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Combination of discrete and finite element method to simulate damage in galvanised steel

Procedia Structural Integrity 2022年 41卷 254-259页

作者： Leandro Friedrich Angélica Colpo Sabrina Vantadori Andrea Zanichelli Vittorio Di Cocco Francesco Iacoviello Ignacio Iturrioz Department of Mechanical Engineering Federal University of Pampa Av. Tiaraju 810 97546-550 Alegrete Brazil Program of Mechanical Pos-Graduation Federal University of Rio Grande do Sul Sarmento Leite 425 90040-060 Porto Alegre Brazil Department of Engineering & Architecture University of Parma Parco Area delle Scienze 181/A 43124 Parma Italy DICeM Università di Cassino e del Lazio Meridionale Via G. Di Biasio 43 03043 Cassino (FR) Italy

In the present paper, the bending behaviour of a hot-rolled hyper-sandelin steel, subjected to hot-dip galvanizing (HDG), is numerically simulated in Ansys LS-DYNA environment by combining the Discrete Element Method (DEM) with Finite Element Method (FEM). The coating examined is composed by different layers: the layers with a ductile behaviour are modelled by using elastoplastic constitutive laws for the FEs, whereas the layers with a quasi-brittle behaviour are simulated by using DEs. Such an approach shows quite satisfactory results and it can be promising as a numerical tool to be used by HDG industry, being accurate to estimate the damage of galvanized steel.

关键词： Finite Element Method Discrete Element Method zinc-based coatings plasticity non-linear fracture mechanics

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Alignment of myoblast cultured on micro striped ridge after centrifuge stimulation: Before and after division 24

Alignment of myoblast cultured on micro striped ridge after ...

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24th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2020

作者： Endo, Yuji Hashimoto, Shigehiro Kageyama, Yoshisato Morita, Yu Yoshinaka, Kiyoshi Biomedical Engineering Department of Mechanical Engineering Kogakuin University Kogakuin University Tokyo163-8677 Japan Health and Medical Research Institute National Institute of Advanced Industrial Science and Technology Tsukuba305-8564 Japan

ISBN: (纸本)9781950492381

The effect of hysteresis of the tangential force field at the surface of the scaffold on the alignment of myoblast has been studied in vitro. The striped pattern (0.7 μm height, 3 μm width, and 3 μm interval) were made on the surface of the scaffold plate to control the orientation of each cell. Variation was made on the angle between the longitudinal direction of the ridge and the direction of the tangential force: 0 degree, 45 degrees, and 90 degrees. C2C12 (mouse myoblast cell line) was used in the experiment. To apply the tangential force field ( © WMSCI 2020 - 24th World Multi-Conference on Systemics, Cybernetics and Informatics, Proceedings. All rights reserved.

关键词： Cell culture

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OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems

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Advanced Intelligent Systems 2025年第3期7卷

作者： Chen, Po-Yuan Ko, Tai-Ming Institute of Bioinformatics and Systems Biology College of Engineering Bioscience National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioinformatics Program Institute of Statistical Science Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei115 Taiwan Institute of Statistical Science Academia Sinica Taipei115 Taiwan Department of Biological Science and Technology College of Engineering Bioscience National Yang Ming Chiao Tung University Hsinchu300 Taiwan National Yang Ming Chiao Tung University Hsinchu300 Taiwan School of Pharmacy College of Pharmacy Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung807 Taiwan

Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, plays a pivotal role in inflammatory responses associated with both chronic diseases and acute injuries. In this study, OXidative Stress PREDictor (OxSpred), a supervised learning model tailored to accurately annotate the oxidative stress state of innate immune cells at the single-cell level, is introduced. Compared to the traditional gene-set-variation-analysis-based enrichment method, OxSpred demonstrates superior accuracy with an area under the receiver operating characteristic curve of 0.89 and offers interpretable embeddings with significant biological relevance. Using the predicted ROS states, precise elucidation and interpretation of the roles of novel innate immune cell subtypes can be achieved. Overall, OxSpred enhances the utility of single-cell transcriptomic datasets by providing a robust in silico method for determining intracellular oxidative stress states, thereby enriching the understanding of innate immune cell functions during inflammation. © 2024 The Author(s). Advanced Intelligent Systems published by Wiley-VCH GmbH.

关键词： Cells

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Algorithmic (Semi-)Conjugacy via Koopman Operator Theory

arXiv

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arXiv 2022年

作者： Redman, William T. Fonoberova, Maria Mohr, Ryan Kevrekidis, Ioannis G. Mezić, Igor The Interdepartmental Graduate Program in Dynamical Neuroscience University of California Santa Barbara United States AIMdyn Inc. Santa Barbara United States The Department of Chemical and Biomolecular Engineering and of Mathematics and Statistics The Johns Hopkins University United States The Department of Mechanical Engineering and of Mathematics University of California Santa Barbara United States

Iterative algorithms are of utmost importance in decision and control. With an ever growing number of algorithms being developed, distributed, and proprietarized, there is a similarly growing need for methods that can provide classification and comparison. By viewing iterative algorithms as discrete-time dynamical systems, we leverage Koopman operator theory to identify (semi-)conjugacies between algorithms using their spectral properties. This provides a general framework with which to classify and compare algorithms. © 2022, CC0.

关键词： Dynamical systems

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Municipal waste management sustainability in developing countries: An analysis of research directions

Journal of Solid Waste Technology and Management

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Journal of Solid Waste Technology and Management 2020年第3期46卷 328-341页

作者： Ighravwe, Desmond Eseoghene Edem, Inyeneobong Ekoi Department of Mechanical and Biomedical Engineering Bells University of Technology Nigeria Department of Industrial and Production Engineering University of Ibadan Nigeria

Currently, there is an increasing clamour for sustainable municipal management systems in developing countries because of the recent growth in waste generation in these countries. Different literature has discussed the issue of waste management systems for developing countries;however, there is sparse information on the synergic relationship among STEEP (Social, Technical, Economic, Environment and Policy) requirements for municipal waste management. This study uses STEEP requirements to evaluate the issue of municipal waste management sustainability in developing countries. These requirements help in aggregating the drawbacks and improvements in municipal waste management among developing countries. A framework for municipal waste management sustainability was proposed based on the discussion of available information on STEEP requirements. Furthermore, several research directions were highlighted to provide decision-makers with empirical tools for municipal waste management sustainability. Its emphasis is on municipal waste management in Africa in general and Lagos, Nigeria in particular. The study concluded that carrying out a detailed analysis of the STEEP requirements is a prerequisite for a sustainable municipal waste management system. © 2020 Widener University School of Civil engineering. All rights reserved.

关键词： Developing countries

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Label- and slide-free tissue histology using 3D epi-mode quantitative phase imaging and virtual H&E staining

arXiv

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arXiv 2023年

作者： Abraham, Tanishq Mathew Costa, Paloma Casteleiro Filan, Caroline Guang, Zhe Zhang, Zhaobin Neill, Stewart Olson, Jeffrey J. Levenson, Richard Robles, Francisco E. Dept. of Biomedical Engineering University of California DavisCA95616 United States School of Electrical and Computer Engineering Georgia Institute of Technology AtlantaGA30332 United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology AtlantaGA30332 United States Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology AtlantaGA30332 United States Winship Cancer Institute Emory University AtlantaGA30322 United States Department of Neurosurgery Emory University School of Medicine AtlantaGA30322 United States Department of Pathology & Laboratory Medicine Emory University School of Medicine AtlantaGA30322 United States Dept. of Pathology and Laboratory Medicine UC Davis Health SacramentoCA95817 United States

Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining, serves as the benchmark for disease diagnosis and comprehensive clinical assessment of tissue. However, the process is laborious and time-consuming, often limiting its usage in crucial applications such as surgical margin assessment. To address these challenges, we combine an emerging 3D quantitative phase imaging technology, termed quantitative oblique back illumination microscopy (qOBM), with an unsupervised generative adversarial network pipeline to map qOBM phase images of unaltered thick tissues (i.e., label- and slide-free) to virtually stained H&E-like (vH&E) images. We demonstrate that the approach achieves high-fidelity conversions to H&E with subcellular detail using fresh tissue specimens from mouse liver, rat gliosarcoma, and human gliomas. We also show that the framework directly enables additional capabilities such as H&E-like contrast for volumetric imaging. The quality and fidelity of the vH&E images are validated using both a neural network classifier trained on real H&E images and tested on virtual H&E images, and a user study with neuropathologists. Given its simple and low-cost embodiment and ability to provide real-time feedback in vivo, this deep learning-enabled qOBM approach could enable new workflows for histopathology with the potential to significantly save time, labor, and costs in cancer screening, detection, treatment guidance, and more. Copyright © 2023, The Authors. All rights reserved.

关键词： Tissue

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Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T_(1)-weighted magnetic resonance imaging

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Chinese Chemical Letters 2021年第2期32卷 842-848页

作者： Jing Qin Guohai Liang Bingxi Feng Gen Wang Na Wu Yonghui Deng Ahmed AElzatahry Abdulaziz Alghamdi Yongxi Zhao Jing Wei The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049China College of Biophotonics South China Normal UniversityGuangzhou 510631China Department of Chemistry Fudan UniversityShanghai 200433China Materials Science and Technology Program College of Arts and SciencesQatar UniversityPO Box 2713DohaQatar Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Plant polyphenol-based coordination polymers(CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applicatio ns,but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. He rein,a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species(e.g., Gd,Cu,Ni,Zn,Fe)and ultra-small diameter(8.6-37.8 nm) using nontoxic plant polyphenol(e.g..tannic acid,gallic acid) as a polymerizable *** molecules react with formaldehyde firstly,which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal *** ultrafine nanoparticles with stably chelated metal io ns are highly water dispersible and thus advantageous for *** an example,ultra-small Gd contained CPs exhibit higher longitudinal relaxivity(r_(1)=25.5 L mmol^(-1) s^(-1)) value with low r2/r1(1.19) than clinically used Magnevist(Gd-DTPA,r1=3.7 L mmol^(-1) s^(-1)) .Due to the enhanced permeability and retention effect,they can be further used as a positive contrast agent for T1-weighted MR imaging of tumour.

关键词： Coordination polymer Nanoparticle Self-assembly Plant polyphenol Contrast agent

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ECG heart-beat classification using multimodal image fusion

arXiv

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arXiv 2021年

作者： Ahmad, Zeeshan Tabassum, Anika Guan, Ling Khan, Naimul Department of Electrical Computer and Biomedical Engineering Ryerson University TorontoON Canada Master of Data Science program Ryerson University TorontoON Canada

In this paper, we present a novel Image Fusion Model (IFM) for ECG heart-beat classification to overcome the weaknesses of existing machine learning techniques that rely either on manual feature extraction or direct utilization of 1D raw ECG signal. At the input of IFM, we first convert the heart-beats of ECG into three different images using Gramian Angular Field (GAF), Recurrence Plot (RP) and Markov Transition Field (MTF) and then fuse these images to create a single imaging modality. We use AlexNet for feature extraction and classification and thus employ end-to-end deep learning. We perform experiments on PhysioNet's MIT-BIH dataset for five different arrhythmias in accordance with the AAMI EC57 standard and on PTB diagnostics dataset for myocardial infarction (MI) classification. We achieved an state-of-an-art results in terms of prediction accuracy, precision and recall. © 2021, CC BY.

关键词： Extraction

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Doxycycline-laden fibrous microparticles as a therapeutic ingredient for etch-and-rinse adhesive systems: Effects on optical, physical and bonding properties to dentin

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Dental materials : official publication of the Academy of Dental Materials 2025年第7期41卷 862-871页

作者： Bianca Tatsch Silveira Evandro Piva Julia Stela Xavier Paim Marco Cícero Bottino Eliseu Aldrighi Münchow Graduate Program in Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil. Electronic address: biancatsilveira@***. Graduate Program in Dentistry School of Dentistry Federal University of Pelotas Rua Gonçalves Chaves 457 Pelotas Brazil. Electronic address: evpiva@***. Department of Biomedicine Health Basic Science Institute Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2600 Porto Alegre Brazil. Electronic address: jsxavierpaim@***. Department of Biomedical Engineering College of Engineering University of Michigan Ann Arbor USA. Electronic address: mbottino@umich.edu. Department of Conservative Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil. Electronic address: eliseu.munchow@ufrgs.br.

OBJECTIVES:To evaluate the effects of the modification of an etch-and-rinse (ER) adhesive system with fibrous particles with or without doxycycline (DOX) as a therapeutic ingredient. METHODS:Polymeric fibers were synthesized via electrospinning using a 10 wt% polymer solution based on poly-(ε-caprolactone) (PCL). The PCL solution was separated into two aliquots: one was kept unchanged, and the other was laden with 25 wt% of DOX. Each electrospun fiber mat was further processed in a cryogenic impact mill to obtain small-sized fibrous particles, which were characterized with morphological, chemical (FTIR), and antibacterial activity (against Streptococcus mutans and Lactobacillus) analyses. The 2-step ER adhesive One-Step (Bisco) was separated into three aliquots: one was kept unmodified to serve as an unfilled control, and the other two aliquots were added with 20 wt% of DOX or PCL fibrous microparticles. The fiber-modified adhesives were tested for degree of conversion (DC), optical properties (color change [ΔE], translucency, and refractive index [RI]), wettability properties, and bonding potential (microtensile bond strength/µTBS) to dentin after immediate testing and one-year of water storage. The data were statistically analyzed using ANOVA and Kruskal-Wallis tests with α= 5 %. The bond strength data was also analyzed using Weibull analysis. RESULTS:The morphology of the PCL and DOX particles demonstrated a nonuniform diameter distribution similar to each other. While the PCL particles did not inhibit the growth of S. mutans and Lactobacillus, the DOX particles resulted in significant inhibition halos greater than chlorhexidine (control). The incorporation of the fibrous particles into the adhesive altered the color appearance of the material (ΔE>1.8 - above the acceptability threshold); translucency was slightly reduced only in the PCL adhesive, and the RI was similar among the tested adhesives. DC was similar among the adhesive groups, but their wetting abilit

关键词： Antibacterial analysis Cryomilling Dental bonding agents Electrospinning FTIR Microtensile bond strength Wettability properties

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Used fuel drying by vacuum and forced gas circulation for dry cask storage 14

Used fuel drying by vacuum and forced gas circulation for dr...

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14th International Nuclear Fuel Cycle Conference, GLOBAL 2019 and Light Water Reactor Fuel Performance Conference, TOP FUEL 2019

作者： Perry, Jonathan E. Farouk, Tanvir Khan, Jamil Tulenko, James S. Niemoller, Arthur Knight, Travis W. Nuclear Engineering Program Department of Mechanical Engineering University of South Carolina ColumbiaSC29208 United States University of Florida GainesvilleFL United States Orano CharlotteNC United States

An experimental facility has been designed and constructed to investigate drying of used nuclear fuel for placement in dry cask storage. The motivation for this study was to demonstrate the drying of used nuclear fuel using industry practice and provide the experimental data for development of drying models. A full size BWR fuel assembly (Areva Atrium 10A) with depleted uranium rods and 12 heater rods to simulate decay heat of used fuel is utilized in experiments. The fuel assembly with an interchangeable rod and chamber are designed to examine drying of key features of concern such as failed fuel rods, a BWR water rod, a PWR guide thimble, porous neutron absorber materials, spacer discs, etc. The vacuum chamber simulating the storage cask contains structure similar to baskets for the fuel assembly and surrounding rails to center in the chamber. Testing included both separate effects tests of individual features with a known amount of water initially and combined tests with selected features and flooding of the chamber to reproduce the chamber wetted environment additionally. The experimental plan followed typical industry practice of vacuum drying in stages stepping down in pressure and separated by hold times to provide indication of excess water retained by observation of pressure rise due to evaporation of water. Forced circulation drying using heated helium was also tested. Copyright © GLOBAL 2019 - International Nuclear Fuel Cycle Conference and TOP FUEL 2019 - Light Water Reactor Fuel Performance *** rights reserved.

关键词： Drying

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