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Biofabrication and biomanufacturing in Ireland and the UK

Bio-Design and Manufacturing 2024年第6期7卷 825-856页

作者： Jack F.Murphy Martha Lavelle Lisa Asciak Ross Burdis Hannah J.Levis Cosimo Ligorio Jamie Mc Guire Marlene Polleres Poppy O.Smith Lucinda Tullie Juan Uribe-Gomez Biqiong Chen Jonathan I.Dawson Julien E.Gautrot Nigel M.Hooper Daniel J.Kelly Vivian S.W.Li Alvaro Mata Abhay Pandit James B.Phillips Wenmiao Shu Molly M.Stevens Rachel L.Williams James P.K.Armstrong Yan Yan Shery Huang Department of Engineering University of CambridgeCambridge CB21PZUK Department of Translational Health Sciences Bristol Medical SchoolUniversity of BristolBristol BS13NYUK Department of Biomedical Engineering University of StrathclydeGlasgow G40NWUK Department of Materials Institute of Biomedical EngineeringImperial College LondonLondon SW72AZUK Department of Bioengineering Institute of Biomedical EngineeringImperial College LondonLondon SW72AZUK Department of Eye and Vision Science Institute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK Biodiscovery Institute University of NottinghamNottingham NG72RDUK Department of Chemical and Environmental Engineering University of NottinghamNottingham NG72RDUK Centre for Human Development Stem Cells and RegenerationHuman Development and HealthFaculty of MedicineUniversity of SouthamptonSouthampton S0166YDUK Division of Neuroscience School of Biological SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PTUK UCL Centre for Nerve Engineering Department of PharmacologyUCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Stem Cell and Cancer Biology Laboratory The Francis Crick InstituteLondon NW11ATUK CÚRAM SFI Research Centre for Medical DevicesUniversity of GalwayGalway H91 W2TYIreland School of Mechanical and Aerospace Engineering Queen’s University BelfastBelfast BT95AHUK School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUK Geoffrey Jefferson Brain Research Centre Manchester Academic Health Science CentreNorthern Care Alliance and University of ManchesterManchester M139PLUK Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences InstituteTrinity College DublinDublin 2Ireland Department of Mechanical Manufacturing and Biomedical EngineeringSchool of EngineeringTrinity College DublinDublin 2Ireland Advanced Materials and Bioengineering Research Centre(AMBER) Royal College of Surgeons in Ireland and T

As we navigate the transition from the Fourth to the Fifth Industrial Revolution,the emerging fields of biomanufacturing and biofabrication are transforming life sciences and *** sectors are benefiting from a synergy of synthetic and engineering biology,sustainable manufacturing,and integrated design *** techniques such as 3D bioprinting,tissue engineering,directed assembly,and self-assembly are instrumental in creating biomimetic scaffolds,tissues,organoids,medical devices,and biohybrid *** field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare,propelled by cutting-edge research and *** on the production of biologically functional products for use in drug delivery,in vitro models,and tissue engineering,research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability,affordability,and healthcare system benefits.

关键词： Bioprinting Drug delivery Biomaterials Tissue engineering Sustainability Biohybrid

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Numerical Study of the Generator Lubricant Cooler Air-Side Flow to Increase the Reliability of GTG#1.3 PLTGU Muara Karang 1

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5th International Conference on mechanical engineering, ICOME 2021

作者： Kurniawan, Aris Sutardi Department of Mechanical Engineering FTIRS-ITS Collaboration Program With PT Perusahaan Listrik Negara Jakarta Indonesia Department of Mechanical Engineering FTIRS-ITS Surabaya Indonesia

ISBN: (数字)9789811915819

ISBN: (纸本)9789811915802

Generator lubricant cooling system in gas turbine 1.3 by flowing lubricant in the tube and blowing air from the outside of the tube. The lubricant cooling device is called an air-cooled heat exchanger (ACHE) which has been operating for 9 years. ACHE has experienced a decrease in reliability because it causes the unit to trip 5 times, trips to ACHE occur when the ACHE exit lubricant temperature is more than 320 K. Based on analysis using a fishbone diagram, the cause comes from the failure of fan operation. The purposes of the study are (i) to investigate the cooling capacity of Air-Cooled Heat Exchanger for GTG#1.3 generator lubricant existing conditions, (ii) to determine the effect of the modification of the number of fans operating on cooling capacity, outlet pressure and temperature outlet lubricants with parallel and series arrangement of Air-Cooled Heat Exchanger Generator Lubricant GTG#1.3, and (iii) to investigate the optimal operation pattern of the GTG#1.3 Generator Lubricant Air-Cooled Heat Exchanger. This research was conducted by modeling and simulating ACHE using Computational Fluid Dynamic (CFD) software. The simulation was validated using actual operational data. The results showed that the operation of the ACHE series with 4 fans had the highest cooling capacity of 247.57 kW so that the ACHE outlet lubricant temperature was 312.02 K. Therefore, to obtain reliability and optimal operation, the ACHE series operating model with 4 fans were selected. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Computational fluid dynamics

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Identification of the most useful configurations and individual elements of a hybrid undergraduate engineering laboratory through a student survey

Identification of the most useful configurations and individ...

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International Symposium on Applied Science 2024, ISAS 2024

作者： Murphy, Michael D. O’Mahony, Tom Herbert, Padraig da Graça, Guilherme Carrilho Department of Process Energy and Transport Engineering Munster Technological University Cork Bishopstown Ireland Department of Electrical and Electronic Engineering Munster Technological University Cork Bishopstown Ireland Department of Mechanical Biomedical and Manufacturing Engineering Munster Technological University Cork Bishopstown Ireland Faculdade de Ciências Universidade de Lisboa Campo Grande Lisboa1749–016 Portugal

The adoption and utilisation of remote, asynchronous and virtual laboratories (VLs) for undergraduate education has substantially increased post COVID-19. These methods can be integrated with traditional synchronous physical laboratories (PLs) to form hybrid laboratories (HLs). HLs have been compared to other laboratory environments in previous research studies. However, no study has explored, from the students’ perspective, how useful different configurations and individual elements of a HL are for learning. Therefore, this study posed questions to determine the most useful individual elements and configurations of an undergraduate engineering HL. To answer these questions a research methodology was designed. A group of undergraduate engineering students (n = 21) in the Munster Technological University were surveyed to determine their perspectives on the individual elements and configurations of a HL they recently completed in energy modelling. The questionnaire employed multi-item psychometric scales that enabled quantitative analysis. The results showed that 85.7% of students preferred HLs, while 9.5% preferred VLs only and 4.8% preferred PLs only. 95.2% of students found VLs and their asynchronous operation useful, with screencasts of modelling found to be the most useful VL element. 76.2% and 90.5% of students found it useful to interact with their peers and teacher in the PLs, respectively. 85.7% of students thought the VLs helped them in developing an understanding of how energy models work. © 2025 Institute of Physics Publishing. All rights reserved.

关键词： Students

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Anxiety Controlling Application using EEG Neurofeedback System

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EAI Endorsed Transactions on Pervasive Health and Technology 2024年 10卷

作者： Kanna, R. Kishore Athawale, Shashikant V. Naniwadekar, Makarand Y. Choudhari, C.S. Talhar, Nitin R. Dhengre, Sumedh Department of Biomedical Engineering Jerusalem College of Engineering Chennai India Department of Computer Engineering AISSMS College of Engineering Pune India Department of Chemical Engineering AISSMS College of Engineering Pune India Department of Mechanical Engineering AISSMS College of Engineering Pune India

INTRODUCTION: This study aims to investigate the correlation between the oscillations of electroencephalography (EEG) bands and the level of anxiety in a sample of sixteen youth athletes aged 17–21. The research utilizes a mobile EEG system to collect data on EEG band oscillations. OBJECTIVES: The aim of this research study is to investigate the brain wave oscillations during relaxation, specifically comparing the contrast between eyes open and eyes closed state Electroencephalography (EEG) using a state-of-the-art wireless EEG headset system. METHODS: The system incorporates dry, non-interacting EEG sensor electrodes, developed exclusively by NeuroSky. In addition, the addition of the ThinkGear module and MindCap XL skull facilitated EEG recording. The aim of the present study was to investigate the effect of eyes open and eyes closed conditions on alpha-band activity in the prefrontal cortex The results showed a statistically significant difference (p≤0.006);appeared between these two states. The present study examined the relationship between the alpha band of the prefrontal cortex and anxiety levels. Specifically, we examined the relationship between these variables in the eyes-closed condition. RESULTS: Our analysis revealed a statistically significant correlation, with the alpha band showing a negative slope (p≤0.029). The present study examines the comparison of data obtained from single-channel wireless devices with data obtained from conventional laboratories The findings of this study show a striking similarity between the results obtained with both types of devices. The aim of the present study was to investigate the specific characteristics of the correlation between electroencephalographic (EEG) alphaband oscillations in the prefrontal cortex in relation to eye position and anxiety levels in young athletes. CONCLUSION: This study seeks to shed light on the possible relationship between this vibration and individuals' internal cognitive and affective sta

关键词： Electroencephalography

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Pose Synchronization for Semi-Autonomous Dynamic Robotic Swarms with a Passivity-Short Human Operator 49

Pose Synchronization for Semi-Autonomous Dynamic Robotic Swa...

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49th Annual Conference of the IEEE Industrial Electronics Society, IECON 2023

作者： Kanazawa, Reo Murao, Toshiyuki Kawai, Hiroyuki Kanazawa Institute of Technology Graduate Program in Mechanical Engineering Ishikawa Japan Kanazawa Institute of Technology Department of Robotics Ishikawa Japan

ISBN: (纸本)9798350331820

This paper presents a pose synchronization method for semi-autonomous dynamic robotic swarms with a passivityshort human operator. In the human-robot network, a human operator sends a command signal to and receives visual information from only a part of the robotic group. In this setting, the proposed dynamic control scheme achieves not only pose synchronization of all mobile robots but also convergence to the reference pose that the human operator specifies. The main advantage of the proposed method is to guarantee convergence of not only the position but also the orientation to the reference ones in the human-robot network. Finally, we provide human-in-the-loop simulation results through the human operation using a tablet PC to illustrate the performance of the proposed control method. © 2023 IEEE.

关键词： Synchronization

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Detecting Diabetes Mellitus from Tongue Image Hybrid Features and Neural Netowrk Classifier 4

Detecting Diabetes Mellitus from Tongue Image Hybrid Feature...

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4th International Conference on Cybernetics, Cognition and Machine Learning Applications, ICCCMLA 2022

作者： Ganesan, Umashankar Paul, N.E. Edwin Krishnan, G. Hari Aarthi, S. Swamy, I. Kumara Department of Biomedical Engineering Grt Institute of Engineering and Technology Tiruttani India Department of Mechanical Engineering Grt Institute of Engineering and Technology Tiruttani India Department of Electrical and Electronics Engineering Sree Vidyanikethan Engineering College Mohan Babu University Tirupati India Department of Biomedical Engineering Sathyabama Institute of Science and Technology Chennai India

ISBN: (数字)9781665462464

ISBN: (纸本)9781665462464

Metabolic disease like Diabetes mellitus (DM) can be diagnosed using tongue image processing. The abnormalities of tongue can be diagnosed by pre-processing stage feature extraction stage and post processing stage. The pre-processing stage denoise the image and crop the particular part. The diagnostic features DM can be extracted as color, texture and shape. For color feature we will go for color histogram and for texture feature we will go for DRLBP pattern. Histogram features and texture features are calculated from HSV image. Thirteen different features like measurement of distances, areas, perimeters, eccentricity, major axis length, minor axis length etc. Neural network classifier was used to differentiate images with DM symptoms © 2022 IEEE.

关键词： Image segmentation

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Experimental assessment of the optical transfer function for quantitative oblique back-illumination microscopy

Experimental assessment of the optical transfer function for...

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2024 Label-free biomedical Imaging and Sensing, LBIS 2024

作者： Li, Zhenmin Filan, Caroline Guang, Zhe Casteleiro Costa, Paloma Robles, Francisco E. School of Electrical and Computer Engineering Georgia Institute of Technology United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology United States Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Emory University United States

ISBN: (纸本)9781510669673

Quantitative oblique back illumination microscopy (qOBM) is a recently developed phase imaging modality that enables 3D quantitative phase imaging and refractive index (RI) tomography of thick scattering samples. The approach uses four oblique illumination images (acquired in epi-mode) at a given focal plane to obtain cross sectional quantitative information. In order to quantify the information, qOBM uses a deconvolution algorithm which requires an estimate of the angular distribution of light at the focal plane to obtain the system's optical transfer function (OTF). This information is obtained using Monte Carlo numerical simulations which uses published scattering parameters of tissues. While this approach has shown robust results with high quantitative fidelity, the reliance on available published scattering parameters is not optimal. Here we present an experimental approach to measure the angular distribution of the back-scattered light at the focal plane. The approach simultaneously obtains information from the imaging plane and the Fourier plane to provide insight into the overall angular distribution of light at the focal plane. Together with the pupil function, given by the known numerical aperture of the system, this approach directly yields the OTF. A theoretical analysis and experimental results will be presented. This approach has the potential to widen the utility of qOBM to also include tissues and samples whose scattering properties are not well documented in the literature. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

关键词： Refractive index

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Novel Fabrication of Ultra-thin Copper/SS304L Composite Microchannels 14th

Novel Fabrication of Ultra-thin Copper/SS304L Composite Micr...

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14th International Conference on Technology of Plasticity, ICTP 2023

作者： Ren, Mengyuan Xie, Haibo Lin, Fei Jia, Fanghui Huo, Mingshuai Wu, Hui Yuan, Shengnan Yang, Ming Manabe, Ken-ichi Jiang, Zhengyi School of Mechanical Materials Mechatronic and Biomedical Engineering University of Wollongong WollongongNSW2522 Australia Graduate School of System Design Tokyo Metropolitan University Tokyo Hino-Shi191-0065 Japan Department of Mechanical Engineering Tokyo Metropolitan University Tokyo Hachioji192-0397 Japan

ISBN: (纸本)9783031409196

Microchannels on metallic substrates are essential parts of microreactors, micro heat exchangers, micro heat sinks, and fuel cell bipolar plates. Because of superior properties, such as good corrosion resistance, excellent thermal conductivity, high strength, excellent ductility and structural stability, composite metal foils are gaining popularity as substrates for microchannels. With the increasing demands of low cost, high efficiency and accuracy, novel micro forming technologies must be capable of creating intricate and precise micro features of microchannels at a low cost. An ultra-thin metal foil rolling for the fabrication of micro composite channels is proposed in this study, which can improve product function and reduce operational costs. Copper/ stainless steel 304L (SS304L) composite foils with a thickness of 0.41 mm after annealing treatment at 800 ℃ and holding for 0.5 h, 1.0 h and 2.0 h are used to fabricate microchannels under the rolling reduction of 60.9%. The hardness of composite foils has been characterised before and after different annealing processes, in which the hardness decreases due to the synergistic effects of decreased dislocation density, grain coarsening and phase transformation. Further, the formability of composite foils after annealing is discussed. In addition, the processing characteristics, material deformation behaviours and mechanisms during micro rolling are also investigated. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Fabrication

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Editorial for: Evaluation of 4D Flow MRI-Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis

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Journal of Magnetic Resonance Imaging 2024年第6期60卷 2602-2603页

作者： Roldán-Alzate, Alejandro Reeder, Scott B. Department of Mechanical Engineering University of Wisconsin–Madison Madison WI United States Department of Radiology University of Wisconsin–Madison Madison WI United States Department of Biomedical Engineering University of Wisconsin–Madison Madison WI United States Department of Medical Physics University of Wisconsin–Madison Madison WI United States

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Mechanics and Morphology of Proliferating Cell Collectives with Self-Inhibiting Growth

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Physical Review Letters 2024年第15期133卷 158402页

作者： Scott Weady Bryce Palmer Adam Lamson Taeyoon Kim Reza Farhadifar Michael J. Shelley Center for Computational Biology Department of Mechanical Engineering Weldon School of Biomedical Engineering New York University New York New York 10012 USA

We study the dynamics of proliferating cell collectives whose microscopic constituents’ growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a growing collective show the emergence of concentric-ring patterns in cell size whose spatiotemporal structure is closely tied to the individual cell’s stress response. Motivated by these observations, we derive a multiscale continuum theory whose parameters map directly to the discrete model. Analytical solutions of this theory show the concentric patterns arise from anisotropically accumulated resistance to growth over many cell cycles. This Letter shows how purely mechanical processes can affect the internal patterning and morphology of cell collectives, and provides a concise theoretical framework for connecting the micro- to macroscopic dynamics of proliferating matter.

关键词： Cell growth Collective behavior Pattern formation Living matter & active matter Multiscale modeling

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