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Molecular simulation-guided and physics-informed mechanistic modeling of multifunctional polymers

Acta Mechanica Sinica 2021年第5期37卷 725-745,I0002页

作者： Guang Chen Weikang Xian Qiming Wang Ying Li Department of Mechanical Engineering University of ConnecticutStorrsCT 06269USA Sonny Astani Department of Civil and Environmental Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Mechanical Engineering and Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsCT 06269USA

Polymeric materials have a broad range of mechanical and physical *** have been widely used in material science,biomedical engineering,chemical engineering,and mechanical *** introduction of active elements into the soft matrix of polymers has enabled much more diversified functionalities of polymeric materials,such as self-healing,electroactive,magnetosensitive,pH-responsive,and many *** further enable applications of these multifunctional polymers,a mechanistic modeling method is required and of great significance,as it can provide links between materials’micro/nano-structures and their macroscopic mechanical *** this goal,molecular simulation plays an important role in understanding the deformation and evolution of polymer networks under external loads and *** molecular insights provide physical guidance in the formulation of mechanistic-based continuum models for multifunctional *** this perspective,we present a molecular simulation-guided and physics-informed modeling framework for polymeric ***,the physical theory for polymer chains and their networks is briefly *** serves as the foundation for mechanistic-models of polymers,linking their chemistry,physics,and mechanics ***,the deformation of the polymer network is used to derive the strain energy density ***,the corresponding continuum models can capture the intrinsic deformation mechanisms of polymer *** then highlight several representative examples across multiphysics coupling problems to describe in detail for this proposed *** but not least,we discuss potential challenges and opportunities in the modeling of multifunctional polymers for future research directions.

关键词： Molecular simulation Multiphysics modeling Multiscale modeling Multifunctional polymers Soft Matter

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Microring Resonator Based Disposable Ultrasound-sensing Chronic Cranial Window

Microring Resonator Based Disposable Ultrasound-sensing Chro...

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Optical Tomography and Spectroscopy, OTS 2022

作者： Lee, Youngseop Zhang, Hao F. Sun, Cheng Department of Biomedical Engineering Northwestern University EvanstonIL60201 United States Department of Mechanical Engineering Northwestern University EvanstonIL60201 United States

This work presents the microring resonator based disposable ultrasound-sensing chronic cranial window. We optimized the sensor design and the fabrication to significantly improve detection sensitivity and reliability ... 详细信息

ISBN: (纸本)9781557528209

关键词： Ultrasonic applications

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Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer

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Bio-Design and Manufacturing 2023年第3期6卷 255-267页

作者： Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li Lingqian Chang Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Department of Stomatology Xiang’an Hospital of Xiamen UniversityXiamen 361000China Institute of Plastic Machinery and Plastic Engineering School of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Department of Biochemistry Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical CollegeBeijing 100005China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai 200011China Laboratory Animal Facility Peking University First HospitalBeijing 100034China

Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s *** lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic *** work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral *** ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin *** vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone *** proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C *** healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in *** as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral *** rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.

关键词： Recurrent oral ulcer Dissolvable microneedle Hyaluronic acid microneedle Multidrug Anti-inflammation Healing promoting effect

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Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

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Microsystems & Nanoengineering 2021年第1期7卷 77-83页

作者： Leela Goel Huaiyu Wu Bohua Zhang Jinwook Kim Paul A.Dayton Zhen Xu Xiaoning Jiang Department of Mechanical&Aerospace Engineering North Carolina State UniversityRaleighNC 27695USA The Joint Department of Biomedical Engineering The University of North Carolina at Chapel Hill and North Carolina State UniversityChapel HillNC 27599USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA

One major challenge in current microbubble(MB)and tissue plasminogen activator(tPA)-mediated sonothrombolysis techniques is effectively treating retracted blood clots,owing to the high density and low porosity of retracted ***(NDs)have the potential to enhance retracted clot lysis owing to their small size and ability to penetrate into retracted clots to enhance drug *** the first time,we demonstrate that a sub-megahertz,forwardviewing intravascular(FVI)transducer can be used for ND-mediated sonothrombolysis,in *** this study,we determined the minimum peak negative pressure to induce cavitation with low-boiling point phase change nanodroplets and clot *** then compared nanodroplet mediated sonothrombolysis to MB and tPA mediate *** clot lysis as a percent mass decrease in retracted clots was 9±8%,9±5%,16±5%,14±9%,17±9%,30±8%,and 40±9%for the control group,tPA alone,tPA+US,MB+US,MB+tPA+US,ND+US,and ND+tPA+US groups,*** retracted blood clots,combined ND-and tPA-mediated sonothrombolysis was able to significantly enhance retracted clot lysis compared with traditional MB and tPA-mediated sonothrombolysis *** nanodroplet with tPA-mediated sonothrombolysis may provide a feasible strategy for safely treating retracted clots.

关键词： thrombolysis directed boiling

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Improvement of stability in long-term motor decoding forelimb movement with a sequence imputation of temporal-based spike patterns

Improvement of stability in long-term motor decoding forelim...

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2022 IEEE biomedical Circuits and Systems Conference, BioCAS 2022

作者： Kuo, Yun-Ting Yang, Shih-Hung Chou, Chin-Yu Chang, Hao-Cheng Chen, Kuan-Yu Chen, You-Yin National Yang Ming Chiao Tung University Department of Biomedical Engineering Taipei Taiwan National Cheng Kung University Department of Mechanical Engineering Tainan Taiwan

ISBN: (数字)9781665469173

ISBN: (纸本)9781665469173

Instability of neural signals is a vital issue in intracortical brain machine interface (iBMI) systems which caused by missing neuron day by day. This study proposed mean-perturbation to impute missing neural spike train during rat forelimb movement. Our results showed that the proposed mean-perturbation for sequence imputation of missing neural spikes was used to enhance the long-term decoding performance. © 2022 IEEE.

关键词： Brain computer interface

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Project Edubot: Exploring Pedagogical Approaches in High School Robotics Education

Project Edubot: Exploring Pedagogical Approaches in High Sch...

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2024 Brazilian Symposium on Robotics (SBR), and 2024 Workshop on Robotics in Education (WRE)

作者： Isabela Nunes Daltro João Victor Silva Santos Guilherme Barbosa De Sousa Rodrigo Martins M. A. Pastrana Roberto De Souza Baptista Mechatronics Engineering Undergraduate Program Department of Mechanical Engineering Mechatronics Graduate Program Faculty of Gama Electronics Engineering Undergraduate Program University of Brasilia Brasilia DF Brazil

ISBN: (数字)9798350391084

ISBN: (纸本)9798350391091

This study focus on passive and active learning within the context of robotics education on public high schools. By synthesizing research findings and practical insights, this paper offers valuable recommendations for educators aiming to optimize the delivery of robotics education in public high schools, addressing the significance of the utilization of appropriate resources and technologies to support effective instruction. We implemented two distinct teaching methodologies to compare and study students' reactions and learning outcomes: Group A experienced a passive methodology, while Group B engaged with an active methodology. We conducted a survey and the results show that the majority of the students prefer the active approach used in classes.

关键词： Surveys Conferences Education Active learning Collaboration Problem-solving Robots Creativity

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A Comparative Study of the Effect of Compounding Methods and Processing of PLA/GNPs on the Micromorphology and Electrical Conductivity 38

A Comparative Study of the Effect of Compounding Methods and...

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38th Technical Conference of the American Society for Composites, ASC 2023

作者： Anurakparadorn, Kanat Taub, Alan Department of Materials Science and Engineering Macromolecular Science and Engineering Program University of Michigan 2300 Hayward St Ann ArborMI48109 United States Department of Mechanical Engineering University of Michigan 2350 Hayward St Ann ArborMI48109 United States

ISBN: (纸本)9781605956916

In this work, the effects of different compounding and processing techniques on the DC electrical conductivity and density of polylactic acid (PLA)/graphene nanoplatelets (GNPs) composites were studied. It is found from the study that compounding by solution mixing via an ultrasonication technique can provide slightly higher DC electrical conductivity after compression molding than mixing through a twin-screw extruder due to better dispersion quality. In addition, a composite pellet from twin screw extrusion showed a slight increase in DC electrical conductivity and anisotropy when processed by filament extrusion due to the shear alignment of GNPs during the extrusion. The fused deposition modeling (FDM) process yields high anisotropy because the crystallization along the printing path allows gaps and polymer coating between the extruded lines and layers. It was found that the 7.5 wt% GNPs composites exhibited the best properties because it provides the best dispersion quality to meet the percolation threshold. Furthermore, the micromorphology of each sample was also studied to observe the dispersion and porosity inside the composite provided by each fabrication technique. This study can be used as a reference for compounding and processing techniques. © 2023 by DEStech Publications, Inc. and American Society for Composites. All rights reserved.

关键词： Mixing

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Benchmarking Randomized Optimization Algorithms on Binary, Permutation, and Combinatorial Problem Landscapes

arXiv

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arXiv 2025年

作者： Odeyemi, Jethro Zhang, Wenjun The University of Saskatchewan The Advanced Engineering Design Laboratory Canada The Department of Mechanical Engineering The Division of Biomedical Engineering University of Saskatchewan SaskatoonSK Canada

In this paper, we evaluate the performance of four randomized optimization algorithms-Randomized Hill Climbing (RHC), Simulated Annealing (SA), Genetic Algorithms (GA), and MIMIC (Mutual Information Maximizing Input Clustering)-across three distinct types of problems: binary, permutation, and combinatorial. We systematically compare these algorithms using a set of benchmark fitness functions that highlight the specific challenges and requirements of each problem category. Our study analyzes each algorithm’s effectiveness based on key performance metrics, including solution quality, convergence speed, computational cost, and robustness. Results show that while MIMIC and GA excel in producing high-quality solutions for binary and combinatorial problems, their computational demands vary significantly. RHC and SA, while computationally less expensive, demonstrate limited performance in complex problem landscapes. The findings offer valuable insights into the trade-offs between different optimization strategies and provide practical guidance for selecting the appropriate algorithm based on the type of problems, accuracy requirements, and computational constraints. © 2025, CC BY.

关键词： Optimization algorithms

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Development Experimental Investigations of Truss Bridge Model for Vibration-Based Structural Health Monitoring 5th

Development Experimental Investigations of Truss Bridge Mode...

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5th International Conference on Sustainable Civil engineering Structures and Construction Materials, SCESCM 2020

作者： Sukamta Alfiannur, Angga Widyanto, Susilo Adi Lie, Han Ay Department of Civil Engineering Diponegoro University Semarang Indonesia Master Program in Civil Engineering Diponegoro University Semarang Indonesia Department of Mechanical Engineering Diponegoro University Semarang Indonesia

ISBN: (纸本)9789811679230

In recent years the need for Structural Health Monitoring (SHM) has become increasingly important. Given current technological developments, a visual inspection can no longer be a reference due to inaccurate accuracy levels. In this case, there is a need for an early warning in detecting fast and accurate damage compared to visual inspection. This study proposes a vibration-based structural health monitoring analytical framework by introducing a modal analysis approach based on the bridges structural response. The test begins with making a small-scale model of a steel frame type bridge using the similarity model theory to project a prototype bridge. In this research, a damage simulation is given to the model to project damage to the structure. Static and dynamic tests are carrying to obtain the response characteristics of the structure. The assessment has delayed consequences exhibit that the variety of the supported discharge shows that contrasts look like the bend of the predominant recurrence that influences the FFT bend. Output values in natural frequency, mode shapes, and capital damping ratios were adopted as damage indicators. As a comparison, we are testing the model using FE simulation with a tolerance level of 10%. This research is using to build an SHM database system of the existing bridge structure model. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Modal analysis

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High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

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biomedical engineering Frontiers 2022年第1期3卷 348-355页

作者： Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A.Czaplewski Hao F.Zhang Cheng Sun Junjie Yao Department of Biomedical Engineering Duke UniversityDurhamNCUSA 27708 Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Optical&Ultrasonic Imaging Laboratory University at BuffaloNorth Campus BuffaloNY 14260USA Center for Nanoscale Materials Argonne National LaboratoryArgonneIL 60439USA

3D photoacoustic computed tomography(3D-PACT)has made great advances in volumetric imaging of biological tissues,with high spatial-temporal resolutions and large penetration *** development of 3D-PACT requires high-performance acoustic sensors with a small size,large detection bandwidth,and high *** this work,we present a new high-frequency 3D-PACT system that uses a microring resonator(MRR)as the acoustic *** MRR sensor has a size of 80μm in diameter and was fabricated using the nanoimprint lithography *** the MRR sensor,we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of~23 MHz,an imaging depth of~8 mm,a lateral resolution of 114μm,and an axial resolution of 57μ*** have demonstrated the 3D PACT’s performance on in vitro phantoms,ex vivo mouse brain,and in vivo mouse ear and *** MRR-based 3D-PACT system can be a promising tool for structural,functional,and molecular imaging of biological tissues at depths.

关键词： resonator lithography resolution

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