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检索条件"机构=Department of Medicine and Program in Bioinformatics and Proteomics/Genomics"
276 条 记 录,以下是51-60 订阅
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Machine learning approaches to identify systemic lupus erythematosus in anti-nuclear antibody-positive patients using genomic data and electronic health records
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BioData Mining 2024年 第1期17卷 1页
作者: Chung, Chih-Wei Chou, Seng-Cho Hsiao, Tzu-Hung Zhang, Grace Joyce Chung, Yu-Fang Chen, Yi-Ming Department of Information Management National Taiwan University Taipei Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan Department of Public Health Fu Jen Catholic University New Taipei Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Department of Cellular and Physiological Sciences The University of British Columbia Vancouver BC Canada Department of Electrical Engineering Tunghai University Taichung Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital 1650 Section 4 Boulevard Xitun Dist. Taichung 407 Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Rong Hsing Research Center for Translational Medicine & Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Precision Medicine Research Center College of Medicine National Chung Hsing University Taichung Taiwan
Background: Although the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus (SLE) has required at least a positive anti-nuclear antibody (ANA) titer (≥ 1:80), it remains challenging for clinician... 详细信息
来源: 评论
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution
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细胞研究(英文版) 2021年 第4期31卷 463-477页
作者: Li Li Lin Li Qingqing Li Xixi Liu Xinyi Ma Jun Yong Shuai Gao Xinglong Wu Yuan Wei Xiaoye Wang Wei Wang Rong Li Jie Yan Xiaohui Zhu Lu Wen Jie Qiao Liying Yan Fuchou Tang Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China Biomedical Pioneering Innovation Center Center for Reproductive MedicineMinistry of EducationKey Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Stem Cell Program Boston Children's HospitalBostonMA 02115USA Department of Stem Cell and Regenerative Biology Harvard UniversityCambridgeMA 02138USA Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China Biomedical Pioneering Innovation Center Center for Reproductive MedicineMinistry of EducationKey Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Key Laboratory of Assisted Reproduction Ministry of EducationBeijing 100191China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics Department of Obstetrics and GynecologyThird HospitalSchool of Life SciencesPeking UniversityBeijing 1008
Proper development of fetal germ cells(FGCs)is vital for the precise transmission of genetic and epigenetic information through *** transcriptional landscapes of human FGC development have been revealed;however,the ep... 详细信息
来源: 评论
ZNF280BY and ZNF280AY: Autosome derived Y-chromosome gene families in Bovidae
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BMC genomics 2011年 第1期12卷 1-15页
作者: Yang, Yang Chang, Ti-Cheng Yasue, Hiroshi Bharti, Arvind K. Retzel, Ernest F. Liu, Wan-Sheng Department of Dairy and Animal Science The Center for Reproductive Biology and Health (CRBH) College of Agricultural Sciences The Pennsylvania State University University Park PA 16802 United States The Integrative Biosciences Program Bioinformatics and Genomics Option The Huck Institute of Life Sciences The Pennsylvania State University University Park PA 16802 United States National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-0901 Japan National Center for Genome Resources Santa Fe NM 87505 United States Department of Pathology and Laboratory Medicine School of Medicine University of North Carolina-Chapel Hill Chapel Hill NC 27599 United States
Background: Recent progress in exploring the Y-chromosome gene content in humans, mice and cats have suggested that "autosome-to-Y" transposition of the male fertility genes is a recurrent theme during the m... 详细信息
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Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-Seq
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BMC Proc 2012年 第SUPPL 6期6卷 P21-P21页
作者: Rebecca L Kusko John Brothers, II Gang Liu Lingqi Luo Brenda Juan Guardela John Tedrow Yuriy Aleksyev Ivana V Yang Mick Correll Mark Geraci John Quackenbush Frank Sciurba Marc Lenburg David A Schwartz Jennifer Beane Naftali Kaminski Avrum Spira Genetics and Genomics Graduate Program Boston University School of Medicine Boston MA USA Bioinformatics Program Boston University Boston MA USA Division of Computational Biomedicine Department of Medicine Boston University School of Medicine Boston MA USA Simmons Center for Interstitial Lung Disease and Department of Medicine University of Pittsburgh Medical Center Pittsburgh PA USA Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston MA USA Center for Genes Environment and Health and Department of Medicine National Jewish Health Denver CO USA Dana-Farber Cancer Institute and Harvard School of Public Health Boston MA USA Department of Medicine University of Colorado School of Medicine Aurora CO USA
来源: 评论
Targeting protein-protein interaction interfaces with antiviral N protein inhibitor in SARS-CoV-2
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Biophysical Journal 2024年 第4期123卷 478-488页
作者: Hong, Jhen-Yi Lin, Shih-Chao Kehn-Hall, Kylene Zhang, Kai-Min Luo, Shun-Yuan Wu, Hung-Yi Chang, Sui-Yuan Hou, Ming-Hon Institute of Genomics and Bioinformatics and Department of Life Sciences National Chung Hsing University Taichung Taiwan Bachelor Degree Program in Marine Biotechnology College of Life Sciences National Taiwan Ocean University Keelung Taiwan Department of Biomedical Sciences and Pathobiology Virginia-Maryland College of Veterinary Medicine Virginia Polytechnic Institute and State University Blacksburg VA United States Center for Emerging Zoonotic and Arthropod-borne Pathogens Virginia Polytechnic Institute and State University Blacksburg VA United States Department of Chemistry National Chung Hsing University Taichung Taiwan Graduate Institute of Veterinary Pathobiology College of Veterinary Medicine National Chung Hsing University. Taichung Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan PhD Program in Medical Biotechnology National Chung Hsing University Taichung Taiwan Biotechnology Center National Chung Hsing University Taichung Taiwan
Coronaviruses not only pose significant global public health threats but also cause extensive damage to livestock-based industries. Previous studies have shown that 5-benzyloxygramine (P3) targets the Middle East resp...
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Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer
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Signal Transduction and Targeted Therapy 2023年 第9期8卷 4365-4379页
作者: Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong Department of Urology Guangzhou First People’s HospitalSouth China University of Technology510180 GuangzhouGuangdongChina Urology Key Laboratory of Guangdong Province The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical University510230 GuangzhouGuangdongChina Guangzhou National Laboratory No.9 XingDaoHuanBei RoadGuangzhou International Bio Island510005 GuangzhouGuangdongChina Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92507USA Graduate Program in Genetics Genomics&BioinformaticsUniversity of CaliforniaRiversideCA 92507USA State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyTaipa999078 MacaoChina
The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical *** treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to dr... 详细信息
来源: 评论
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
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Cellular & Molecular Immunology 2024年 第8期21卷 918-931页
作者: Bilal Alashkar Alhamwe Viviane Ponath Fahd Alhamdan Bastian Dörsam Clara Landwehr Manuel Linder Kim Pauck Sarah Miethe Holger Garn Florian Finkernagel Anna Brichkina Matthias Lauth Dinesh Kumar Tiwari Malte Buchholz Daniel Bachurski Sabrina Elmshäuser Andrea Nist Thorsten Stiewe Lisa Pogge von Strandmann Witold Szymański Vanessa Beutgen Johannes Graumann Julia Teply-Szymanski Corinna Keber Carsten Denkert Ralf Jacob Christian Preußer Elke Pogge von Strandmann Institute for Tumor Immunology Philipps-University35043MarburgGermany Core Facility Extracellular Vesicles Philipps-University35043MarburgGermany Department of Anesthesiology Critical Careand Pain MedicineCardiac Anesthesia DivisionBoston Children’s HospitalBostonUSA Department of Immunology and Anaesthesia Harvard Medical SchoolBostonMAUSA Translational Inflammation Research Division&Core Facility for Single Cell Multiomics Philipps-University35043MarburgGermany Core Facility Bioinformatics Philipps-University35043MarburgGermany Clinic for Gastroenterology Endocrinology and MetabolismCenter for Tumor and Immune BiologyPhilipps-University35043MarburgGermany Institute of Systems Immunology Philipps-University35043MarburgGermany Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of CologneCologneGermany Institute of Molecular Oncology and Genomics Core Facility Member of the German Center for Lung Research(DZL)Philipps-University35043MarburgGermany Institute of Lung Health Justus Liebig University35392GiessenGermany Institute of Translational Proteomics&Core Facility Translational Proteomics Biochemical/Pharmacological CentrePhilipps-University35043MarburgGermany Institute of Pathology Philipps-University Marburg and University Hospital Marburg(UKGM)MarburgGermany Department of Cell Biology and Cell Pathology Philipps-University35043MarburgGermany
Recent studies reveal a critical role of tumor cell-released extracellular vesicles(EVs)in pancreatic cancer(PC)***,driver genes that direct EV function,the EV-recipient cells,and their cellular response to EV uptake ... 详细信息
来源: 评论
Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing
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BMC Proceedings 2012年 第6期6卷 1-2页
作者: John Brothers II Paola Sebastiani Marc Lenburg Avrum Spira Rebecca Kusko Yuriy Alekesyev Gang Liu Lingqi Luo Jennifer Beane Brenda Juan Guardela John Tedrow Frank Sciurba Naftali Kaminski Ivana V Yang David A Schwartz Mick Correll John Quackenbush Mark Geraci Bioinformatics Program Boston University Boston MA 02115 USA Genetics and Genomics Graduate Program Boston University School of Medicine Boston MA 02118 USA Department of Medicine Boston University School of Medicine Section of Computational Biomedicine Boston MA 02118 USA Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston MA 02118 USA Simmons Center for Interstitial Lung Disease and Department of Medicine University of Pittsburgh Medical Center Pittsburgh PA 15213 USA Center for Genes Environment and Health and Department of Medicine National Jewish Health Denver CO 80206 USA Dana-Farber Cancer Institute and Harvard School of Public Health Boston MA 02115 USA Department of Medicine University of Colorado School of Medicine Aurora CO 80045 USA
来源: 评论
The cell surface marker CD36 selectively identifies matured,mitochondria-rich hPSC-cardiomyocytes
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细胞研究(英文版) 2020年 第7期30卷 626-629页
作者: Ellen Ngar-Yun Poon Xiao-ling Luo Sarah E.Webb Bin Yan Rui Zhao Stanley Chun Ming Wu Yong Yang Peng Zhang Huajun Bai Jiaofang Shao Ching Man Chan Godfrey Chi-Fung Chan Suk Ying Tsang Rebekah L.Gundry Huang-Tian Yang Kenneth R.Boheler Department of Medicine and Therapeutics and Centre for Cardiovascular Genomics and Medicine The Chinese University of Hong Kong (CUHK) HKSAR China CAS Key Laboratory of Tissue Microenvironment and Tumor Laboratory of Molecular CardiologyShanghai Institute of Nutrition and Health University of Chinese Academy of Sciences (CAS) CAS Shanghai China Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology HKSAR China Department of Computer Science The University of Hong Kong (HKU) HKSAR China Intervention and Cell Therapy Center Peking University Shenzhen Hospital Shenzhen China School of Life Sciences CUHK HKSAR China Department of Paediatrics and Adolescent Medicine HKU HKSAR China School of Biomedical Sciences HKU HKSAR China SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology (SUSTech) Shenzhen China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical University Nanjing Jiangsu China State Key Laboratory of Agrobiotechnology CUHK HKSAR China Department of Biochemistry and Center for Biomedical Mass Spectrometry Research Medical College of Wisconsin Milwaukee WIUSA CardiOmics Program Center for Heart and Vascular Research Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology University of Nebraska Medical Center Omaha NE USA Institute for Stem Cell and Regeneration Medicine CASBeijing China Division of Cardiology Department of Medicineand Department of Biomedical Engineering The Johns Hopkins University Baltimore MD USA
Dear Editor,Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) are of significant translational value to in vitro studies of human cardiac development, drug and cardiotoxicity testing and cardiac disease ... 详细信息
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Identification of microRNA in the protist Trichomonas vaginalis
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genomics 2009年 第5期93卷 487-493页
作者: Lin, Wei-Chen Li, Sung-Chou Lin, Wen-Chang Shin, Jyh-Wei Hu, Song-Nian Yu, Xiao-Min Huang, Ting-Yun Chen, Shih-Chieh Chen, Hua-Chien Chen, Shu-Jen Huang, Po-Jung Ruei-Chi Gan, Richie Chiu, Cheng-Hsun Tang, Petrus Molecular Regulation and Bioinformatics Laboratory Chang Gung University Taoyuan 333 Taiwan Division of Microbiology Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan 333 Taiwan Institute of Biomedical Informatics National Yang-Ming University Taipei 112 Taiwan Taiwan International Graduate Program in Bioinformatics Academia Sinica Taipei 115 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 115 Taiwan Department of Parasitology National Cheng Kung University Tainan 701 Taiwan Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing China Graduate University Chinese Academy of Sciences Beijing China Department of Life Sciences Chang Gung University Taoyuan 333 Taiwan Molecular Medicine Research Center Chang Gung University Taoyuan 333 Taiwan Bioinformatics Center Chang Gung University Tao-Yuan 333 Taiwan Chang Gung Molecular Infectious Diseases Research Center Chang Gung Memorial Hospital Taoyuan 333 Taiwan
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have important regulatory roles in multicellular organisms. However, miRNA has never been identified experimentally in protist. Direct cloning of 438 express... 详细信息
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