respirology Department of Medicine McMaster University HamiltonONL8N 4A6 Canada Department of Mechanical Engineering McMaster University HamiltonONL8S 4L7 Canada Department of Chemical Engineering McMaster University HamiltonONL8S 4L7 Canada School of Biomedical Engineering McMaster University HamiltonONL8S 4K1 Canada Division of Respiratory Medicine Department of Medicine University of British Columbia VancouverBCV6H 3Z6 Canada Department of Biology University of Waterloo WaterlooONN2L 3G1 Canada

Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and assists the fabrication of complicated geometries at micro-and nano-scales, it does not optimally interact with cells for adherence and proliferation. Various strategies have been proposed to render PDMS to enhance cell attachment. The majority of these surface modification techniques have been offered for a static cell culture system. However, dynamic cell culture systems such as organ-on-a-chip devices are demanding platforms that recapitulate a living tissue microenvironment’s complexity. In organ-on-a-chip platforms, PDMS surfaces are usually coated by extracellular matrix (ECM) proteins, which occur as a result of a physical and weak bonding between PDMS and ECM proteins, and this binding can be degraded when it is exposed to shear stresses. This work reports static and dynamic coating methods to covalently bind collagen within a PDMS-based microfluidic device using polydopamine (PDA). These coating methods were evaluated using water contact angle measurement and atomic force microscopy (AFM) to optimize coating conditions. The biocompatibility of collagen-coated PDMS devices was assessed by culturing primary human bronchial epithelial cells (HBECs) in microfluidic devices. It was shown that both PDA coating methods could be used to bind collagen, thereby improving cell adhesion (approximately three times higher) without showing any discernible difference in cell attachment between these two methods. These results suggested that such a surface modification can help coat extracellular matrix protein onto PDMS-based microfluidic devices. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

关键词： Microfluidics

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Diagnostic tools for assessing cryoprotective agents dielectric properties over broad temperature/frequency ranges

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Cryobiology 2023年 113卷

作者： Yicheng Jiang Lakshya Gangwar Michael Etheridge John C. Bischof Rhonda Franklin Department of Electrical and Computer Engineering University of Minnesota Minneapolis USA Department of Mechanical Engineering University of Minnesota Minneapolis USA Department of Biomedical Engineering University of Minnesota Minneapolis USA

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Studying Hair Growth Cycle and its Effects on Mouse Skin

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The Journal of investigative dermatology 2023年第9期143卷 1638-1645页

作者： Wei-Hung Wang Raul Ramos Kang-Yu Tai Yun-Shan Wu Tso-Yu Chang Jia-Yu Yan Maksim V Plikus Ji Won Oh Sung-Jan Lin Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan. Department of Developmental and Cell Biology University of California Irvine Irvine California USA Sue and Bill Gross Stem Cell Research Center University of California Irvine Irvine California USA. Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan. School of Medicine College of Medicine National Taiwan University Taipei Taiwan. Department of Anatomy Yonsei University College of Medicine Seoul Korea. Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan Center for Frontier Medicine National Taiwan University Hospital Taipei Taiwan. Electronic address: drsjlin@ntu.edu.tw.

Researchers should be aware that hair growth cycle drives prominent molecular, cellular, and morphological changes to the entire skin. Thus, hair growth constitutes a major experimental variable that influences the interpretation of dermatological studies. Hair growth in mice is neither asynchronous nor fully synchronized; rather, it occurs in waves that dynamically propagate across the skin. In consequence, any given area of mouse skin can contain hair follicles in different stages of the cycle in close physical proximity. Furthermore, hair growth waves in mice are initiated by probabilistic events at different time points and across stochastic locations. The consequence of such stochasticity is that precise patterns of hair growth waves differ from mouse to mouse, even in littermates of the same sex. However, such physiological stochasticity is commonly misconstrued as a significant hair growth phenotype in mutant mice or in drug-treated mice. The purpose of this article is to provide a set of guidelines for designing reliably interpretable murine studies on hair growth and to highlight key experimental caveats to be avoided. It also informs on how to account for and minimize the impact of physiological hair cycle differences when designing and interpreting nonhair growth dermatological studies in mice.

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Investigation of different membrane porosities on the permeate flux of direct contact membrane distillation 6th

Investigation of different membrane porosities on the permea...

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6th International Conference on Composite Materials and Material engineering, ICCMME 2021

作者： Elrasheedy, Asmaa Rabie, Mohammed Elshazly, Ahmed Bassyouni, Mohamed El-Moneim, Ahmed Abd Kady, Marwa El Alexandria21934 Egypt Department of Chemical Engineering Faculty of Engineering Port Said University Port Said42526 Egypt Mechanical Power Engineering Department Mansoura University El-Mansoura35516 Egypt Chemical Engineering Department Faculty of Engineering Alexandria University Alexandria21544 Egypt Materials Science Program Zewail University of Science and Technology City of Science and Technology October Gardens 6th of October Giza12578 Egypt Materials Science and Engineering Department Egypt-Japan University of Science and Technology NewBorg El-Arab Alexandria21934 Egypt Institute of Basic and Applied Sciences Egypt-Japan University of Science and Technology New Borg El-Arab Alexandria21934 Egypt Borg El-Arab City Alexandria21934 Egypt

ISBN: (纸本)9783035718195

In the present study the surface morphology of electrospun fibers at different polystyrene (PS) solution concentration was studied by SEM imaging to determine the best PS solution concentration yielding continuous uniform beadles fibers. Contact angle measurements of the optimum fabricated PS-18 membrane confirmed the super hydrophobic property of the membrane that exhibited a static water contact angle of 145o . Numerical investigation of the performance of PS-18 membrane at different membrane thicknesses and porosities on direct contact membrane distillation showed that increasing the membrane porosity increases the permeate flux considerably. © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Polystyrenes

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Development of a Bioactive, Piezoelectric PVDF-TrFE Scaffold to Modulate Wound Response in the Peripheral Nervous System

SSRN

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SSRN 2024年

作者： Bryan, Andrew E. Krutko, Maksym Rebholz, Sandra Marquez, Lindsey E. Busch, Emma Dong, Kevin Pixley, Sarah K. Cushion, Melanie T. Esfandiari, Leyla Harris, Greg M. Department of Chemical and Environmental Engineering University of Cincinnati CincinnatiOH45221 United States Department of Biomedical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Internal Medicine University of Cincinnati College of Medicine CincinnatiOH45267 United States Medical Research Service Cincinnati Veterans Affairs Medical Center CincinnatiOH45220 United States Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine CincinnatiOH45267 United States Department of Electrical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Environmental & Public Health Sciences University of Cincinnati College of Medicine CincinnatiOH45267 United States Neuroscience Graduate Program University of Cincinnati College of Medicine CincinnatiOH45267 United States

To address current limitations in biomaterials for peripheral nerve repair regarding a lack of physiologically relevant signaling and immune response following implantation, this study evaluated the development and feasibility of a multi-cue biomaterial with physiologically relevant chemical, electrical, and physical signaling. To accomplish this, a bulk-functionalized poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) scaffold was fabricated using blend electrospinning to incorporate decellularized extracellular matrix (dECM) to mediate the foreign body response in vivo and promote enhanced wound healing. Decellularized ECM was secreted and assembled by fibroblast cells and incorporated into the electrospinning solution with concentration values ranging from 0% to 0.4% (m/v). Physical, chemical, and electrical properties of the scaffold were analyzed by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), mechanical tensile testing, and voltage readings for piezoelectricity. Blended scaffolds were evaluated in vitro for analysis of cell-material interactions in the context of peripheral nerve injury (PNI) repair and in vivo for immune response. In vitro work demonstrated increased cell metabolism and elongated, repair-like morphologies in Schwann cells on scaffolds with higher dECM concentrations. Subcutaneous implantation of blended scaffolds in rats at 7 days revealed limited multi-nucleated giant cell formation. Following 28 days in vivo, regenerative characteristics of the proliferative phase of wound healing were present with enhanced nerve growth and vasculature to scaffold. Overall, blend-electrospun scaffolds with native dECM showed promise in mitigating pro-inflammatory responses and promote advanced regenerative behaviors, thereby providing an implantable biomaterial with the necessary physical, chemical, and electrical characteristics desired for c

关键词： Fourier transform infrared spectroscopy

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A novel strong duality-based reformulation for trilevel infrastructure models in energy systems development

arXiv

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arXiv 2023年

作者： Herrala, Olli Gabriel, Steven A. Oliveira, Fabricio Ekholm, Tommi Aalto University Department of Mathematics and Systems Analysis Espoo Finland University of Maryland Department of Mechanical Engineering/Applied Mathematics Statistics & Scientific Computing Program College ParkMD United States Norwegian University of Science and Technology Department of Industrial Economics and Technology Management Trondheim Norway Finnish Meteorological Institute Helsinki Finland

We explore the class of trilevel equilibrium problems with a focus on energy-environmental applications and present a novel single-level reformulation for such problems, based on strong duality. To the best of our knowledge, only one alternative single-level reformulation for trilevel problems exists. This reformulation uses a representation of the bottom-level solution set, whereas we propose a reformulation based on strong duality. Our novel reformulation is compared to this existing formulation, discussing both model sizes and computational performance. In particular, we apply this trilevel framework to a power market model, exploring the possibilities of an international policymaker in reducing emissions of the system. Using the proposed methods, we are able to obtain globally optimal solutions for a five-node case study representing the Nordic countries and assess the impact of a carbon tax on the electricity production portfolio. Copyright © 2023, The Authors. All rights reserved.

关键词： Energy resources

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Left Atrial Appendage Occlusion: Current Stroke Prevention Strategies and a Shift Toward Data-Driven, Patient-Specific Approaches

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Journal of the Society for Cardiovascular Angiography and Interventions 2022年第5期1卷 100405-100405页

作者： Mendez, Keegan Kennedy, Darragh G. Wang, Dee Dee Roche, Ellen T. Harvard/MIT Health Sciences and Technology Program Massachusetts Institute of Technology Cambridge MA United States Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA United States Department of Biomedical Engineering Columbia University New York NY United States Henry Ford Health Detroit MI United States Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA United States

The left atrial appendage (LAA) is a complex structure with unknown physiologic function protruding from the main body of the left atrium. In patients with atrial fibrillation, the left atrium does not contract effectively. Insufficient atrial and LAA contractility predisposes the LAA morphology to hemostasis and thrombus formation, leading to an increased risk of cardioembolic events. Oral anticoagulation therapies are the mainstay of stroke prevention options for patients;however, not all patients are candidates for long-term oral anticoagulation. Percutaneous occlusion devices are an attractive alternative to long-term anticoagulation therapy, although they are not without limitations, such as peri-implant leakage and device-related thrombosis. Although efforts have been made to reduce these risks, significant interpatient heterogeneity inevitably yields some degree of device-anatomy mismatch that is difficult to resolve using current devices and can ultimately lead to insufficient occlusion and poor patient outcomes. In this state-of-the-art review, we evaluated the anatomy of the LAA as well as the current pathophysiologic understanding and stroke prevention strategies used in the management of the risk of stroke associated with atrial fibrillation. We highlighted recent advances in computed tomography imaging, preprocedural planning, computational modeling, and novel additive manufacturing techniques, which represent the tools needed for a paradigm shift toward patient-centric LAA occlusion. Together, we envisage that these techniques will facilitate a pipeline from the imaging of patient anatomy to patient-specific computational and bench-top models that enable customized, data-driven approaches for LAA occlusion that are engineered specifically to meet each patient's unique needs. © 2022 The Authors

关键词： computed tomography imaging left atrial appendage left atrial appendage occlusion stroke

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