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2024 Design of Medical Devices Conference, DMD 2024

作者： Morales, Brianna Rossmeisl, John Rylander, Chris Department of Biomedical Engineering The University of Texas at Austin AustinTX United States Department of Small Animal Clinical Sciences VA-MD College of Veterinary Medicine Virginia Tech BlacksburgVA United States Walker Department of Mechanical Engineering The University of Texas at Austin AustinTX United States

ISBN: (纸本)9780791887752

Convection-enhanced delivery is an experimental method for glioblastoma treatment. This work evaluates the Convection-Enhanced Therapy Catheter System (CETCS) by subjecting it to several cadaveric fetal bovine and porcine brain tests that replicate the anticipated future clinical use of the device. CETCS includes a cannula containing six microneedles. First, the CETCS cannula and microneedle visibility were evaluated with CT imaging in cadaveric tissue. Second, the cannula and microneedles were subjected to a cadaveric tissue insertion test and evaluated for tissue accumulation post-insertion. This test was also performed with a silicone elastomer material similar to a predicate device. A third test evaluated the microneedle's ability to undergo a syringe drop test with 3, 10, and 20 mL water-filled syringes. The results of this study prove that the CETCS cannula and microneedles are visible with CT imaging. CETCS and the predicate device material for the tissue insertion tests behave similarly, with an average tissue accumulation mass of 16.4 ± 3.6 mg and 21.4 ± 4.0 mg, respectively. The microneedles did not experience function-limiting damage with any attached syringes in the syringe drop test. The passing of all tests suggests that CETCS will satisfactorily meet regulatory testing milestones required for future clinical use. © 2024 by ASME.

关键词： Silicones

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Thermoresponsive polymers with LCST transition: synthesis, characterization, and their impact on biomedical frontiers

RSC Applied Polymers

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RSC Applied Polymers 2023年第2期1卷 158-189页

作者： Yuan, Yichun Raheja, Konpal Milbrandt, Nathalie B. Beilharz, Sophia Tene, Steffy Oshabaheebwa, Solomon Gurkan, Umut A. Samia, Anna Cristina S. Karayilan, Metin Department of Chemistry Case Western Reserve University (CWRU) Cleveland 44106 OH United States Department of Biomedical Engineering CWRU Cleveland 44106 OH United States Department of Mechanical and Aerospace Engineering Case Comprehensive Cancer Center CWRU Cleveland 44106 OH United States

Advances in thermoresponsive materials have significantly impacted many biomedical fields. The unique behavior of reversible phase transition close to the physiological temperatures makes these types of materials a great candidate for a wide variety of biomedical applications including bioimaging, biosensing, injectables, smart surfaces, adhesives, biomanufacturing, and tissue engineering. Thermoresponsive behavior, mainly lower critical solution temperature (LCST) can be easily tuned by shifting the balance between hydrophobicity and hydrophilicity (e.g., by using comonomers or changing end groups) and modifying the molecular weight and architecture of the polymer. Hence, synthetic and characterization tools are critical in tailoring and precisely determining these properties. This review aims to show the full scope of the journey of thermoresponsive polymers from benchtop to potential applications. We especially intend to emphasize the effects of the structural heterogeneity of polymers on thermal transition and highlight the modern characterization techniques used to study thermoresponsive behavior. A better understanding of these structural effects and benchtop tools can help us design and implement more advanced materials for future applications in public health. © 2023 RSC.

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The Essence of Intermetallic Phases in AA6061/Clay Composites 1st

The Essence of Intermetallic Phases in AA6061/Clay Composite...

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1st International Conference on Energy and Biochemical engineering, ICEBE 2021

作者： Udoye, N.E. Fayomi, O.S.I. Inegbenebor, A.O. Department of Mechanical Engineering College of Engineering Covenant University Lagos state Ota Nigeria Department of Mechanical and Biomedical Engineering Bells University of Technology Ogun State Ota Nigeria Department of Chemical Metallurgical and Materials Engineering Tshwane University of Technology Pretoria South Africa

ISBN: (纸本)9783030958190

Aluminium alloy is applied in a variety of products, including structural supports, engine components, cooking utensils and beverage cans. AA6061 aluminium alloy strengthened with different percentages of clay in the range of 2 to 8 wt.% at 75 and 150 μm was produced. SEM/EDS analysed the impact of clay particles in AA6061 used to characterized surface morphology. XRD analysis of the prepared samples showed aluminium silicate, silicon IV oxide and aluminium oxide intermetallic phases at different peaks in the matrix alloy. The result depicts enriched hardness, tensile strength and percentage elongation of developed material to about 15.1%, 5.5% and 16.7%, respectively. The mechanical properties revealed higher results compared with AA6061 aluminium alloy. It was observed that intermetallic phases play a major role in supporting the reinforcement of AA6061 aluminium alloy. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Mullite

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DEVELOPING A DIGITAL TWIN FOR SINGLE-CELL mechanical PHENOTYPING MICROFLUIDIC DEVICES 26

DEVELOPING A DIGITAL TWIN FOR SINGLE-CELL MECHANICAL PHENOTY...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Roychowdhury, Sayan Mahmud, Samreen T. Puleri, Daniel F. Lai, Andre Rex, Rachel Li, Brian Sohn, Lydia L. Randles, Amanda Department of Biomedical Engineering Duke University United States UC Berkeley-UC San Francisco Graduate Program in Bioengineering University of California Berkeley United States Department of Mechanical Engineering University of California Berkeley United States

ISBN: (纸本)9781733419048

Microfluidics can be used to characterize individual cells in a population based on their mechanical traits. In this work, we digitally replicate the microfluidic device developed by Li et al. [1] and perform simulations of a representative AP-1060 cell. We show that the numerical model is able to recover whole-cell deformability index, a metric used to quantify the resistance of cells to compressive deformation, within 3% of the experimental average. These results pave the way for future studies which utilize experimental and computational approaches to optimize geometric design parameters, complement signal analysis, and enhance the acquisition of mechanical information. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Fluid structure interaction

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Correction: Materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

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MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA" to "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

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Flexible organic solar cells for biomedical devices

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Nano Research 2021年第9期14卷 2891-2903页

作者： Bin Kan Faheem Ershad Zhoulyu Rao Cunjiang Yu Department of Mechanical Engineering University of HoustonHoustonTX 77204USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA Materials Science and Engineering Program University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204USA Texas Center for Superconductivity University of HoustonHoustonTX 77204USA

Organic solar cells(OSCs),particularly made based on solution processing methods,have made significant progress over the past decades through the concurrent evolution of organic photovoltaic materials and device ***,high power conversion efficiencies around 18%and over 16%have been demonstrated in both rigid and flexible OSCs,*** most of the OSC research has centered on efficiency and cost,their emerging and potential usages in many critical applications,particularly in biomedical fields have been *** this mini-review,we will briefly discuss the high-performance organic photovoltaic materials and the representative flexible OSCs to give a scope on the recent rapid development of ***,we will review some progress on the applications of OSCs in biomedical devices and integrated *** potential challenges associated with integrating OSCs for biomedical devices will be put forward.

关键词： organic solar cells photovoltaic flexible biomedical bioelectronics

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Kinematic Variability in Healthy and Hemiplegic Gait using OpenSim: A Quantitative Study 15

Kinematic Variability in Healthy and Hemiplegic Gait using O...

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15th International Conference on Computing Communication and Networking Technologies, ICCCNT 2024

作者： Younis, Sadia Narayan, Jyotindra Mio, Renato Bishnoi, Alka Department of Biomedical Engineering GCET Safapora Ganderbal India Department of Mechanical Engineering Indian Institute of Technology Guwahati Guwahati India Chair of Digital Health Universität Bayreuth Bayreuth Germany Department of Physical Therapy The College of Health Professions and Human Services Kean University NJ United States

ISBN: (纸本)9798350370249

This research investigates how Opensim, a tool for biomechanical modeling, can be used to analyze musculoskeletal changes in all three planes, namely, sagittal, frontal, and transverse planes, in individuals with hemiplegia compared to those in a healthy model. Contralateral hemiplegia (CH), marked by one-sided paralysis, triggers significant alterations in bone size and notably affects an individual’s walking pattern. Driven to comprehend the biomechanical impacts of CH on human motion, we examined ten CH patients with a median age of 46 years (range: 39−52.0 years) and a height of 1.75±0.6 m. OpenSim’s inverse kinematics feature allows for a thorough comparison of joint angles between individuals with health conditions and those with unhealthy ones. Ten individuals with similar body characteristics and in good health were also enlisted. We evaluated musculoskeletal alterations following CH by analyzing bone length data extracted from MRI reports acquired from a hospital. The gait data is presented and scrutinized through statistical methods, including mean absolute deviation, box plots, and a two-sample t-test. The outcomes uncovered substantial disparities in hip flexion, lumbar bending, lumbar extension, pelvis tilt, and ankle joint angles between healthy individuals and those with hemiplegia, supported by significantly low p-values. Notably, no significant distinction was detected in hip adduction, hip rotation, lumbar rotation, pelvic rotation, or knee and subtalar joint angles (p > 0.05). These findings enrich our comprehension of hemiplegia-related musculoskeletal changes, suggesting potential avenues for personalized interventions to enhance mobility. ©2024 IEEE.

关键词： Inverse kinematics

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Rapid sterilisation and diabetic cutaneous regeneration using cascade bio-heterojunctions through glucose oxidase-primed therapy

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Bioactive Materials 2023年第7期25卷 748-765页

作者： Yi Deng Xumei Ouyang Jiyu Sun Xiuyuan Shi Yunfei Li Yau Kei Chan Weizhong Yang Shaojun Peng College of Biomedical Engineering School of Chemical EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Zhuhai Institute of Translational Medicine Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)ZhuhaiGuangdong519000China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China Department of Materials Imperial College LondonSW72AZLondonUnited Kingdom Department of Biomedical Engineering The City College of the City University of New YorkNew YorkUnited States Department of Mechanical Engineering The University of Hong KongHong KongChina Department of Ophthalmology The University of Hong KongHong KongChina

The cutaneous wound in diabetic patients frequently encounters intractable pathogenic infections due to the hyperglycemia micromilieu which is conducive to bacterial growth and *** the extensive clinical use of antibiotics to treat bacterial infections,the emergence of drug-resistant and super pathogens as well as the potential side effects of antibiotics have elicited alarming challenges to public *** address this daunting concern,we devise and develop a photo-activated cascade bio-heterojunctions(C-bio-HJs)for rapid sterilization and diabetic cutaneous *** the designed C-bio-HJs,photo-generated electron-hole pairs of graphite-phase carbon nitride(g-C_(3)N_(4))are effectively separated with the marriage of molybdenum disulfide(MoS_(2)),which achieves the augmented photodynamic antibacterial ***,glucose oxidase(GOx)tethered on the bio-HJs catalyzes glucose into hydrogen peroxide(H_(2)O_(2))in diabetic wounds for starvation ***,Mo4+enables the catalysis of H_(2)O_(2)into a highly effective hydroxyl radical(⋅OH)for chemodynamic-photothermal combined antibacterial *** in vitro and in vivo results authenticate the cascading antibacterial properties and skin regeneration-promoting effects of the C-bio-HJs,which provide a facile strategy to combat diabetic wound healing through the synergistic GOx-primed dynamic therapies.

关键词： Antibacterial therapy Bio-heterojunction g-C_(3)N_(4) Rapid sterilization Tissue regeneration

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Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays

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biomedical engineering Frontiers 2022年第1期3卷 262-283页

作者： Robert Wodnicki Haochen Kang Di Li Douglas N.Stephens Hayong Jung Yizhe Sun Ruimin Chen Lai-Ming Jiang Nestor E.Cabrera-Munoz Josquin Foiret Qifa Zhou Katherine W.Ferrara Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Department of Biomedical Engineering University of CaliforniaDavisDavisCAUSA Molecular Imaging Program at Stanford University StanfordCAUSA USC Roski Eye Institute University of Southern CaliforniaLos AngelesCAUSA

Large aperture ultrasonic arrays can be implemented by tiling together multiple pretested modules of high-density acoustic arrays with closely integrated multiplexing and buffering electronics to form a larger aperture with high *** modular arrays can be used to implement large 1.75D array apertures capable of focusing in elevation for uniform slice thickness along the axial direction which can improve image *** important goal for large array tiling is obtaining high yield and sensitivity while reducing extraneous image *** have been developing tileable acoustic-electric modules for the implementation of large array apertures utilizing Application Specific Integrated Circuits(ASICs)implemented using 0.35μm high voltage(50 V)*** generations of ASICs have been designed and *** ASICs were integrated with high-density transducer arrays for acoustic testing and *** modules were further interfaced to a Verasonics Vantage imaging system and were used to image industry standard ultrasound *** first-generation modules comprise ASICs with both multiplexing and buffering electronics on-chip and have demonstrated a switching artifact which was visible in the images.A second-generation ASIC design incorporates low switching injection circuits which effectively mitigate the artifacts observed with the first-generation ***,we present the architecture of the two ASIC designs and module types as well imaging results that demonstrate reduction in switching artifacts for the second-generation devices.

关键词： Highly Large utilizing

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Effect of Cu addition on electrochemical activity of ribbons of Mg-Al-Ca anode materials for magnesium rechargeable batteries manufactured by rapid solidification method

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Keikinzoku/Journal of Japan Institute of Light Metals 2024年第1期74卷 14-17页

作者： Fukui, Shunsaku Tsukeda, Tadayoshi Aida, Tetsuo Tabata, Hironobu Kurihara, Hideki Suzuki, Mayumi Program of Materials Science and Engineering Studies in Science and Engineering Graduate School of Science and Engineering University of Toyama 3190 Gofuku Toyama-shi Toyama930-8555 Japan Faculty of Sustainable Design Academic Assembly University of Toyama Toyama-shi Toyama Japan CHUETSU METAL WORKS CO. LTD. Nakaniikawa-gun Toyama Japan Saitama Industrial Technology Center Kawaguchi Kawaguchi-shi Saitama Japan Department of Mechanical Systems Engineering Faculty of Engineering Toyama Prefectural University Imizu-shi Toyama Japan

The potential for magnesium storage batteries to become the next generation of rechargeable batteries is high. This is largely due to the abundance of magnesium metal resources and their high safety and electric capacity per volume. Our research team has been studying magnesium alloys as anode materials for these batteries. Specifically, we have been investigating the electrochemical activity and mechanism of adding copper to Mg-9mass%Al and Mg-9mass%Al-3mass%Ca. Our findings indicate that the electrochemical activity increased with the addition of 1mass%Cu, but decreased with the addition of 3mass%Cu. In addition, changes in lattice constant and basal orientation were also observed. These changes decreased with 1mass%Cu and increased with 3mass%Cu. SEM observations showed that the cell delimitation was indistinct for the 1%Cu addition. © 2024 The Japan Institute of Light Metals.

关键词： Secondary batteries

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