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检索条件"机构=Department of Medicine and Program in Bioinformatics and Proteomics/Genomics"
276 条 记 录,以下是31-40 订阅
排序:
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2
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Cell 2025年
作者: Pekar, Jonathan E. Lytras, Spyros Ghafari, Mahan Magee, Andrew F. Parker, Edyth Wang, Yu Ji, Xiang Havens, Jennifer L. Katzourakis, Aris Vasylyeva, Tetyana I. Suchard, Marc A. Hughes, Alice C. Hughes, Joseph Rambaut, Andrew Robertson, David L. Dellicour, Simon Worobey, Michael Wertheim, Joel O. Lemey, Philippe Institute of Ecology and Evolution University of Edinburgh Edinburgh United Kingdom Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla 92093 CA United States Department of Biomedical Informatics University of California San Diego La Jolla 92093 CA United States Department of Medicine University of California San Diego La Jolla 92093 CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Medical Research Council University of Glasgow Centre for Virus Research Glasgow United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States Department of Immunology and Microbiology The Scripps Research Institute La Jolla 92037 CA United States Institute of Genomics and Global Health Redeemer's University Osun State Ede Nigeria Department of Computer Science and Engineering University of California San Diego La Jolla 92093 CA United States Department of Mathematics School of Science and Engineering Tulane University New Orleans LA United States Department of Population Health and Disease Prevention University of California Irvine Irvine 92617 CA United States Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles 90095 CA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States School of Biological Sciences University of Hong Kong Hong Kong Hong Kong China Biodiversity Green Development Foundation Beijing China Spatial Epidemiology Lab (SpELL) Université Libre de Bruxelles CP160/12 50 av. FD Roosevelt Bruxelles 1050 Belgium Department of Microbiology Immunology and Transplantation Rega Institute
The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecovir... 详细信息
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In vitro activity of imipenem/relebactam, meropenem/vaborbactam and comparators against Enterobacterales from patients with intra-abdominal infections: Results of the study for Monitoring Antimicrobial Resistance Trends (SMART) in Taiwan, 2020
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Journal of Microbiology, Immunology and Infection 2023年 第1期56卷 75-83页
作者: Lee, Yu-Lin Ko, Wen-Chien Hsueh, Po-Ren Department of Internal Medicine Changhua Christian Hospital Changhua Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan Department of Medicine College of Medicine National Cheng Kung University Tainan Taiwan Departments of Laboratory Medicine and Internal Medicine China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Ph.D Program for Aging School of Medicine China Medical University Taichung Taiwan Departments of Laboratory Medicine and Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan
Background: Multi-drug resistant Enterobacterales is a growing health threat. Imipenem/relebactam and meropenem/vaborbactam, are not clinically used in Taiwan and the susceptibility is lack from routine laboratory tes... 详细信息
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Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence
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Molecular and Cellular proteomics 2009年 第12期8卷 2613-2623页
作者: Lin, Miao-Hsia Hsu, Tung-Li Lin, Shu-Yu Pan, Yi-Jiun Jan, Jia-Tsrong Wang, Jin-Town Khoo, Kay-Hooi Wu, Shih-Hsiung Institute of Biochemical Sciences College of Life Sciences National Taiwan University Taipei 106 Taiwan Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan National Research Program for Genomic Medicine Core Facilities for Proteomics Research Academia Sinica Taipei 115 Taiwan Genomics Research Center Academia Sinica Taipei 115 Taiwan Department of Microbiology National Taiwan University College of Medicine Taipei 100 Taiwan
Encapsulated Klebsiella pneumoniae is the predominant causative agent of pyogenic liver abscess, an emerging infectious disease that often complicates metastatic meningitis or endophthalmitis. The capsular polysacchar...
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A Bayesian mixture model for clustering on the stiefel manifold
arXiv
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arXiv 2017年
作者: Sengupta, Subhajit Pal, Subhadip Mitra, Riten Guo, Ying Banerjee, Arunava Ji, Yuan Program for Computational Genomics and Medicine NorthShore University HealthSystem Department of Bioinformatics and Biostatistics University of Louisville Department of Biostatistics and Bioinformatics Emory University Department of Computer and Information Science and Engineering University of Florida Department of Public Health Sciences University of Chicago
Analysis of a Bayesian mixture model for the Matrix Langevin distribution on the Stiefel manifold is presented. The model exploits a particular parametrization of the Matrix Langevin distribution, various aspects of w... 详细信息
来源: 评论
Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq
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Nature communications 2025年 第1期16卷 4785页
作者: Hefei Zhang Xuhang Li Dongyuan Song Onur Yukselen Shivani Nanda Alper Kucukural Jingyi Jessica Li Manuel Garber Albertha J M Walhout Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. Bioinformatics Interdepartmental Ph.D. Program University of California Los Angeles CA USA. Department of Genetics and Genome Sciences University of Connecticut Health Center Farmington CT USA. Via Scientific Inc. Cambridge MA USA. Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. Department of Statistics and Data Science Department of Biostatistics Department of Computational Medicine and Department of Human Genetics University of California Los Angeles CA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. manuel.garber@umassmed.edu. Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. marian.walhout@umassmed.edu.
Transcriptomes provide highly informative molecular phenotypes that, combined with gene perturbation, can connect genotype to phenotype. An ultimate goal is to perturb every gene and measure transcriptome changes, how...
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PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults
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Neuroscience letters 2025年 138272页
作者: Diane Joss Gunes Sevinc John W Denninger Sat Bir Singh Khalsa Elizabeth A Hoge Manoj Bhasin Jeffery A Dusek Eric Macklin Towia A Libermann Gregory L Fricchione Herbert Benson Sara W Lazar Department of Psychiatry Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA. Electronic address: djoss@cha.harvard.edu. Department of Psychiatry Massachusetts General Hospital Boston MA USA. Harvard Medical School Boston MA USA Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital Boston MA USA. Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital Boston MA USA Department of Medicine Brigham and Women's Hospital Harvard Medical School USA. Department of Psychiatry Georgetown University Medical Center Washington DC USA. Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA. Susan Samueli Integrative Health Institute University of California-Irvine Irvine CA USA School of Medicine University of California-Irvine Irvine CA USA. Harvard Medical School Boston MA USA. Genomics Proteomics Bioinformatics and Systems Biology Center Beth Israel Deaconess Medical Center Boston MA USA.
Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Fun... 详细信息
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Evaluation of using WGS/WES to characterize ACMG actionable genes in genetic testing reports
Evaluation of using WGS/WES to characterize ACMG actionable ...
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2021 IEEE International Conference on bioinformatics and Biomedicine, BIBM 2021
作者: Yang, Wen-Tse Wu, Dong-Chi Liu, Jen-Feng Hong, Jin-Bon Wu, June-Tai Chen, Pei-Lung Chen, Chien-Yu National Taiwan University Department of Biomechatronics Engineering Taipei Taiwan National Taiwan University and Academia Sinica Genome and Systems Biology Degree Program Taipei Taiwan Institute of Molecular Medicine National Taiwan University College of Medicine Taipei Taiwan National Taiwan University Hospital Department of Dermatology Taipei Taiwan Graduate Institute of Medical Genomics and Proteomics National Taiwan University College of Medicine Taipei Taiwan
Since the American College of Medical Genetics and genomics (ACMG) published recommendations for reporting incidental findings in clinical exome and genome sequencing in 2013, the list of suggested actionable genes ap... 详细信息
来源: 评论
Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation (vol 21, pg 432, 2018)
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NATURE NEUROSCIENCE 2018年 第7期21卷 1015-1015页
作者: Preissl, Sebastian Fang, Rongxin Huang, Hui Zhao, Yuan Raviram, Ramya Gorkin, David U. Zhang, Yanxiao Sos, Brandon C. Afzal, Veena Dickel, Diane E. Kuan, Samantha Visel, Axel Pennacchio, Len A. Zhang, Kun Ren, Bing Ludwig Institute for Cancer Research La Jolla CA USA Center for Epigenomics Department of Cellular and Molecular Medicine University of California San Diego School of Medicine La Jolla CA USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA Department of Bioengineering University of California San Diego La Jolla CA USA Environmental Genomics and Systems Biology Division Lawrence Berkeley National Laboratory Berkeley CA USA US Department of Energy Joint Genome Institute Walnut Creek CA USA School of Natural Sciences University of California Merced Merced CA USA Comparative Biochemistry Program University of California Berkeley Berkeley CA USA Institute of Genomic Medicine Moores Cancer Center University of California San Diego School of Medicine La Jolla CA USA
Analysis of chromatin accessibility can reveal transcriptional regulatory sequences, but heterogeneity of primary tissues poses a significant challenge in mapping the precise chromatin landscape in specific cell types... 详细信息
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Distinct adipose progenitor cells emerging with age drive active adipogenesis
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Science (New York, N.Y.) 2025年 第6745期388卷 eadj0430页
作者: Wang, Guan Li, Gaoyan Song, Anying Zhao, Yutian Yu, Jiayu Wang, Yifan Dai, Wenting Salas, Martha Qin, Hanjun Medrano, Leonard Dow, Joan Li, Aimin Armstrong, Brian Fueger, Patrick T. Yu, Hua Zhu, Yi Shao, Mengle Wu, Xiwei Jiang, Lei Campisi, Judith Yang, Xia Wang, Qiong A. Department of Molecular and Cellular Endocrinology Arthur Riggs Diabetes and Metabolism Research Institute City of Hope Medical Center Duarte CA USA Department of Integrative Biology and Physiology University of California Los Angeles CA United States Light Microscopy Core City of Hope Medical Center Duarte CA USA The Integrative Genomics Core City of Hope Medical Center Duarte CA USA Division of Developmental and Translational Diabetes and Endocrinology Research City of Hope Medical Center Duarte CA USA Comprehensive Metabolic Phenotyping Core City of Hope Medical Center Duarte CA USA Pathology Core of Shared Resources City of Hope Medical Center Duarte CA USA Comprehensive Cancer Center Beckman Research Institute City of Hope Medical Center Duarte CA USA Children's Nutrition Research Center Department of Pediatrics Baylor College of Medicine Houston TX United States Key Laboratory of Immune Response and Immunotherapy Shanghai Institute of Immunity and Infection Chinese Academy of Sciences Shanghai China Buck Institute for Research on Aging Novato CA United States Bioinformatics Interdepartmental Program University of California Los Angeles CA United States Institute for Quantitative and Computational Biosciences University of California Los Angeles CA United States Molecular and Medical Pharmacology University of California Los Angeles CA United States
Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive a...
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Importance of surface charge of soot nanoparticles in determining inhalation toxicity in mice
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Environmental Science and Pollution Research 2023年 第7期30卷 18985-18997页
作者: Hsiao, Ta-Chih Han, Chia-Li Yang, Tzu-Ting Lee, Yueh-Lun Shen, Yu-Fang Jheng, Yu-Teng Lee, Chii-Hong Chang, Jer-Hwa Chung, Kian Fan Kuo, Han-Pin Chuang, Hsiao-Chi Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan Master Program in Clinical Genomics and Proteomics College of Pharmacy Taipei Medical University Taipei Taiwan Department of Environmental Engineering and Health Yuanpei University of Medical Technology Hsin Chu City Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Environmental Engineering National Center University Tauyoun Taiwan Genome and Systems Biology Degree Program Academia Sinica and National Taiwan University Taipei Taiwan Department of Pathology Taipei City Hospital Heping Fuyou Branch Taipei Taiwan School of Respiratory Therapy College of Medicine Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan National Heart and Lung Institute Imperial College London London United Kingdom Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan
Physicochemical properties of nanoparticles are important in regulating nanoparticle toxicity;however, the contribution of nanoparticle charge remains unclear. The objective of this study was to investigate the pulmon... 详细信息
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