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Visualizing unleashed latent heat of liquid metal for soft intelligence

Frontiers in Energy 2024年第5期18卷 545-549页

作者： Jianbo Tang Bo Yuan Hongzhang Wang Jing Liu School of Chemical Engineering University of New South Wales(UNSW)KensingtonNSW 2052Australia School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Institute of Materials Research Center of Double HelixShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Biomedical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academyof SciencesBeijing 100190China

Liquid metals offer liquid-like fluidity and excellent conductivity at readily accessible temperatures[1].These futuristic metallic liquids have enabled kaleidoscopic applications,among which there are high performance electronic devices and thermal systems built with liquid metals[2-5].The fluidity(or conformability)and conductivity are arguably the most widely recognized and utilized traits of liquid metals,in particular for energybased applications.

关键词： liquid metals conductivity

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Statistical Device Simulation and Machine Learning of Process Variation Effects of Vertically Stacked Gate-All-Around Si Nanosheet CFETs

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IEEE Transactions on Nanotechnology 2024年 23卷 386-392页

作者： Kola, Sekhar Reddy Li, Yiming Butola, Rajat National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Department of Electronics and Electrical Engineering Institute of Communications Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Institute of Biomedical Engineering Institute of Pioneer Semiconductor Innovation Institute of Artificial Intelligence Innovation Hsinchu300093 Taiwan

In this study, we report the process variation effect (PVE) including the work function fluctuation (WKF) on the DC/AC characteristic fluctuation of stacked gate-all-around silicon complementary field-effect transistors (CFETs). The PVE affects characteristic fluctuation significantly;in particular, for the variability of off-state current. Owing to the bottom channel of a fin-type, the P-FET suffers from the worst off-state current fluctuation (more than 200% variation) compared to the N-FET. The device variability induced by the WKF is marginal because of amorphous-type metal grains. As input features to an artificial neural network (ANN) model, low and high work function values, as well as parameters of PVE that have prevalent effects on CEFT transfer characteristics are further considered and modeled. The estimated values of R2-score prove that the ANN model properly grasps information from the dataset successfully;thus, it can be used to model emerging CFETs for circuit simulation. © 2002-2012 IEEE.

关键词： Neural networks

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Point-of-Care Microchip Electrophoresis Test for Glycosylated Hemoglobin

Point-of-Care Microchip Electrophoresis Test for Glycosylate...

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2022 IEEE-EMB Special Topic Conference on Healthcare Innovations and Point of Care Technologies, HI-POCT 2022

作者： Sekyonda, Zoe Fraiwan, Arwa An, Ran Gurkan, Umut A. Case Western Reserve University Biomedical Engineering Department ClevelandOH44106 United States Case Western Reserve University Mechanical and Aerospace Engineering Department ClevelandOH44106 United States Case Western Reserve University Mechanical and Aerospace Engineering Department Biomedical Engineering Department ClevelandOH44106 United States

ISBN: (纸本)9781665496155

Diabetes is responsible for 4.6 million deaths worldwide each year, and the prevalence of diabetes is expected to rise to 552 million by 2030. Diabetes is not only a leading cause of morbidity and mortality, but its complications also impose a large financial burden on patients and their families. Diabetes outcomes can be improved by early detection and monitoring. However, accurate diabetes diagnosis and monitoring remain a challenge, particularly in low- and middle-income nations. Here, we present a new microchip electrophoresis approach and point-of-care (POC) technology platform to feasibly detect and quantify glycosylated hemoglobin. Clinical Relevance - We present a novel microchip electrophoresis point-of-care test for diagnosis and monitoring of diabetes. © 2022 IEEE.

关键词： Electrophoresis

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Low intensity mechanical signals promote proliferation in a cell-specific manner:Tailoring a non-drug strategy to enhance biomanufacturing yields

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Mechanobiology in Medicine 2024年第4期2卷 59-68页

作者： M.Ete Chan Christopher Ashdown Lia Strait Sishir Pasumarthy Abdullah Hassan Steven Crimarco Chanpreet Singh Vihitaben S.Patel Gabriel Pagnotti Omor Khan Gunes Uzer Clinton T.Rubin Department of Biomedical Engineering College of Engineering and Applied SciencesRenaissance School of MedicineStony Brook UniversityStony BrookNY11794-5280USA Medical Scientist Training Program Renaissance School of MedicineStony Brook UniversityStony BrookNY11794USA Department of Endocrine Neoplasia and Hormonal Disorders MD Anderson Cancer CenterHoustonTX77030USA Department of Mechanical and Biomedical Engineering College of EngineeringBoise State UniversityBoiseID83725-205USA Center for Biotechnology New York State Center for Advanced Technology in Medical BiotechnologyStony Brook UniversityStony BrookNY11794-5281USA

Biomanufacturing relies on living cells to produce biotechnology-based therapeutics,tissue engineering constructs,vaccines,and a vast range of agricultural and industrial *** the escalating demand for these bio-based products,any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the *** these goals are primarily achieved using biological or chemical strategies,harnessing cell mechanosensitivity represents a promising–albeit less studied–physical pathway to promote bioprocessing endpoints,yet identifying which mechanical parameters influence cell activities has remained *** tested the hypothesis that mechanical signals,delivered non-invasively using low-intensity vibration(LIV;<1 g,10–500 Hz),will enhance cell expansion,and determined that any unique signal configuration was not equally influential across a range of cell *** frequency,intensity,duration,refractory period,and daily doses of LIV increased proliferation in Chinese Hamster Ovary(CHO)-adherent cells(t79%in 96 hr)using a particular set of LIV parameters(0.2 g,500 Hz,3-30 min/d,2 hr refractory period),yet this same mechanical input suppressed proliferation in CHO-suspension cells(-13%).Another set of LIV parameters(30 Hz,0.7 g,2-60 min/d,2 hr refractory period)however,were able to increase the proliferation of CHO-suspension cells by 210%and T-cells by 20.3%.Importantly,we also reported that T-cell response to LIV was in-part dependent upon AKT phosphorylation,as inhibiting AKT phosphorylation reduced the proliferative effect of LIV by over 60%,suggesting that suspension cells utilize mechanism(s)similar to adherent cells to sense specific LIV *** image velocimetry combined with finite element modeling showed high transmissibility of these signals across fluids(>90%),and LIV effectively scaled up to T75 ***,when LIV is tailored to the target cell populati

关键词： Biomanufacturing Cell proliferation mechanical stimulation Biomechanics Adherent cells Suspension cells Stem cells Vibration

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Motion Detection Method of Electrostatic MEMS Resonators Operating in Aqueous Media 6

Motion Detection Method of Electrostatic MEMS Resonators Ope...

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6th International Youth Conference on Radio Electronics, Electrical and Power engineering, REEPE 2024

作者： Hemid, Mohamed Alattar, Basil Ghommem, Mehdi Ahmed, Alaaeldin Abdel-Rahman, Eihab Sabouni, Rana Mechatronics Graduate Program American University of Sharjah Sharjah United Arab Emirates American University of Sharjah Mechanical Engineering Department Sharjah United Arab Emirates Systems Design Engineering University of Waterloo Ontario Canada American University of Sharjah Chemical Engineering Department Sharjah United Arab Emirates

ISBN: (纸本)9798350382891

This paper introduces an experimental method to detect the motion of an electrostatic Micro-Electro-mechanical Systems (MEMS) resonator in aqueous media. The resonator comprises a micro cantilever beam subject to electrostatic actuation through a side electrode. A Finite Element Method (FEM) model of the resonator is developed to determine the in-plane mode shapes and their natural frequencies in order to facilitate the experimental study. The motion of the resonator lead to variations in its capacitance and induce a current. The developed experiments demonstrate that motion-induced current can be measured and analyzed to detect the motion of the resonator's higher-order modes and can be used in chemical sensing. © 2024 IEEE.

关键词： Electrostatics

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Robotic Printed Combinatorial Droplet (RoboDrop) for Antibiotic Combination Screening 17

Robotic Printed Combinatorial Droplet (RoboDrop) for Antibio...

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17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022

作者： Shao, Fangchi Li, Hui Hsieh, Kuangwen Zhang, Pengfei Wang, Tza-Huei Johns Hopkins University Department of Biomedical Engineering Baltimore United States Johns Hopkins University Department of Mechanical Engineering Baltimore United States

ISBN: (纸本)9781665483018

Antibiotic resistance has become a critical public health issue. Combination therapies have become a promising solution that leverages the existing antibiotics to combat drug-resistance bacteria. To widely adopt combination therapies, it is important to develop efficient screening platforms to investigate the combination effects among different antibiotics and find the rational combination choices. In response, we have developed a Robotic Printed Combinatorial Droplet (RoboDrop) platform that can programmatically control the droplet compositions and automatically print thousands of droplets onto petri dishes. In RoboDrop, the upstream is a valve-based droplet microfluidic device that can generate droplets with desired composition on demand. The droplets are subsequently transported via a PTFE tubing, which is mounted on a robotic arm. As the robotic arm moves, the droplets are orderly ejected from the tubing and printed as an array onto a petri dish. We have demonstrated to print around 2,700 droplets onto a single petri dish using RoboDrop, indicating its high scalability. For demonstration of the feasibility and robustness of RoboDrop, we integrated a resazurin-based cell viability assay with RoboDrop and verified two known pairwise antibiotic combinations and further found a new synergistic three-drug combination for treating a model Escherichia coli (E. coll) strain © 2022 IEEE.

关键词： Antibiotics

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Analysis of the morphological and mechanical characterization of aluminium matrix composite reinforced with chitosan

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Materials Today: Proceedings 2024年 105卷 276-286页

作者： N.E. Udoye V. Ezekiel O.S.I. Fayomi I.P. Okokpujie J.O. Dirisu Department of Mechanical Engineering College of Engineering Covenant University Ota Lagos state Nigeria Department of Mechanical and Biomedical Engineering Bells University of Technology P.M.B 1015 Ota Ogun State Nigeria Department of Mechanical Engineering Science University of Johannesburg Johannesburg 2006 South Africa Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado-ekiti Ekiti State Nigeria

Recent studies acknowledge that convectional ceramic particulate could be replaced by several agricultural by-products in the development of aluminium matrix composites because of its selected for their low cost and relative ubiquity. This study explores the development of aluminium matrix composite from AA6061 alloy reinforced with chitosan particulates at weight proportions (3, 6, 9, and 12 wt%). The study further characterizes the developed composites using Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffractometer (XRD), hardness, tensile and thermal and electrical conductivity test techniques. Results indicated that increasing chitosan content up to 10 wt% enhanced the hardness performance, while tensile strength of the composites increased sporadically, as SEM images observed reinforcement links embedded in grain boundaries. However, the thermal and electrical conductivity diminished due to the addition of chitosan particulates to the alloy matrix. The overall study showed the great potential of chitosan polymer as reinforcement to aluminium alloy .

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Flexible fiber cholangioscope for detection of near-infrared fluorescence

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VideoGIE 2023年第3期8卷 110-112页

作者： Chang, Tse-Shao Zhou, Yaxuan Zhang, Ruoliu Kwon, Richard S. Wamsteker, Erik J. Turgeon, D. Kim Seibel, Eric J. Wang, Thomas D. Department of Mechanical Engineering University of Michigan Ann Arbor MI United States Department of Electrical and Computer Engineering University of Washington Seattle WA United States Human Photonics Laboratory Department of Mechanical Engineering University of Washington Seattle WA United States Department of Biomedical Engineering University of Michigan Ann Arbor MI United States Division of Gastroenterology Department of Internal Medicine University of Michigan Ann Arbor MI United States

VideoVideo 1Flexible fiber cholangioscope for detection of near-infrared fluorescence.

关键词： NIR near-infrared T/B target-to-background

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Manufacturing of PEEK-PDMS Composite Materials for Intervertebral Disc Implants 23

Manufacturing of PEEK-PDMS Composite Materials for Intervert...

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23rd International Conference on Electronics Packaging, ICEP 2024

作者： Mie, Heng-Ching Liu, Yu-Chen Mizuno, Jun National Cheng Kung University Department Of Materials Science And Engineering Taiwan National Cheng Kung University Program On Smart And Sustainable Manufacturing Academy Of Innovative Semiconductor And Sustainable Manufacturing Taiwan National Cheng Kung University Department Of Mechanical Engineering Taiwan

ISBN: (纸本)9784991191176

The current treatment approach for lower back pain caused by intervertebral disc (IVD) degeneration involves the use of PEEK (polyether ether ketone) polymer or titanium alloy based spinal cages to replace the degenerated IVD. However, this method not only restricts the natural mobility of the vertebrae but also fails to mimic the structure and function of the human IVD with a single material. Additionally, the use of high-hardness materials may lead to vertebral settling, further contributing to lower back pain. Therefore, this study is dedicated to utilizing high-biocompatibility polymer (PEEK and Polydimethylsiloxane (PDMS)) composites to create an artificial IVD closely mimics the real intervertebral disc. Through adjusting the manufacture parameters, the proportion of PEEK and PDMS, and the porosity we were able to achieve the elastic modulus that is close to those of humans' IVD. Furthermore, the dual-layer structure can better replicate the functions and structure of human intervertebral disc then spinal cage. © 2024 Japan Institute of Electronics Packaging.

关键词： Polydimethylsiloxane

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Wall Stress Analysis of Patient-Specific Left Ventricular Hypertrophy Models 6th

Wall Stress Analysis of Patient-Specific Left Ventricular Hy...

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6th Kuala Lumpur International Conference on biomedical engineering, BioMed 2021

作者： Goh, Wei Jan Chan, Bee Ting Ab Naim, Wan Naimah Wan Chuah, Shoon Hui Lim, Einly Liew, Yih Miin Department of Mechanical Materials and Manufacturing Engineering Faculty of Science and Engineering University of Nottingham Selangor Malaysia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang Pahang Malaysia Department of Biomedical Engineering Faculty of Engineering Universiti Malaya Kuala Lumpur Malaysia

ISBN: (纸本)9783030907235

Left ventricular hypertrophy (LVH) is a complex heart disease characterised by abnormal heart wall. A wall stress analysis may provide insight on ventricular wall mechanics, and it should be conducted with patient-specific geometry for accurate assessment. This study aims to investigate the distribution of stress on the left ventricular (LV) wall of LVH patients in diastolic filling phase using the finite element method. The patient-specific LV geometries of two LVH patients were compared with two healthy subjects. The effect of individual factors in contributing to wall stress was also studied by adapting the model settings for investigation. Our results showed that the excessive wall stress observed in LVH patients (σ_c: 6068±342Pa, σ_z: 3785±161Pa, σ_r: 384±649Pa ), when compared to healthy subjects (σ_c: 2662±82Pa, σ_z: 1486±239Pa, σ_r: 0.1±47Pa ), were mainly contributed by the elevated filling pressure. Besides, an abnormal stress variation was also observed in LVH patients, especially near the region with wall thickening and distinct local wall curvature. A high convexity area was observed to have high circumferential stress and low longitudinal stress, while the opposite was noted at the local high concavity area. These findings indicate the importance of patient-specific models in wall stress assessment of LVH patients. © 2022, Springer Nature Switzerland AG.

关键词： Stress analysis

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