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An exploration of frictional and vibrational behaviors of textured deep groove ball bearing in the vicinity of requisite minimum load

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Friction 2021年第6期9卷 1749-1765页

作者： K.E.Ch.VIDYASAGAR R.K.PANDEY Dinesh KALYANASUNDARAM Center for Biomedical Engineering Indian Institute of Technology DelhiNew Delhi 110016India Department of Biomedical Engineering College of EngineeringOsmania UniversityTelangana 500007India Department of Mechanical Engineering Indian Institute of Technology DelhiNew Delhi 110016India Department of Biomedical Engineering Indian Institute of Technology DelhiNew Delhi 110016India

In case of lightly loaded radial ball bearings,failure mechanisms other than fatigue such as smearing of raceways due to increased frictional torque and vibrations often ***,attempts have been made herein for reducing the frictional torque and minimizing the vibrations of a radial deep groove ball bearing employing surface textures at the inner *** pulsed laser was used to create texture(involving micro-dimples having different dimple area density)on the inner race of test *** an in-house developed test rig,frictional torque and vibrational parameters were measured at different speeds and light loads(*** vicinity of 0.01C,where C is dynamic load capacity of radial ball bearing).Significant reduction in frictional torque and overall vibrations were found in the presence of micro-dimples on inner race at light loads irrespective of operating *** without satisfying the minimum load needed criteria for the satisfactory operation,substantial reduction in smearing marks was found on the races of textured ball bearings in comparison to conventional cases.

关键词： ball bearing textured inner race grease lubricated frictional torque vibration

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Bioinspiration review of Aquatic Unmanned Aerial Vehicle(AquaUAV)

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Biomimetic Intelligence & Robotics 2024年第2期4卷 1-11页

作者： Xinyang Wang Jjiawei Zhao Xuan Pei Tianmiao Wang Taogang Hou Xingbang Yang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Bioengineering Imperial College LondonLondon SW72AZUK School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Biological Science and Medical Engineering Bejing Advanced Innovation Centre for Biomedical EngineeringKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationBeihang UniversityBeijing 100191China

The performance of Aquatic Unmanned Aerial Vehicle(AquaUAV)has always been limited so far and far from practical applications,due to insufficient propulsion,large-resistance structure ***-aquatic amphibians in nature may facilitate the development of AquaUAV since their excellent amphibious locomotion capabilities evolved under long-term natural *** article will take four typical aerial-aquatic amphibians as representatives,i.e.,gannet,cormorant,flying fish and flying *** summarized the multi-mode locomotion process of common aerial-aquatic amphibians and the evolutionary trade-offs they have made to adapt to amphibious *** four typical propulsion mechanisms were investigated,which may further inspire the propulsion design of the *** their morphological models could guide the layout ***,we reviewed the state of art in AquaUAV to validate the potential value of our bioinspiration,and discussed the futureprospects.

关键词： Aerial-aquatic amphibians Multi-mode locomotion trade-offs Propulsion mechanism Morphological design

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Multiplane differential saturated excitation microscopy using varifocal lenses

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biomedical Optics Express 2024年第2期15卷 953-964页

作者： Luo, Chi-Hao Vyas, Sunil Huang, Kuang-Yuh Chu, Shi-Wei Luo, Yuan Institute of Mechanical Engineering National Taiwan University Taipei10617 Taiwan Institute of Medical Device and Imaging National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University 10051 Taiwan Department of Biomedical Engineering National Taiwan University 10051 Taiwan YongLin Institute of Health National Taiwan University Taipei10087 Taiwan

Saturated excitation microscopy, which collects nonlinear fluorescence signals generated by saturation, has been proposed to improve three-dimensional spatial resolution. Differential saturated excitation (dSAX) microscopy can further improve the detection efficiency of a nonlinear fluorescence signal. By comparing signals obtained at different saturation levels, high spatial resolution can be achieved in a simple and efficient manner. High-resolution multiplane microscopy is perquisite for volumetric imaging of thick samples. To the best of our knowledge, no reports of multiplane dSAX have been made. Our aim is to obtain multiplane high-resolution optically sectioned images by adapting differential saturated excitation in confocal laser scanning fluorescence microscopy. To perform multiplane dSAX microscopy, a variable focus lens is employed in a telecentric design to achieve focus tunability with constant magnification and contrast throughout the axial scanning range. Multiplane fluorescence imaging of two different types of pollen grains shows improved resolution and contrast. Our system’s imaging performance is evaluated using standard targets, and the results are compared with standard confocal microscopy. Using a simple and efficient method, we demonstrate multiplane high-resolution fluorescence imaging. We anticipate that high-spatial resolution combined with high-speed focus tunability with invariant contrast and magnification will be useful in performing 3D imaging of thick biological samples. © 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Fluorescence imaging

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Design single-stranded DNA aptamer of cluster of differentiation 47 protein by stochastic tunnelling-basin hopping-discrete molecular dynamics method

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Journal of Biomolecular Structure and Dynamics 2024年第8期42卷 3969-3982页

作者： Yang, Hung-Wei Ju, Shin-Pon Hsieh, Yun-Te Yang, Yung-Cheng Department of Biomedical Engineering National Cheng Kung University Tainan City Taiwan Medical Device Innovation Center National Cheng Kung University Tainan City Taiwan Department of Mechanical and Electro-Mechanical Engineering National Sun Yat-sen University Kaohsiung Taiwan Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung Taiwan

The formation of the Cluster of Differentiation 47 (CD47, PDB code: 2JJT)/signal regulatory protein α (SIRPα) complex is very important as it protects healthy cells from immune clearance while promoting macrophage phagocytosis for tumour elimination. Although several antibodies have been developed for cancer therapy, new function-blocking aptamers are still under development. This study aims to design the aptamer Apt_CD47, which can block the formation of the CD47/SIRPα complex. This study employs the MARTINI coarse-grained (CG) force field and the stochastic tunnelling-basin hopping-discrete molecular dynamics (STUN-BH-DMD) method to identify the most stable Apt_CD47/CD47 complexes. Coarse-grained molecular dynamics (CGMD) simulations were used to obtain root-mean-square deviation (RMSD) and root-mean-square fluctuation (RMSF) analyses. The results demonstrate that the formation of Apt_CD47/CD47 complexes renders the CD47 structure more stable than the single CD47 molecule in a water environment. The minimum energy pathway (MEP) obtained by the nudged elastic band (NEB) method indicates that the binding processes of 5′-ATTCAATTCC-3′ and 5′-AGTGCAATCT-3′ to CD47 are barrierless, which is much lower than the binding barrier of SIRPα to CD47 of about 14.23 kcal/mol. Therefore, these two Apt_CD47/CD47 complexes can create a high spatial binding barrier for SIRPα, preventing the formation of a stable CD47/SIRPα complex. The proposed numerical process with the MARTINI CG force field can be used to design CD47 aptamers that efficiently block SIRPα from binding to CD47. Communicated by Ramaswamy H. Sarma. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Aptamer design cluster of differentiation 47 coarse-grained molecular dynamics MARTINI force field signal regulatory protein α single-stranded DNA

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Feasibility Study of a Teleoperation System With Haptics for Tip-Force Sensing Active Needles

Feasibility Study of a Teleoperation System With Haptics for...

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IEEE/RAS-EMBS International Conference on biomedical Robotics and Biomechatronics (BioRob)

作者： Sooyeon Kim Sujin Yu Yuri Lim Suhyun Lee Seok Chang Ryu Department of Mechanical and Biomedical Engineering BioRobotics Laboratory Graduate Program in Smart Factory Ewha Womans University Seoul South Korea Department of Mechanical and Biomedical Engineering BioRobotics Laboratory Ewha Womans University

ISBN: (数字)9798350386523

ISBN: (纸本)9798350386530

This paper presents the design of a teleoperation system with a haptic display for the active needles with tip-force sensing and tip-steering capabilities. The active needle design employs sensorized tendons by fiber Bragg gratings sensor (FBGs), while the teleoperation system combines a general haptic interface with electrical stimulation as its steering interface, delivering not only general force feedback but also tip-force information measured by the FBGs-based tendons to the operators. The essential features, such as tip-force sensing, teleoperation of the tip-joint, and human perception of the measured tip-force, were experimentally evaluated with their prototypes in tissue phantoms. Based on the results obtained, necessary follow-up studies were identified and suggested for the effective teleoperation of force-sensing steerable instruments in clinical environments. If successfully developed, such systems can enable surgeons to perceive clinical situations and perform operations more precisely and safely.

关键词： Instruments Surgery Prototypes Phantoms biomedical measurement Robot sensing systems Needles Fiber gratings Sensors Tendons

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Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

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Introducing a comprehensive methodology for optimizing the mass of realistic roofing structural systems using cold-formed steel profiles

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Discover Civil engineering 2024年第1期1卷 1-22页

作者： Fruet, Gustavo Miguel, Letícia Fleck Fadel Federal University of Rio Grande Do Sul Department of Civil Engineering Postgraduate Program in Civil Engineering Porto Alegre Brazil Federal University of Rio Grande do Sul Department of Mechanical Engineering Postgraduate Program in Mechanical Engineering Postgraduate Program in Civil Engineering Porto Alegre Brazil

This study aims to introduce a comprehensive methodology for optimizing complete real structural systems for roofs involving trusses, purlins, and bracing systems jointly, taking into account realistic loads and constraints dictated by technical codes, thereby offering a more accurate representation of practical scenarios. The objective is to achieve the minimum mass through size, shape, and topology optimization of both the main truss and purlin structural subsystems. To achieve this goal, the Enhanced Particle Swarm Optimization (EPSO) algorithm is implemented. An example of a realistic case, which takes into account multiple actual constraints such as stress, displacement, buckling, and natural frequency limits, is thoroughly evaluated. After that, 144 other interactions among dimensions of the building and loads applied are simulated, and the mass of the system is obtained for each one of them. The results indicated that the graphs generated from the various simulations allow for the determination of the optimized mass for different building dimensions. Consequently, the cost and raw material consumption can be estimated for common applications. Therefore, it is concluded that this work presents a significant contribution to structural designers, as the proposed methodology enables structural optimization quickly and easily for practical engineers.

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HCCL: Hierarchical Channels and Contrastive Learning for Drug-Gene Multi-Relation Prediction

HCCL: Hierarchical Channels and Contrastive Learning for Dru...

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2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： Shang, Yizhe Chen, Jianrui Lei, Xiujuan Wu, Fang-Xiang Shaanxi Normal University School of Computer Science Xi'an China University of Saskatchewan Department of Mechanical Engineering Division of Biomedical Engineering Department of Computer Science SaskatoonS7N 5A9 Canada

ISBN: (纸本)9798350386226

Drug-gene interaction plays a crucial role in drug discovery and personalized medicine. Although existing methods have improved the accuracy of exploring multiple relationships between drugs and genes, there are still some limitations, such as susceptibility to data sparsity and poor generalization, which pose some challenges for practical applications. To address these challenges, we propose a novel Hierarchical Channels and Contrastive Learning (HCCL) framework in which drug feature extractor captures structural information of drug molecules from atom and bond channels. After obtaining the initial features of drugs and genes, we employ high-low-order channels to update them, where the low-order channel adopts graph convolutional networks while the high-order channel leverages hypergraph structures for message propagation. Finally, we adopt contrastive learning and inter-channel attention to fuse high-low-order features, which improves the robustness of the model and prevents feature information loss. Experimental results demonstrate the superior performance of HCCL. © 2024 IEEE.

关键词： Contrastive Learning

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Multidisciplinary Learning Using Online Networking in biomedical engineering 26

Multidisciplinary Learning Using Online Networking in Biomed...

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26th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2022

作者： Hashimoto, Shigehiro Doctor of Engineering Doctor of Medicine Biomedical Engineering Department of Mechanical Engineering Kogakuin University Tokyo163-8677 Japan

ISBN: (纸本)9781950492640

Multifaceted thinking is important to tackle global issues for a sustainable society. It is difficult to select useful information from big data with one-sided thinking. This article takes as an example the controversy related to "vaccines" and "masks" in pandemics. Online is useful under the control of infectious diseases. Face-to-face group meetings make it easy to interrupt group activities for individual activities. Online meetings are considering various ideas as an alternative to face-to-face meetings. The field of biomedical engineering includes faculties and students from diverse backgrounds. "Cross-cultural exchange" is also useful for multifaceted experiences. With the keyword "life support technology", Japanese academic society and Thai university conducted online networking for information exchange. The academic society is working to encourage students. The university is developing new fields. Information exchange is expected to lead to further development in complex fields. It is expected to lead to the development of human resources who can deal with global problems. Copyright 2022. © by the International Institute of Informatics and Systemics. All rights reserved.

关键词： Students

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Magnetic Force Enhanced Sustainability and Power of Cam-Based Triboelectric Nanogenerator

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Research 2021年第1期2021卷 370-380页

作者： Hakjeong Kim Hee Jae Hwang Nghia Dinh Huynh Khanh Duy Pham Kyungwho Choi Dahoon Ahn Dukhyun Choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee UniversityYongin 17104Republic of Korea Department of Mechanical Engineering Korea Aerospace UniversityGoyang 10540Republic of Korea Division of Mechanical Engineering Kongju National UniversityCheonan 31080Republic of Korea

Since the first invention of triboelectric nanogenerators(TENGs)in 2012,many mechanical systems have been applied to operate TENGs,but mechanical contact losses such as friction and noise are still big obstacles for improving their output performance and ***,we report on a magnet-assembled cam-based TENG(MC-TENG),which has enhanced output power and sustainability by utilizing the non-contact repulsive force between the *** investigate the theoretical and experimental dynamic behaviors of MC-TENGs according to the effects of the contact modes,contact and separation times,and contact forces(i.e.,pushing and repulsive forces).We suggest an optimized arrangement of magnets for the highest output performance,in which the charging time of the capacitor was 2.59 times faster than in a mechanical cam-based TENG(C-TENG).Finally,we design and demonstrate a MC-TENG-based windmill system to effectively harvest low-speed wind energy,~4 m/s,which produces very low ***,it is expected that our frictionless MC-TENG system will provide a sustainable solution for effectively harvesting a broadband of wasted mechanical energies.

关键词： friction magnets generator

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