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Scalable fabrication of microneedle arrays via spatially controlled UV exposure

microsystems & Nanoengineering 2016年第1期2卷 73-81页

作者： Hidetoshi Takahashi Yun Jung Heo Nobuchika Arakawa Tesuo Kan Kiyoshi Matsumoto Ryuji Kawano Isao Shimoyama Department of Mechano-Informatics Graduate School of Information Science and Technologythe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Department of Mechanical Systems Engineering Graduate School of EngineeringTokyo University of Agriculture and Technology2-24-16 Naka-choKoganei-shiTokyo 184-8588Japan Department of Mechanical Engineering and Intelligent Systems Graduate School of Informatics and Engineeringthe University of Electro-Communications1-5-1 ChofugaokaChofu-shiTokyo 182-8585Japan IRT Research Initiative the University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Department of Biotechnology and Life Science Graduate School of EngineeringTokyo University of Agriculture and Technology2-24-16 Naka-choKoganei-shiTokyo 184-8588Japan

This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet(UV)lithography based on spatially controlled UV exposure *** comparison with other methods based on UV lithography,the present method can create microneedle structures with high *** negative photoresist is exposed to inclined/rotated UV through circular mask patterns,a three-dimensional,needle-shaped distribution of the exposure dose forms in the irradiated *** the inclination angles and the exposure dose modifies the photo-polymerized portion of the photoresist,thus allowing the variation of the heights and contours of microneedles formed by using the same mask *** an experimental study,the dimensions of the fabricated needles agreed well with the theoretical predictions for varying inclination angles and exposure *** results demonstrate that our theoretical approach can provide a simple route for fabricating microneedles with on-demand *** fabricated microneedles can be used as solid microneedles or as a mold master for dissolving microneedles,thus simplifying the microneedle fabrication *** envision that this method can improve fabrication accuracy and reduce fabrication cost and time,thereby facilitating the practical applications of microneedle-based drug delivery technology.

关键词： inclined/rotated lithography microneedle array UV exposure ratio

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Self-folding and self-actuating robots: A pneumatic approach

Self-folding and self-actuating robots: A pneumatic approach

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IEEE International Conference on Robotics and Automation (ICRA)

作者： Xu Sun Samuel M. Felton Ryuma Niiyama Robert J. Wood Sangbae Kim Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA USA the School of Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA USA Department of Mechano-Informatics and Intelligent Systems & Informatics Lab University of Tokyo Bunkyo-Ku Tokyo Japan

ISBN: (纸本)9781479969241

Self-assembling robots can be transported and deployed inexpensively and autonomously in remote and dangerous environments. In this paper, we introduce a novel self-assembling method with a planar pneumatic system. Inflation of pouches translate into shape changes, turning a sheet of composite material into a complex robotic structure. This new method enables a flat origami-based robotic structure to self-fold to desired angles with pressure control. It allows a static joint to become dynamic, self-actuate to reconfigure itself after initial folding. Finally, the folded robot can unfold itself at the end of a robotic application. We believe this new pneumatic approach provides an important toolkit to build more powerful and capable self-assembling robots.

关键词： Fasteners Joints Valves Robots Grippers Pneumatic systems Shape

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One double-stranded DNA probes as classifier of multi targeting strand

One double-stranded DNA probes as classifier of multi target...

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International Symposium on micromechatronics and Human Science (MHS)

作者： Wibowo Adi Kosuke Sekiyama Department of Informatics Diponegoro University Central Java Indonesia Department of Micro-nano Systems Engineering Nagoya University Nagoya Japan

In this paper, we investigate an alternative double-stranded probe (dsProbe) system as detection platform that employs a similarity-based classifiers in DNA strand displacement reactions. We formulate label propagation based on DNA toehold domain as classifier, where a node propagates to neighboring nodes according to their proximity. We observe mismatch attributes of DNA strand sequences to recognize the effect of this model. The attributes are position, length and location number of mismatches. We carry out simulation using Nupack software and also experimental investigation..

关键词： DNA Fluorescence Probes Educational institutions Software Sensors Classification algorithms

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18th European Symposium on Radiopharmacy and Radiopharmaceuticals Salzburg, Austria. 7-10 April 2016

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EJNMMI RADIOPHARMACY AND CHEMISTRY 2016年第1期1卷 1-37页

作者： [Anonymous] Los Alamos National Laboratory Los Alamos USA Oak Ridge National Laboratory Oak Ridge USA Department of Nuclear Medicine Medical University Innsbruck Innsbruck Austria Department of Radiology & Nuclear Medicine Radboud University Medical Center Nijmegen The Netherlands Institute of Molecular and Translational Medicine Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic Département de Médecine Nucléaire et Radiobiologie Faculté de Médecine et Sciences de la Santé Université de Sherbrooke Sherbrooke Canada Centre d’Imagerie Moléculaire de Sherbrooke (CIMS) CR-CHUS Sherbrooke Canada Division of Molecular Biology/Biocenter Medical University Innsbruck Innsbruck Austria Department of Nuclear Medicine Radboud University Medical Center Nijmegen The Netherlands IENI-CNR Padua Italy DiSCOG-University of Padua Padua Italy IOV Padua Padua Italy IC-CNR Bari Italy IBB-CNR Naples Italy Laboratory of Radiopharmacy KU Leuven Leuven Belgium Micro Flow Chemistry & Process Technology Chemical Engineering and Chemistry Department TU Eindhoven Eindhoven The Netherlands Laboratory for Radiopharmacy University of Leuven Leuven Belgium Department of Nuclear Medicine and Molecular Imaging University of Leuven Leuven Belgium Department of Medicine and Surgery Tecnomed Foundation University of Milano-Bicocca Milan Italy Dipartimento di Biotecnologie Mediche e Medicina Traslazionale Università degli Studi di Milano Milan Italy Department of Radiology & Nuclear Medicine VU University Medical Center Amsterdam The Netherlands Department of Clinical Pharmacology & Pharmacy VU University Medical Center Amsterdam The Netherlands Université de Lorraine Vandoeuvre les Nancy France NancycloTEP Plateforme d’imagerie expérimentale Vandoeuvre les Nancy France CNRS UMR 7565 SRSMC Vandoeuvre les Nancy France CHU de Nancy-Brabois Vandoeuvre les Nancy France Department of Biomedical Imaging and Image-guided Therapy Division of Nuclear Medicine Medical Univers

Table of contents OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets V. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. Fassbender OP04 Comparison of [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD for PET imaging of alpha v beta 3 integrin expression Chuangyan Zhai, Gerben M. Franssen, Milos Petrik, Peter Laverman, Clemens Decristoforo OP05 A new NPY-Y1R targeting peptide for breast cancer PET imaging Ait-Mohand Samia, Dumulon-Perreault Veronique, Guerin Brigitte OP06 The influence of multivalency on CCK 2 receptor targeting D. Summer, A. Kroess, C. Rangger, H. Haas, P. Laverman, F. Gerben, E. von Guggenberg, *** OP07 SPECT Imaging of alpha v beta 3 Expression by [99mTc(N)PNP43]- Bifunctional Chimeric RGD Peptide not Cross-Reacting with alpha v beta 5 Cristina Bolzati, Nicola Salvarese, Fiorenzo Refosco, Laura Melendez-Alafort, Debora Carpanese, Antonio Rosato, Michele Saviano, Annarita Del Gatto, Daniela Comegna, Laura Zaccaro OP09 New dienophiles for the inverse-electron-demand Diels-Alder reaction and for pretargeted PET imaging Emilie Billaud, Muneer Ahamed, Frederik Cleeren, Elnaz Shahbazali, Tim Noel, Volker Hessel, Alfons Verbruggen and Guy Bormans OP10 New complexing agent for Al18F-labelling of heat-sensitive biomolecules: Synthesis and preclinical evaluation of Al18F-RESCA1-HAS Cleeren F, Lecina J, Koole M, Verbruggen A and Bormans G OP11 A novel versatile precursor efficient for F-18 radiolabelling via click-chemistry B. Lugatoa, S. Stucchia, E.A. Turollaa, L. Giulianoa, ***, P. Ferraboschib OP12 A general applicable method to quantify unidentified UV impurities in radiopharmaceuticals R.P. Klok, M.P.J. Mooijer, N.H. Hendrikse, A.D. Windhorst OP13 Development of [F-18]Fluoro-C-glycosides to radiolabel peptides Collet C., Petry N., Chretien F., Karcher G., Pellegrini-Moise N., Lamande-Langle S. OP14 A microfluidic Approach for the 68

关键词： Positron Emission Tomography Single Photon Emission Compute Tomography Standard Uptake Value Positron Emission Tomography Imaging High Pressure Liquid Chromatography

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Human arm optimal motion analysis in industrial screwing task

Human arm optimal motion analysis in industrial screwing tas...

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IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)

作者： N. Sylla V. Bonnet G. Venture N. Armande P. Fraisse PSA Peugeot Citroen Research and Development Department Centre Technique de Vlizy France LIRMM (Montpellier laboratory of Informatics Robotics and Micro-electronics) Montpellier France Dpt. of Mechanical Systems Engineering Tokyo University Japan

In this study, we propose to explore inverse optimization process to better understand human arm motion in industrial screwing task. The process combines several criteria to minimize such as energy expenditure or trajectory smoothness leading to the optimal trajectory of a typical screwing task, often performed by workers. Estimated joint trajectories are similar with the measured ones, with a mean square error of 4 degrees. The resulting cost-function is mainly composed of energy expenditure and geodesic criteria. Results show the relevance of using composite cost function in human motion planning. This study has been conducted to assist workers by using collaborative robots in painful task in PSA Peugeot Citroen factories to improve ergonomics of manual workstations.

关键词： Joints Cost function Trajectory Torque Shoulder Wrist

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Novel Liquid Equilibrium Valving on Centrifugal microfluidic CD Platform

Novel Liquid Equilibrium Valving on Centrifugal Microfluidic...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Wisam Al-Faqheri Fatimah Ibrahim Tzer Hwai Gilbert Thio Hamzah Arof Marc Madou Medical Informatics & Biological Micro-electro-mechanical Systems (MIMEMS) Specialized Laboratory Department of Biomedical Engineering Faculty of Engineering University of Malaya

ISBN: (纸本)9781457702150

One of the main challenges faced by researchers in the field of microfluidic compact disc (CD) platforms is the control of liquid movement and sequencing during spinning. This paper presents a novel microfluidic valve based on the principle of liquid equilibrium on a rotating CD. The proposed liquid equilibrium valve operates by balancing the pressure produced by the liquids in a source and a venting chamber during spinning. The valve does not require external forces or triggers, and is able to regulate burst frequencies with high accuracy. In this work, we demonstrate that the burst frequency can be significantly raised by making just a small adjustment of the liquid height in the vent chamber. Finally, the proposed valve ng method can be used separately or combined with other valving methods in advance microfluidic processes.

关键词： liquids Compact disc microfluidics CTLA4 gene NOD2 gene cadmium PRESSURE BALANCE TRIGGERS VALVE GATE Platform Spin Spinning

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Is the developmental order of fetal behaviors self-organized in an uterine environment?

Is the developmental order of fetal behaviors self-organized...

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IEEE International Conference on Development and Learning, ICDL

作者： Hiroki Mori Yasuo Kuniyoshi Department of Adaptive Machine Systems Graduate School of Engineering Osaka University Department of Mechano-Informatics Graduate School of Information Science and technology The University of Tokyo

Developmental order is one of the fundamental issues of developmental science. de Vries et al. 1982 observed fetal behaviors and suggested that the orders of the timing of first appearance of the behaviors are consistent among fetuses in utero. We have investigated the fetal behavioral development by a computer simulation that has a whole fetal musculoskeletal body, a uterine environment and a nervous system. In this paper, we analyzed data of our simulated fetal behaviors from a perspective of the first appearance. The analysis shows that the order is consistently same as the observation by de Vries et al. 1982 regardless of the value of a nervous system model parameter. The result indicates that physical constraints, including musculoskeletal system, tactile cell distribution, and uterine environment, induce the self-organization of the developmental order.

关键词： Face Indexes Nervous system Standards Educational institutions Timing Pediatrics

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A Comparative Approach to ECG Feature Extraction Methods

A Comparative Approach to ECG Feature Extraction Methods

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International Conference on Intelligent systems, Modelling and Simulation (ISMS)

作者： Fatemeh Molaei Vaneghi Maysam Oladazimi F. Shiman Afshan Kordi M.J. Safari F. Ibrahim Medical Informatics and Biological Micro-electro-mechanical Systems (MIMEMS) Specialized laboratory Department of Biomedical Engineering Faculty of Engineering University Malaya Kuala Lumpur Malaysia

This paper discusses six most frequent methods used to extract different features in Electrocardiograph (ECG) signals namely Autoregressive (AR), Wavelet Transform (WT), Eigenvector, Fast Fourier Transform (FFT), Linear Prediction (LP), and Independent Component Analysis (ICA). The study reveals that Eigenvector method gives better performance in frequency domain for the ECG feature extraction.

关键词： Electrocardiography Feature extraction Wavelet transforms Noise Time frequency analysis

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A numerical analysis of electric field strength over planar microarray dot electrode for dielectrophoretic lab-on-chip device

A numerical analysis of electric field strength over planar ...

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IEEE EMBS Conference on Biomedical engineering and Sciences (IECBES)

作者： B. Yafouz N.A. Kadri F. Ibrahim Medical Informatics and Biological Micro-Electro-Mechanical Systems (MIMEMS) Specialized Laboratory Department of Biomedical Engineering Faculy of Engineering University of Malaya Kuala Lumpur Malaysia

Dielectrophoresis (DEP) has been proven as a method of manipulating and analyzing the electrophysiological properties of bioparticles by applying non-uniform electric fields generated through special electrodes. Various electrode geometries have been developed to address different applications. Simulation of the electric field strength over electrodes is essential in order to optimize the generated DEP force for enhancing cell manipulation. This paper describes the study of electric field distribution over planar multiple microarray dot electrode using numerical modeling of Comsol Multiphysics 4.2a ® . Results show that the electric field strength is axisymmetrical around the centre of the dot aperture and that is higher at the dot edges than the dot centers. Further studies will be conducted to investigate the effect of applying different frequencies, varying dots size and adding ground plane in between the electrode dots.

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