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检索条件"机构=Department of Medicine and Program in Bioinformatics and Proteomics/Genomics"
276 条 记 录,以下是11-20 订阅
排序:
Gut mucosal microbiota profiles linked to colorectal cancer recurrence
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World Journal of Gastroenterology 2022年 第18期28卷 1946-1964页
作者: Rui-Xue Huo Yi-Jia Wang Shao-Bin Hou Wei Wang Chun-Ze Zhang Xue-Hua Wan Department of Oncology Tianjin Union Medical CenterNankai UniversityTianjin 300121China Laboratory of Oncologic Molecular Medicine Tianjin Union Medical CenterNankai UniversityTianjin 300121China Advanced Studies in Genomics Proteomics and BioinformaticsUniversity of Hawaii at ManoaHonoluluHI 96822United States TEDA Institute of Biological Sciences and Biotechnology Nankai UniversityTianjin 300457China Department of Colorectal Surgery Tianjin Union Medical CenterNankai UniversityTianjin 300121China Tianjin Institute of Coloproctology Tianjin 300121China
BACKGROUND Emerging evidence links gut microbiota to various human diseases including colorectal cancer(CRC)initiation and ***,gut microbiota profiles associated with CRC recurrence and patient prognosis are not compl... 详细信息
来源: 评论
Proteome-Wide Analysis Using SOMAscan Identifies and Validates Epidermal Growth Factor as a Disease Marker of Collagenous Gastritis
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Gastro Hep Advances 2022年 第5期1卷 689-702页
作者: Curci, Debora Dillon, Simon T. Gu, Xuesong Winter, Harland Libermann, Towia A. Institute for Maternal and Child Health - IRCCS “Burlo Garofolo” Advanced Diagnostic and Translational Medicine Laboratory Trieste Italy Division of Interdisciplinary Medicine and Biotechnology Beth Israel Deaconess Medical Center Boston MA United States Beth Israel Deaconess Medical Center Genomics Proteomics Bioinformatics and Systems Biology Center Boston MA United States Department of Medicine Harvard Medical School Boston MA United States Center for Pediatric Inflammatory Bowel Disease Massachusetts General Hospital Boston MA United States
Background and Aims: Collagenous gastritis (CG) is a rare disorder characterized by increased subepithelial collagen deposition and inflammatory infiltrates. The mechanisms involved in CG pathogenesis are poorly under... 详细信息
来源: 评论
Targeting protein-protein interaction interfaces with antiviral N protein inhibitor in SARS-CoV-2
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Biophysical Journal 2024年 第4期123卷 478-488页
作者: Hong, Jhen-Yi Lin, Shih-Chao Kehn-Hall, Kylene Zhang, Kai-Min Luo, Shun-Yuan Wu, Hung-Yi Chang, Sui-Yuan Hou, Ming-Hon Institute of Genomics and Bioinformatics and Department of Life Sciences National Chung Hsing University Taichung Taiwan Bachelor Degree Program in Marine Biotechnology College of Life Sciences National Taiwan Ocean University Keelung Taiwan Department of Biomedical Sciences and Pathobiology Virginia-Maryland College of Veterinary Medicine Virginia Polytechnic Institute and State University Blacksburg VA United States Center for Emerging Zoonotic and Arthropod-borne Pathogens Virginia Polytechnic Institute and State University Blacksburg VA United States Department of Chemistry National Chung Hsing University Taichung Taiwan Graduate Institute of Veterinary Pathobiology College of Veterinary Medicine National Chung Hsing University. Taichung Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan PhD Program in Medical Biotechnology National Chung Hsing University Taichung Taiwan Biotechnology Center National Chung Hsing University Taichung Taiwan
Coronaviruses not only pose significant global public health threats but also cause extensive damage to livestock-based industries. Previous studies have shown that 5-benzyloxygramine (P3) targets the Middle East resp...
来源: 评论
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
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Cellular & Molecular Immunology 2024年 第8期21卷 918-931页
作者: Bilal Alashkar Alhamwe Viviane Ponath Fahd Alhamdan Bastian Dörsam Clara Landwehr Manuel Linder Kim Pauck Sarah Miethe Holger Garn Florian Finkernagel Anna Brichkina Matthias Lauth Dinesh Kumar Tiwari Malte Buchholz Daniel Bachurski Sabrina Elmshäuser Andrea Nist Thorsten Stiewe Lisa Pogge von Strandmann Witold Szymański Vanessa Beutgen Johannes Graumann Julia Teply-Szymanski Corinna Keber Carsten Denkert Ralf Jacob Christian Preußer Elke Pogge von Strandmann Institute for Tumor Immunology Philipps-University35043MarburgGermany Core Facility Extracellular Vesicles Philipps-University35043MarburgGermany Department of Anesthesiology Critical Careand Pain MedicineCardiac Anesthesia DivisionBoston Children’s HospitalBostonUSA Department of Immunology and Anaesthesia Harvard Medical SchoolBostonMAUSA Translational Inflammation Research Division&Core Facility for Single Cell Multiomics Philipps-University35043MarburgGermany Core Facility Bioinformatics Philipps-University35043MarburgGermany Clinic for Gastroenterology Endocrinology and MetabolismCenter for Tumor and Immune BiologyPhilipps-University35043MarburgGermany Institute of Systems Immunology Philipps-University35043MarburgGermany Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of CologneCologneGermany Institute of Molecular Oncology and Genomics Core Facility Member of the German Center for Lung Research(DZL)Philipps-University35043MarburgGermany Institute of Lung Health Justus Liebig University35392GiessenGermany Institute of Translational Proteomics&Core Facility Translational Proteomics Biochemical/Pharmacological CentrePhilipps-University35043MarburgGermany Institute of Pathology Philipps-University Marburg and University Hospital Marburg(UKGM)MarburgGermany Department of Cell Biology and Cell Pathology Philipps-University35043MarburgGermany
Recent studies reveal a critical role of tumor cell-released extracellular vesicles(EVs)in pancreatic cancer(PC)***,driver genes that direct EV function,the EV-recipient cells,and their cellular response to EV uptake ... 详细信息
来源: 评论
Global epidemiology and antimicrobial resistance of Enterobacterales harbouring genes encoding OXA-48-like carbapenemases: insights from the results of the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme 2018-2021
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The Journal of antimicrobial chemotherapy 2024年 第7期79卷 1581-1589页
作者: Yu-Lin Lee Wei-Yao Wang Wen-Chien Ko Po-Ren Hsueh Division of Infectious Disease Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan. PhD Program in Medical Biotechnology Institute of Genomics and Bioinformatics National Chung-Hsing University Taichung Taiwan. School of Medicine Chung Shan Medical University Taichung Taiwan. Department of Medicine College of Medicine National Cheng Kung University Tainan Taiwan. Departments of Laboratory Medicine and Internal Medicine China Medical University Hospital Chin Medical University Taichung Taiwan. School of Medicine China Medical University Taichung Taiwan. PhD Program for Ageing School of Medicine China Medical University Taichung Taiwan. Departments of Laboratory Medicine and Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan.
OBJECTIVES:The recent emergence of carbapenem-resistant Enterobacterales poses a major and escalating threat to global public health. This study aimed to analyse the global distribution and antimicrobial resistance of...
来源: 评论
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
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Science (New York, N.Y.) 2025年 第6730期387卷 192-201页
作者: Varanasi, Siva Karthik Chen, Dan Liu, Yingluo Johnson, Melissa A. Miller, Cayla M. Ganguly, Souradipta Lande, Kathryn LaPorta, Michael A. Hoffmann, Filipe Araujo Mann, Thomas H. Teneche, Marcos G. Casillas, Eduardo Mangalhara, Kailash C. Mathew, Varsha Sun, Ming Jensen, Isaac J. Farsakoglu, Yagmur Chen, Timothy Parisi, Bianca Deota, Shaunak Havas, Aaron Lee, Jin Chung, H Kay Schietinger, Andrea Panda, Satchidananda Williams, April E. Farber, Donna L. Dhar, Debanjan Adams, Peter D. Feng, Gen-Sheng Shadel, Gerald S. Sundrud, Mark S. Kaech, Susan M. NOMIS Center for Immunobiology and Microbial Pathogenesis Salk Institute for Biological Studies La Jolla CA United States Department of Pathology School of Medicine University of California San Diego La Jolla CA United States Sanford Burnham Prebys Medical Discovery Institute La Jolla CA United States Department of Medicine School of Medicine University of California San Diego CA United States Razavi Newman Integrative Genomics and Bioinformatics Core Facility Salk Institute for Biological Studies La Jolla CA United States Department of Microbiology and Immunology Columbia University Irving Medical Center New York NY USA Department of Surgery Columbia University Irving Medical Center New York NY USA Regulatory Biology Laboratory Salk Institute for Biological Studies La Jolla CA United States Immunology Program Memorial Sloan Kettering Cancer Center New York NY USA Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical Sciences New York NY USA Parker Institute for Cancer Immunotherapy New York NY USA Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth Hanover NH USA Department of Medicine Geisel School of Medicine at Dartmouth Hanover NH USA Center for Digestive Health Dartmouth Health NH United States Dartmouth Cancer Center Dartmouth Health NH United States
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that accumulation of ...
来源: 评论
Early-Life Risks of Central Precocious Puberty
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Endocrine Practice 2025年
作者: Yin, Wei-Jou Hsu, Jhih-Wei Chen, Chun-Chang Su, Emily Chia-Yu Wang, San-Yuan Chen, Yan-Jen Chen, Yang-Ching College of Medicine Taipei Medical University Taipei Taiwan Department of Family Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Informatics Taipei Medical University Taipei Taiwan Master Program in Clinical Genomics and Proteomics Department of Pharmaceutical Sciences Taipei Medical University Taipei Taiwan Department of Family Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan Nutrition Research Center Taipei Medical University Hospital Taipei Taiwan
Objectives: To investigate the factors in early life that may contribute to central precocious puberty (CPP). Methods: The study utilized data from the Taiwan Puberty Longitudinal Study, including 2241 children under ... 详细信息
来源: 评论
Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer
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Signal Transduction and Targeted Therapy 2023年 第9期8卷 4365-4379页
作者: Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong Department of Urology Guangzhou First People’s HospitalSouth China University of Technology510180 GuangzhouGuangdongChina Urology Key Laboratory of Guangdong Province The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical University510230 GuangzhouGuangdongChina Guangzhou National Laboratory No.9 XingDaoHuanBei RoadGuangzhou International Bio Island510005 GuangzhouGuangdongChina Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92507USA Graduate Program in Genetics Genomics&BioinformaticsUniversity of CaliforniaRiversideCA 92507USA State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyTaipa999078 MacaoChina
The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical *** treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to dr... 详细信息
来源: 评论
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy
Nature Cancer
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Nature Cancer 2024年 第3期5卷 400-419页
作者: Huang, Yu-Kai Cheng, Wei-Chung Kuo, Ting-Ting Yang, Juan-Cheng Wu, Yang-Chang Wu, Heng-Hsiung Lo, Chia-Chien Hsieh, Chih-Ying Wong, Sze-Ching Lu, Chih-Hao Wu, Wan-Ling Liu, Shih-Jen Li, Yi-Chuan Lin, Ching-Chan Shen, Chia-Ning Hung, Mien-Chie Lin, Jaw-Town Yeh, Chun-Chieh Sher, Yuh-Pyng Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Cancer Biology and Precision Therapeutics Center China Medical University Taichung Taiwan Ph.D. Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung Taiwan Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology College of Medical and Health Science Asia University Taichung Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Division of Hematology and Oncology China Medical University Hospital Taichung Taiwan Genomics Research Center Academia Sinica Taipei Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine E-Da Hospital Kaohsiung Taiwan Department of Medicine School of Medicine China Medical University Taichung Taiwan Department of Surgery Organ Transplantation Center China Medical University Hospital Taichung Taiwan Institute of Biochemistry and Molecular Biology China Medical University Taichung Taiwan
Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (ADAM)9 as a modulato...
来源: 评论
Double negative T cells,a potential biomarker for systemic lupus erythematosus
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Precision Clinical medicine 2020年 第1期3卷 34-43页
作者: Jessy J.Alexander Alexander Jacob Anthony Chang Richard J.Quigg James N.Jarvis Department of Pathology University of ChicagoChicagoIL 60637USA Departments of Medicine PediatricsJacobs School of Medicine and Biomedical Sciences and GeneticsGenomics&Bioinformatics ProgramUniversity at BuffaloBuffaloNY 14203USA
Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and *** is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T... 详细信息
来源: 评论