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2024 ASEE Annual Conference and Exposition

作者： Assanah, Fayekah Garcia, Jorge Paricio Scoggin, Jake Huber, Martin Cohen, Michael Santos, Stephany Ionkin, Kathrine Pavel Hirt, Sean Patrick Russell, Britney Hubbard, Cameron Hirt, Sean University of Connecticut United States Department of Biomedical Engineering University of Connecticut United States School of Mechanical Aerospace and Manufacturing Engineering University of Connecticut United States School of Computing University of Connecticut United States Department of Civil and Environmental Engineering University of Connecticut United States Department of Chemical and Biomolecular Engineering University of Connecticut United States

The long process of educating a new generation of engineers requires more than just the progressive accumulation of classes as students move through a departmental *** education goes beyond solving equations and retaining systematic *** requires cultivating ethical values, honing creative skills in engineering, working collaboratively and iteratively, and solving complex problems in a multidisciplinary *** Accreditation Board of engineering and Technology (ABET) formally acknowledged the importance of these notions in their most recent requirements-(students' outcome 5): "an ability to function effectively on a team whose members together provide leadership, create a collaborative and inclusive environment, establish goals, plan tasks, and meet objectives." Project-based teamwork is particularly crucial in a first-year engineering design *** experiential learning environment promotes acquiring essential skills and abilities that will be used in future projects throughout their *** addition, multidisciplinary teams cultivate a respectful and inclusive work environment, support a deeper understanding of engineering concepts, and encourage students to apply these concepts to meaningful solutions to engineering problems while nurturing a healthy and interactive classroom *** Work in Progress paper describes the design and implementation of a semester-long project as part of the first-year design class at the University of Connecticut and how it promoted teamwork on *** class had over 400 first-year engineering students (from all engineering fields except computing) divided into 16 multidisciplinary sections, all working in the First-Year Design *** in each section were further divided into smaller groups of 4-5 students using the guidelines on equitable teams and inclusion discussed in the *** ten-week project emphasized improved collaboration and teamwork through it

关键词： Students

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Quantifying Joint Movement Variability in Healthy and Hemiplegic Gait using OpenSim 2

Quantifying Joint Movement Variability in Healthy and Hemipl...

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2nd IEEE International Conference on Interdisciplinary Approaches in Technology and Management for Social Innovation, IATMSI 2024

作者： Rafiq, Tabassum Younis, Sadia Narayan, Jyotindra Institute of Information Management and Technology Department of Biotechnology Uttar Pradesh Aligarh202001 India Government College of Engineering and Technology Department of Biomedical Engineering Jammu and Kashmir Ganderbal193504 India Indian Institute of Technology Guwahati Mechatronics and Robotics Laboratory Department of Mechanical Engineering Assam Guwahati781039 India

ISBN: (纸本)9798350360523

This study delves into the scaling capabilities of OpenSim, a biomechanical modeling tool, to scrutinize musculoskeletal alterations accompanying the hemiplegic condition compared to a healthy model. Contralateral hemiplegia (CH), characterized by unilateral paralysis, induces profound changes in bone size and significantly influences an individual's gait. Motivated by understanding the biomechanical repercussions of CH on human movement, we conducted a comprehensive investigation involving ten patients with CH, with a median age of 46 years (range: 39 to 52.0 years and height: 1.75 0.6 m). Ten healthy controls with similar body attributes were±also recruited. We assessed musculoskeletal changes post-CH using bone length data from MRI reports obtained from a hospital. Inverse kinematics in OpenSim are facilitated for a detailed comparison of joint angles between unhealthy and healthy individuals. The gait data is visualized and analyzed using statistical metrics such as mean absolute deviation, box plots, and a two-sample t-test. The results revealed significant differences in hip and ankle joint angles between healthy and hemiplegic individuals, underscored by low p-values. Interestingly, no significant difference was observed in knee joint angles (p-value = 0.9126). These findings contribute to a valuable understanding of hemiplegia-related musculoskeletal changes, offering potential avenues for tailored interventions to improve mobility and quality of life. © 2024 IEEE.

关键词： Inverse kinematics

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Development of paper-based rna amplification devices for point-of-care detection of hiv

Development of paper-based rna amplification devices for poi...

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ASME 2023 International mechanical engineering Congress and Exposition, IMECE 2023

作者： Adedokun, George Sidhu, Gurjit Wang, Gary P. Hugh Fan, Z. Department of Mechanical and Aerospace Engineering United States Department of Medicine United States Purrit Family Department of Biomedical Engineering University of Florida PO Box 116250 GainesvilleFL32611 United States

ISBN: (纸本)9780791887622

Point-of-care (POC) testing of human immunodeficiency virus (HIV) infection is challenging in resource-limited settings, where conventional nucleic acid tests are costly and complex. Paper-based devices offer a low-cost, simple, and rapid alternative, but most of them rely on antibody or antigen detection, which have limitations in sensitivity and specificity. In this work, we develop and evaluate a miniaturized platform for the detection of HIV infection in resource-limited settings. The platform uses low-cost and environment-friendly paper for sample preparation as a nucleic-Acid-extraction substrate followed by isothermal amplification in a battery-powered coffee mug and colorimetric detection. Our platform can detect HIV in human serum and plasma samples with high sensitivity and specificity. We demonstrate the feasibility and performance of our platform using clinical samples and compare it with conventional nucleic acid tests. © 2023 American Society of mechanical Engineers (ASME). All rights reserved.

关键词： Biomolecules

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All-Textile Pressure Sensitive Sock for Mobile Health Applications

All-Textile Pressure Sensitive Sock for Mobile Health Applic...

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2024 International Conference on the Challenges, Opportunities, Innovations and Applications in Electronic Textiles, E-Textiles 2024

作者： Galli, Valeria Kohler, Tobias Menon, Carlo ETH Zurich Biomedical and Mobile Health Technology Group Department of Health Sciences and Technology Zurich Switzerland ETH Zurich Biomedical and Mobile Health Technology group Department of Health Sciences and Technology Department of Mechanical and Process Engineering Zurich Switzerland

ISBN: (纸本)9783000804298

Monitoring plantar pressure continuously is relevant in different applications, e.g., in gait monitoring, foot ulcer prevention, and more. Current solutions include pressure sensitive insoles that are expensive and cannot fully conform to the feet or shoes surface (e.g., in orthotics for diabetic patients). We propose a soft and flexible smart sock to monitor pressure continuously and unobtrusively. The sock features eight textile-based capacitive pressure sensors on the load-bearing areas of the foot. Electromechanical characterization showed suitability of the sensors for the intended application (high pressure up to 500 kPa). Preliminary tests on a healthy participant walking with the sock showed good agreement with commercial smart insoles. This is the first example of a fully textile smart sock with more than four capacitive pressure sensors for in-shoe plantar pressure measurement. The presented prototype shows potential as an inexpensive and comfortable solution for day-to-day monitoring of plantar pressure across various applications. © 2024 Fraunhofer IZM.

关键词： Smart textiles

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Comparison of Hemodynamic Circulation in Pulsatile and Nonpulsatile Extracorporeal Membrane Oxygenation Systems Using an In-Vitro Heart Model

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ASAIO Journal 2025年 2025 Apr 17页

作者： Yoo, Changyoung Jang, Hyun-Woo Kang, Seongmin Choi, Seong-Wook Interdisciplinary Program in Biohealth-Machinery Convergence Engineering Kangwon National University Chuncheon-si Korea Republic of Program of Mechanical and Biomedical Engineering College of Engineering Kangwon National University Chuncheon-si Korea Republic of

This study conducts an in-vitro experiment using a mock circulation system that mimics human circulation to assess the veno-arterial extracorporeal membrane oxygenation (ECMO) system. This study aims to compare the hemodynamic effects of centrifugal and pulsatile ECMO systems on the body using an in-vitro cardiogenic shock model. The heart model used in this study involves a contracting blood sac with inlet and outlet valves, capable of maintaining arterial pressure between 80 and 120 mm Hg while delivering a blood flow of 1.8-2 L/min, effectively replicating a cardiogenic shock model. The contraction force in the heart model was generated using a pneumatic cylinder and gradually decreased to simulate reduced cardiac function. The initial blood flow rates of both ECMO systems were maintained at 2 L/min under identical conditions for a fair comparison. Upon reducing the stroke volume of the heart to 35 ml, the ECMO system with counter-pulsation control increased the cardiac output by 10.7% and systemic circulation by 3.8% compared with the conventional ECMO system. This study demonstrates the hemodynamic benefits provided by the sustained counter-pulsation in an in-vitro weakened heart model. Pulsatile flow ECMO systems may serve as an alternative to address the limitations of continuous flow ECMO systems. © ASAIO 2025.

关键词： Heart

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Removal of As(V)in the presence of Cr(VI)in contaminated water from the Bajio region of Mexico using ferrihydrite-functionalized graphene oxide(GOFH):A case study

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Emerging Contaminants 2024年第3期10卷 134-144页

作者： D.R.Joya-Cardenas J.P.Rodríguez-Caicedo M.A.Corona-Rivera N.Saldana-Robles C.E.Damian-Ascencio A.Saldana-Robles Graduate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad de Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico Department of Agricultural Engineering University of GuanajuatoIrapuato36500Mexico Department of Mechanical Engineering University of GuanajuatoSalamanca36800Mexico Mechanical Engineering Department Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and chromium(Cr)can be considered one of the most toxic heavy *** study aims to develop and evaluate a graphene oxide(GO)based material functionalized with ferrihydrite for the removal of As(V)in the presence of Cr(VI).The adsorbent ferrihydrite-functionalized graphene oxide(GOFH)was characterized by SEM,FTIR,XRD,XPS,surface charge,BET and *** adsorption capacities for As(V)and Cr(VI)were 160 and 66 mg g^(-1)respectively at pH 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(V)with an adsorption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(VI)at room *** analysis revealed an exothermic and spontaneous ***,GOFH effectively removed several coexisting anions from groundwater,including SO_(4)^(2-),CO_(3)^(2-)and Cl^(-).This work evidences the potential of GOFH for competitive adsorption of priority pollutants from complex *** GOFH material represents a technically and economically viable technology for application in groundwater decontamination,as it requires inexpensive precursors and ambient conditions during synthesis and operation.

关键词： Competition Ions Contamination Groundwater Adsorption capacity

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A novel label-free electrochemical immunosensor for the detection of heat shock protein 70 of lung adenocarcinoma cell line following paclitaxel treatment using l-cysteine-functionalized Au@MnO2/MoO3 nanocomposites

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RSC Advances 2023年第43期13卷 29847-29861页

作者： Chen, Yi-An Shie, Ming-You Ho, Chia-Che Ye, Sheng-Wen Chen, I.-Wen Peter Shih, Yu-Yin Shen, Yu-Fang Chen, Yi-Wen x-Dimension Center for Medical Research and Translation China Medical University Hospital Taichung City404332 Taiwan The Master Program for Biomedical Engineering China Medical University Taichung City406040 Taiwan Department of Biomedical Engineering China Medical University Taichung City40447 Taiwan Department of Bioinformatics and Medical Engineering Asia University Taichung City41354 Taiwan Department of Chemistry National Cheng Kung University Tainan70101 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung City40447 Taiwan

The future trend in achieving precision medicine involves the development of non-invasive cancer biomarker sensors that offer high accuracy, low cost, and time-saving benefits for risk clarification, early detection, disease detection, and therapeutic monitoring. A facile approach for the synthesis of MoO3 nanosheets was developed by thermally oxidizing MoS2 nanosheets in air followed by thermal annealing. Subsequently, Au@MnO2 nanocomposites were prepared using a combined hydrothermal process and in situ chemical synthesis. In this study, we present a novel immunosensor design strategy involving the immobilization of antiHSP70 antibodies on Au@MnO2/MoO3 nanocomposites modified on a screen-printed electrode (SPE) using EDC/NHS chemistry. This study establishes HSP70 as a potential biomarker for monitoring therapeutic response during anticancer therapy. Impedance measurements of HSP70 on the Au@MnO2/MoO3/SPE immunosensor using EIS showed an increase in impedance with an increase in HSP70 concentration. The electrochemical immunosensor demonstrated a good linear response in the range of 0.001 to 1000 ng mL−1 with a detection limit of 0.17 pg mL−1 under optimal conditions. Moreover, the immunosensor was effective in detecting HSP70 at low concentrations in a lung adenocarcinoma cell line following Paclitaxel treatment, indicating its potential for early detection of the HSP70 biomarker in organ-on-a-chip and clinical applications. © 2023 The Royal Society of Chemistry.

关键词： Nanosheets

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Plasma-Enabled Graphene Quantum Dot Hydrogel-Magnesium Composites as Bioactive Scaffolds for In Vivo Bone Defect Repair

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ACS Applied Materials and Interfaces 2023年第38期15卷 44607-44620页

作者： Wong, Pei-Chun Kurniawan, Darwin Wu, Jia-Lin Wang, Wei-Ru Chen, Kuan-Hao Chen, Chieh-Ying Chen, Ying-Chun Veeramuthu, Loganathan Kuo, Chi-Ching Ostrikov, Kostya Ken Chiang, Wei-Hung Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Orthopedics Research Center Taipei Medical University Hospital Taipei110 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei110 Taiwan Centers for Regional Anesthesia and Pain Medicine Wan Fang Hospital Taipei Medical University Taipei110 Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei235 Taiwan Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Molecular Science and Engineering Institute of Organic and Polymeric Materials National Taipei University of Technology Taipei106 Taiwan BrisbaneQLD4000 Australia

Bioactive and mechanically stable metal-based scaffolds are commonly used for bone defect repair. However, conventional metal-based scaffolds induce nonuniform cell growth, limiting damaged tissue restoration. Here, we develop a plasma nanotechnology-enhanced graphene quantum dot (GQD) hydrogel-magnesium (Mg) composite scaffold for functional bone defect repair by integrating a bioresource-derived nitrogen-doped GQD (NGQD) hydrogel into the Mg ZK60 alloy. Each scaffold component brings major synergistic advantages over the current alloy-based state of the art, including (1) mechanical support of the cortical bone and calcium deposition by the released Mg2+ during degradation;(2) enhanced uptake, migration, and distribution of osteoblasts by the porous hydrogel;and (3) improved osteoblast adhesion and proliferation, osteogenesis, and mineralization by the NGQDs in the hydrogel. Through an in vivo study, the hybrid scaffold with the much enhanced osteogenic ability induced by the above synergy promotes a more rapid, uniform, and directional bone growth across the hydrogel channel, compared with the control Mg-based scaffold. This work provides insights into the design of multifunctional hybrid scaffolds, which can be applied in other areas well beyond the demonstrated bone defect repair. © 2023 American Chemical Society.

关键词： Semiconductor quantum dots

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Live Demonstration: A fully embedded adaptive real-time hand gesture classifier leveraging HD-sEMG and deep learning

Live Demonstration: A fully embedded adaptive real-time hand...

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2023 IEEE biomedical Circuits and Systems Conference, BioCAS 2023

作者： Isabel, Xavier Labbe, Thomas Chamberland, Felix Buteau, Etienne Campbell, Evan Cote-Allard, Ulysse Tam, Simon Fortier, Paul Campeau-Lecours, Alexandre Boukadoum, Mounir Scheme, Erik Gosselin, Benoit Laval University Electrical Engineering and Computer Engineering Department Canada University of New-Brunswick Institute of Biomedical Engineering Canada University of Oslo Department off Technology Systems Norway Laval University Mechanical Engineering Department Canada University of Quebec at Montreal Computer Science Department Canada

ISBN: (纸本)9798350300260

In a fully immersive virtual reality setting, visitors will actively participate in our demonstration, engaging in an interactive videogame utilizing our cutting-edge HD-sEMG Bracelet. Prior to this, they will undergo state-of-the-art training to personalize their machine learning gesture recognition model. The gameplay will be broadcast on a computer monitor, allowing onlookers to observe while the demonstrator explains the core concept of our work. By wearing the bracelet, the player gains control over their limb in a game inspired by Simon Says. Throughout the demonstration, visitors will gain firsthand experience and knowledge about the forthcoming advantages of HD-sEMG for control applications, such as prosthesis control. They will also discover how the EMaGer HD-sEMG Bracelet capitalizes on its uniform and high electrode density to enhance the reliability of hand gesture recognition models utilized in myoelectric prosthesis control. © 2023 IEEE.

关键词： Armband Control Convolution Deep Learning Edge Computing Electromyography Gesture HD-EMG Machine Learning Myoelectric Neural Network

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Degradation of Tattoo Inks by Cold Atmospheric Plasma Treatment: A Proof-of-Concept Study

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Plasma Medicine 2022年第3期12卷 1-21页

作者： Çukur, Elif Ercan, Utku Kürşat Department of Biomedical Engineering School of Engineering and Architecture İzmir Katip Çelebi University Çiğli İzmir35620 Turkey Isparta University of Applied Sciences Uluborlu Vocational School Biomedical Device Technologies Program Isparta32200 Turkey

Tattoos have been a part of the culture and a way of expression for a remarkable portion of society throughout history. However, different dissatisfactions related to tattoos lead people to tattoo removal procedures that can be carried out in various ways. Among them, laser tattoo removal is the most common technique. However, laser tattoo removal could have downsides;thus, novel technologies that either support or replace conventional methods are needed. In the present study, the degradation of red, yellow, green, blue, black and white tattoo inks by plasma treatment was evaluated for possible future use of cold plasma in tattoo removal. Tattoo inks were treated with DBD air plasma in the aqueous form and in the agarose gel. Furthermore, also tattoo pigments were exposed to plasma-treated water. The KI-starch reagent was used to correlate the oxidative strength of plasma-treated water with the degradation of tattoo inks. Degradation of tattoo inks was determined by reflectance measurements and was measured as color change with respect to plasma treatment time. Color changes of tattoo inks were represented using the CIELAB color system and CIE xyY color space. Our results suggest that air DBD plasma treatment and plasma-treated water are capable of degrading tattoo inks. The color change of tattoo inks due to degradation by plasma was clearly distinguishable by the naked eye, and the maximum value corresponding to color change was measured for red tattoo ink. © 2022 by Begell House, Inc.

关键词： Color

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