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Systematic designs of single metal compounds synthesized using ammonia fluoride-based complex as structure directing agents for energy storage

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Journal of Colloid and Interface Science 2023年第PartA期652卷 294-304页

作者： Kuo, Tsung-Rong Zher Yu, You Wu, Chung-Hsien Lee, Pin-Yan Kongvarhodom, Chutima Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso

Tailoring morphology and composition of metal organic frameworks (MOF) can improve energy storage by establishing high surface area, large porosity and multiple redox states. Structure directing agents (SDA) is functional of designing surface properties of electroactive materials. Ammonium fluoride has functional abilities for designing MOF derivatives with excellent energy storage abilities. Systematic design of MOF derivatives using ammonia fluoride-based complex as SDA can essentially create efficient electroactive materials. Metal species can also play significant roles on redox reactions, which are the main energy storage mechanism for battery-type electrodes. In this work, 2-methylimidazole, two novel SDAs of NH4BF4 and NH4HF2, and six metal species of Al, Mn, Co, Ni, Cu and Zn are coupled to synthesize MOF derivatives for energy storage. Metal species-dependent compositions including hydroxides, oxides, and hydroxide nitrates are observed. The nickel-based derivative (Ni-HBF) shows the highest specific capacitance (CF) of 698.0F/g at 20 mV/s, due to multiple redox states and advanced flower-like surface properties. The diffusion and capacitive-control contributions of MOF derivatives are also analyzed. The battery supercapacitor hybrid with Ni-HBF electrode shows a maximum energy density of 27.9 Wh/kg at 325 W/kg. The CF retention of 170.9% and Coulombic efficiency of 93.2% are achieved after 10,000 cycles. © 2023 Elsevier Inc.

关键词： Supercapacitor

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Characteristics of fatal and serious cyclist collisions in Ireland: Analysis of police investigation files

Characteristics of fatal and serious cyclist collisions in I...

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2022 International Research Council on the Biomechanics of Injury, IRCOBI 2022

作者： Gildea, Kevin Kervick, Aoife Simms, Ciaran Department of Mechanical Manufacturing & Biomedical Engineering Trinity College Dublin Ireland The Research Department of the Road Safety Authority Ireland

Cycling has been increasing in popularity in many countries, including the Republic of Ireland. Concurrently, the modal share of cyclist casualties has been increasing. However, there has been limited analysis of the pre-crash manoeuvres and impact configurations of cyclist collisions in Ireland, which inhibits the prioritization of engineering solutions. Accordingly, in this study, police investigation files are analysed for a convenience sample of 59 fatal and 45 serious cyclist collisions in Ireland between 2005 and 2015 to ascertain the distribution of pre-crash manoeuvres of the cyclist/vehicle and resulting impact configurations, and highlight important environmental factors. A number of common scenarios have been identified. In particular, this study emphasizes the prevalence of left/nearside-turning Heavy Goods Vehicles (HGVs) at junctions in urban environments, and overtaking manoeuvres from bonnet-type vehicles in rural environments. Furthermore, we found that single cyclist collisions are common. Future safety interventions should aim to address these collision types. © 2022 International Research Council on the Biomechanics of Injury. All rights reserved.

关键词： Law enforcement

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Self-Evaluation of the Introduction to Scientific Research Course Design Based on the Affinity Research Groups (ARG) Model

Self-Evaluation of the Introduction to Scientific Research C...

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2024 ASEE Annual Conference and Exposition

作者： Gupta, Navarun Barkana, Buket D. Hu, Jungling DiLuggo, Deana Badara, Ioanna Department of Electrical Engineering The University of Bridgeport BridgeportCT06604 United States Department of Biomedical Engineering The University of Akron AkronOH44325 United States Department of Mechanical Engineering The University of Bridgeport BridgeportCT06604 United States School of Education The University of Bridgeport BridgeportCT06604 United States Departments of Education Post University WaterburyCT United States

Our paper reports the self-evaluation of a research-based course taught in the School of engineering at the University of Bridgeport. The University of Bridgeport received funding from the National Science Foundation Hispanic Serving Institution program in 2022. The project, called Project Achieve, aimed to foster, engage, and retain underserved and underrepresented undergraduate men and women, with particular emphasis on Hispanic students in engineering and computer science majors. As a part of the project, a multi-disciplinary effort among faculty in mechanical, electrical, computer engineering, and computer science designed an undergraduate course, Introduction to Scientific Research, based on the evidence-based Affinity Research Group model, one of the signature models in the Computing Alliance of Hispanic-Serving Institutions (CAHSI) Network. This 2-credit yearlong course offered undergraduate engineering and computer science students an opportunity to participate in authentic research experiences with faculty and graduate students. It had two components: lecture and research activities. Students spent two to four hours per week working on research projects as a team. The course, Introduction to Scientific Research, is cross-listed among Computer, Electrical, mechanical, and Computer Science programs. The course objectives are (1) To identify real-world problems and survey their broader impacts, (2) To brainstorm possible solutions to real-world research problems, (3) To apply the scientific method while solving a real-world research problem, (4) To develop basic laboratory skills and safety procedures relevant to the project, (5) To communicate scientific information in oral formats effectively, (6) To collaborate effectively with a team to solve a scientific problem. The paper presents the faculty, graduate students, and undergraduate students' feedback and experiences following participation in the project as the outcome while providing the details of the co

关键词： Students

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Isoleucine Enriched Branched-Chain Amino Acid Supplement Improves Glucose and Insulin Sensitivity in Healthy College-Age Males but Not in Females

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Food and Nutrition Sciences 2025年第1期16卷 137-152页

作者： Michael Dellogono Lyra Clark Mahdi Garelnabi Thomas A. Wilson Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA USA Department of Biomedical and Nutritional Sciences University of Massachusetts Lowell Lowell MA USA

Athletes often use branched-chain amino acid (BCAAs) supplements with a ratio of 2:1:1 (leucine:isoleucine:valine) for their impact on muscle building. Research suggests that by altering the ratio, an improvement in glucose metabolism might be possible. The purpose of this study was to examine how isoleucine would influence glucose tolerance. We recruited healthy male (n = 13) and female (n = 5) participants who were asked to fast for 12 hours before coming to the laboratory. A fasting blood sample was collected, followed by the subjects consuming a breakfast containing 113 g carbohydrates, 8 g protein, 1.5 g fat, and BCAA powder in the 2:1:1 ratio (Control) or BCAA powder enriched with Isoleucine (2:6:1), both added to orange juice. The opposite meal was consumed on a second visit one week apart. Blood was collected at 30, 60, 90, and 120 minutes post-meal. No differences were observed between the Control and Isoleucine for changes in serum glucose or insulin response when examining all subjects together. However, when comparing between genders, males tended to have a significantly lower serum glucose response compared to females when consuming the Isoleucine, with no difference between the genders when consuming the Control. Also, males had significantly lower serum glucose responses when consuming the Isoleucine compared to when they consumed the Control, while females had significantly higher serum glucose responses when consuming the Isoleucine compared to when they consumed the Control. In general, males tended to have a lower serum insulin response than females when consuming both the Control and the Isoleucine. Our study indicates a significant difference in the way genders respond to BCAA supplementation, where isoleucine may improve glucose tolerance and insulin response in males but not females.

关键词： Isoleucine Branched-Chain Amino Acids Glucose Tolerance Insulin

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Effects of Acid Etching on the Microstructure and Stiffness of Human Teeth

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Journal of engineering and Science in Medical Diagnostics and Therapy 2025年第3期8卷 031005页

作者： Zhai, Yingnan Shi, Zhenshan Premaraj, Thyagaseely Premaraj, Sundaralingam Karpova, Tatiana Dong, Pengfei Gu, Linxia Department of Biomedical Engineering and Science Florida Institute of Technology 150 W. University Blvd MelbourneFL32901 United States Department of Mechanical and Civil Engineering Florida Institute of Technology 150 W. University Blvd MelbourneFL32901 United States College of Dental Medicine Nova Southeastern University 3300 S. University Drive Fort LauderdaleFL33328 United States

The mechanical properties of acid-etched enamel and dentin are important for understanding tooth erosion and developing innovative dental restorative materials. In this study, the microstructure and mechanical properties of both enamel and dentin were characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM) to quantify the impact of acid etching. SEM images demonstrated that enamel rods have a diameter of approximately 5 lm, while dentinal tubules have a diameter of around 2 lm. After acid etching, the intertubular and peritubular regions were exposed, with the peritubular regions showing a thickness of approximately 1 lm. AFM measurements showed that the stiffness of enamel at the bottom, middle, and top layers is 26.2864.24 GPa, 32.0368.68 GPa, and 23.9463.53 GPa, respectively. For dentin, the stiffness is 16.2862.76 GPa at the bottom layer and 17.5965.33 GPa at the middle layer. AFM morphology and stiffness maps illustrated the microstructures of enamel rod and sheaths, as well as dentin tubules in both unetched and acid-etched tooth sections. The stiffness of the acid-etched enamel rod and peritubular dentin decreased by 7-fold and 3.6-fold, respectively, compared to the unetched enamel rod and peritubular dentin. Copyright © 2025 by ASME.

关键词： Stiffness

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Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice

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Journal of Controlled Release 2023年第1期359卷 287-301页

作者： Gracioso Martins, Ana Maria Snider, Douglas B. Popowski, Kristen D. Schuchard, Karl G. Tenorio, Matias Akunuri, Sandip Wee, Junghyun Peters, Kara J. Jansson, Anton Shirwaiker, Rohan Cheng, Ke Freytes, Donald O. Cruse, Glenn P. Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University RaleighNC United States Comparative Medicine and Translational Research Training Program North Carolina State University RaleighNC United States Comparative Medicine Institute North Carolina State University RaleighNC United States Joint Department of Biomedical Engineering College of Engineering North Carolina State University & University of North Carolina-Chapel Hill NC United States Edward P. Fitts Department of Industrial and Systems Engineering North Carolina State University RaleighNC United States Department of Mechanical and Aerospace Engineering North Carolina State University RaleighNC United States Analytical Instrumentation Facility Monteith Research Center North Carolina State University RaleighNC United States

Although nebulizers have been developed for delivery of small molecules in human patients, no tunable device has been purpose-built for targeted delivery of modern large molecule and temperature-sensitive therapeutics to mice. Mice are used most of all species in biomedical research and have the highest number of induced models for human-relevant diseases and transgene models. Regulatory approval of large molecule therapeutics, including antibody therapies and modified RNA highlight the need for quantifiable dose delivery in mice to model human delivery, proof-of-concept studies, efficacy, and dose-response. To this end, we developed and characterized a tunable nebulization system composed of an ultrasonic transducer equipped with a mesh nebulizer fitted with a silicone restrictor plate modification to control the nebulization rate. We have identified the elements of design that influence the most critical factors to targeted delivery to the deep lungs of BALB/c mice. By comparing an in silico model of the mouse lung with experimental data, we were able to optimize and confirm the targeted delivery of over 99% of the initial volume to the deep portions of the mouse lung. The resulting nebulizer system provides targeted lung delivery efficiency far exceeding conventional nebulizers preventing waste of expensive biologics and large molecules during proof-of-concept and pre-clinical experiments involving mice. (Word Count =207). © 2023 Elsevier B.V.

关键词： Molecules

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Quantitative Thrombogenesis Analysis in an In-vitro Microfluidic Chip Using Image Analysis and CFD 9th

Quantitative Thrombogenesis Analysis in an In-vitro Microflu...

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9th International Conference on the Development of biomedical engineering in Vietnam, BME 2022

作者： Choi, Ji-Seob Ham, Dong-Hwi Kim, Jung-Hyun Jeong, Pyeong-Ho Marcial, Helem Betsua Flores Choi, Jin-Ho Park, Woo-Tae Department of Mechanical Engineering Seoul National University of Science and Technology Seoul01811 Korea Republic of Convergence Institute of Biomedical Engineering and Biomaterials Seoul National University of Science and Technology Seoul01811 Korea Republic of Samsung Medical Center Seoul06351 Korea Republic of

ISBN: (纸本)9783031446290

A thrombus is a blood coagulated by external stimuli. Excessive thrombi are dangerous because they have some potential to block blood vessels. The formation of a thrombus is closely related to the wall shear rate (WSR), and studies on this relationship have been investigated worldwide. In this paper, the thrombus formation process as a function of WSR was observed and analyzed using an in-vitro microfluidic chip. In order to locally realize a high WSR, a stenosis section in which the diameter of the channel becomes narrow was designed. The channel with the stenosis section was fabricated with a microfluidic chip made of transparent polydimethylsiloxane (PDMS) material through the thermal expansion method. A blood experiment was conducted to flow whole blood into a microfluidic chip constantly. It was recorded in real-time through a portable microscope. Through the image analysis method presented in this paper, the thrombus formation process was visualized without using fluorescent material, and the thrombus area was quantitatively calculated. In this process, it was observed that the thrombus was formed over three stages: lag time (adhesion of thrombus to the wall), aggregation (thrombus growth), and occlusion (blockage of a channel by the thrombus). In addition, computational fluid dynamics was performed to predict the location of thrombus formation. The volume fraction of plasma was simulated using a two-phase model, assuming that blood is a mixture of red blood cells and plasma. After the stenosis, it was confirmed that the volume fraction of plasma increased as it approached the channel wall. © The Author(s), under exclusive license to Springer Nature Switzerland AG. 2024.

关键词： Microfluidic chips

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DrugEL: Ensemble Learning Model for Identification of Druggable Proteins

DrugEL: Ensemble Learning Model for Identification of Drugga...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Md. Mamun Ali Kawsar Ahmed Francis M. Bui Fang-Xiang Wu Division of Biomedical Engineering University of Saskatchewan Saskatoon Canada Department of Electrical and Computer Engineering University of Saskatchewan Saskatoon Canada Department of Mechanical Engineering and Department of Computer Science Division of Biomedical Engineering University of Saskatchewan Saskatoon Canada

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Druggable proteins are defined as proteins that can interact with drugs to modulate certain biological activity. The identification of druggable proteins holds significant clinical importance, directly impacting the development of targeted therapies for diseases like cancer and metabolic disorders. Identifying druggable proteins involves various methods, including computational prediction models, mass spectrometry (MS), and biochemical assays, but achieving high accuracy remains a challenge. This study proposes DrugEL, an ensemble learning model that uses Bayesian inference to integrate predictions from multiple algorithms: Random Forest (RF), K-Nearest Neighbor (KNN), LightGBM (LGBM), and Decision Tree (DT) with seven feature extraction methods (LSA, AAC, PAAC, GAAC, NMBroto, AAIndex, and KNN). The results show that DrugEL outperforms existing models in terms of accuracy (0.9758), MCC (0.9515), AUC (0.9758), sensitivity (0.9742) and specificity (0.9774), particularly excelling with the LSA method.

关键词： Proteins Analytical models Accuracy Sensitivity Biological system modeling Computational modeling Nearest neighbor methods Predictive models Ensemble learning Random forests

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Soft Tubular Strain Sensors for Contact Detection 12th

Soft Tubular Strain Sensors for Contact Detection

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Proceedings of the 12th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2023

作者： Dai, Kevin Elangovan, Abirami Whirley, Karen Webster-Wood, Victoria A. Department of Mechanical Engineering Carnegie Mellon University Pittsburgh United States Department of Biomedical Engineering Carnegie Mellon University PittsburghPA United States McGowan Institute for Regenerative Medicine Carnegie Mellon University PittsburghPA United States

ISBN: (纸本)9783031388569

Sensing and actuation are intricately connected in soft robotics, where contact may change actuator mechanics and robot behavior. To improve soft robotic control and performance, proprioception and contact sensors are needed to report robot state without altering actuation mechanics or introducing bulky, rigid components. For bioinspired McKibben-style fluidic actuators, prior work in sensing has focused on sensing the strain of the actuator by embedding sensors in the actuator bladder during fabrication, or by adhering sensors to the actuator surface after fabrication. However, material property mismatches between sensors and actuators can impede actuator performance, and many soft sensors available for use with fluidic actuators rely on costly or labor-intensive fabrication methods. Here, we demonstrate a low-cost and easy-to manufacture-tubular liquid metal strain sensor for use with soft actuators that can be used to detect actuator strain and contact between the actuator and external objects. The sensor is flexible, can be fabricated with commercial-off-the-shelf components, and can be easily integrated with existing soft actuators to supplement sensing, regardless of actuator shape or size. Furthermore, the soft tubular strain sensor exhibits low hysteresis and high sensitivity. The approach presented in this work provides a low-cost, soft sensing solution for broad application in soft robotics. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

关键词： Actuators

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Retaining spatial resolution multifocal confocal fluorescence microscopy with deep learning

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Optics Express 2025年第6期33卷 12288-12303页

作者： Suresh, Surag Athippillil Vyas, Sunil Yeh, J. Andrew Luo, Yuan Institute of Nano Engineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Institute of Medical Device and Imaging National Taiwan University Taipei10051 Taiwan Program for Precision Health and Intelligent Medicine National Taiwan University Taipei106319 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10051 Taiwan YongLin Institute of Health National Taiwan University Taipei10087 Taiwan

Confocal microscopy is a standard modality for volumetric imaging of biological samples due to its high spatial resolution and signal-to-noise ratio (SNR). However, the slow point-by-point scanning process limits its image acquisition speed. Multifocal illumination allows for faster acquisition but compromises spatial resolution. Here, we introduce a deep learning approach for multifocal confocal microscopy that achieves faster acquisition while preserving high resolution. The proposed model is based on image-to-image translation, implemented using modified U-Net, ResU-Net, and Attention U-Net architectures. The model is trained and tested on paired experimental datasets, with conventional confocal images as groundtruth and multifocal confocal images as input from various biological samples. The modified Attention U-Net significantly improves image quality and retains structural details, with higher peak SNR (32.83 dB) and structural similarity index measure (0.935) values. Additionally, spatial frequency analysis and Fourier ring correlation confirm that the Attention U-Net outperforms other models in preserving both low-frequency (>0.92 accuracy) and high-frequency information (0.90 vs. 0.83 for U-Net). Performance metrics demonstrate that our models match the quality of traditional confocal imaging, increasing imaging speed and addressing the trade-off between speed and resolution in multifocal confocal microscopy. These findings underscore the potential of combining deep learning with various confocal imaging applications. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Fluorescence microscopy

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