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mechanical and Corrosion Behavior of a biomedical Mg–6Zn–0.5Zr Alloy Containing a Large Number of Twins

Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 439-455页

作者： Chang‑Jian Yan Bo Guan Yun‑Chang Xin Ling‑Yu Zhao Guang‑Jie Huang Rui Hong Xiao‑Bo Chen Paul K.Chu Institute of Corrosion Science and Technology Guangdong 510070China International Joint Laboratory for Light Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400030China Key Laboratory for Light‑Weight Materials Nanjing Tech UniversityNanjing 210009China School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China School of Engineering RMIT UniversityCarlton 3053VICAustralia Department of Physics Department of Materials Science&EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The strong texture of Mg alloys can lead to strong tension–compression yield asymmetry and corrosion anisotropy,and this will consequently affect the effectiveness of hard tissue implants.A biomedical Mg–6Zn–0.5Zr alloy containing a large number of{1012}primary twins and{1012}–{1012}secondary twins is successfully prepared by cross *** dual twin structure not only removes the tension–compression yield asymmetry completely,but effectively reduces the corrosion anisotropy without compromise of corrosion *** difference between the largest corrosion rate and smallest one is~1.2 times compared to~1.6 times of the original *** is found that the reduced corrosion anisotropy is related to re-distribution of crystallographic orientations by twins.

关键词： biomedical Mg alloy Corrosion mechanical anisotropy Texture Twins

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Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

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Bioactive Materials 2023年第5期23卷 471-507页

作者： Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos Department of Biomedical Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic *** addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in *** this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer ***,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles ***,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this *** review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer.

关键词： Phototherapy Cancer Nanoparticles Therapeutic effect Clinical potential

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Modeling of an external force estimator for an end-effector of a robot by neural networks

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Journal of the Chinese Institute of Engineers, Transactions of the Chinese Institute of Engineers,Series A 2023年第8期46卷 895-904页

作者： Junplod, Goragod Kornmaneesang, Woraphrut Chen, Shyh-Leh Wongsa, Sarawan Department of Control Systems and Instrumentation Engineering King Mongkut’s University of Technology Thonburi Bangkok Thailand International Bachelor Program in Engineering Yuan Ze University Taoyuan Taiwan Department of Mechanical Engineering National Chung Cheng University Chiayi Taiwan Advanced Institute of Manufacturing with High-Tech Innovations National Chung Cheng University Chiayi Taiwan

This paper proposes a method to estimate external forces at the tip of a robot end-effector by using a neural network model. In order to avoid the use of an expensive force sensor in the training purpose, the proposed method implements the indirect training method by including the inverse dynamic model of the robot manipulator to the training algorithm with available information from a default robot system. In this method, the robot dynamics equations are necessary for the training, therefore a disturbance observer is adopted to deal with the existing uncertainties and errors. The performance of the proposed estimation method is evaluated through experiments of a 5-DOF robotic experimental platform, comparing to another existing estimation method using recurrent neural network with a type-1 disturbance observer for the external force estimation. The estimation results show that the behavior of the estimated external forces strongly correlates with the applied external forces and the proposed method is superior to the other method. © 2023 The Chinese Institute of Engineers.

关键词： Recurrent neural networks

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Stem cell-derived embryo models:a frontier of human embryology

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Medical Review 2023年第4期3卷 343-346页

作者： Norio Kobayashi Jianping Fu Department of Mechanical Engineering University of MichiganAnn ArborMIUSA Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA

Studying human development remains difficult due to limited accessibility to human embryonic *** by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos,researchers have now successfully developed stem cellbased human embryo models that are promising as experimental tools for studying early human *** this Perspective,we discuss the current progress in mouse and human stem cell-derived embryo models and highlight their promising applications in advancing the fundamental understanding of mammalian development.

关键词： embryo models embryonic development pluripotent stem cells

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Developments of microfluidics for orthopedic applications: A review

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Smart Materials in Medicine 2023年 4卷 111-122页

作者： Sun, Miao Gong, Jiaxing Cui, Wushi Li, Congsun Yu, Mengfei Ye, Hua Cui, Zhanfeng Chen, Jing He, Yong Liu, An Wang, Huiming The Affiliated Stomatology Hospital Zhejiang University School of Medicine Hangzhou China Key Laboratory of Oral Biomedical Research of Zhejiang Province Zhejiang University School of Stomatology China Department of Orthopedics The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Orthopedics Research Institute of Zhejiang University Hangzhou China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang University Hangzhou China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical Engineering Zhejiang University Hangzhou China Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford United Kingdom Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Cixi Ningbo315300 China

With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics. © 2022 The Authors

关键词： Microfluidics

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Nonlinear dynamic of turbulent bearing-rotor system under quadratic damping with HSFD and active control

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Journal of the Brazilian Society of mechanical Sciences and engineering 2024年第3期46卷 1-13页

作者： Chang-Jian, Cai-Wan Chu, Li-Ming Chen, Tsung-Chia Yau, Her-Terng Department of Mechanical Engineering National Chin-Yi University of Technology No.57 Sec. 2 Zhongshan Rd. Taiping Dist. Taichung411030 Taiwan Interdisciplinary Program of Green and Information Technology National Taitung University Taitung City95092 Taiwan Department of Mechanical Engineering National Chung Cheng University No.168 Sec. 1 University Rd. Chiayi Minhsiung621301 Taiwan

Traditional squeeze-film dampers are used in modern aircraft generators as vibration-suppressing devices. However, the conventional squeeze-film damper has the disadvantage of highly nonlinear oil film force. This study aims to improve the dynamic characteristics of the squeeze-film damper by changing its geometric structure, so a hybrid squeeze-film damper (HSFD) is proposed. Besides, the turbulent flow could also be found in lubrication analysis of high rotating speed turbo-machineries, and the ignorance of turbulent flow would lead to significant failure results. Accordingly, the study presents a nonlinear dynamic analysis of a turbulent bearing-rotor system under quadratic damping equipped with HSFD. The dimensionless speed ratio and dimensionless unbalance parameter are used to plot the bifurcation diagrams, and abundant harmonic, subharmonic, quasi-periodic, and even chaotic motions are found with dynamic trajectories, power spectrum, Poincaré maps, Lyapunov exponent, and fractal dimension, simultaneously. Finally, an active control method is applied to suppress the chaotic responses. The simulation results will provide valuable suggestions for designing and developing rotating machinery, such as rotor-bearing systems operating at high rotational speeds and nonlinearity. © The Author(s), under exclusive licence to The Brazilian Society of mechanical Sciences and engineering 2024.

关键词： Rotating machinery

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Identification of benefits, challenges, and pathways in E-commerce industries: An integrated two-phase decision-making model

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Sustainable Operations and Computers 2023年第1期4卷 200-218页

作者： Gupta, Srikant Kushwaha, Pooja.S. Badhera, Usha Chatterjee, Prasenjit Gonzalez, Ernesto D.R. Santibanez Department of Operations and Decision Sciences Jaipuria Institute of Management Jaipur India Department of Business Analytics Jaipuria Institute of Management Indore India Department of Business Analytics Jaipuria Institute of Management Jaipur India Department of Mechanical Engineering MCKV Institute of Engineering West Bengal 711204 India Post-Doctoral Fellow Management Graduate Program Universidade Paulista Indianópolis Campus Brazil Department of Industrial Engineering and CES 4.0 Faculty of Engineering University of Talca Curico Chile

The e-commerce industry has seen significant growth over the past decade as it focuses on convenience and accessibility, leading to a surge in online shopping with more and more consumers opting for it. At the same time, the e-commerce industry faces various challenges. In order to fully harness the potential of this industry, it is important to identify its benefits and challenges and focus on pathways to mitigate the challenges and harness its growth. This study utilizes the Delphi approach and involves experts from the e-commerce domain to get their opinions to identify the top ten benefits, challenges, and pathways for the e-commerce industry. Analytic Hierarchy Process (AHP) and Criteria Importance Through Intercriteria Correlation (CRITIC) methods are subsequently, employed to prioritize the identified factors. Results of the study revealed that factors such as affordable advertising & marketing;availability and product variety;and Global reachability are the most important benefits, while technological upgradation;returns or refunds;and counterfeit products posed the greatest challenges for the industry. Government compliance check;better relationship with delivery partners;and strong data privacy and online security policies emerged as the best pathways. This study also provides valuable insights to businesses, policymakers, and researchers in the e-commerce industry on how to navigate the benefits, challenges, and pathways of this rapidly growing sector. © 2023

关键词： Electronic commerce

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Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

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A MAGNETIC BEAD-BASED PROXIMITY EXTENSION ASSAY FOR HIGHLY-SENSITIVE PROTEIN DETECTION 26

A MAGNETIC BEAD-BASED PROXIMITY EXTENSION ASSAY FOR HIGHLY-S...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Hu, Jiumei Zhang, Pengfei Park, Joon Soo Hsieh, Kuangwen Chen, Liben Wang, Tza-Huei Department of Mechanical Engineering Johns Hopkins University United States Department of Biomedical Engineering Johns Hopkins University United States

ISBN: (纸本)9781733419048

Convenient and highly sensitive protein detection methods are in great demand for biomedical research and clinical diagnostics. Here, we present a magnetic bead-based proximity extension assay that achieves subfemtomolar sensitivity of proteins with minimal requirement for complicated equipment and technical skills. Our method utilizes well-optimized assay conditions and the triple antigen recognition enabled by capture antibody-coated magnetic beads and a pair of detection antibody-oligo conjugates for superior quantification capability. Using three inflammatory cytokines, including IL-6, IL-8 and GM-CSF, as validation, our method showed orders-of-magnitude sensitivity improvement compared to conventional ELISA, homogeneous PEA and solid-phase PLA, and achieved limit of detections (LODs) close to digital ELISA. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Antibodies

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Performance Analysis of Ducted-Fan Modules with Axial Impeller

Performance Analysis of Ducted-Fan Modules with Axial Impell...

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2024 International Conference on Precision engineering and mechanical Manufacturing, PEMM 2024

作者： Shiau, Yau-Ren Fang, Jiunn Huang, Yuan-Chi Department of Industrial Engineering and Systems Management Feng Chia University Taichung407 Taiwan Department of Aerospace and Systems Engineering Feng Chia University Taichung407 Taiwan Ph.D. Program of Mechanical and Aeronautical Engineering Feng Chia University Taichung407 Taiwan

ISBN: (纸本)9781510683129

Impellers are extensively employed across various industrial sectors and in different industrial systems, such as ducted-fan modules. The configuration of ducted-fan modules can be optimized to achieve high impeller performance, safe and stable operation, and high operational efficiency. This study designed two ducted-fan modules with axial impellers composed of airfoil cascades by using the Fan Calculator software program to analyze their performance and efficiency. The study discovered that the module efficiency varied with the internal impeller diameter, external impeller diameter, and rotational speed. An increase in the outlet angle of the blade tip caused increases in the power generated by, pressure change produced in, and flow rate of the modules, thereby enhancing fan efficiency and module performance. The study makes two contributions. First, it constructed two ducted-fan modules with axial impellers by using the duct to isolate the blades, thus increasing the safety and stability of the fan. Second, it explored the performance and efficiency of impellers with airfoil cascades to enhance fan efficiency and optimize the design of a ducted-fan module. © 2024 SPIE.

关键词： Ducted fan engines

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