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Advances in Finite Element Analysis for Cancer Therapy Focusing on Magnetic Nanoparticle Hyperthermia

Multiscale Science and engineering 2024年第2期6卷 113-123页

作者： Raouf, Izaz Gas, Piotr Kim, Heung Soo Department of Mechanical Robotics and Energy Engineering Dongguk University-Seoul Seoul Republic of Korea Department of Electrical and Power Engineering Faculty of Electrical Engineering Automatics Computer Science and Biomedical Engineering AGH University of Krakow Krakow Poland

This mini review provides a thorough examination of recent advances in finite element analysis (FEA) for cancer therapy, with a focus on magnetic nanoparticle (MNP) hyperthermia. The paper begins by discussing the fundamental principles of FEA and their applications in biomedical sciences. It then describes the application of FEA to the in vitro and in vivo modeling of MNP hyperthermia, including the development and validation of computational models that simulate magnetic nanoparticles behavior under alternating magnetic field (AMF), heat generation, its transfer, and cellular/tissue responses. The review further explores the emerging trends and future directions in the application of FEA for MNP hyperthermia, including the integration of experimental data, incorporation of patient-specific parameters, and optimization of treatment protocols. The paper also discusses the key challenges and limitations of current FEA models, shedding light on potential areas for future research and development. By synthesizing the most recent advances in this field, the review aims to provide a valuable resource for researchers, clinicians, and engineers working on the optimization and clinical translation of MNP hyperthermia for effective cancer therapy.

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Homogenization Technique of Magnetostriction Calculation in Laminated Iron Core 26

Homogenization Technique of Magnetostriction Calculation in ...

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26th International Conference on Electrical Machines and Systems, ICEMS 2023

作者： Gao, Yanhui Fujita, Hiroki Guan, Weimin Muramatsu, Kazuhiro Oita University Intelligent Mechanical Systems Program Oita Japan Wuhan University School of Electrical Engineering and Automation Wuhan China Saga University Department of Electrical and Electronic Engineering Saga Japan

ISBN: (纸本)9798350317589

Accurate displacement calculation in the laminated iron cores of electric machines is important for the accurate prediction of noise generation in the electric machines. The authors proposed a modeling method of displacements due to magnetostriction in the laminated iron core using a homogenization model with equivalent anisotropic magnetic and elastic parameters. The calculated displacements obtained from the homogenization model are compared with those of the real laminated iron core model, and the solid core model neglecting the laminated structure. The homogenization model shows good agreement with the real model. © 2023 IEEE.

关键词： Iron

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Electro-mechanical Finite Element Model of Left Ventricular Hypertrophy 6th

Electro-Mechanical Finite Element Model of Left Ventricular ...

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6th Kuala Lumpur International Conference on biomedical engineering, BioMed 2021

作者： Hew, Zhi Chin Chan, Bee Ting Wan Ab Naim, Wan Naimah Dokos, Socrates Tey, Wah Yen Liew, Yih Miin Department of Mechanical Engineering Faculty of Engineering UCSI University Kuala Lumpur Malaysia Department of Mechanical Materials and Manufacturing Engineering Faculty of Science and Engineering University of Nottingham Malaysia Selangor Malaysia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang Pahang Malaysia Graduate School of Biomedical Engineering UNSW Sydney Sydney Australia Malaysia-Japan International Institute of Technology University Teknologi Malaysia Skudai Malaysia Department of Biomedical Engineering Faculty of Engineering Universiti Malaya Kuala Lumpur Malaysia

ISBN: (纸本)9783030907235

Left ventricular hypertrophy (LVH) is one of the common heart diseases that contribute to global morbidity and mortality. LVH can be further classified into concentric LVH (cLVH), eccentric LVH (eLVH) and concentric left ventricular remodeling (cLVR) based on the changes in wall structure and cardiac function. This study simulated LVH cases by using an electro-mechanical left ventricular (LV) model. The simulation was performed on three LVH cases, with a healthy model used for baseline reference. The pressure–volume loops, LV wall thickening index (TI), shortening strain (SS) and thickening strain (TS) were evaluated. Although all LV models had a preserved ejection fraction, differences in TI, SS and TS were noted. The cLVH (TI: 24.4%, SS: −20.2%, TS: −52.5%) and eLVH (TI: 10.3%, SS: −81.2%, TS: 9.4%) models showed remarkable difference compared to the healthy model, whereas less significant discrepancy was noted in cLVR (TI: 5.1%, SS: −0.6%, TS: −7.3%). Distinct geometric features of increased wall thickness and chamber enlargement were observed to affect the operative chamber stiffness in cLVH and eLVH. The TI, SS and TS results indicate wall mechanics impairment in cLVH and eLVH patients. © 2022, Springer Nature Switzerland AG.

关键词： Strain

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The Effect of Dimple-Based TMJ Design and Its Biomechanical Effect on Reducing Stress

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Journal of Long-Term Effects of Medical Implants 2025年第2期35卷 33-39页

作者： Dommeti, Vamsi Krishna Rajaeirad, Mohadese Jamshidi, Nima Roy, Sandipan Department of Mechanical Engineering SRM Institute of Science and Technology Kattankulathur Kanchipuram Tamil Nadu Chennai603203 India Department of Biomedical Engineering University of Isfahan Isfahan81746-73441 Iran

Temporomandibular joint (TMJ) disorders significantly impact orofacial health and quality of life, necessitating effective interventions. This study presents a comprehensive finite element analysis (FEA) focusing on the design and material modifications of temporomandibular joint implants, with the aim of improving their long-term stability and performance. Accurate mandible models extracted from Computational Tomography (CT) scans were used to create three variations of implants, each attached using varying screw configurations ranging from 2 to 5 for each analysis. The variations included implants without dimples, implants with 10% dimples, and implants with 20% dimples. The FEA considered material properties of Titanium and Ti-Nb-Zr alloy for the implants. The FEA results revealed that for 10% dimples models, equivalent stress was reduced by 6.25% with two screws fixation and further decreased by 14.28% with three screws, irrespective of the implant volume, reaffirming the significance of screw fixation. The model secured with three screws exhibited the least amount of stress for both titanium and zirconium alloys and dimple implants showed promise in reducing stress levels, particularly in low bone density conditions. These findings not only underscore the potential advantages of dimple implants in facilitating bone in growth and stability at the bone-implant interface but also highlight the pivotal role of implant dimples in modulating stress levels. The study contributes valuable insights for future advancements in TMJ implantology, offering potential optimizations for implant design and clinical outcomes. © 2025 by Begell House, Inc.

关键词： Binary alloys

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Controlling action potentials with magnetoelectric nanoparticles

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Brain Stimulation 2024年第5期17卷 1005-1017页

作者： Zhang, Elric Shotbolt, Max Chang, Chen-Yu Scott-Vandeusen, Aidan Chen, Shawnus Liang, Ping Radu, Daniela Khizroev, Sakhrat Department of Electrical and Computer Engineering University of Miami Coral Gables FL United States Department of Biomedical Engineering University of Miami Coral Gables FL United States Department of Mechanical and Materials Engineering Florida International University Miami FL United States Department of Chemical Environmental and Materials Engineering University of Miami Coral Gables FL United States Cellular Nanomed Irvine CA United States The Miami Project to Cure Paralysis Department of Biochemistry and Molecular Biology Miller School of Medicine University of Miami Miami FL United States

Non-invasive or minutely invasive and wireless brain stimulation that can target any region of the brain is an open problem in engineering and neuroscience with serious implications for the treatment of numerous neurological diseases. Despite significant recent progress in advancing new methods of neuromodulation, none has successfully replicated the efficacy of traditional wired stimulation and improved on its downsides without introducing new complications. Due to the capability to convert magnetic fields into local electric fields, MagnetoElectric NanoParticle (MENP) neuromodulation is a recently proposed framework based on new materials that can locally sensitize neurons to specific, low-strength alternating current (AC) magnetic fields (50Hz 1.7 kOe field). However, the current research into this neuromodulation concept is at a very early stage, and the theoretically feasible game-changing advantages remain to be proven experimentally. To break this stalemate phase, this study leveraged understanding of the non-linear properties of MENPs and the nanoparticles' field interaction with the cellular microenvironment. Particularly, the applied magnetic field's strength and frequency were tailored to the M − H hysteresis loop of the nanoparticles. Furthermore, rectangular prisms instead of the more traditional “spherical” nanoparticle shapes were used to: (i) maximize the magnetoelectric effect and (ii) improve the nanoparticle-cell-membrane surface interface. Neuromodulation performance was evaluated in a series of exploratory in vitro experiments on 2446 rat hippocampus neurons. Linear mixed effect models were used to ensure the independence of samples by accounting for fixed adjacency effects in synchronized firing. Neural activity was measured over repeated 4-min segments, containing 90 s of baseline measurements, 90 s of stimulation measurements, and 60 s of post stimulation measurements. 87.5 % of stimulation attempts produced statistically significant (P < 0.0

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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Analysis of the morphological and mechanical characterization of aluminium matrix composite reinforced with chitosan

Analysis of the morphological and mechanical characterizatio...

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International Conference on engineering for a Sustainable World, ICESW 2022

作者： Udoye, N.E. Ezekiel, V. Fayomi, O.S.I. Okokpujie, I.P. Dirisu, J.O. Department of Mechanical Engineering College of Engineering Covenant University Ota Lagos state Nigeria Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado-ekiti Ekiti State Nigeria Department of Mechanical and Biomedical Engineering Bells University of Technology P.M.B 1015 Ogun State Ota Nigeria Department of Mechanical Engineering Science University of Johannesburg Johannesburg2006 South Africa

Recent studies acknowledge that convectional ceramic particulate could be replaced by several agricultural byproducts in the development of aluminium matrix composites because of its selected for their low cost and relative ubiquity. This study explores the development of aluminium matrix composite from AA6061 alloy reinforced with chitosan particulates at weight proportions (3, 6, 9, and 12 wt%). The study further characterizes the developed composites using Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffractometer (XRD), hardness, tensile and thermal and electrical conductivity test techniques. Results indicated that increasing chitosan content up to 10 wt% enhanced the hardness performance, while tensile strength of the composites increased sporadically, as SEM images observed reinforcement links embedded in grain boundaries. However, the thermal and electrical conductivity diminished due to the addition of chitosan particulates to the alloy matrix. The overall study showed the great potential of chitosan polymer as reinforcement to aluminium alloy. © 2023 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on engineering for a Sustainable World.

关键词： Energy dispersive spectroscopy

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Additively manufactured composite metastructure for broadband vibration and noise control applications 30

Additively manufactured composite metastructure for broadban...

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30th International Conference on Noise and Vibration engineering, ISMA 2022 and 9th International Conference on Uncertainty in Structural Dynamics, USD 2022

作者： Muhammad, J. Kennedy Trinity College Dublin Department of Mechanical Manufacturing and Biomedical Engineering College Green Dublin 02 Ireland

ISBN: (纸本)9789082893151

Artificial synthetic structures as metamaterials have seen tremendous amount of research interest for vibration and noise control and wave manipulation applications. The present study proposes a new type of composite metastructure that is capable of inducing a low-frequency ultrawide bandgap. The metastructure consists of a polymeric housing, constructed by 3-D printing and, rigid steel masses which are embedded inside the housing. The bandgap is generated by the principle of mode separation where the frequency difference between the global resonant mode and local resonant mode are manipulated to widen the bandgap. These locally resonant modes are studied by numerical modal analysis and wave attenuation over broadband frequency range are demonstrated by a frequency response study. The metastructure design morphology and study findings will have a wide range of applications in structural vibration and noise control and elastic wave manipulation. © 2022 Proceedings of ISMA 2022 - International Conference on Noise and Vibration engineering and USD 2022 - International Conference on Uncertainty in Structural Dynamics. All rights reserved.

关键词： Energy gap

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Bending stiffness variability between a deployable robotic laser osteotome and its insertion device

Bending stiffness variability between a deployable robotic l...

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作者： Tomooka, Yukiko Rauter, Georg Gerig, Nicolas Takeda, Ryo Cattin, Philippe Eugster, Manuela BIROMED-Lab Department of Biomedical Engineering University of Basel Gewerbestrasse 14 Allschwil4123 Switzerland Laboratory of Deformation Control Division of Mechanical and Aerospace Engineering Faculty of Engineering Hokkaido University Hokkaido Japan Cian Department of Biomedical Engineering University of Basel Allschwil Switzerland

Varying device stiffness on purpose can provide safety and performance improvements in interventions involving flexible minimal-invasive surgical robotic devices. For example, when flexible robotic devices are used for inserting minimal-invasive tools along curved paths into the knee joint for arthroscopy, a high device stiffness can allow precise path following where desirable. In contrast, when the minimalinvasive flexible device has reached its desired location inside the patient's body, decoupling the surgical tool (end-effector) from the flexible robotic insertion device can be beneficial in avoiding transferring disturbances such as vibrations to the robot-patient interaction. In this paper, we investigate bending stiffness variability in dependence on the length of a flexible supply channel. Our experiments have shown that bending stiffness in fact decreases with the length of the supply channel but the highest stiffness connection is not sufficiently rigid and we plan to implement a more rigid connection to allow precise path following during insertion. © 2022 by Walter de Gruyter Berlin/Boston.

关键词： Robotic surgery

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HYBRID MANUFACTURING FOR STEEL BOAT PROPELLERS

HYBRID MANUFACTURING FOR STEEL BOAT PROPELLERS

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2022 ASPE and euspen Summer Topical Meeting on Advancing Precision in Additive Manufacturing

作者： Penney, Joshua Cornelius, Aaron Quigley, Tiffany Hamel, William Jared, Bradley Schmitz, Tony Department of Mechanical Aerospace and Biomedical Engineering University of Tennessee Knoxville KnoxvilleTN37996 United States

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