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检索条件"机构=Department of Medicine and Program in Bioinformatics and Proteomics/Genomics"
283 条 记 录,以下是11-20 订阅
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The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription
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Nature Communications 2025年 第1期16卷 1-19页
作者: Umphred-Wilson, Katharine Ratnayake, Shashikala Tang, Qianzi Wang, Rui Chaudhary, Sneha Ghosh Ballachanda, Devaiah N. Trichka, Josephine Wisniewski, Jan Zhou, Lan Chen, Qingrong Meerzaman, Daoud Singer, Dinah S. Adoro, Stanley Experimental Immunology Branch National Cancer Institute National Institutes of Health Bethesda 20892 MD United States Immunology Training Program Department of Pathology Case Western Reserve University School of Medicine Cleveland 44106 OH United States Computational Genomics and Bioinformatics Branch Center for Biomedical Informatics & Information Technology National Cancer Institute National Institutes of Health Bethesda 20850 MD United States College of Animal Science and Technology Sichuan Agricultural University Chengdu 611130 China Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston 77030 TX United States
Addiction to oncogene-rewired transcriptional networks is a therapeutic vulnerability in cancer cells, underscoring a need to better understand mechanisms that relay oncogene signals to the transcriptional machinery. ...
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Human endogenous retroviruses (HERVs) associated with glioblastoma risk and prognosis
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Cancer Gene Therapy 2025年 1-11页
作者: Mazumder, Harun Lin, Hui-Yi Baddoo, Melody Gałan, Wojciech Polania-Villanueva, Diana Hicks, Chindo Otohinoyi, David Peruzzi, Francesca Madeja, Zbigniew Belancio, Victoria P. Flemington, Erik K. Reiss, Krzysztof Rak, Monika Biostatistics Program Louisiana State University Health Sciences Center School of Public Health New Orleans LA United States Louisiana Cancer Research Center New Orleans LA United States Tulane Cancer Center Tulane Health Sciences Center New Orleans LA United States Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA United States Department of Genetics and the Bioinformatics and Genomics Program Louisiana State University Health Sciences Center School of Medicine New Orleans LA United States Department of Medicine Louisiana State University Health Sciences Center School of Medicine New Orleans LA United States Department of Cell Biology Jagiellonian University in Kraków Faculty of Biochemistry Biophysics and Biotechnology Kraków Poland Department of Structural and Cellular Biology Tulane University School of Medicine New Orleans LA United States Department of Pathology and Laboratory Medicine Tulane University School of Medicine New Orleans LA United States Department of Interdisciplinary Oncology Louisiana State University Health Sciences Center School of Medicine New Orleans LA United States
Emerging evidence suggests expression from human endogenous retrovirus (HERV) loci likely contributes to, or is a biomarker of, glioblastoma multiforme (GBM) disease progression. However, the relationship between HERV...
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Repurposed Nrf2 activator dimethyl fumarate rescues muscle inflammation and fibrosis in an aggravated mdx mouse model of Duchenne muscular dystrophy
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Redox Biology 2025年 84卷 103676页
作者: Kourakis, Stephanie Timpani, Cara A. Bagaric, Ryan M. Qi, Bo Ali, Benazir A. Boyer, Rebecca Spiesberger, Guinevere Kandhari, Nitika Yan, Xu Kuang, Jujiao Tulangekar, Ankita de Haan, Judy B. Deveson-Lucas, Deanna Stupka, Nicole Fischer, Dirk Rybalka, Emma Institute for Health and Sport (IHeS) Victoria University Melbourne VIC Australia Inherited and Acquired Myopathies Program Australian Institute for Musculoskeletal Science (AIMSS) St Albans VIC Australia Department of Medicine – Western Health Melbourne Medical School The University of Melbourne St Albans VIC Australia Monash Genomics and Bioinformatics Platform Biomedical Discovery Institute Monash University Clayton VIC Australia Sarcopenia Research Program Australian Institute for Musculoskeletal Science (AIMSS) St Albans VIC Australia Basic Science Domain Oxidative Stress Laboratory Baker Heart and Diabetes Institute Melbourne VIC Australia Baker Department of Cardiometabolic Health University of Melbourne Parkville VIC Australia Division of Neuropediatric and Developmental Medicine University Children's Hospital of Basel (UKBB) Basel Switzerland
In inherited neuromuscular disease, Duchenne muscular dystrophy (DMD), glucocorticoids significantly slow disease progression yet impart side effects severe enough to preclude use in a significant proportion of patien... 详细信息
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Spliceosomal genes in the *** genome:a comparison with those in ***,***,*** and ***
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Protein & Cell 2011年 第5期2卷 395-409页
作者: Bing Yu Petra Fey Karen E.Kestin-Pilcher Alexei Fedorov Ashwin Prakash Rex L.Chisholm Jane Y.Wu Department of Molecular and Clinical Genetics Royal Prince Alfred Hospital and Sydney Medical School(Central)the University of SydneyNSW 2006Australia dictyBase Center for Genetic MedicineNorthwestern UniversityChicagoIL 60611USA Department of Neurology and Lurie Comprehensive Cancer Center Center for Genetic MedicineNorthwestern University Feinberg Medical SchoolChicagoIL 60611USA Department of Medicine and Program in Bioinformatics and Proteomics/Genomics The University of ToledoToledoOH 43614USA
Little is known about pre-mRNA splicing in Dictyostelium discoideum although its genome has been completely *** analysis suggests that pre-mRNA splicing plays an important role in *** gene expression as two thirds of ... 详细信息
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Protecting centrosomes from fracturing enables efficient cell navigation
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Science Advances 2025年 第17期11卷
作者: Schmitt, Madeleine T. Kroll, Janina Ruiz-Fernandez, Mauricio J.A. Hauschild, Robert Ghosh, Shaunak Kameritsch, Petra Merrin, Jack Schmid, Johanna Stefanowski, Kasia Thomae, Andreas W. Cheng, Jingyuan Öztan, Gamze Naz Konopka, Peter Ortega, Germán Camargo Penz, Thomas Bach, Luisa Baumjohann, Dirk Bock, Christoph Straub, Tobias Meissner, Felix Kiermaier, Eva Renkawitz, Jörg Biomedical Center Walter Brendel Center of Experimental Medicine Institute of Cardiovascular Physiology and Pathophysiology Klinikum der Universität Ludwig Maximilians Universität München Munich Germany Institute of Science and Technology Austria Klosterneuburg Austria Institute Immune and Tumor Biology University of Bonn Bonn Germany Bioimaging Facility Biomedical Center Faculty of Medicine Ludwig Maximilians Universität München Munich Germany Institute of Innate Immunity Department of Systems Immunology and Proteomics Medical Faculty University of Bonn Bonn Germany Institute of Stem Cell Research Helmholtz Center Munich German Research Center for Environmental Health Munich Germany Physiological Genomics Biomedical Center Ludwig-Maximilians University Munich Germany CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Medical Clinic III for Oncology Hematology Immuno-Oncology and Rheumatology University Hospital Bonn University of Bonn Bonn Germany Medical University of Vienna Institute of Artificial Intelligence Center for Medical Data Science Vienna Austria Bioinformatics Unit Biomedical Center Faculty of Medicine Ludwig Maximilians Universität München Munich Germany
The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules that grow radially and exert forces on cargos. At the same time, mechanical stresses from the microenvironment and cellular shape cha... 详细信息
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Double negative T cells,a potential biomarker for systemic lupus erythematosus
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Precision Clinical medicine 2020年 第1期3卷 34-43页
作者: Jessy J.Alexander Alexander Jacob Anthony Chang Richard J.Quigg James N.Jarvis Department of Pathology University of ChicagoChicagoIL 60637USA Departments of Medicine PediatricsJacobs School of Medicine and Biomedical Sciences and GeneticsGenomics&Bioinformatics ProgramUniversity at BuffaloBuffaloNY 14203USA
Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and *** is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T... 详细信息
来源: 评论
Long-term PM2.5 exposure is associated with asthma prevalence and exhaled nitric oxide levels in children
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Pediatric research 2025年 第1期97卷 370-377页
作者: Yi-Giien Tsai Chia-Pin Chio Kuender D Yang Ching-Hsiung Lin Yen-Po Yeh Yu-Jun Chang Jien-Wen Chien Shu-Li Wang Shau-Ku Huang Chang-Chuan Chan Department of Pediatrics Changhua Christian Children's Hospital Changhua Taiwan ROC. School of Medicine Kaohsiung Medical University Kaohsiung Taiwan ROC. School of Medicine Chung Shan Medical University Taichung Taiwan ROC. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan ROC. Department of Medical Research Tungs' Taichung MetroHarbor Hospital Taichung Taiwan ROC. Institute of Environmental and Occupational Health Sciences College of Public Health National Taiwan University Taipei Taiwan ROC. Department of Pediatrics Mackay Memorial Hospital and Department of Microbiology & Immunology National Defense Medical Center Taipei Taiwan ROC. Division of Chest Medicine Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan ROC. Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan ROC. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan ROC. Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan ROC. Changhua County Public Health Bureau Changhua Taiwan ROC. Epidemiology and Biostatistics Center Changhua Christian Hospital Changhua Taiwan ROC. National Institute of Environmental Health Sciences National Health Research Institutes 35 Keyan Rd Zhunan Miaoli County Miaoli Taiwan ROC. slwang@nhri.edu.tw. National Institute of Environmental Health Sciences National Health Research Institutes 35 Keyan Rd Zhunan Miaoli County Miaoli Taiwan ROC. skhuang@nhri.edu.tw. Johns Hopkins Asthma and Allergy Center School of Medicine Johns Hopkins University Baltimore MD USA. skhuang@nhri.edu.tw. Institute of Environmental and Occupational Health Sciences College of Public Health National Taiwan University Taipei Taiwan ROC. ccchan@ntu.edu.tw.
BACKGROUND:Exhaled nitric oxide concentration (FENO) is a marker of airway inflammation. This study aimed to evaluate the association of air pollution exposure with FENO levels and asthma prevalence with respiratory s...
来源: 评论
From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis
Osteoarthritis and Cartilage Open
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Osteoarthritis and Cartilage Open 2025年 第3期7卷 100621-100621页
作者: Roberts, Jack B. Rockel, Jason S. Mulders, Rick Capellini, Terence D. Appleton, C. Thomas Phanstiel, Douglas H. Lories, Rik Geurts, Jeroen Ali, Shabana Amanda Bhutani, Nidhi Stone, Laura Cruz-Almeida, Yenisel Jurisica, Igor Boer, Cindy G. Ramos, Yolande F.M. Rice, Sarah J. Kapoor, Mohit Biosciences Institute Newcastle University Newcastle upon Tyne United Kingdom Division of Orthopedics Osteoarthritis Research Program Schroeder Arthritis Institute University Health Network and Krembil Research Institute University Health Network Toronto ON Canada Department of Medical Biophysics and Computer Science University of Toronto Toronto ON Canada Department of Biomedical Data Sciences Section Molecular Epidemiology Leiden University Medical Center Leiden Netherlands Department of Human Evolutionary Biology Harvard University Cambridge MA United States Bone and Joint Institute and Department of Medicine Schulich School of Medicine and Dentistry Western University London Canada Curriculum in Bioinformatics and Computational Biology University of North Carolina Chapel Hill NC United States Laboratory of Tissue Homeostasis and Disease Skeletal Biology and Engineering Research Centre Department of Development and Regeneration KU Leuven Leuven Belgium Division of Rheumatology University Hospitals Leuven Leuven Belgium Rheumatology Department of Musculoskeletal Medicine Lausanne University Hospital and University of Lausanne (CHUV-UNIL) Lausanne Switzerland Bone and Joint Center Henry Ford Health + Michigan State University Health Sciences Detroit MI United States Department of Orthopaedic Surgery Stanford School of Medicine Stanford CA United States Department of Anesthesiology School of Medicine University of Minnesota Minneapolis MN United States Pain Research and Intervention Center of Excellence (PRICE) at the University of Florida Gainesville FL United States Department of Internal Medicine Genomics Medicine Center Erasmus MC University Medical Center Rotterdam Netherlands Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada Department of Surgery University of Toronto Toronto ON Canada
Objective: Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies...
来源: 评论
Revelation of potential antiviral activity of Azadirachta indica against Zika virus protease: An integrated molecular docking and dynamic simulation approach
Computational and Structural Biotechnology Reports
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Computational and Structural Biotechnology Reports 2025年 2卷
作者: Md. Habib Ullah Masum Rehana Parvin Syed Mohammad Lokman Zarin Tasnim Md. Mazharul Alam Jannatul Ferdous Department of Genomics and Bioinformatics Faculty of Biotechnology and Genetic Engineering Chattogram Veterinary and Animal Sciences University Khulshi 4225 Bangladesh Department of Pathology and Parasitology Faculty of Veterinary Medicine Chattogram Veterinary and Animal Sciences University Khulshi 4225 Bangladesh Asian University for Women (AUW) Chattogram 4000 Bangladesh Department of Industrial Biotechnology Faculty of Biotechnology and Genetic Engineering Chattogram Veterinary and Animal Sciences University Khulshi 4225 Bangladesh Functional Genomics and Proteomics Laboratory (FGPL) Department of Genetic Engineering and Biotechnology Faculty of Biological Sciences University of Chittagong Chattogram 4331 Bangladesh Department of Obstetrics and Gynecology Chittagong Medical College Hospital Chattogram 4203 Bangladesh
The Zika virus (ZIKV) is an RNA virus that mostly affects humans and primates and is transmitted via Aedes mosquitoes . The emergence of ZIKV has intensified global health concerns, emphasizing the urgent need for eff... 详细信息
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Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development
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Nature Neuroscience 2025年 1-14页
作者: Ya’el Courtney Joshua P. Head Neil Dani Frederick B. Shipley Maria K. Lehtinen Olga V. Chechneva Cameron Sadegh Yong Zhang Michael J. Holtzman Towia A. Libermann Department of Pathology Boston Children’s Hospital and Harvard Medical School Boston MA USA Graduate Program in Neuroscience Harvard Medical School Boston MA USA Department of Cell and Developmental Biology Vanderbilt University Nashville TN USA Graduate Program in Biophysics Harvard University Cambridge MA USA Department of Neurosurgery University of California Davis Sacramento CA USA Pulmonary and Critical Care Medicine Department of Medicine Washington University School of Medicine St. Louis MO USA Proteomics Bioinformatics and Systems Biology Center Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA
The choroid plexus (ChP) regulates cerebrospinal fluid (CSF) composition, providing essential molecular cues for brain development; yet, embryonic ChP secretory mechanisms remain poorly defined. Here we identify apocr...
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