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Comparative cellular analysis of motor cortex in human, marmoset and mouse (vol 598, pg 111, 2021)

NATURE 2022年第7904期604卷 E8-E8页

作者： Bakken, Trygve E. Jorstad, Nikolas L. Hu, Qiwen Lake, Blue B. Tian, Wei Kalmbach, Brian E. Crow, Megan Hodge, Rebecca D. Krienen, Fenna M. Sorensen, Staci A. Eggermont, Jeroen Yao, Zizhen Aevermann, Brian D. Aldridge, Andrew I. Bartlett, Anna Bertagnolli, Darren Casper, Tamara Castanon, Rosa G. Crichton, Kirsten Daigle, Tanya L. Dalley, Rachel Dee, Nick Dembrow, Nikolai Diep, Dinh Ding, Song-Lin Dong, Weixiu Fang, Rongxin Fischer, Stephan Goldman, Melissa Goldy, Jeff Graybuck, Lucas T. Herb, Brian R. Hou, Xiaomeng Kancherla, Jayaram Kroll, Matthew Lathia, Kanan van Lew, Baldur Li, Yang Eric Liu, Christine S. Liu, Hanqing Lucero, Jacinta D. Mahurkar, Anup McMillen, Delissa Miller, Jeremy A. Moussa, Marmar Nery, Joseph R. Nicovich, Philip R. Niu, Sheng-Yong Orvis, Joshua Osteen, Julia K. Owen, Scott Palmer, Carter R. Pham, Thanh Plongthongkum, Nongluk Poirion, Olivier Reed, Nora M. Rimorin, Christine Rivkin, Angeline Romanow, William J. Sedeno-Cortes, Adriana E. Siletti, Kimberly Somasundaram, Saroja Sulc, Josef Tieu, Michael Torkelson, Amy Tung, Herman Wang, Xinxin Xie, Fangming Yanny, Anna Marie Zhang, Renee Ament, Seth A. Behrens, M. Margarita Bravo, Hector Corrada Chun, Jerold Dobin, Alexander Gillis, Jesse Hertzano, Ronna Hof, Patrick R. Hollt, Thomas Horwitz, Gregory D. Keene, C. Dirk Kharchenko, Peter V. Ko, Andrew L. Lelieveldt, Boudewijn P. Luo, Chongyuan Mukamel, Eran A. Pinto-Duarte, Antonio Preiss, Sebastian Regev, Aviv Ren, Bing Scheuermann, Richard H. Smith, Kimberly Spain, William J. White, Owen R. Koch, Christof Hawrylycz, Michael Tasic, Bosiljka Macosko, Evan Z. McCarroll, Steven A. Ting, Jonathan T. Zeng, Hongkui Zhang, Kun Feng, Guoping Ecker, Joseph R. Linnarsson, Sten Lein, Ed S. Allen Institute for Brain Science Seattle WA USA Department of Physiology and Biophysics University of Washington Seattle WA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Bioengineering University of California San Diego La Jolla CA USA The Salk Institute for Biological Studies La Jolla CA USA Epilepsy Center of Excellence Department of Veterans Affairs Medical Center Seattle WA USA Stanley Institute for Cognitive Genomics Cold Spring Harbor Laboratory Cold Spring Harbor NY USA Department of Genetics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA LKEB Department of Radiology Leiden University Medical Center Leiden The Netherlands Pattern Recognition and Bioinformatics group Delft University of Technology Delft The Netherlands J. Craig Venter Institute La Jolla CA USA Department of Pathology University of California San Diego CA USA Division of Vaccine Discovery La Jolla Institute for Immunology La Jolla CA USA Genomic Analysis Laboratory The Salk Institute for Biological Studies La Jolla CA USA Computer Science and Engineering Program University of California San Diego La Jolla CA USA Howard Hughes Medical Institute The Salk Institute for Biological Studies La Jolla CA USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Institute for Genomes Sciences University of Maryland School of Medicine Baltimore MD USA Center for Epigenomics Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA Ludwig Institute for Cancer Research La Jolla CA USA Department of Computer Science University of Maryland College Park College Park MD USA Sanford Burnham Prebys Medical Discovery Institute La Jolla CA USA Biomedical Sciences Program School of Medicine University of California San Diego La Jolla CA USA University of Connecticut Storrs CT USA Department

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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation (vol 618, pg 365, 2023)

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NATURE 2023年第7968期619卷 E24-E24页

作者： Paredes, Ana Justo-Mendez, Raquel Jimenez-Blasco, Daniel Nunez, Vanessa Calero, Irene Villalba-Orero, Maria Alegre-Marti, Andrea Fischer, Thierry Gradillas, Ana Sant'Anna, Viviane Aparecida Rodrigues Were, Felipe Huang, Zhiqiang Hernansanz-Agustin, Pablo Contreras, Carmen Martinez, Fernando Camafeita, Emilio Vazquez, Jesus Ruiz-Cabello, Jesus Area-Gomez, Estela Sanchez-Cabo, Fatima Treuter, Eckardt Bolanos, Juan Pedro Estebanez-Perpina, Eva Ruperez, Francisco Javier Barbas, Coral Enriquez, Jose Antonio Ricote, Mercedes Cardiovascular Regeneration Program Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid Spain Departamento de Medicina y Cirugía Animal Universidad Complutense de Madrid (UCM) Madrid Spain CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES) Madrid Spain Institute of Functional Biology and Genomics (IBFG) University of Salamanca CSIC Salamanca Spain Institute for Biomedical Research of Salamanca (IBSAL) Salamanca Spain Department of Biochemistry and Molecular Biomedicine Institute of Biomedicine (IBUB) of the University of Barcelona (UB) Barcelona Spain Department of Immunology and Oncology Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM) Madrid Spain Centro de Metabolómica y Bioanálisis (CEMBIO) Facultad de Farmacia Universidad San Pablo-CEU CEU Universities Madrid Spain Bioinformatics Unit Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid Spain CIBER de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid Spain CIC biomaGUNE Basque Research and Technology Alliance (BRTA) San Sebastian Spain Ikerbasque Basque Foundation for Science Bilbao Spain CIBER de Enfermedades Respiratorias (CIBERES) Madrid Spain Departamento de Ciencias Farmacéuticas Facultad de Farmacia Universidad Complutense Madrid (UCM) Madrid Spain Departament of Cellular and Molecular Biology Centro de Investigaciones Biológicas Margarita Salas-CSIC Madrid Spain Department of Neurology Columbia University Medical Campus New York NY USA

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Africa-specific human genetic variation near CHD1L associates with HIV-1 load (vol 620, pg 1025, 2023)

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NATURE 2023年第7979期621卷 E42-E42页

作者： McLaren, Paul J. Porreca, Immacolata Iaconis, Gennaro Mok, Hoi Ping Mukhopadhyay, Subhankar Karakoc, Emre Cristinelli, Sara Pomilla, Cristina Bartha, Istvan Thorball, Christian W. Tough, Riley H. Angelino, Paolo Kiar, Cher S. Carstensen, Tommy Fatumo, Segun Porter, Tarryn Jarvis, Isobel Skarnes, William C. Bassett, Andrew DeGorter, Marianne K. Moorthy, Mohana Prasad Sathya Tuff, Jeffrey F. Kim, Eun-Young Walter, Miriam Simons, Lacy M. Bashirova, Arman Buchbinder, Susan Carrington, Mary Cossarizza, Andrea De Luca, Andrea Goedert, James J. Goldstein, David B. Haas, David W. Herbeck, Joshua T. Johnson, Eric O. Kaleebu, Pontiano Kilembe, William Kirk, Gregory D. Kootstra, Neeltje A. Kral, Alex H. Lambotte, Olivier Luo, Ma Mallal, Simon Martinez-Picado, Javier Meyer, Laurence Miro, Jose M. Moodley, Pravi Motala, Ayesha A. Mullins, James I. Nam, Kireem Obel, Niels Pirie, Fraser Plummer, Francis A. Poli, Guido Price, Matthew A. Rauch, Andri Theodorou, Ioannis Trkola, Alexandra Walker, Bruce D. Winkler, Cheryl A. Zagury, Jean-Francois Montgomery, Stephen B. Ciuffi, Angela Hultquist, Judd F. Wolinsky, Steven M. Dougan, Gordon Lever, Andrew M. L. Gurdasani, Deepti Groom, Harriet Sandhu, Manjinder S. Fellay, Jacques Sexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre National Microbiology Laboratory Branch Public Health Agency of Canada Winnipeg Manitoba Canada Department of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg Manitoba Canada Vaccine and Therapeutics Laboratory Medical and Scientific Affairs National Microbiology Laboratory Branch Public Health Agency of Canada Winnipeg Manitoba Canada Wellcome Trust Sanger Institute Hinxton UK Department of Medicine University of Cambridge Cambridge UK Department of Medicine National University of Singapore Singapore Singapore Peter Gorer Department of Immunobiology School of Immunology and Microbial Sciences King’s College London London UK Institute of Microbiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland Global Health Institute School of Life Sciences École Polytechnique Fédérale de Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland Precision Medicine Unit Biomedical Data Science Center Lausanne University Hospital (CHUV) and University of Lausanne Lausanne Switzerland The African Computational Genomics (TACG) Research Group MRC/UVRI and LSHTM Uganda Research Unit Entebbe Uganda Department of Non-Communicable Disease Epidemiology Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London UK The Jackson Laboratory for Genomic Medicine Farmington CT USA Department of Pathology Stanford University School of Medicine Stanford CA USA Department of Genetics Stanford University School of Medicine Stanford CA USA Division of Infectious Diseases Feinberg School of Medicine Northwestern University Chicago IL USA Basic Science Program Frederick National Laboratory for Cancer Research National Cancer Institute Frederick MD USA Laboratory of Integrative Cancer Immunology Center for Cancer Research National Cancer Institute Bethesda

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Clinical and Immunophenotypic Analysis of Donor-Derived T Cells Targeting Twelve Viral Antigens Administered to Patients after Hematopoietic Stem Cell Transplant

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Transplantation and Cellular Therapy 2025年第2期31卷 S513-S513页

作者： Kinoshita, Hannah, MD Chansky, Pamela Adhikari, Nisha Motta, Cecilia, PhD Jensen-Wachspress, Mariah, BA Hanley, Patrick J., PhD Tanna, Jay, MS Lang, Haili, MS Hoq, Fahmida, MD Saldaña, Blachy J Dávila, MD Perez-Albuerne, Evelio, MD PhD Jacobsohn, David A, MD, MBA Abraham, Allistair, MD Bollard, Catherine M., MD, FRACP, FRCPA Keller, Michael D., MD Center for Cancer and Blood Disorders Children's National Hospital Washington DC Department of Pediatrics The George Washington School of Medicine and Health Sciences Washington DC Genomics and Bioinformatics Program The George Washington University Washington DC Center for Cancer and Immunology Research Children's National Hospital Washington DC Children's National Hospital Washington DC Program for Cell Enhancement and Technologies for Immunotherapy Center for Cancer & Immunology Research Children's National Research Institute Washington DC Center for Cancer and Immunology Research Children's National Medical Center Washington DC Children's National Medical Center Washington DC Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Hospital Cincinnati OH Blood and Marrow Transplantation Center for Cancer and Blood Disorders Children's National Hospital； George Washington University School of Medicine and Health Sciences Washington DC Bone Marrow Transplant Children's National Medical Center Washington DC Department of Pediatrics The George Washington University Washington DC

Hematopoietic-stem-cell transplantation (HSCT) remains the only curative option for many patients with relapsed or high-risk malignancies, immunodeficiency disorders and hemoglobinopathies. In mis-matched transplant donors, immunosuppression is required post-HSCT to prevent graft-versus-host disease (GVHD), increasing the risk of virus infections before immune reconstitution is achieved. Use of multi-virus-specific T cells (mVST) therapy following HSCT may help to restore antiviral immunity, including targeting of latent and respiratory viruses. Aims: To evaluate the safety and antiviral activity of a “first-in-human” mVST targeting 12 viral antigens of 6 viruses. Methods: Recipients of allogeneic-HSCT were enrolled on a phase-I dose-escalation (1 × 10 7/m 2–5 × 10 7/m 2 /dose) trial evaluating donor-derived mVSTs targeting cytomegalovirus, Epstein-Barr virus, adenovirus, human herpes virus 6, BK virus and human-parainfluenza-3 for the prevention or treatment of infection (Fig. 1). Clinical and immunobiological responses were measured and gene expression profiles and T cell receptor (TCR) clonotypes from the products were tracked in the patient over time. Results: Fourteen patients (median age 14.7, range 0.9-62 years) with primary and/or treatment-related immunodeficiency received mVSTs post-HSCT. Six patients had inborn errors of immunity, 4 patients had sickle cell anemia, 4 with malignancy and 1 had myelofibrosis. Four patients received mVSTs as prophylaxis, of whom 75% (n=3/4) remained virus-free post-mVSTs. One patient (n=1/4) had reactivation of EBV, requiring rituximab treatment. Of the 10 patients receiving mVSTs for treatment, 90% achieved a partial or complete response to at least one target virus by 90 days post-mVSTs. Unique TCR clonotypes from the product were tracked over time in the patient post-mVSTs, persisting up to 180 days. (Fig. 2) Expression of high-frequency clones by individual cell phenotype demonstrated predominance in CD8+ T cells. (Fig.

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Author Correction: Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer

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NPJ breast cancer 2023年第1期9卷 11页

作者： Shivangi Yadav Ranya Virk Carolina H Chung Mariana Bustamante Eduardo David VanDerway Duojiao Chen Kirsten Burdett Hongyu Gao Zexian Zeng Manish Ranjan Gannon Cottone Xiaoling Xuei Sriram Chandrasekaran Vadim Backman Robert Chatterton Seema Ahsan Khan Susan E Clare Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. Department of Biomedical Engineering Northwestern University Evanston IL 60208-2850 USA. Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 USA. Center of for Medical Genomics Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Preventive Medicine Northwestern University Chicago IL 60611 USA. Department of Data Sciences Dana Farber Cancer Institute Harvard T.H. Chan School of Public Health Boston MA 02215 USA. Program in Chemical Biology University of Michigan Ann Arbor MI 48109 USA. Rogel Cancer Center University of Michigan Medical School Ann Arbor MI 48109 USA. Center for Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI 48109 USA. Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago IL 60611 USA. Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. s-khan2@northwestern.edu. Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. susan.clare@northwestern.edu.

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Stroke genetics informs drug discovery and risk prediction across ancestries (vol 611, pg 115, 2022)

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NATURE 2022年第7938期612卷 E7-E7页

作者： Mishra, Aniket Malik, Rainer Hachiya, Tsuyoshi Jurgenson, Tuuli Namba, Shinichi Posner, Daniel C. Kamanu, Frederick K. Koido, Masaru Le Grand, Quentin Shi, Mingyang He, Yunye Georgakis, Marios K. Caro, Ilana Krebs, Kristi Liaw, Yi-Ching Vaura, Felix C. Lin, Kuang Winsvold, Bendik Slagsvold Srinivasasainagendra, Vinodh Parodi, Livia Bae, Hee-Joon Chauhan, Ganesh Chong, Michael R. Tomppo, Liisa Akinyemi, Rufus Roshchupkin, Gennady V. Habib, Naomi Jee, Yon Ho Thomassen, Jesper Qvist Abedi, Vida Carcel-Marquez, Jara Nygaard, Marianne Leonard, Hampton L. Yang, Chaojie Yonova-Doing, Ekaterina Knol, Maria J. Lewis, Adam J. Judy, Renae L. Ago, Tetsuro Amouyel, Philippe Armstrong, Nicole D. Bakker, Mark K. Bartz, Traci M. Bennett, David A. Bis, Joshua C. Bordes, Constance Borte, Sigrid Cain, Anael Ridker, Paul M. Cho, Kelly Chen, Zhengming Cruchaga, Carlos Cole, John W. de Jager, Phil L. de Cid, Rafael Endres, Matthias Ferreira, Leslie E. Geerlings, Mirjam I. Gasca, Natalie C. Gudnason, Vilmundur Hata, Jun He, Jing Heath, Alicia K. Ho, Yuk-Lam Havulinna, Aki S. Hopewell, Jemma C. Hyacinth, I. Hyacinth Inouye, Michael Jacob, Mina A. Jeon, Christina E. Jern, Christina Kamouchi, Masahiro Keene, Keith L. Kitazono, Takanari Kittner, Steven J. Konuma, Takahiro Kumar, Amit Lacaze, Paul Launer, Lenore J. Lee, Keon-Joo Lepik, Kaido Li, Jiang Li, Liming Manichaikul, Ani Markus, Hugh S. Marston, Nicholas A. Meitinger, Thomas Mitchell, Braxton D. Montellano, Felipe A. Morisaki, Takayuki Mosley, Thomas H. Nalls, Mike A. Nordestgaard, Borge G. O'Donnell, Martin J. Okada, Yukinori Onland-Moret, N. Charlotte Ovbiagele, Bruce Peters, Annette Psaty, Bruce M. Rich, Stephen S. Rosand, Jonathan Sabatine, Marc S. Sacco, Ralph L. Saleheen, Danish Sandset, Else Charlotte Salomaa, Veikko Sargurupremraj, Muralidharan Sasaki, Makoto Satizabal, Claudia L. Schmidt, Carsten O. Shimizu, Atsushi Smith, Nicholas L. Sloane, Kelly L. Sutoh, Yoichi Sun, Yan V. Tanno, Kozo Tiedt, Steffen Tatlisumak, Turgut Torres-Aguila, Nuria P. Tiwari, Hemant K. Tregouet, Bordeaux Population Health Research Center University of Bordeaux Inserm UMR 1219 Bordeaux France Department of Public Health Bordeaux University Hospital Bordeaux France Department of Neurology Memory Clinic Bordeaux University Hospital Bordeaux France Department of Neurology Institute for Neurodegenerative Diseases CHU de Bordeaux Bordeaux France Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of Harvard and the Massachusetts Institute of Technology Cambridge MA USA Munich Cluster for Systems Neurology Munich Germany German Center for Neurodegenerative Diseases (DZNE) Munich Germany Iwate Tohoku Medical Megabank Organization Iwate Medical University Iwate Japan Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia Institute of Mathematics and Statistics University of Tartu Tartu Estonia Department of Computational Biology University of Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland University Center for Primary Care and Public Health Lausanne Switzerland Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan Department of Genome Informatics Graduate School of Medicine The University of Tokyo Tokyo Japan Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan Integrated Frontier Research for Medical Science Division Institute for Open and Transdisciplinary Research Initiatives Osaka University Suita Japan Center for Infectious Disease Education and Research (CiDER) Osaka University Suita Japan Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA TIMI S

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Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

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European journal of medical research 2024年第1期29卷 286页

作者： Wen-Chien Cheng Chia-Ling Chang Chau-Chyun Sheu Ping-Huai Wang Meng-Heng Hsieh Ming-Tsung Chen Wei-Fan Ou Yu-Feng Wei Tsung-Ming Yang Chou-Chin Lan Cheng-Yi Wang Chih-Bin Lin Ming-Shian Lin Yao-Tung Wang Ching-Hsiung Lin Shih-Feng Liu Meng-Hsuan Cheng Yen-Fu Chen Chung-Kan Peng Ming-Cheng Chan Ching-Yi Chen Lun-Yu Jao Ya-Hui Wang Chi-Jui Chen Shih-Pin Chen Yi-Hsuan Tsai Shih-Lung Cheng Horng-Chyuan Lin Jung-Yien Chien Hao-Chien Wang Wu-Huei Hsu Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan. wcchengdr@***. Critical Medical Center China Medical University Hospital Taichung Taiwan. wcchengdr@***. School of Medicine College of Medicine China Medical University Taichung Taiwan. wcchengdr@***. Department of Internal Medicine National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan. Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan. Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Thoracic Medicine Far Eastern Memorial Hospital Taipei Taiwan. Department of Thoracic Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. College of Medicine Chang Gung University Taoyuan Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Internal Medicine E-Da Cancer Hospital I-Shou University Kaohsiung Taiwan. School of Medicine for International Students College of Medicine I-Shou University Kaohsiung Taiwan. Division of Pulmonary and Critical Care Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan Republic of China. Department of Internal Medicine Cardinal Tien Hospital and School of Medicine College of Medicine Fu Jen Catholic University New Taipei City Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Hualien Tzu Chi Hospital Buddhi

BACKGROUND:Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB). METHODS:This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic). Furthermore, we established relationships between the severity of clinical factors, including symptom scores, pulmonary function, pseudomonas aeruginosa colonization, exacerbation and admission rates, and HRCT parameters using modified Reiff scores. RESULTS:Data from 2,753 patients were classified based on HRCT patterns (cylindrical, varicose, and cystic) and severity, assessed by modified Reiff scores (mild, moderate, and severe). With increasing HRCT severity, a significant correlation was found with decreased forced expiratory volume in the first second (FEV1) (p < 0.001), heightened clinical symptoms (p < 0.001), elevated pathogen colonization (pseudomonas aeruginosa) (p < 0.001), and an increased annual hospitalization rate (p < 0.001). In the following multivariate analysis, elderly age, pseudomonas aeruginosa pneumonia, and hospitalizations per year emerged as the only independent predictors of mortality. CONCLUSION:Based on our large cohort study, the simplified CT scoring system (Reiff score) can serve as a useful adjunct to clinical factors in predicting disease severity and prognosis among Taiwanese patients with NCFB.

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Phase I Trial of Ex Vivo Expanded Donor Gamma Delta T Cell Immunotherapy to Prevent Acute Myeloid Leukemia Relapse after Allogeneic Transplantation

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Blood 2024年 144卷 4826-4826页

作者： Nelli Bejanyan Hany Elmariah Jongphil Kim Cheryl Cox Melissa Lowden Xiaofei Song Hien Liu Bin Yu Kayla Reid Sean J. Yoder Christopher Cubitt Rawan Faramand Sayeef Mirza Farhad Khimani Lia Perez Jose L. Ochoa-Bayona Justin Boucher Jose Alejandro Guevara David Sallman Jeffrey E Lancet Marco Davila Department of Blood and Marrow Transplantation and Cellular Immunotherapy H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center and Research Institute Tampa FL Cell Therapy Facility Moffitt Cancer Center Tampa FL Department of Blood and Marrow Transplantation and Cellular Immunotherapy Moffitt Cancer Center Tampa FL Moffitt Cancer Center Tampa FL Immune Monitoring Core Moffitt Cancer Center Tampa FL Department of Clinical Science Moffitt Cancer Center Tampa FL Molecular Genomics Core Facility H. Lee Moffitt Cancer Center & Research Institute Tampa FL Immuno-Oncology Program Moffitt Cancer Center Tampa FL Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Malignant Hematology Moffitt Cancer Center Tampa FL Department of Medicine Roswell Park Comprehensive Cancer Center Buffalo NY

Background Patients with adverse risk acute myeloid leukemia (AML) by European LeukemiaNet (ELN) risk stratification are at high risk (~50%) of relapse after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT). We developed a novel cellular therapy using ex vivo expanded donor-derived gamma delta T (GDT) cells to prevent post-HCT relapse and cure more patients with adverse risk AML. GDT cells that are rare in circulating blood have MHC-independent potent antitumor cytotoxicity against AML. They cause no graft-versus-host-disease (GVHD) in preclinical studies, which allows the potential for a healthy donor-derived cellular immunotherapy for AML. Methods This first-in-human trial enrolled patients with ELN adverse risk AML who received either HLA-identical sibling donor (MSD) or haploidentical donor RIC alloHCT. The same donor used for HCT underwent non-mobilized leukapheresis for large scale expansion of GDT cells with use of artificial antigen presented cells (Boucher J. Immunother. 2023). Expanded GDT cells were infused to patients between days 60-100 after alloHCT in the absence of uncontrolled infection and/or GVHD requiring systemic steroids. The trial followed a 3+3 design to study the primary endpoint of maximum-tolerated dose (MTD) of donor GDT cell infusion. Three dose levels (DL) of GDT cells were studied where DL1 was 6.25 x 10 6 cells/kg, DL2 was 3.13 x 10 7 cells/kg and DL3 was 1.10 x 10 8 cells/kg. Dose-limiting toxicities (DLT) were evaluated for 42 days following GDT cell infusion and were defined as grade 3-4 cytokine release syndrome (CRS), grade 3-4 immune effector cell-associated neurotoxicity syndrome (ICANS), or any grade 4 organ toxicity by CTCAE 5.0. Results We treated 9 patients with ELN adverse risk AML in morphological complete remission (CR), including 5 patients who had detectable measurable residual disease (MRD) prior to HCT. Median age was 63 years, and all patients received RIC alloHCT prior to

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Characterization of the genetic variation and evolutionary divergence of the CLEC18 family

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Journal of biomedical science 2024年第1期31卷 53页

作者： Che-Mai Chang Wei-Chiao Chang Shie-Liang Hsieh Genomics Research Center Academia Sinica No. 128 Sec. 2 Academia Rd. Nangang Dist. Taipei City 115 Taiwan. Department of Clinical Pharmacy School of Pharmacy Taipei Medical University No.250 Wuxing St. Xinyi Dist Taipei City 110 Taiwan. Department of Clinical Pharmacy School of Pharmacy Taipei Medical University No.250 Wuxing St. Xinyi Dist Taipei City 110 Taiwan. wcc@tmu.edu.tw. Master Program in Clinical Genomics and Proteomics School of Pharmacy Taipei Medical University Taipei City 110 Taiwan. wcc@tmu.edu.tw. Department of Pharmacy Wan Fang Hospital Taipei Medical University Taipei City 116 Taiwan. wcc@tmu.edu.tw. Integrative Research Center for Critical Care Wan Fang Hospital Taipei Medical University Taipei City 116 Taiwan. wcc@tmu.edu.tw. Department of Pharmacology National Defense Medical Center Taipei City 114 Taiwan. wcc@tmu.edu.tw. Genomics Research Center Academia Sinica No. 128 Sec. 2 Academia Rd. Nangang Dist. Taipei City 115 Taiwan. slhsieh@gate.sinica.edu.tw. Master Program in Clinical Genomics and Proteomics School of Pharmacy Taipei Medical University Taipei City 110 Taiwan. slhsieh@gate.sinica.edu.tw. Immunology Research Center National Health Research Institutes No. 35 Keyan Rd. Zhunan Township Miaoli County 350 Taiwan. slhsieh@gate.sinica.edu.tw. Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei City 112 Taiwan. slhsieh@gate.sinica.edu.tw. Department of Medical Research Taipei Veterans General Hospital Taipei City 112 Taiwan. slhsieh@gate.sinica.edu.tw.

BACKGROUND:The C-type lectin family 18 (CLEC18) with lipid and glycan binding capabilities is important to metabolic regulation and innate immune responses against viral infection. However, human CLEC18 comprises three paralogous genes with highly similar sequences, making it challenging to distinguish genetic variations, expression patterns, and biological functions of individual CLEC18 paralogs. Additionally, the evolutionary relationship between human CLEC18 and its counterparts in other species remains unclear. METHODS:To identify the sequence variation and evolutionary divergence of human CLEC18 paralogs, we conducted a comprehensive analysis using various resources, including human and non-human primate reference genome assemblies, human pangenome assemblies, and long-read-based whole-genome and -transcriptome sequencing datasets. RESULTS:We uncovered paralogous sequence variants (PSVs) and polymorphic variants (PVs) of human CLEC18 proteins, and identified distinct signatures specific to each CLEC18 paralog. Furthermore, we unveiled a novel segmental duplication for human CLEC18A gene. By comparing CLEC18 across human and non-human primates, our research showed that the CLEC18 paralogy probably occurred in the common ancestor of human and closely related non-human primates, and the lipid-binding CAP/SCP/TAPS domain of CLEC18 is more diverse than its glycan-binding CTLD. Moreover, we found that certain amino acids alterations at variant positions are exclusive to human CLEC18 paralogs. CONCLUSIONS:Our findings offer a comprehensive profiling of the intricate variations and evolutionary characteristics of human CLEC18.

关键词： CAP/SCP/TAPS domain CLEC18 CTLD Human pangenome Long-read sequencing Molecular evolution Paralogous sequence variant Polymorphic variant Single amino acid variant

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