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In silico screening method for non-responders to cardiac resynchronization therapy in patients with heart failure: a pilot study

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International Journal of Arrhythmia 2022年第1期23卷 1-8页

作者： Hwang, Minki Uhm, Jae-Sun Park, Min Cheol Shim, Eun Bo Lee, Chan Joo Oh, Jaewon Yu, Hee Tae Kim, Tae-Hoon Joung, Boyoung Pak, Hui-Nam Kang, Seok-Min Lee, Moon-Hyoung AI Medic Inc. Seoul Republic of Korea Department of Cardiology Yongin Severance Hospital Yonsei University College of Medicine Yongin-si Republic of Korea Department of Mechanical and Biomedical Engineering Kangwon National University Chuncheon Republic of Korea Division of Cardiology Department of Internal Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea

Cardiac resynchronization therapy (CRT) is an effective treatment option for patients with heart failure (HF) and left ventricular (LV) dyssynchrony. However, the problem of some patients not responding to CRT remains unresolved. This study aimed to propose a novel in silico method for CRT simulation. Three-dimensional heart geometry was constructed from computed tomography images. The finite element method was used to elucidate the electric wave propagation in the heart. The electric excitation and mechanical contraction were coupled with vascular hemodynamics by the lumped parameter model. The model parameters for three-dimensional (3D) heart and vascular mechanics were estimated by matching computed variables with measured physiological parameters. CRT effects were simulated in a patient with HF and left bundle branch block (LBBB). LV end-diastolic (LVEDV) and end-systolic volumes (LVESV), LV ejection fraction (LVEF), and CRT responsiveness measured from the in silico simulation model were compared with those from clinical observation. A CRT responder was defined as absolute increase in LVEF ≥ 5% or relative increase in LVEF ≥ 15%. A 68-year-old female with nonischemic HF and LBBB was retrospectively included. The in silico CRT simulation modeling revealed that changes in LVEDV, LVESV, and LVEF by CRT were from 174 to 173 mL, 116 to 104 mL, and 33 to 40%, respectively. Absolute and relative ΔLVEF were 7% and 18%, respectively, signifying a CRT responder. In clinical observation, echocardiography showed that changes in LVEDV, LVESV, and LVEF by CRT were from 162 to 119 mL, 114 to 69 mL, and 29 to 42%, respectively. Absolute and relative ΔLVESV were 13% and 31%, respectively, also signifying a CRT responder. CRT responsiveness from the in silico CRT simulation model was concordant with that in the clinical observation. This in silico CRT simulation method is a feasible technique to screen for CRT non-responders in patients with HF and LBBB.

关键词： Cardiac resynchronization therapy In silico modeling Non-responder Virtual CRT

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Magnetic structure and field-induced transitions in the triangular spin-1 antiferromagnet NiNb2O6: Observation of a triple point

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Physical Review B 2023年第22期108卷 224430-224430页

作者： Maruthi R Sobhit Singh Sayandeep Ghosh Mohindar S. Seehra Bruno Weise Wilfrid Prellier Subhash Thota Department of Physics Indian Institute of Technology Guwahati Assam 781039 India Department of Physics B.M.S. College of Engineering Bangalore 560019 Karnataka India Department of Mechanical Engineering University of Rochester Rochester New York 14627 USA Materials Science Program University of Rochester Rochester New York 14627 USA Department of Physics Chungnam National University Daejeon 34134 Republic of Korea Department of Physics Kunsan National University Gunsan 54150 Republic of Korea Department of Physics & Astronomy West Virginia University Morgantown West Virginia 26506 USA Leibniz-IFW Dresden Institute for Complex Materials D-01069 Dresden Germany CRISMAT laboratory Normandy University ENSICAEN UNICAEN National Center for Scientific Research 14000 Caen France

A comprehensive experiment-theory study on the magnetic field-induced spin-flip transitions (HC1 and HC2) and the field-temperature (H−T) phase diagram of nickel niobate (NiNb2O6) polycrystals is reported. Magnetic susceptibility (χ) measurements reveal the presence of quasi-one-dimensional magnetism with spin-1 Ni2+ Heisenberg spin chains, instead of Ising chains, along the easy axis (c axis). The ferromagnetic intrachain exchange-interaction strength, J0/kB (=4.20 K), between Ni2+ ions in the c axis is estimated from the molecular-field theory approximation. The interchain exchange interactions J1/kB=−1.335 K and J2/kB=−1.298 K have been determined from the experimentally obtained magnitudes of HC1=10.8 kOe and spin-saturated field HS=38 kOe. These magnitudes are consistent with the total magnetic exchange-interaction strength, J/kB=7.00 K obtained from χ−T data fitted with the Heisenberg linear chain model and our density-functional theory (DFT+U) calculations. The overall antiferromagnetic behavior of the NiNb2O6 system, correctly captured within our DFT+U calculations, occurs below TN=5.59±0.02 K as determined from the analysis of the specific heat (CP−T) data. The CP vs T data near TN is fitted to power-law expression CP=A|T−TN|−α yielding the critical exponent α=0.349(2) [0.349(1)] for T>TN (T

关键词： Magnetic interactions Magnetic phase transitions Magnetism Structural properties

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The Role of Surfaces, Interfaces and Morphology on Silver Diffusion in Hard Coatings

SSRN

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SSRN 2023年

作者： Cavaleiro, Diogo Munnik, Frans Krause, Matthias Carbo, Enrique Ferreira, Paulo J. Cavaleiro, Albano Fernandes, Filipe University of Coimbra SEG-CEMMPRE - Centre for Mechanical Engineering Materials and Processes Department of Mechanical Engineering Rua Luís Reis Santos Coimbra3030-788 Portugal Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstrasse 400 Dresden01328 Germany INL – International Iberian Nanotechnology Laboratory Av. Mestre José Veiga s/n Braga4715-330 Portugal Mechanical Engineering Department IDMEC Instituto Superior Técnico University of Lisbon Av. Rovisco Pais Lisboa1049-001 Portugal Materials Science and Engineering Program The University of Texas at Austin AustinTX78712 United States IPN - LED&MAT - Instituto Pedro Nunes Laboratório de Ensaios Desgaste e Materiais Rua Pedro Nunes Coimbra3030-199 Portugal ISEP - School of Engineering Polytechnic of Porto Rua Dr. António Bernardino de Almeida 431 Porto4200-072 Portugal

One of the main approaches to increase the tool lifetime during dry machining of "hard-to-machine" aerospace alloys is self-lubrication by the incorporation of noble metals in hard matrixes with good mechanical and diffusion barrier properties. In this paper, the diffusion of an Ag-rich layer sandwiched between two layers of either TiN or TiSiN is studied by transmission electron microscopy and in situ Rutherford backscattering spectrometry. The layer stacks were subjected to annealing treatments at 600 ºC and 800 ºC for 2 hours. Three processes were found to control the diffusion of silver: the morphology of the "sandwich" layers, the formation of small voids in the involved interfaces and the sublimation of Ag in the surface at temperatures near the melting point. The study revealed that the dense TiSiN matrix allowed a significantly better control of Ag diffusion than the more open TiN matrix. © 2023, The Authors. All rights reserved.

关键词： High resolution transmission electron microscopy

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Export- and import-based economic models for predicting global trade using deep learning

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Expert Systems with Applications 2023年 218卷

作者： Yang, Cheng-Hong Lee, Cheng-Feng Chang, Po-Yin Department of Information Management Tainan University of Technology Tainan City710302 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung80708 Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung80708 Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Business Administration National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Department of Computer Science and Information Engineering National Quemoy University Kinmen County 892 Taiwan

Forecasting global foreign trade is essential for developing government trade policies and management strategies for multinational corporations. However, achieving an accurate trade forecast is challenging because of the complex structural relationships between exports, imports and other economic variables. Many traditional forecasting models, such as time series, econometric, and machine learning, provide less accurate forecasts for trade data. This paper proposes an ensemble learning approach to improve forecasting performance by hybridizing the structural relationships between trade and deep learning models to predict foreign trade for ten major countries. The proposed method first establishes a cointegration relationship between exports and imports and their structural variables. The cointegrated models are then used to predict the future of trade, which is used as a benchmark model for comparison. A hybrid deep learning algorithm uses the cointegrated variables as input variables to predict trade data, and then are compared with time-series forecasts and economic structural models. The experimental results reveal that the ensemble learning method can achieve excellent forecasting performance for the tested periods of trade data. In most cases, the root means square error and mean absolute percentage error values are smaller than the time series and economic structural models. © 2023 Elsevier Ltd

关键词： Forecasting

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Corrigendum to “Amorphous boron carbide from ab initio simulations” [Comput. Mater. Sci. 173 (2020) 109397]

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Computational Materials Science 2023年 216卷

作者： Tevhide Ayça Yıldız Murat Durandurdu Materials Science & Mechanical Engineering Program and Department of Materials Science & Nanotechnology Engineering Abdullah Gül University Kayseri 38080 Turkey

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3D Printing of Near-Ambient Responsive Liquid Crystal Elastomers with Enhanced Nematic Order and Pluralized Transformation

arXiv

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arXiv 2024年

作者： Li, Dongxiao Sun, Yuxuan Li, Xingjian Li, Xingxiang Zhu, Zhengqing Sun, Boxi Nong, Shutong Wu, Jiyang Pan, Tingrui Li, Weihua Zhang, Shiwu Li, Mujun Institute of Humanoid Robots Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei230026 China School of Microelectronics University of Science and Technology of China Hefei230026 China Suzhou Institute for Advanced Research University of Science and Technology of China Suzhou215123 China School of Mechanical Materials Mechatronic and Biomedical Engineering University of Wollongong WollongongNSW2522 Australia

Liquid Crystal Elastomers with near-ambient temperature-responsiveness (NAT-LCEs) have been extensively studied for building bio-compatible, low-power consumption devices and robotics. However, conventional manufacturing methods face limitations in programmability (e.g., molding) or low nematic order (e.g., DIW printing). Here, a hybrid cooling strategy is proposed for programmable 3D printing of NAT-LCEs with enhanced nematic order, intricate shape forming, and morphing capability. By integrating a low-temperature nozzle and a cooling platform into a 3D printer, the resulting temperature field synergistically facilitates mesogen alignment during extrusion and disruption-free UV cross-linking. This method achieves a nematic order 3000% higher than NAT-LCEs fabricated using traditional room temperature 3D printing. Enabled by shifting of transition temperature during hybrid cooling printing, printed sheets spontaneously turn into 3D structures after release from the platform, exhibiting bidirectional deformation with heating and cooling. By adjusting the nozzle and plate temperatures, NAT-LCEs with graded properties can be fabricated for intricate shape morphing. A wristband system with enhanced heart rate monitoring is also developed based on 3D-printed NAT-LCE. Our method may open new possibilities for soft robotics, biomedical devices, and wearable electronics. Copyright © 2024, The Authors. All rights reserved.

关键词： Nozzles

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Comparative analysis of gene regulation in single cells using Compass

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Cell Reports Methods 2025年第5期5卷 101035页

作者： Wan, Changxin Qu, Yilong Ye, Zhiyou Zhang, Tianbei Ma, Huifang Chen, Ming Hou, Wenpin Ji, Zhicheng Department of Biostatistics and Bioinformatics Duke University School of Medicine Durham NC United States Program of Computational Biology and Bioinformatics Duke University School of Medicine Durham NC United States Department of Biomedical Engineering Pratt School of Engineering Duke University Durham NC United States Department of Pathology Duke University School of Medicine Durham NC United States Duke Cancer Institute Duke University Durham NC United States Department of Biostatistics Columbia University Mailman School of Public Health New York City NY United States

Single-cell multi-omics is a transformative technology that measures both gene expression and chromatin accessibility in individual cells. However, most studies concentrate on a single tissue and are unable to determine whether a gene is regulated by a cis-regulatory element (CRE) in just one tissue or across multiple tissues. We developed Compass for comparative analysis of gene regulation across a large number of human and mouse tissues. Compass consists of a database, CompassDB, and an open-source R software package, CompassR. CompassDB contains processed single-cell multi-omics data of more than 2.8 million cells from hundreds of cell types. Building upon CompassDB, CompassR enables visualization and comparison of gene regulation across multiple tissues. We demonstrated that CompassR can identify CRE-gene linkages specific to a tissue type and their associated transcription factors in real examples. © 2025 The Author(s)

关键词： cis-regulatory elements CP: Systems biology gene regulation single-cell ATAC-seq single-cell multi-omics

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A portable device for rapid influenza A (H1N1) diagnosis 21

A portable device for rapid influenza A (H1N1) diagnosis

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21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Ma, Yu-Dong Chou, Shang-Ta Lee, Yung-Mao Lai, Yue-Yuan Li, Kuang-Hsien Lee, Wen-Bin Chen, Yi-Hong Lin, Zhi-Da Lee, Tsung-Mu Huang, Po-Chiun Ma, Hsi-Pin Lee, Gwo-Bin Department of Power Mechanical Engineering National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu Taiwan

ISBN: (纸本)9780692941836

This study presents a portable device for rapid Influenza A (H1N1) diagnosis utilizing a loop-mediated isothermal amplification (LAMP) approach, which may carry out molecular diagnosis with high sensitivity and specificity. The entire procedure could be automated on a passive microfluidic chip, controlled and monitored via a smart phone. The diagnostic results could be observed colorimetrically and detected by an integrated color sensor. This is the first time that an automated portable device was demonstrated which could perform a molecular diagnosis process including virus purification and nucleic acid amplification to diagnose Influenza A H1N1 virus and may become a promising tool for point-of-care applications. © 17CBMS-0001.

关键词： Diagnosis

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Microfluidic nanodevices for drug sensing and screening applications

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Biosensors and Bioelectronics 2023年 219卷 114783页

作者： Pal, Arnab Kaswan, Kuldeep Barman, Snigdha Roy Lin, Yu-Zih Chung, Jun-Hsuan Sharma, Manish Kumar Liu, Kuei-Lin Chen, Bo-Huan Wu, Chih-Cheng Lee, Sangmin Choi, Dongwhi Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan333 Taiwan Center of Quality Management National Taiwan University Hospital Hsinchu Branch Hsinchu30059 Taiwan College of Medicine National Taiwan University Taipei10051 Taiwan Institute of Cellular and System Medicine National Health Research Institute Zhunan 35053 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Kyung Hee University Gyeonggi 17104 Korea Republic of

The outbreak of pandemics (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging population have created unprecedented urgency for developing new drugs to improve disease treatment. As a result, extensive efforts have been made to design novel techniques for efficient drug monitoring and screening, which form the backbone of drug development. Compared to traditional techniques, microfluidics-based platforms have emerged as promising alternatives for high-throughput drug screening due to their inherent miniaturization characteristics, low sample consumption, integration, and compatibility with diverse analytical strategies. Moreover, the microfluidic-based models utilizing human cells to produce in-vitro biomimetics of the human body pave new ways to predict more accurate drug effects in humans. This review provides a comprehensive summary of different microfluidics-based drug sensing and screening strategies and briefly discusses their advantages. Most importantly, an in-depth outlook of the commonly used detection techniques integrated with microfluidic chips for highly sensitive drug screening is provided. Then, the influence of critical parameters such as sensing materials and microfluidic platform geometries on screening performance is summarized. This review also outlines the recent applications of microfluidic approaches for screening therapeutic and illicit drugs. Moreover, the current challenges and the future perspective of this research field is elaborately highlighted, which we believe will contribute immensely towards significant achievements in all aspects of drug development. © 2022 Elsevier B.V.

关键词： Microfluidics

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Study on Ag(I) Loaded ZIF-8 and Ag(I) Ion Release in Artificial Seawater

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Materials 2023年第5期16卷 2040页

作者： Tsai, Shang-Tien Tang, Wei-Cheng Wei, Yeu-Kuen Wu, Kevin C.-W. Program of Green Materials and Precision Devices National Taiwan University Taipei10617 Taiwan Material and Chemical Research Laboratories Industrial Technology Research Institute Hsinchu30011 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes 35 Keyan Road Miaoli35053 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Yonsei Frontier Lab Yonsei University 50 Yonsei-ro Seoul03722 Korea Republic of

From a porous structure perspective, the one-stage de novo synthesis method and impregnation method were applied to synthesize Ag(I) ion-containing ZIF-8 samples. With the de novo synthesis method, Ag(I) ions could be located inside micropores or adsorbed on the external surface of the ZIF-8 by selecting AgNO3 in water or Ag2CO3 in ammonia solution as precursors, respectively. The ZIF-8 confining Ag(I) ion exhibited a much lower constant releasing rate than the Ag(I) ion adsorbed on the ZIF-8 surface in artificial seawater. As such, strong diffusion resistance in association with the confinement effect is contributed by ZIF-8’s micropore. On the other hand, the release of Ag(I) ions adsorbed on the external surface was diffusion limited. Therefore, the releasing rate would reach a maximum not increasing with Ag(I) loading in the ZIF-8 sample. © 2023 by the authors.

关键词： Ions

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