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SSRN 2024年

作者： Wu, Honglian Zhang, Ruolin Lai, Huang Lai, Luogen Liu, Yi Fan, Yadi Zhang, Yu Shi, Jingyu Yang, Mo Department of Biomedical Engineering The Hong Kong Polytechnic University Kowloon999077 Hong Kong The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518000 China Joint Research Center of Biosensing and Precision Theranostics The Hong Kong Polytechnic University Kowloon999077 Hong Kong Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University Kowloon999077 Hong Kong Department of Mechanical and Automotive Engineering Royal Melbourne Institute of Technology MelbourneVIC3000 Australia Jiangxi Science and Technology Normal University China

Endotoxins or lipopolysaccharides (LPS) are potent inflammatory agents that pose serious health risks even at low concentrations, thus requiring sensitive and reliable detection methods. Current methods for endotoxin detection, such as the Limulus Amebocyte Lysate (LAL) assay and (enzyme-linked immunosorbent assays) ELISA, are limited by complex procedures, prolonged assay times, and susceptibility to interference. To address these challenges, we developed a novel MXene-Au nanosheets-based fluorescence-SERS dual-mode biosensor integrated with the CRISPR/Cas12a system for endotoxin detection. This platform utilizes the excellent fluorescence quenching and SERS-enhancing properties of MXene-Au nanosheets, combined with the specific trans-cleavage capability of the CRISPR/Cas12a system, to achieve signal amplification and dual-mode detection. In our design, Cy5-labeled single-stranded DNA (ssDNA) was adsorbed onto MXene-Au nanosheets, where the CRISPR/Cas12a system modulates the dual-mode signals in response to the presence of target endotoxins. This dual-mode biosensor demonstrated exceptional sensitivity with LODs of 0.26 ng/mL for fluorescence mode detection and 0.04 ng/mL for SERS mode detection, along with a detection time of 30 min. Its performance in real sample analysis, including spiked water and milk, was comparable with commercial endotoxin detection kits, highlighting its potential for practical applications. Overall, our CRISPR-Cas12a-mediated fluorescence-SERS dual-mode biosensor based on MXene-Au nanosheets enhances sensitivity, reduces false positives and negatives, and improves result reliability through cross-verification of signals, representing a significant advancement in endotoxin detection technology. © 2024, The Authors. All rights reserved.

关键词： Health risks

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-Classified Topological Phases and Bound States in the Continuum Induced by Multiple Orbitals

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Advanced Science 2025年第10期12卷

作者： Li, Shi-Feng Yang, Wen-Jie Zhou, Cui-Yu-Yang Zhu, Yi-Fan Zou, Xin-Ye Cheng, Jian-Chun Assouar, Badreddine Key Laboratory of Modern Acoustics MOE Institute of Acoustics Department of Physics Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing210093 China Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical Engineering Southeast University Nanjing211189 China Université de Lorraine CNRS Institut Jean Lamour Nancy54000 France

-classified higher-order topological insulators (HOTIs) with chiral-symmetric higher-order topological phases protected by multipole chiral numbers (MCNs) have attracted extensive interest recently. However, how to design artificial -classified HOTIs with multiple topological phases remains an unresolved issue. Here, multiorbital degrees of freedom are introduced to acoustic crystals and the various methods of topological phase transitions are achieved for the orbital -classified HOTIs. Experimental results demonstrate the realization the coexistence of corner modes with distinct mechanisms within one single model. This provides a pathway for finding -classified with large MCNs independent of long-range coupling. Additionally, a universal approach is introduced here to fabricate topological bound states in the continuum derived from the discrepant onsite energy of degenerate p-orbitals. These findings provide new insights into the study of topological wave physics using orbital degrees of freedom and may pave the way for designing innovative orbital topological devices for sensing and computing. © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH.

关键词： Topological insulators

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Optimization of an aerostructural machining process using physics-guided Bayesian stability modelling 20

Optimization of an aerostructural machining process using ph...

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20th CIRP Conference on Modeling of Machining Operations in Mons, CIRP CMMO 2025

作者： Cornelius, Aaron Karandikar, Jaydeep Burns, Judy Burns, Robert Burns, David Daugherty, Julia Farrow, Clint Yurescko, Matthew Kim, Kevin Mekelburg, Jackob Grant, Richard Delio, Thomas Dosmann, Clay Kantner, Chris Wang, Zhigang Schmitz, Tony Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee Knoxville KnoxvilleTN United States Oak Ridge National Laboratory Oak RidgeTN United States Patriot Machine Inc. 76 S Corporate Hills Dr St CharlesMO63301 United States Manufacturing Laboratories Inc. 2696 54th Avenue 54th Ave N St. PetersburgFL33714 United States Third Wave Systems 6475 City W Pkwy Eden PrairieMN55344 United States Physical Sciences Department RTX Technology Research Center 411 Silver Lane MS 129-22 East HartfordCT06108 United States

Existing algorithms for predicting milling chatter have not been widely adopted in industry since they require specialized instruments to measure the stability inputs. This study describes how the machining process for a meter-scale aluminum aerostructure was optimized using a physics-guided Bayesian stability model. The study was performed in collaboration with an industrial partner on production machines to evaluate the practicality of the proposed method under real-world conditions. For each cutting tool, the Bayesian approach automatically selected a small number of cutting tests, which were monitored using a microphone to observe the chatter frequency. The algorithm learned the system dynamics, cutting forces, and stability map from these test results. A novel algorithm for predicting tool bending stress was incorporated into the test selection algorithm to avoid tool breakage. On average, each set of optimized cutting parameters required less than six tests to identify and were 97% more productive than baseline parameters from the cutting tool manufacturer. The machining program was then further optimized using commercial feedrate scheduling software to remove cutting force spikes and reduce air cutting time. Five components were machined using the optimized process. These results demonstrate the potential for physics-guided Bayesian models to improve productivity in industrial settings. © 2025 The Authors.

关键词： Milling (machining)

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Super-resolution Monitoring of React-on-demand Photo-assisted Electrochemical Printing via Microsphere Nanoscopy 2

Super-resolution Monitoring of React-on-demand Photo-assiste...

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2nd Annual IEEE International Conference on Micro/Nano Sensors for Al, Healthcare, and Robotics, NSENS 2019

作者： Li, Pan Yu, Haibo Wang, Feifei Lee, Gwo-Bin Liu, Lianqing Li, Wen Jung State Key Laboratory of Robotics Shenyang110016 China Stanford University Department of Chemistry StanfordCalifornia94305 United States National Tsing Hua University Department of Power Mechanical Engineering Hsinchu Taiwan City University of Hong Kong Department of Mechanical and Biomedical Engineering Kowloon Tong Hong Kong

ISBN: (纸本)9781728166513

Nanoscale material surface patterning on semiconductor requires multi-scale measurements for the determination of their geometric dimensions and shapes. In this paper, we propose an in-situ,real-time super-resolution imaging technique using a simple microsphere microlens to monitor the dynamic process of photo-assisted electrochemical printing in a microfluidic chip. The microsphere microlens with diameters of 30 60 μ m were set close to a semiconductor surface to image the electrochemical printing process underneath. With the microsphere-based imaging system, both the depositing process of silver nanoparticles with 200 nm 300 nm in diameter and the growing process of silver belts were observed. Also, we experimentally observed how a typical 120° angle formed at the terminal of a silver belt through the microsphere superlens. Super-resolution monitoring ability provided by microsphere lens will shine a light on the sub-diffraction process of micro/nano fabrication. © 2019 IEEE.

关键词： Microspheres

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Improving iPSC Differentiation Using a Nanodot Platform

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ACS Applied Materials and Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

Differentiation of induced pluripotent stem cells (iPSCs) is an extremely complex process that has proven difficult to study. In this research, we utilized nanotopography to elucidate details regarding iPSC differentiation by developing a nanodot platform consisting of nanodot arrays of increasing diameter. Subjecting iPSCs cultured on the nanodot platform to a cardiomyocyte (CM) differentiation protocol revealed several significant gene expression profiles that were associated with poor differentiation. The observed expression trends were used to select existing small-molecule drugs capable of modulating differentiation efficiency. BRD K98 was repurposed to inhibit CM differentiation, while iPSCs treated with NSC-663284, carmofur, and KPT-330 all exhibited significant increases in not only CM marker expression but also spontaneous beating, suggesting improved CM differentiation. In addition, quantitative polymerase chain reaction was performed to determine the gene regulation responsible for modulating differentiation efficiency. Multiple genes involved in extracellular matrix remodeling were correlated with a CM differentiation efficiency, while genes involved in the cell cycle exhibited contrasting expression trends that warrant further studies. The results suggest that expression profiles determined via short time-series expression miner analysis of nanodot-cultured iPSC differentiation can not only reveal drugs capable of enhancing differentiation efficiency but also highlight crucial sets of genes related to processes such as extracellular matrix remodeling and the cell cycle that can be targeted for further investigation. Our findings confirm that the nanodot platform can be used to reveal complex mechanisms behind iPSC differentiation and could be an indispensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published by American Chemical Society.

关键词： Efficiency

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Cognitive disorder and dementia in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第4期13卷 319-337页

作者： Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela Department of Philosophical and Methodological Disciplines University Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Neurology Movement Disorders ClinicSub-Specialty Medical UnitNational Western Medical CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico University Biomedical Research Center University of ColimaColima 28040Mexico Department of Medical and Life Sciences University Center of‘La Ciénega’University of GuadalajaraOcotlán 47810JaliscoMexico Department of Chemistry University Center of Exact Sciences and EngineeringUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico Gerontology Postgraduate Program Public Health DepartmentUniversity Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico

Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and *** the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative *** the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are *** and animal model studies suggest that memory improvements are due to changes in insulin ***,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis ***, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, a

关键词： Alzheimer´s disease Diabetes mellitus Insulin Vascular dementia Cognitive decline

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Novel Circuit Design for a 3D Position Sensitive Scintillation TOF-PET Detector that Achieves ~100 ps CTR

Novel Circuit Design for a 3D Position Sensitive Scintillati...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Shirin Pourashraf Zhixiang Zhao Derek Innes Andrea Gonzalez-Montoro Joshua W. Cates Craig S. Levin Department of Radiology Stanford University Stanford CA USA Shanghai Jiao Tong University School of Biomedical EngineeringShanghaiPeople's Republic of China Applied Nuclear Physics Program Lawrence Berkeley National Laboratory Berkeley CA USA Departments of Radiology Bioengineering Physics and Electrical Engineering Molecular Imaging Program Stanford University Stanford CA USA

We have built a scalable mixed-signal readout circuit for a 3D position sensitive PET detector that achieves ~100 ps FWHM CTR. For this work we used individual 3×3×3 mm 3 and 3×3×10 mm 3 LGSO crystals, as well as 2×4 arrays of 3×3×10 mm 3 crystals side-coupled to arrays of 3.16×3.16 mm 2 SiPMs. The preliminary results verify that the CPLD is able to resolve 3D interaction positions along the array with < 3 mm positioning resolution along the length of each 10 mm long crystal element. We also present the readout strategy to compensate the CPLD digital noise that otherwise reduces the sensitivity and CTR performance. With this novel strategy we achieved nearly %100 sensitivity recovery as well as ~11 ps improved CTR.

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Development of a Self-Powered Microneedle Based Wearable Electrochemical Sensor for Glucose Monitoring

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ECS Meeting Abstracts 2023年第34期MA2023-01卷 1891-1891页

作者： Anindita Ganguly Jun-Hsuan Chung Kai Po Fan Kuei-Lin Liu Manish Kumar Sharma Zong-Hong Lin Institute of Biomedical Engineering National Tsing Hua University Dept. of Power Mechanical Engineering National Tsing Hua University Materials Science and Engineering National Tsing-Hua University Department of Biomedical Engineering National Taiwan University

Diabetes is increasingly being recognized as a worldwide public health concern owing to the affected rate of the patients in the past years. One of the major barriers to the disease control is the lack of sensitive and reliable point-of-care device that can provide quantitative diagnosis and monitoring. The wearable sensing technology has the potential of revolutionizing the precision medicine and personalized healthcare system. Within the emerging class of wearables, the microneedle-based sensors play a key role in combining the advantages of monitoring the analytes in interstitial fluid (ISF) and minimally invasive skin pricking. However, such devices require appropriate power sources to realize their full capacity, and the increasing power costs, global warming, and environmental pollution are certain aspects that needs to be pondered upon. Researches are dedicated on power generators with focus on wearable energy harvesters to address the issue of power supply. Thermoelectric generators (TEGs) have the ability to generate power by transforming thermal energy to electrical power output. Herein, we have developed a microneedle based enzymatic, electrochemical glucose sensing system powered by TEG utilizing the body heat. 1 mm stainless steel microneedles were sputtered with gold and platinum, and further coated with graphene paste, glucose oxidase, poly-hydroxyethyl methacrylate, and nafion. The fabricated device exhibited a good sensitivity, and a wide linear range. According to the World Health Organization (WHO), the normal glucose level in human body are between 4.0 mM to 5.6 mM, and our device has shown a concentration dependent output current signal from 4.0 mM to 24.0 mM. The device has also exhibited excellent detection results in real-sample (artificial ISF) in vitro study as well as in vivo analysis performed in 12 – 15 weeks SD rats. The device is completely self-powered where the TEG derives power from the temperature gradient betwe

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Journal of Neurophysiology 2025年第6期133卷 1761-1794页

作者： Salminen, Jacob Liu, Chang Pliner, Erika M. Tenerowicz, Madison Roy, Arkaprava Richer, Natalie Hwang, Jungyun Hass, Chris J. Clark, David J. Seidler, Rachael D. Manini, Todd M. Cruz-Almeida, Yenisel Ferris, Daniel P. Department of Biomedical Engineering University of Florida Gainesville FL United States Department of Kinesiology and Nutrition University of Illinois Chicago Chicago IL United States Department of Mechanical Engineering University of Utah Salt Lake City UT United States Department of Biostatistics University of Florida Gainesville FL United States Department of Kinesiology and Applied Health University of Winnipeg Winnipeg MB Canada Department of Neurology University of Florida Gainesville FL United States Department of Applied Physiology and Kinesiology University of Florida Gainesville FL United States Brain Rehabilitation Research Center Malcom Randall VA Medical Center Gainesville FL United States Norman Fixel Institute for Neurological Diseases University of Florida Gainesville FL United States McKnight Brain Institute University of Florida Gainesville FL United States Department of Health Outcomes and Biomedical Informatics University of Florida Gainesville FL United States Department of Community Dentistry and Behavioral Science University of Florida Gainesville FL United States Pain Research and Intervention Center of Excellence University of Florida Gainesville FL United States Department of Neuroscience University of Florida Gainesville FL United States

Preferred and maximum walking speeds decline as we age, and the decline has been associated with worsening health. Slowing of gait in older individuals is correlated with biomechanical and neural factors, but historically it has been difficult to measure whole brain activity during walking. Recent advances in mobile brain imaging with high-density electroencephalography (EEG) allow for separation and localization of electrical brain activity during walking. We studied younger (N = 31) and older (N = 59) adults walking on a treadmill at different speeds (0.25–1.0 m/s) while we recorded electrocortical dynamics with EEG. We hypothesized that faster walking speeds would result in greater sensorimotor and posterior parietal theta-band (4–7 Hz) spectral power and lower beta-band (13–30 Hz) spectral power compared to slower walking speeds for older adults, consistent with previous studies on younger adults. Additionally, we used a standardized test of physical function to group older adults into high-functioning [Short Physical Performance Battery (SPPB) ≥ 10] and low-functioning (SPPB < 10) groups for comparison. In agreement with our hypotheses, sensorimotor and posterior parietal theta power increased and beta power decreased at faster walking speeds. We also found that left posterior parietal, mid cingulate, and cuneus exhibited differences in theta power at faster speeds between younger and older adults. The results suggest that older and younger adults activate cortical areas throughout the brain while walking at different speeds and older adults, particularly those with lower mobility, recruit greater cognitive resources in parietal cortex compared to younger adults. These results could inform stimulation protocols targeting parietal cortex. Copyright © 2025 The Authors.

关键词： aging clinical electroencephalography gait mobile brain imaging

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An in-vitro biomechanical assessment of humeral head migration following irreparable rotator cuff tear and subacromial balloon reconstruction

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Shoulder and Elbow 2020年第4期12卷 265-271页

作者： Reeves, Jacob M Singh, Supriya Langohr, G Daniel G Athwal, George S Johnson, James A Department of Mechanical Engineering The University of Western Ontario London Canada The Roth|McFarlane Hand and Upper Limb Centre St. Joseph’s Hospital London Canada Department of Surgery The University of Western Ontario London Canada Department of Biomedical Engineering The University of Western Ontario London Canada

Background: A resorbable subacromial balloon has been developed to address humeral head migration following posterosuperior rotator cuff tears. The purpose of this experimental assessment was to quantify the effect of balloon augmentation on humeral head position. Methods: Eight cadaveric shoulders were subjected to 0°, 30°, 60° and 90° of abduction via a shoulder simulator. The deltoid was activated at 40N, then 80N. The subscapularis and infraspinatus with teres minor were then applied independently and together to create four muscle activation states for each deltoid load. The shoulder was tested intact, torn, then with the balloon. The centre of the humeral head was tracked using active optical markers. Results: When the rotator cuff was torn, the humeral head translated superior by 1.4 ± 1 mm overall (P = 0.009). Following balloon augment, the humeral head translated inferiorly by 2 ± 2 mm relative to the intact state (P = 0.042), and significantly more anterior than the intact (3 ± 2 mm;P = 0.005) state. Rotator cuff variation was only significantly different when the balloon was used, with the subscapularis translating the humeral head posteriorly (P = 0.006). Discussion: The subacromial balloon inferiorized the humeral head compared to the torn state. Unexpected anterior humeral head translation was attributed to the posterosuperior balloon placement relative to the humeral head. © 2019 The British Elbow & Shoulder Society.

关键词： cuff tear arthropathy InSpace balloon proximal migration reverse shoulder arthropasty rotator cuff tear shoulder subacromial balloon

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