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Corrigendum to “Predicting protein thermal stability changes upon single and multi-point mutations via restricted attention subgraph neural network”[ Journal of the Mechanics and Physics of Solids, 184 , 105,531.]

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Journal of the Mechanics and Physics of Solids 2025年 194卷

作者： Mohammad Madani Anna Tarakanova School of Mechanical Aerospace and Manufacturing Engineering University of Connecticut Storrs CT United States Department of Computer Science & Engineering University of Connecticut Storrs CT United States Department of Biomedical Engineering University of Connecticut Storrs CT United States

We regret to say that in our recent publication (Madani and Tarakanova, 2024), we identified two errors in Figs. 2 and 5. Here in this corrigendum, 1) we have corrected these errors and updated the figures based on our original best-performing models. 2) Additionally, we retrained our model with new hyperparameters, resulting in slightly improved performance across almost all datasets compared to the original models.

关键词： N/A

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Incorporating extended neck Helmholtz resonators into an advanced multi-degree of freedom acoustic metamaterial for low-frequency, broadband acoustic absorption

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Applied Acoustics 2025年 238卷

作者： Wang, Jiayu Bennett, Gareth J. Department of Mechanical Manufacturing and Biomedical Engineering Trinity College Dublin the University of Dublin D02 PN40 Ireland

This study investigates the novel design and evaluation of a low-frequency, broadband, noise-absorbing acoustic metamaterial. The technology combines the sound-absorbing characteristics of micro-perforated panels with extended neck Helmholtz resonators. Individual sub-chambers can have unique properties such as depth, porosity, hole diameter, extended neck length, and neck internal diameter. An optimisation algorithm is implemented to ensure that broadband absorption is maximised in a low-frequency range of interest. The Helmholtz resonators couple with the response of the micro-perforated panels so that the combined response is both more broadband and of lower frequency than could be attained by the elements individually. Low frequencies below 500 Hz are of interest in the study, and the area exposed to the sound field is limited to 0.04 m2, so the technology is considered to be a locally reacting absorber. Experimental results indicate that perfect sound absorption of over 99.9% at 329.6 Hz with a 51 mm thickness (sub-wavelength ratio = 1/20.4) can be achieved with one configuration, which emphasises maximum absorption. A second configuration, which emphasises broadband absorption, achieves an average sound absorption coefficient of 0.8 in the 254 Hz to 500 Hz range. Experimental results compare well with analytical and numerical results and outperform some results found in the literature. © 2025 The Author(s)

关键词： Acoustic resonators

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The Impact of Fidget Spinners on Fine Motor Skills in Individuals with and without ADHD: An Exploratory Analysis

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Journal of Behavioral and Brain Science 2022年第3期12卷 82-101页

作者： Reza Koiler Austin Schimmel Elham Bakhshipour Patricia A. Shewokis Nancy Getchell Biomechanics and Movement Sciences Program University of Delaware Newark DE USA Department of Kinesiology and Applied Physiology University of Delaware Newark DE USA Nutrition Sciences Department College of Nursing and Health Professions School of Biomedical Engineering Science and Health Systems School of Education Drexel University Philadelphia USA

Fidget spinners have been marketed as repetitive motion devices that improve attention and motor performance, and as such, they have become quite appealing to individuals with Attention Deficit Hyperactive Disorder (ADHD). To date, no studies have explored changes in brain activity that may occur due to fidgeting in ADHD. Our aim was to use functional Near-Infrared Spectroscopy (fNIRS) to examine the prefrontal cortex (PFC) during the performance of a standardized fine motor skills test after using a fidget spinner. Eight right-handed adults with ADHD and eight age and gender matched adults without ADHD (4F/4M, 4 control/4 fidget) performed the Purdue Pegboard Test (PPT) while their brain oxygenation was monitored using fNIRS. Relative neural efficiency (RNE) and involvement (RNI) were calculated and analyzed for all subtasks of PPT including the less cognitively demanding fine motor subtasks and more complex assembly tasks. The fidget spinner improved both task performance and RNE in the ADHD group but not the non-ADHD group for the less cognitively demanding subtasks. Our results indicate Fidget spinners may improve both relative neural efficiency and fine motor performance in adults with ADHD for less cognitively demanding tasks.

关键词： Fidget Spinners fNIRS ADHD Executive Function Motor Skill

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To: Energy Storage Materials October 13, 2022

SSRN

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SSRN 2022年

作者： Nie, Bo Li, Mingxin Yao, Tiankai Yang, Haoqing Duan, Linrui Zhang, Juchen Xin, Guoqing Liu, Tengxiao Sun, Hongtao Lian, Jie The Harold & Inge Marcus Department of Industrial & Manufacturing Engineering The Pennsylvania State University University ParkPA16802 United States Department of Biomedical Engineering The Pennsylvania State University University ParkPA16802 United States The Pennsylvania State University University ParkPA16802 United States Department of Mechanical Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute New York12180 United States

Developing electrochemical energy storage that enables simultaneously delivering high areal, volumetric, and gravimetric performance is a grand fundamental and technological challenge. It is straightforward but problematic to make electrodes thicker and denser for high areal and volumetric performance while sustaining a high level of gravimetric performance. The insufficient charge transports in these electrodes with high mass loading and density could severely degrade the energy storage performance. Herein, we developed an energy-efficient fast sintering method (e.g., Spark Plasma Sintering) to fabricate a structural cathode with a high electrode density (~ 2.0-2.3 g cm-3) and high active material mass loading (> 70-100 mg cm-2). The vertically aligned carbon networks and anisotropic pore channels in thick electrodes are designed and tailored for efficient charge transports throughout the whole thickness. The sintered structural electrodes are demonstrated to deliver high battery performance in gravimetric (164 mAh g-1), volumetric (246 mAh cm-3), and areal metrics (8.6 mAh cm-2), which enables improved energy and power outputs in a new battery configuration with reduced weight and cost of passive components. © 2022, The Authors. All rights reserved.

关键词： Lithium-ion batteries

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Non-Invasive Coronary Ct Angiography-Derived Fractional Ow Reserve: A Benchmark Study Comparing the Diagnostic Performance of Four Different Computational Methodologies

SSRN

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SSRN 2024年

作者： Bourantas, Georgios C. Zwick, Benjamin Siogkas, Panagiotis Sakellarios, Antonis A. Katsanos, Konstantinos Burganos, Vasilios N. Miller, Karol Tsigkas, Grigorios Davlouros, Periklis Fotiadis, Dimitrios I. University of Patras Department of Agriculture New buildings Messolonghi 30200 Greece Intelligent Systems for Medicine Laboratory School of Engineering The University of Western Australia 35 Stirling Highway PerthWA Australia Medlytic Labs Patras Greece Department of Mechanical Engineering and Aeronautics University of Patras Rio26504 Greece Department of Interventional Radiology School of Medicine University Hospital of Patras Patras Greece PatrasGR-26504 Greece Department of Cardiology School of Medicine University of Patras Patras Greece Unit of Medical Technology and Intelligent Information Systems Dept. of Materials Science and Engineering University of Ioannina Ioannina Greece Foundation for Research and Technology-Hellas Biomedical Research Institute Ioannina Greece University of Ioannina Greece

We benchmark the diagnostic performance of four distinct numerical methodologies for assessing the functional significance of obstructive coronary lesions using coronary computed tomography angiography (CCTA) data. Specifically, we non-invasively compute the fractional ow reserve (FFR) index by applying an established mathematical formula for pressure drop calculation, utilizing the geometrical data (centerlines) from a limited data set of 14 vessels from 10 patients. We compare the FFR values obtained using our mathematical formula-based approach with those obtained using 0D-1D numerical models. Our approach is fast (less than 5 seconds) and straightforward compared to the other methods. The clinical data used in the FFR work ow are publicly available. © 2024, The Authors. All rights reserved.

关键词： Numerical methods

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Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging

Research Square

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Research Square 2021年

作者： Lin, Yuechuan Leartprapun, Nichaluk Luo, Justin C. Adie, Steven G. Meinig School of Biomedical Engineering Cornell University IthacaNY14853 United States Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139 United States

Microscale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions play an important role in pathophysiological processes, including the onset, progression, and attenuation of disease. The ability to quantitatively image cell-mediated micromechanical dynamics of the ECM in physiologically relevant 3D engineered cellular systems can significantly enhance the clinical translational potential of fundamental discoveries in the rapidly growing field of mechanobiology. However, it remains a challenge for current mechanical characterization methods to combine quantitative 3D imaging of ECM mechanics with cellular-scale resolution and dynamic monitoring of cell-mediated changes to pericellular viscoelasticity. Here, we present light-sheet photonic force optical coherence elastography (LS-pfOCE) to address this challenge by leveraging a light-sheet for parallelized, non-invasive, and localized mechanical loading. We demonstrate the capabilities of LS-pfOCE by imaging the micromechanical heterogeneity of fibrous 3D collagen matrices and perform a live-cell study to image micromechanical heterogeneity induced by NIH-3T3 cells seeded in 3D fibrin constructs. We also show that LS-pfOCE is able to quantify temporal variations in pericellular viscoelasticity in response to drug-induced altered cellular activity. By providing access to 4D spatiotemporal variations in the micromechanical properties of 3D biopolymer constructs and engineered cellular systems, LS-pfOCE has the potential to drive new discoveries in mechanobiology and contribute to the development of novel biomechanics-based clinical diagnostics and therapies. © 2021, CC BY.

关键词： Cells

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On the generalized eigenvalue problem for robust coil sensitivities of MRI 8

On the generalized eigenvalue problem for robust coil sensit...

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8th IEEE International Conference on Smart Instrumentation, Measurement and Applications, ICSIMA 2022

作者： Chen, Hsin-Chia Tsai, Tzu-Hsueh Yang, Hao Chiao Chao, Yu-Chieh Chen, Chih-Ching Chang, Hing-Chiu Chung, Hsiao-Wen Chang, Chin-Kuo Yu, Wei-Hsuan Hwang, Feng-Nan Lin, Jyh-Miin Graves, Martin Department of Diagnostic Imaging Madou Sin-Lau Hospital Tainan Taiwan Department of Medical Imaging Kaohsiung Medical University Hospital Graduate Institute of Clinical Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Finance Chung Yuan Christian University Taoyuan City Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong Hong Kong Department of Electrical Engineering National Taiwan University Taipei Taiwan Institute of Psychiatry Psychology and Neuroscience Kings College London London United Kingdom Global Health Program College of Public Health National Taiwan University Taipei Taiwan Department of Mathematics National Central University Taoyuan City Taiwan Robinson College University of Cambridge Cambridge United Kingdom Nhs Foundation Trust University of Cambridge Cambridge United Kingdom

ISBN: (数字)9781665488006

ISBN: (纸本)9781665488006

Although parallel imaging is a routine technique in clinical magnetic resonance imaging (MRI), estimating coil sensitivities remains a constant challenge to accelerated MRI. Recent coil estimation methods are computationally expensive, requiring external libraries to compute the singular-value decomposition (SVD) of a large matrix. Moreover, phase variations can appear in the final complex-valued coil sensitivity profiles. For instance, phase singularity is frequently observed in contrast-enhanced MRI. In this study, a robust generalized eigenvalue problem (GEP) approach is proposed to address the phase variations (also known as phase flipping or phase singularity) in complex-valued coil sensitivity of parallel MRI. Based on the inexact inverse iteration method in the outer loop and the conjugate gradient method in the inner loop, the low-cost inexact inverse iteration improves the homogeneity of the coil sensitivity without phase variations of the existing method. We performed repeated simulation studies. Results of 2D and 3D computational simulations are demonstrated, and the potential use of the method is also discussed. © 2022 IEEE.

关键词： Magnetic resonance imaging

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Smart Wearable Wristband for Patients' Health Monitoring System through IoT

Smart Wearable Wristband for Patients' Health Monitoring Sys...

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International Conference on Power, Energy, Control and Transmission Systems (ICPECTS)

作者： Shannmukha Naga Raju Vonteddu PrasanthiKumari Nunna Shubhi Jain Samson Isaac. J Nitya S G. Diwakar Department of Electrical and Electronics Engineering University College of Engineering Kakinada Jawaharlal Nehru Technological University Kakinada Kakinada Andhra Pradesh India Department of Electrical and Electronics Engineering School of Engineering University of Petroleum and Energy Studies Dehradun Uttarakhand India Department of Electronics and Communication Swamikeshvanand Institute of Technology Management and Gramothan Jaipur Rajasthan India Departrnent of Biomedical Engineering Surgical and Critical care Equipments Laboratory Karunya Institute of Technology &Sciences Coimbatore Tamil Nadu India School of Electronics and Communication Reva University Bangalore Karnataka India Department of Mechanical Engineering KoneruLakshmaiah Education Foundation Vaddeswaram Andhra Pradesh India

ISBN: (纸本)9781665462761

In today's modern world, technology takes part an important role in the medical field. It is must necessary to monitor the patient's health continuously after the operation of the patient. In the healthcare field Internet of Things (IoT) plays the main roleinmonitoring health with lots of applications. To monitor the health parameters of the patient, the smart wearable wristband monitoring system is implemented by using the IoT domain. In this article, the NodeMCU microcontroller act as a gateway between the hardware devices and the software. The parameters to be measured from the patient's body are temperature, heart rate, glucose level, oxygen level, and Blood Pressure (BP). These parameters are measured by using the sensors. The sensors are interfaced with the microcontroller. Then the microcontroller sends the data from the sensors to the cloud. The cloud will analyse the data from the normal values given in the microcontroller. If any of the parameter's data from the sensor are measured as abnormal values, the cloud will send the alert message and the location of the patient to the patient's relatives, to the doctor who is attending that patient, and to the patients' mobile via Global System for Mobile communication (GSM), and Global Positioning System (GPS) for location.

关键词： Temperature measurement Temperature sensors GSM Cloud computing Microcontrollers Medical services biomedical monitoring

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Gradients in solid surface tension drive Marangoni-like motions in cell aggregates

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Physical Review Fluids 2022年第3期7卷 L031101-L031101页

作者： Vikrant Yadav Md. Sulaiman Yousafzai Sorosh Amiri Robert W. Style Eric R. Dufresne Michael Murrell Department of Biomedical Engineering Yale University 55 Prospect Street New Haven Connecticut 06511 USA Systems Biology Institute Yale University 850 West Campus Drive West Haven Connecticut 06516 USA Department of Physics Yale University 217 Prospect Street New Haven Connecticut 06511 USA Department of Mechanical Engineering and Material Science Yale University 10 Hillhouse Avenue New Haven Connecticut 06511 USA Department of Materials ETH Zurich Zurich 8093 Switzerland

The surface tension of living cells and tissues originates from the generation of nonequilibrium active stresses within the cell cytoskeleton. Here, using laser ablation, we generate gradients in the surface tension of cellular aggregates as models of simple tissues. These gradients of active surface stress drive large-scale and rapid toroidal motion. Subsequently, the motions spontaneously reverse as stresses reaccumulate and cells return to their original positions. Both forward and reverse motions resemble Marangoni flows in viscous fluids. However, the motions are faster than the timescales of viscoelastic relaxation and the surface tension gradient is proportional to mechanical strain at the surface. Further, due to active stress, both the surface tension gradient and surface strain are dependent upon the volume of the aggregate. These results indicate that surface tension can induce rapid and highly correlated elastic deformations in the maintenance of tissue shape and configuration.

关键词： Biological fluid dynamics Biomechanics Cell mechanics Tissues

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Replacing metal-based lightning strike protection layer of CFRPs by 3D printed electrically conductive polymer layer 6

Replacing metal-based lightning strike protection layer of C...

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6th Annual Composites and Advanced Materials Expo, CAMX 2019

作者： Kumar, Vipin Smith, Tyler Condon, Justin C. Yeole, Pritesh S. Hassen, Ahmed A. Kunc, Vlastimil KnoxvilleTN37932 United States Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee Middle Drive KnoxvilleTN37996 United States

Electrically conductive adhesive layers were deposited on top of aerospace grade carbon fiber reinforced plastic (CFRP) panels using a small-scale 3D printer. Polylactic acid (PLA) filaments with copper filler (CU-PLA) and graphene filler (GO-PLA) were used to print around 0.7 mm thick electrically conductive layer on top of CFRP panels. 3D printed polymeric layers were tested for their effectiveness as a lightning strike protection (LSP) material by subjected to a simulated lightning strike. A painted, electrically non-conductive unprotected panel was also tested for comparison. In the case of the CU-PLA protected sample, a high electrical conductivity proved to be useful in fast dissipation of the lightning current. Fast current dissipation helped to reduce the resistive heating after a lightning strike. Thermography and high-speed camera analysis were employed to study the heat generation and current dissipation during the lightning strike. These results established that a useful Faraday Cage was applied via additive manufacturing successfully. This work shows the successful application of 3D printing for producing LSP technologies, with future work aimed at investigating optimal printable electrically conductive thermoset material candidates. © 2019 by Ever J. Barbero. Published by CAMX - The Composites and Advanced Materials Expo.

关键词： 3D printers

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