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2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： Shang, Yizhe Chen, Jianrui Lei, Xiujuan Wu, Fang-Xiang Shaanxi Normal University School of Computer Science Xi'an China University of Saskatchewan Department of Mechanical Engineering Division of Biomedical Engineering Department of Computer Science SaskatoonS7N 5A9 Canada

ISBN: (纸本)9798350386226

Drug-gene interaction plays a crucial role in drug discovery and personalized medicine. Although existing methods have improved the accuracy of exploring multiple relationships between drugs and genes, there are still some limitations, such as susceptibility to data sparsity and poor generalization, which pose some challenges for practical applications. To address these challenges, we propose a novel Hierarchical Channels and Contrastive Learning (HCCL) framework in which drug feature extractor captures structural information of drug molecules from atom and bond channels. After obtaining the initial features of drugs and genes, we employ high-low-order channels to update them, where the low-order channel adopts graph convolutional networks while the high-order channel leverages hypergraph structures for message propagation. Finally, we adopt contrastive learning and inter-channel attention to fuse high-low-order features, which improves the robustness of the model and prevents feature information loss. Experimental results demonstrate the superior performance of HCCL. © 2024 IEEE.

关键词： Contrastive Learning

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Multidisciplinary Learning Using Online Networking in biomedical engineering 26

Multidisciplinary Learning Using Online Networking in Biomed...

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26th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2022

作者： Hashimoto, Shigehiro Doctor of Engineering Doctor of Medicine Biomedical Engineering Department of Mechanical Engineering Kogakuin University Tokyo163-8677 Japan

ISBN: (纸本)9781950492640

Multifaceted thinking is important to tackle global issues for a sustainable society. It is difficult to select useful information from big data with one-sided thinking. This article takes as an example the controversy related to "vaccines" and "masks" in pandemics. Online is useful under the control of infectious diseases. Face-to-face group meetings make it easy to interrupt group activities for individual activities. Online meetings are considering various ideas as an alternative to face-to-face meetings. The field of biomedical engineering includes faculties and students from diverse backgrounds. "Cross-cultural exchange" is also useful for multifaceted experiences. With the keyword "life support technology", Japanese academic society and Thai university conducted online networking for information exchange. The academic society is working to encourage students. The university is developing new fields. Information exchange is expected to lead to further development in complex fields. It is expected to lead to the development of human resources who can deal with global problems. Copyright 2022. © by the International Institute of Informatics and Systemics. All rights reserved.

关键词： Students

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Omnichannel Retail in Small and Medium-Sized Enterprises: Insights from Indonesia

Omnichannel Retail in Small and Medium-Sized Enterprises: In...

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2023 IEEE International Conference on Industrial engineering and engineering Management, IEEM 2023

作者： Febriani, Atik Sopha, Bertha Maya Wibisono, Muhammad Arif Universitas Gadjah Mada Department of Mechanical and Industrial Engineering Yogyakarta Indonesia Institut Teknologi Telkom Purwokerto Industrial Engineering Program Faculty of Industrial Engineering and Design Purwokerto Indonesia

ISBN: (纸本)9798350323153

An omnichannel retail strategy integrates multiple channels, enabling customers to shop across all available online and offline channels at the same time. This strategy is required to overcome different obstacles that develop as a result of changes in the retailer's business environment. This study aims to provide an overview of the extent to which SMEs in Indonesia implement an omnichannel strategy. Omnichannel retail implementation in SMEs has shown positive developments in recent years. They recognize the importance of providing a consistent and unified shopping experience across multiple channels. In this context, the marketplace is essential for SMEs to expand their reach of customers in various locations. However, despite positive developments, there are still some challenges to implementing omnichannel for SMEs in Indonesia. These challenges include dynamic changes in consumer behavior, limited staff capabilities, and the mindset of SME leaders or owners. © 2023 IEEE.

关键词： multichannel omnichannel retail SMEs strategy

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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

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Acta Biomaterialia 2023年 170卷 344-359页

作者： Yeh, Ying-Yu Lin, Yi-Yun Wang, Ting-Teng Yeh, Yu-Jia Chiu, Ting-Hsiang Wang, Reuben Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei Taiwan Institute of Biomedical Engineering National Taiwan University Taipei Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Institute of Food Safety and Health National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Program National Taiwan University Taipei Taiwan GIP-TRIAD Master's Degree in Agro-Biomedical Science National Taiwan University Taipei Taiwan

Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-

关键词： Polyols

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Improving Control Theory Education Through Face-to-Face Implementation of a Mobile Robotics Methodology 16

Improving Control Theory Education Through Face-to-Face Impl...

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16th Brazilian Symposium on Robotics and 15th Workshop on Robotics in Education, SBR-WRE 2024

作者： Pastrana, M.A. Cuéllar Sánchez, William Humberto Mendoza-Peñaloza, Jose Santana, M.S. Muñoz, Daniel M. Department of Mechanical Engineering Mechatronics Graduate Program University of Brasilia DF Brasilia Brazil Faculty of Gama Electronics Engineering Undergraduate Program University of Brasilia DF Brasilia Brazil University of Federal District UDF DF Brasilia Brazil

ISBN: (纸本)9798350391084

Advances in information and communication technologies have significantly transformed engineering education. Virtual laboratories are increasingly adopted to enhance student interaction with control system simulations. The improved visualization and interaction capabilities of modern computers offer a more organic way to teach theoretical foundations. This paper describes the implementation of a methodology for teaching control theory that until now was entirely online in a face-to-face environment at the University of the Federal District in Brasilia, Brazil. This methodology utilizes virtual laboratories with CoppeliaSim, MATLAB, and the EVA mobile robot to teach control theory focused on single-input, single-output (SISO) systems for mobile robot tracking and obstacle avoidance applications. The results of the face-to-face implementation are compared to those of the fully online methodology, revealing that in-person teaching significantly enhances the quality of instruction. ©2024 IEEE.

关键词： MATLAB

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

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Bioactive Materials 2023年第9期27卷 303-326页

作者： Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong SARPR China Faculty of Science University of WaterlooWaterlooOntarioCanada State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouPR China

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy.

关键词： Microneedles Microfabrication Wound healing Tissue regeneration Drug delivery

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Application of Response Surface Methodology (RSM) for the optimization of energy generation from Jebba hydro-power plant, Nigeria

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ISH Journal of Hydraulic engineering 2022年第1期28卷 1-9页

作者： Onokwai, A.O. Owamah, H.I. Ibiwoye, M.O. Ayuba, G.C. Olayemi, O.A. Department of Mechanical and Biomedical Engineering Bells University Ogun State Ota Nigeria Department of Civil Engineering Delta State University Oleh Campus Delta State Abraka Nigeria Department of Mechanical Engineering Kwara State University Kwara State Maleta Nigeria Department of Mechanical Maintenance Jebba Hydropower Station Niger State Jebba Nigeria Department of Aeronautical and Astronautics Engineering Kwara State University Kwara State Maleta Nigeria

This research was performed to optimize the performance characteristics of the Nigerian Jebba Hydropower Plant in order to enhance its generation of electricity. Pertinent hydropower data were hourly collected from the plant from 8:00 am to 5:00 pm between 2016 and 2018. The coefficient of determination obtained from the response surface methodology (RSM) showed that discharge, pressure drop, stator temperature and water pressure strongly influenced the generation of estimated power. Also, the contour and surface plots suggested that the discharge (D) 8200.00–8600.00 m3/s and pressure drop (Pd) ranging from 27.50–28.50 m gave the optimal power generation indicating that both factors must be kept high when the hydropower plant is in operation. The instability of power generation was attributed to the reduction in the net available head as turbine inlet decreased. The study, therefore, showed that net power output, speed of the turbine, and efficiency of the hydropower plant could be optimized with increase discharge and gross head. Predicted optimal values for discharge, pressure drop, stator temperature, and water pressure were 8783.3667 m3, 28.59 m, 58.00°C, and 31.00 N/m2 respectively. © 2020 Indian Society for Hydraulics.

关键词： Stators

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Highly stretchable hydroxyapatite bionanocomposite for high-performance triboelectric nanogenerators

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Nanoscale 2023年第34期15卷 14205-14214页

作者： Luu, Thien Trung Huynh, Nghia Dinh Kim, Hakjeong Lin, Zong-Hong Choi, Dukhyun School of Mechanical Engineering College of Engineering Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi Suwon16419 Korea Republic of Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Sungkyunkwan Univeristy 2066 Seobu-ro Jangan-gu Gyeonggi Suwon16419 Korea Republic of

Renewable energy has been a focus in recent years. Triboelectric nanogenerators (TENGs) have potential for converting mechanical energy into electricity. However, there are restrictions on the use of biological materials and bionanocomposites, such as the high cost and complexity of the synthesis process, poor stability, and inadequate output performance. To overcome the constraints of TENGs, we have turned to hydroxyapatite, a biological substance with great biocompatibility and high mechanical strength that can be manufactured from waste materials. We successfully developed a negative triboelectric bionanocomposite hydroxyapatite (HA) loaded polydimethylsiloxane (PDMS) to harness energy from biomechanical sources such as wearable devices. A TENG (2 × 2 cm2) with a pushing force of 2 N and different amounts of HA in PDMS can produce highly stable output voltage, current, surface charge density, and power density values of 300 V, 22.4 μA, 90.36 μC m−2, and 27.34 W m−2, which are 6, 9, and 10 times higher than those without HA, respectively. These improvements were attributed to the highest observed surface potential of 1512 mV. After 20 000 cycles of contact-separation, the HA/PDMS-TENG shows exceptionally stable performance. Furthermore, adding HA improves the mechanical properties and the stretchability of the bionanocomposite. The HA/PDMS bionanocomposite exhibits remarkable stretchability of more than 290%. Effectively harvesting energy from body movements, the TENG gadget may be used to charge multiple commercial capacitors, drive up to 100 LEDs, and power a low-power electronic device. Self-powered sensing and wearable devices are made possible by the HA/PDMS-TENG, which allows their large-scale preparation and deployment. © 2023 The Royal Society of Chemistry.

关键词： Nanogenerators

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Tribology Performance of Silica Nanoparticles as Lubricant Additives in a Reciprocating Four-Stroke Engine Motorcycle

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International Journal of Automotive Technology 2023年第2期24卷 435-444页

作者： Lue, Yeou-Feng Hsiao, Wei-Liang Chen, Yi-Shun Undergraduate Program of Vehicle and Energy Engineering National Taiwan Normal University Taipei10610 Taiwan Department of Industrial Education National Taiwan Normal University Taipei10610 Taiwan Department of Mechanical Engineering Asia Eastern University of Science and Technology Taipei22061 Taiwan

Lubricants, such as any types of greases and oils, are usually used to reduce the effect of friction. However, they also have multifunctions that increase the overall performance and application life. To clarify how lubricants decrease friction and reduce friction-related issues, this study evaluated the performance of specific fuel consumption and exhaust emissions (such as hydrocarbon, carbon monoxide, and particulate matter) of motorcycle with nanosilica (nano-SiO2) added to the original lubricant. Lubricants with 0.5, 1.5, 2.5, 3.5, and 4.5 wt.% nano-SiO2 were evaluated after testing their basic properties and conducting tribology tests. The lubricant with 3.5 wt.% nano-SiO2 was the best candidate for the four-stroke engine motorcycle experiments. The results of the tribology experiment with nano-SiO2 lubricant showed that the abrasion loss corresponding to the 3.5 wt.% nano-SiO2 lubricant decreased by an average of 42.43 %. Overall, the 3.5 wt.% nano-SiO2 lubricant improved the effect of lubrication. The primary focus of the current study was the development of nano-SiO2 lubricant technology for applications in industry environments. © 2023, The Korean Society of Automotive Engineers.

关键词： Tribology

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Lumbar spine localisation method based on feature fusion

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 931-945页

作者： Yonghong Zhang Ning Hu Zhuofu Li Xuquan Ji Shanshan Liu Youyang Sha Xiongkang Song Jian Zhang Lei Hu Weishi Li Robotics Institute School of Mechanical Engineering and AutomationBeihang UniversityBeijingChina Beijing Zhuzheng Robot Co. LTDBeijingChina Department of Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxvilleTennesseeUSA Department of Orthopaedics Peking University Third HospitalBeijingChina Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijingChina Beijing Key Laboratory of Spinal Disease Research BeijingChina School of Biological Science and Medical Engineering Beihang UniversityBeijingChina Department of Computer Science University of WarwickCoventryUK

To eliminate unnecessary background information,such as soft tissues in original CT images and the adverse impact of the similarity of adjacent spines on lumbar image segmentation and surgical path planning,a two‐stage approach for localising lumbar segments is ***,based on the multi‐scale feature fusion technology,a non‐linear regression method is used to achieve accurate localisation of the overall spatial region of the lumbar spine,effectively eliminating useless background information,such as soft *** the second stage,we directly realised the precise positioning of each segment in the lumbar spine space region based on the non‐linear regression method,thus effectively eliminating the interference caused by the adjacent *** 3D Intersection over Union(3D_IOU)is used as the main evaluation indicator for the positioning *** an open dataset,3D_IOU values of 0.8339�0.0990 and 0.8559�0.0332 in the first and second stages,respectively is *** addition,the average time required for the proposed method in the two stages is 0.3274 and 0.2105 s ***,the proposed method performs very well in terms of both pre-cision and speed and can effectively improve the accuracy of lumbar image segmentation and the effect of surgical path planning.

关键词： CT image lumbar spatial orientation multi‐scale information fusion

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