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检索条件"机构=Department of Medicine and Program in Bioinformatics and Proteomics/Genomics"
283 条 记 录,以下是31-40 订阅
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A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes
Cell Reports Medicine
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Cell Reports medicine 2025年 第5期6卷 102084-102084页
作者: Han, Xudong Zhang, Yichi Petrosky, Jillian N. Bald, Sarah Sherva, Richard M. Labadorf, Adam Cherry, Jonathan D. Chung, Jaeyoon Farrell, Kurt Abdolmohammadi, Bobak Durape, Shruti Martin, Brett M. Palmisano, Joseph N. Farrell, John J. Alvarez, Victor E. Huber, Bertrand R. Dwyer, Brigid Daneshvar, Daniel H. Jun, Gyungah R. Lunetta, Kathryn L. Goldstein, Lee E. Katz, Douglas I. Cantu, Robert C. Shenton, Martha E. Cummings, Jeffrey L. Reiman, Eric M. Stern, Robert A. Alosco, Michael L. Tripodis, Yorghos Farrer, Lindsay A. Stein, Thor D. Crary, John F. McKee, Ann C. Mez, Jesse Bioinformatics Graduate Program Boston University Boston MA United States Section of Biomedical Genetics Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston MA United States Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston MA United States Boston University Alzheimer's Disease Research Center Boston University Chobanian & Avedisian School of Medicine Boston MA United States Boston VA Healthcare System Boston MA United States Boston University Chronic Traumatic Encephalopathy Center Boston University Boston MA United States Department of Pathology and Laboratory Medicine Boston University Chobanian & Avedisian School of Medicine Boston MA United States Departments of Pathology Neuroscience and Artificial Intelligence & Human Health Neuropathology Brain Bank & Research CoRE Friedman Brain Institute Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York NY United States Biostatistics and Epidemiology Data Analytics Center Boston University School of Public Health Boston MA United States Bedford VA Healthcare System Bedford MA United States Braintree Rehabilitation Hospital Braintree MA United States Department of Physical Medicine and Rehabilitation Harvard Medical School Boston MA United States Department of Rehabilitation and Human Performance Brain Injury Research Center Icahn School of Medicine at Mount Sinai New York NY United States Department of Neurology Icahn School of Medicine at Mount Sinai New York NY United States Department of Biostatistics Boston University School of Public Health Boston MA United States Department of Ophthalmology Boston University Chobanian & Avedisian School of Medicine Boston MA United States Departments of Biomedical Electrical & Computer Engineering Boston University College of Engineering Boston MA United States Departments of Radiology and Psychiatry Boston University Chobanian & Avedisia
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. Genetic variation in the 17q21.31 region, containing microtubule-associated protein tau (M... 详细信息
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A novel framework for human leukocyte antigen (HLA) genotyping using probe capture-based targeted next-generation sequencing and computational analysis
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Computational and Structural Biotechnology Journal 2024年 23卷 1562-1571页
作者: Lai, Sheng-Kai Luo, Allen Chilun Chiu, I-Hsuan Chuang, Hui-Wen Chou, Ting-Hsuan Hung, Tsung-Kai Hsu, Jacob Shujui Chen, Chien-Yu Yang, Wei-Shiung Yang, Ya-Chien Chen, Pei-Lung Genome and Systems Biology Degree Program Academia Sinica and National Taiwan University Taipei Taiwan Department of Medical Genetics National Taiwan University Hospital Taipei Taiwan Graduate Institute of Medical Genomics and Proteomics College of Medicine National Taiwan University Taipei Taiwan Department of Biomechatronics Engineering National Taiwan University Taipei Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan Division of Endocrinology and Metabolism Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan
Human leukocyte antigen (HLA) genes play pivotal roles in numerous immunological applications. Given the immense number of polymorphisms, achieving accurate high-throughput HLA typing remains challenging. This study a... 详细信息
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Lessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays – navigating the transition from research to clinical practice
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Clinical proteomics 2024年 第1期21卷 1-11页
作者: Han, Chia-Li Lai, Chi-Ting Reyes, Aaron James Yang, Hao-Chin Lu, Jin-Ying Shih, Shyang-Rong Chen, Kuen-Yuan Hoofnagle, Andrew N. Yu, Sung-Liang Bocik, William Hiltke, Tara Chiu, Huan-Chi Wan, Ching-Yi Rodriguez, Henry Zhang, Victoria Chen, Yu-Ju Master Program in Clinical Genomics and Proteomics College of Pharmacy Taipei Medical University Taipei Taiwan Institute of Chemistry Academia Sinica Taipei Taiwan Division of Endocrinology and Metabolism Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan Department of Surgery National Taiwan University Hospital Taipei Taiwan Department of Laboratory Medicine and Pathology University of Washington Seattle WA United States Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Taipei Taiwan Centers for Genomics and Precision Medicine National Taiwan University Taipei Taiwan Cancer Research Technology Program Proteome Characterization Laboratory Frederick National Laboratory for Cancer Research Frederick MD United States Office of Cancer Clinical Proteomics Research National Cancer Institute Rockville MD United States Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY United States Department of Chemistry National Taiwan University Taipei Taiwan
Mass spectrometry (MS) assays offer exceptional capabilities in high multiplexity, specificity, and throughput. As proteomics technologies continue advancements to identify new disease biomarkers, transition of these ... 详细信息
来源: 评论
Identify Non-mutational p53 Functional Deficiency in Human Cancers
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genomics, proteomics & bioinformatics 2024年 第5期22卷 85-98页
作者: Qianpeng Li Yang Zhang Sicheng Luo Zhang Zhang Ann L.Oberg David E.Kozono Hua Lu Jann N.Sarkaria Lina Ma Liguo Wang National Genomics Data Center China National Center for BioinformationBeijing 100101China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Division of Computational Biology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Department of Radiation Oncology Dana-Farber Cancer Institute and Brigham and Women's HospitalBostonMA 02215USA Department of Biochemistry&Molecular Biology and Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA Department of Radiation Oncology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine and ScienceRochesterMN 55905USA Bioinformatics and Computational Biology Graduate Program University of Minnesota RochesterRochesterMN 55904USA
An accurate assessment of p53's functional statuses is critical for cancer genomic ***,there is a significant challenge in identifying tumors with non-mutational p53 inactivation which is not detectable through DN... 详细信息
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Gut mucosal microbiota profiles linked to colorectal cancer recurrence
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World Journal of Gastroenterology 2022年 第18期28卷 1946-1964页
作者: Rui-Xue Huo Yi-Jia Wang Shao-Bin Hou Wei Wang Chun-Ze Zhang Xue-Hua Wan Department of Oncology Tianjin Union Medical CenterNankai UniversityTianjin 300121China Laboratory of Oncologic Molecular Medicine Tianjin Union Medical CenterNankai UniversityTianjin 300121China Advanced Studies in Genomics Proteomics and BioinformaticsUniversity of Hawaii at ManoaHonoluluHI 96822United States TEDA Institute of Biological Sciences and Biotechnology Nankai UniversityTianjin 300457China Department of Colorectal Surgery Tianjin Union Medical CenterNankai UniversityTianjin 300121China Tianjin Institute of Coloproctology Tianjin 300121China
BACKGROUND Emerging evidence links gut microbiota to various human diseases including colorectal cancer(CRC)initiation and ***,gut microbiota profiles associated with CRC recurrence and patient prognosis are not compl... 详细信息
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Proteome-Wide Analysis Using SOMAscan Identifies and Validates Epidermal Growth Factor as a Disease Marker of Collagenous Gastritis
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Gastro Hep Advances 2022年 第5期1卷 689-702页
作者: Curci, Debora Dillon, Simon T. Gu, Xuesong Winter, Harland Libermann, Towia A. Institute for Maternal and Child Health - IRCCS “Burlo Garofolo” Advanced Diagnostic and Translational Medicine Laboratory Trieste Italy Division of Interdisciplinary Medicine and Biotechnology Beth Israel Deaconess Medical Center Boston MA United States Beth Israel Deaconess Medical Center Genomics Proteomics Bioinformatics and Systems Biology Center Boston MA United States Department of Medicine Harvard Medical School Boston MA United States Center for Pediatric Inflammatory Bowel Disease Massachusetts General Hospital Boston MA United States
Background and Aims: Collagenous gastritis (CG) is a rare disorder characterized by increased subepithelial collagen deposition and inflammatory infiltrates. The mechanisms involved in CG pathogenesis are poorly under... 详细信息
来源: 评论
Post-COVID-19 Effects on Chronic Gastritis and Gastric Cellular and Molecular Characteristics in Male Mice
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Cellular and Molecular Gastroenterology and Hepatology 2025年 第8期19卷 101511-101511页
作者: Jeong, Haengdueng Kim, Sung-Hee Kim, Jiseon Jeon, Donghun Uhm, Chanyang Oh, Heeju Cho, Kyungrae Park, In Ho Oh, Jooyeon Kim, Jeong Jin Jeong, Sang-Ho Park, Ji-Ho Park, Jun Won Yun, Jun-Won Seo, Jun-Young Shin, Jeon-Soo Goldenring, James R. Seong, Je Kyung Nam, Ki Taek Department of Biomedical Sciences Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea Epithelial Biology Center and Department of Surgery Vanderbilt University School of Medicine Nashville TN United States Institute of Immunology and Immunological Diseases Yonsei University College of Medicine Seoul South Korea Department of Microbiology Yonsei University College of Medicine Seoul South Korea Department of Surgery Gyongsang National University Hospital Jinju South Korea Korea Mouse Phenotyping Center Seoul National University Seoul South Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science Brain Korea 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul South Korea Laboratory Animal Medicine College of Veterinary Medicine Seoul National University Seoul South Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul South Korea BIO-MAX Institute Seoul National University Seoul South Korea Interdisciplinary Program for Bioinformatics Seoul National University Seoul South Korea
Backgrounds & Aims: Since the Omicron variant emerged as a major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, COVID-19-associated mortality has decreased remarkably. Nevertheless, patients... 详细信息
来源: 评论
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2
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Cell 2025年
作者: Pekar, Jonathan E. Lytras, Spyros Ghafari, Mahan Magee, Andrew F. Parker, Edyth Wang, Yu Ji, Xiang Havens, Jennifer L. Katzourakis, Aris Vasylyeva, Tetyana I. Suchard, Marc A. Hughes, Alice C. Hughes, Joseph Rambaut, Andrew Robertson, David L. Dellicour, Simon Worobey, Michael Wertheim, Joel O. Lemey, Philippe Institute of Ecology and Evolution University of Edinburgh Edinburgh United Kingdom Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla 92093 CA United States Department of Biomedical Informatics University of California San Diego La Jolla 92093 CA United States Department of Medicine University of California San Diego La Jolla 92093 CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Medical Research Council University of Glasgow Centre for Virus Research Glasgow United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States Department of Immunology and Microbiology The Scripps Research Institute La Jolla 92037 CA United States Institute of Genomics and Global Health Redeemer's University Osun State Ede Nigeria Department of Computer Science and Engineering University of California San Diego La Jolla 92093 CA United States Department of Mathematics School of Science and Engineering Tulane University New Orleans LA United States Department of Population Health and Disease Prevention University of California Irvine Irvine 92617 CA United States Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles 90095 CA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States School of Biological Sciences University of Hong Kong Hong Kong Hong Kong China Biodiversity Green Development Foundation Beijing China Spatial Epidemiology Lab (SpELL) Université Libre de Bruxelles CP160/12 50 av. FD Roosevelt Bruxelles 1050 Belgium Department of Microbiology Immunology and Transplantation Rega Institute
The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecovir... 详细信息
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In vitro activity of imipenem/relebactam, meropenem/vaborbactam and comparators against Enterobacterales from patients with intra-abdominal infections: Results of the study for Monitoring Antimicrobial Resistance Trends (SMART) in Taiwan, 2020
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Journal of Microbiology, Immunology and Infection 2023年 第1期56卷 75-83页
作者: Lee, Yu-Lin Ko, Wen-Chien Hsueh, Po-Ren Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan Department of Medicine College of Medicine National Cheng Kung University Tainan Taiwan Departments of Laboratory Medicine and Internal Medicine China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Ph.D Program for Aging School of Medicine China Medical University Taichung Taiwan Departments of Laboratory Medicine and Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan
Background: Multi-drug resistant Enterobacterales is a growing health threat. Imipenem/relebactam and meropenem/vaborbactam, are not clinically used in Taiwan and the susceptibility is lack from routine laboratory tes... 详细信息
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Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence
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Molecular and Cellular proteomics 2009年 第12期8卷 2613-2623页
作者: Lin, Miao-Hsia Hsu, Tung-Li Lin, Shu-Yu Pan, Yi-Jiun Jan, Jia-Tsrong Wang, Jin-Town Khoo, Kay-Hooi Wu, Shih-Hsiung Institute of Biochemical Sciences College of Life Sciences National Taiwan University Taipei 106 Taiwan Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan National Research Program for Genomic Medicine Core Facilities for Proteomics Research Academia Sinica Taipei 115 Taiwan Genomics Research Center Academia Sinica Taipei 115 Taiwan Department of Microbiology National Taiwan University College of Medicine Taipei 100 Taiwan
Encapsulated Klebsiella pneumoniae is the predominant causative agent of pyogenic liver abscess, an emerging infectious disease that often complicates metastatic meningitis or endophthalmitis. The capsular polysacchar...
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