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Helical swimming motion driven by coordinated rotation of flagellar apparatus in marine bacterial cells

Journal of Biomechanical Science and engineering 2025年第1期20卷 1-11页

作者： SHIMOGONYA, Yuji RUAN, Juanfang KATO, Takayuki ISHIKAWA, Takuji NAMBA, Keiichi WU, Long-Fei NISHIYAMA, Masayoshi Department of Mechanical Engineering College of Engineering Nihon University 1 Nakagawara Tokusada Tamuramachi Koriyama Fukushima963-8642 Japan Graduate School of Frontier Biosciences Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Institute for Protein Research Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Department of Biomedical Engineering Graduate School of Biomedical Engineering Tohoku University 6-6-01 Aoba Sendai Miyagi980-8579 Japan Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aoba Sendai Miyagi980-8579 Japan JEOL YOKOGUSHI Research Alliance Laboratories Osaka University 1-3 Yamadaoka Suita Osaka565-0871 Japan Aix Marseille Université CNRS Laboratoire de Chimie Bactérienne Marseille CedexF-13402 France Department of Science Faculty of Science and Engineering KINDAI University 3-4-1 Kowakae Higashiosaka Osaka577-8502 Japan

The magnetotactic bacterium MO-1 possesses a pair of unique flagellar apparatuses. Each apparatus comprises seven flagella and 24 thin fibrils enclosed in a sheath. Using these apparatuses, the cells swim at high speed through solutions, tracing helical trajectories. The mechanism by which MO-1 cells utilize their two flagellar apparatuses to propel the cell body remains unclear. Due to the short length of the flagellar apparatus, direct observation of individual movements under a microscope is technically challenging. In this study, we performed numerical simulations based on the boundary element method to investigate the swimming motility of MO-1 cells. Our cell models successfully reproduced the helical trajectories of active MO-1 cells. The two flagellar apparatuses were positioned at the front and back of the cell body relative to the direction of movement. The cell body was pulled by the anterior flagellar apparatus and pushed by the posterior apparatus. The swimming motion of the cell model exhibited minimal changes near a wall. This unique swimming behavior of MO-1 cells could only be achieved through the rotation of both flagellar apparatuses. Based on the revolution rate of active MO-1 cells, we estimated the rotational speed of the flagellar apparatus to be approximately 1200 s-1. This rapid rotation may result from the tight packing of flagellar filaments within the sheath. Our study elucidates the mechanism by which active MO-1 cells swim in helical trajectories. © 2025 The Japan Society of mechanical Engineers.

关键词： Rotation

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Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

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Bioactive Materials 2023年第9期27卷 113-124页

作者： Clyde Overby Soomin Park Austin Summers Danielle S.W.Benoit Department of Biomedical Engineering University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biology University of Rochester RochesterNYUSA Department of Biology Duquesne UniversityPAUSA Department of Chemical Engineering University of RochesterRochesterNYUSA Materials Science Program University of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake

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Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM SUNA ARIKAN SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE UÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(p<0.05).Significant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(p<0.05).Furthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(p<0.05).Cell apoptosis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

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An Innovative Shopping System with GSM Based Automation for Physically Challenging and Old Age People 3

An Innovative Shopping System with GSM Based Automation for ...

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3rd International Conference on Innovative Practices in Technology and Management, ICIPTM 2023

作者： Getsy, Mary Kousar, Heena Shanmugam, A. Isaac, J. Samson Kulkarni, Nirzar Raja, P. Sudhakar, M. Manakula Vinayagar Institute of Technology Department of Electronics and Communication Tamil Nadu Puducherry India East Point College of Engineering Department of Computer Science Karnataka Bengaluru India Kongu Engineering College Department of Mechatronics Tamil Nadu Perundurai India Karunya Institute of Technology Department of Biomedical Engineering Tamil Nadu Coimbatore India Dr. Ambedkar Institute of Management Studies Department of Computer Science Maharashtra Nagpur India Prathyusha Engineering College Department of Mechanical Engineering Tamil Nadu Thiruvallur India Sri Sai Ram Engineering College Department of Mechanical Engineering Chennai India

ISBN: (纸本)9798350336238

The Automated Buying Cart, or 'Smart Cart,' is a cutting-edge consumer device created to speed up the shopping process for customers! The Automated Shopping Cart collects all the data from the moment a customer removes an item from the shelf of the store until the final bill is generated and ready for final checkout. The time needed to shop and pay is significantly decreased. When speed and efficiency are the main concerns in today's shopping systems, an automated shopping system using Radio Frequency Identification technology emerges as a convergent technology. The evaluation's findings were presented together with suggestions for future prototype development improvements. © 2023 IEEE.

关键词： Radio frequency identification (RFID)

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Simulation Of Public Transportation Operations For Infectious Disease Spreading Among Passengers

Simulation Of Public Transportation Operations For Infectiou...

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Annual Modeling and Simulation Conference (ANNSIM)

作者： Longfei Zhou Chun Sen Liu Department of Biomedical Industrial and Systems Engineering Gannon University USA Department of Mechanical Engineering Pennsylvania State University USA

ISBN: (数字)9781713899310

ISBN: (纸本)9798350350562

Public transportation operation strategies’ impact on spreading infectious diseases among passengers is critical due to managing diseases like COVID-19. Public transportation can act as significant vectors for transmission due to high passenger densities and close contact. However, few studies have quantitatively compared disease transmission between different operation strategies. In this work, we examine transmission among passengers by considering the number of public vehicles and their travel directions. A novel evaluation method assesses the spread of diseases. Simulation models for eight bus operation strategies indicate that adding more buses decreases passenger close contact on buses and stations. Uniform bus travel direction ensures evenly distributed passengers, lowering close contact compared to varied directions. These findings inform the development of effective strategies to mitigate transmission risks, ensuring public transportation safety and protecting public health during pandemics.

关键词： COVID-19 Analytical models Infectious diseases Pandemics Simulation Vectors Data models Safety Public healthcare Public transportation

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A Kinetic Theory for the Mechanics and Remodeling of Transient Anisotropic Networks

SSRN

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SSRN 2024年

作者： Vernerey, Franck J. Rezai, Behnam Lamont, Samuel C. Department of Mechanical Engineering Program of Materials Science and Engineering University of Colorado Boulder United States

We present a statistically-based theoretical framework to describe the mechanical response of dynamically cross-linked semi-flexible polymer networks undergoing finite deformation. The theory starts from a statistical description, via a distribution function, of the chain conformation and orientation. Assuming a so-called tangent affine deformation of the chains, this distribution is then allowed to evolve in time due to a combination of elastic network distortion and a permanent chain reconfiguration enabled by dynamic cross-links. After presenting the evolution law for the chain distribution function, we reduce the theory to the evolution of the network conformation tensor in both its natural and current state. With this model, we use classical thermodynamics to determine how the stored elastic energy, energy dissipation, and true stress evolve in terms of the network conformation. We show that the model degenerates to classical anisotropic hyperelastic models when cross-links are permanent, while we recover the classical form of the transient network theory (that describes hyper-viscoelasticity) when chains are fully flexible. Theoretical predictions are then illustrated and compared to the literature for both basic model problems and biomechanically relevant situations. © 2024, The Authors. All rights reserved.

关键词： Statistical mechanics

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EVALUATION OF A 3D PRINTED SINGLE LAYER POLYVINYLIDENE FLUORIDE-TRIFLUOROETHYLENE (PVDFTRFE) SENSOR AS A WALL SHEAR STRESS MEASURING DEVICE IN HIGH FREQUENCY OSCILLATORY FLOWS

EVALUATION OF A 3D PRINTED SINGLE LAYER POLYVINYLIDENE FLUOR...

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ASME 2024 International mechanical engineering Congress and Exposition, IMECE 2024

作者： Akanji, Sunday Lalsen, Dane Marandi, Mohammadrafi Cavalline, Tara Smith, Michael S. Hewlin, Rodward L. University of North Carolina at Charlotte Infrastructure and Environmental Systems CharlotteNC United States University of North Carolina at Charlotte Department of Engineering Technology and Construction Management CharlotteNC United States University of North Carolina at Charlotte Department of Mechanical Engineering and Engineering Science CharlotteNC United States University of North Carolina at Charlotte Center for Biomedical Engineering and Science CharlotteNC United States

ISBN: (纸本)9780791888667

This paper presents the first implementation of a novel class of dynamic time-resolved direct wall shear stress (WSS) measurement sensors based on active Polyvinylidene fluoride (PVDF-TrFE) piezoelectric materials. These piezoelectric sensors have the advantage that they contain no moving parts, perform a direct measurement of WSS, and can be mounted directly to the surface of an existing vessel with no modification to the sensor and produces minimal to zero flow disturbing effects to the surrounding flow environment. The design and development methodology and characterization of the sensor dynamic signal response are discussed. This work explores a double layer sensor configuration consisting of a single layer of printed PVDF with an additional layer of printed PVDF-TrFE with silver painted electrodes. Both sensor types were tested in an in-house developed Stokes plane wave tube, and the results demonstrate the potential for using PVDF-TrFE sensors to perform accurate, high frequency measurements of WSS in unsteady flow applications. Copyright © 2024 by ASME.

关键词： Shear stress

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Optimizing Organic Rankine Cycle (ORC) configurations integrated with transient industrial waste heat: a multi-objective approach

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Discover Energy 2024年第1期4卷 1-20页

作者： Engineer, Yohan Rezk, Ahmed Elsheniti, Mahmoud B. Baniasadi, Ehsan Fouly, Ahmed Energy and Bioproducts Research Institute (EBRI) College of Engineering and Physical Science Aston University Birmingham UK Mechanical Biomedical and Design Engineering Department (MBDE) College of Engineering and Physical Science Aston University Birmingham UK Mechanical Engineering Department College of Engineering King Saud University Riyadh Saudi Arabia

Decarbonizing heat-intensive industries by reusing the waste heat for power or combined heat and power systems is becoming increasingly important to address global warming. The Organic Rankine Cycle has shown a high level of feasibility and performed efficiently for utilizing medium-to-low-grade heat from renewable resources and heat-intensive industries for direct power generation. This study contributes to the field by conducting a techno-economic investigation of various Organic Rankine Cycle configurations to enhance energy conversion when real-life transient waste heat sources are available. These configurations were optimized to maximize energy output along with economic benefits. The non-linear programming by quadratic Lagrangian, a computational unintensive yet accurate optimization algorithm, was utilized for the multi-objective optimization. The optimized cycle configurations showed a 12.57% enhancement of turbine efficiency. Combining regeneration and recuperation enhanced the superheating by 32%, and the optimized air preheater cycle improved the overall objective by 64.2% compared to the pre-optimized conventional cycle, leading to a feasible 1.72-year payback period.

关键词：

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Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography

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Bioactive Materials 2022年第4期7卷 367-377页

作者： Huaiyu Shi Xiangjun Wu Shiyang Sun Chenyan Wang Zacharias Vangelatos Ariel Ash-Shakoor Costas P.Grigoropoulos Patrick T.Mather James H.Henderson Zhen Ma Department of Biomedical&Chemical Engineering Syracuse UniversitySyracuseNY13244USA BioInspired Syracuse Institute for Materials and Living Systems Syracuse UniversitySyracuseNY13244USA Department of Mechanical Engineering University of CaliforniaBerkeleyPA94720USA Department of Chemical Engineering Bucknell UniversityLewisburgPA17837USA

Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular *** studies have demonstrated that cardiomyocyte focal adhesions can be modulated by surface topographic ***,the response of focal adhesions to dynamic surface topographic changes remains *** study this dynamic responsiveness of focal adhesions,we utilized a shape memory polymer-based substrate that can produce a flat-to-wrinkle surface transition triggered by an increase of *** this dynamic culture system,we analyzed three proteins(paxillin,vinculin and zyxin)from different layers of the focal adhesion complex in response to dynamic extracellular topographic ***,we quantified the dynamic profile of cardiomyocyte focal adhesion in a time-dependent manner,which provides new understanding of dynamic cardiac mechanobiology.

关键词： Stimuli-responsive biomaterials Shape memory polymer Focal adhesion Costamere Dynamic mechanobiology Human induced pluripotent stem cells

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Overview of Gel Casted Fused Silica Ceramics

Overview of Gel Casted Fused Silica Ceramics

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International Conference on Chemical, Bio and Environmental engineering, CHEMBIOEN 2021

作者： Kanakam, Rakesh Subhash Chandra Bose, P. Raghavendra, G. Ojha, S. Dheeraj, G. Anjireddy, B. Aswani kumar, B. vardhan, Harsha Department of Mechanical Engineering NIT Telangana Warangal India Department of Mechanical Engineering KITS Telangana Warangal506004 India Chemical Engineering Dr. B R Ambedkar NIT Punjab Jalandhar144011 India Mechanical/Biomedical Engineering Munster Technological University cork Ireland Mechanical Engineering PVKK Institute of Technology Andhra Pradesh Ananthapuramu India

ISBN: (纸本)9783030965532

The current review mainly emphasizes about the importance of water, low cost water filtration applications and fabrication technique. Pressure driven ceramic membranes are widely accepted for water purification/filtration applications. These membranes are processed using conventional techniques such as slip casting, dip coating and pressure casting, however they have processing difficulties for complex shapes. As a result, gel casting process has received significant attention in the scientific community for the fabrication of ceramic membrane. Gel casting process has an advantage to fabricate complex shapes, exhibiting homogeneous microstructure and better strength to weight ratio compared to the other conventional processes. Gel casting processing is one of the forming techniques developed to address the constraints of prolonged binder burnout, geometry and range of size and non-uniform density issues associated with traditional complex forms. In lieu of this, the current paper reviews the gel casting processed silica members and their applications for the purification/filtration applications. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Water filtration

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