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Inhibition of Pathogen Adhesion by Bacterial Outer Membrane‐Coated Nanoparticles

Angewandte Chemie 2019年第33期131卷

作者： Yue Zhang Yijie Chen Christopher Lo Jia Zhuang Pavimol Angsantikul Qiangzhe Zhang Xiaoli Wei Zhidong Zhou Marygorret Obonyo Ronnie H. Fang Weiwei Gao Liangfang Zhang Department of NanoEngineering Chemical Engineering Program Moores Cancer Center University of California San Diego La Jolla CA 92039 USA Department of Medicine University of California San Diego La Jolla CA 92093 USA

Anti‐adhesion therapies interfere with the bacterial adhesion to the host and thus avoid direct disruption of bacterial cycles for killing, which may alleviate resistance development. Herein, an anti‐adhesion nanomedicine platform is made by wrapping synthetic polymeric cores with bacterial outer membranes. The resulting bacterium‐mimicking nanoparticles (denoted “OM‐NPs”) compete with source bacteria for binding to the host. The “top‐down” fabrication of OM‐NPs avoids the identification of the adhesins and bypasses the design of agonists targeting these adhesins. In this study, OM‐NPs are made with the membrane of Helicobacter pylori and shown to bind with gastric epithelial cells (AGS cells). Treatment of AGS cells with OM‐NPs reduces H. pylori adhesion and such anti‐adhesion efficacy is dependent on OM‐NP concentration and its dosing sequence.

关键词： Antiadhäsion Bakterienmembranen Biomimetische Nanopartikel Infektiöse Krankheiten Nanomedizin

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Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls:Nanoshuttles for targeted on-demand theranostics

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Bone Research 2017年第4期5卷 343-356页

作者： Liping Wang Grace Jang Deependra Kumar Ban Vrinda Sant Jay Seth Sami Kazmi Nirav Patel Qingqing Yang Joon Lee Woraphong Janetanakit Shanshan Wang Brian P Head Gennadi Glinsky Ratneshwar Lai School of Biomedical Engineering Shanghai Jiaotong UniverityShanghaiChina Department of Mechanical and Aerospace Engineering La JollaCAUSA Materials Science and Engineering Program La JollaCAUSA Department of Nanoengineering La JollaCAUSA Department of Chemical Engineering University of California San DiegoLa JollaCAUSA Departrnenf of Bioengineering La JollaCAUSA Department of Anesthesiology La JollaCAUSA Veterans Affairs San Diego Healthcare System San DiegoCAUSA Institute of Engineering in Medicine La JollaCAUSA

Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles （NP）-embedded silica nanoshuttles （MGNSs） with nanopores on their surface. Fluorescently labeled Doxombicin （DOX）, a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P（NIPAM-co- MAA） to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in：（a） a glass capillary tube to simulate their delivery via blood vessels; and （b） porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood-brain barrier {BBB）. The viscoelastic properties of hydrogels were examined by atomic force microscopy （AFM）. Cellular uptake of DOX- loaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells （iPSCs） as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells＇ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and ep

关键词： Multifunctional stimuli responsive polymer-gated iron

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Exploiting Mechanistic Solvation Kinetics for Dual‐Graphite Batteries with High Power Output at Extremely Low Temperature

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Angewandte Chemie 2019年第52期131卷

作者： John Holoubek Yijie Yin Mingqian Li Mingyu Yu Ying Shirley Meng Ping Liu Zheng Chen Department of NanoEngineering University of California San Diego La Jolla CA 92093 USA Program of Materials Science University of California San Diego La Jolla CA 92093 USA Program of Chemical Engineering University of California San Diego La Jolla CA 92093 USA Sustainable Power and Energy Center University of California San Diego La Jolla CA 92093 USA

Improving the extremely low temperature operation of rechargeable batteries is vital to the operation of electronics in extreme environments, where systems capable of high‐rate discharge are in short supply. Herein, we demonstrate the holistic design of dual‐graphite batteries, which circumvent the sluggish ion‐desolvation process found in typical lithium‐ion batteries during discharge. These batteries were enabled by a novel electrolyte, which simultaneously provides high electrochemical stability and ionic conductivity at low temperature. The dual‐graphite cells, when compared to industry‐type graphite ∥ LiCoO 2 full‐cells demonstrated an 11 times increased capacity retention at −60 °C for a 10 C discharge rate, indicative of the superior kinetics of the “dual‐ion” storage mechanism. These trends are further supported by galvanostatic intermittent titration technique (GITT) and electrochemical impedance spectroscopy (EIS) measurements at reduced temperature. This work provides a new design strategy for extreme low‐temperature batteries.

关键词： Dual-Ionen-Batterien Flüssige Elektrolyte Graphit Ionensolvatation Niedrigtemperatur-Batterien

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Electrophoretic deposition of nanoparticles into three-dimensional felt as an electrocatalyst for the solar sulfur ammonia thermochemical cycle 229

Electrophoretic deposition of nanoparticles into three-dimen...

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Symposium on Electrophoretic Deposition - 229th ECS Meeting

作者： Pacheco, N.S. Talbot, J.B. Chemical Engineering Program Department of NanoEngineering University of California San DiegoCA92093 United States

ISBN: (纸本)9781623323899

The penetration and coating of nanoparticles by electrophoretic deposition (EPD) into three-dimensional substrates was studied. Specifically, EPD of cobalt ferrite nanoparticles was investigated as a possible electrocatalyst to improve the kinetically slow anodic reaction of the oxidation of ammonium sulfite to ammonium sulfate in the hydrogen production sub-cycle of the proposed solar sulfur-ammonia thermochemical water-splitting process. The primary goals were to uniformly penetrate and coat nanoparticles into 3D substrates by electrophoretic deposition and then to test their electrocatalytic activity by linear sweep voltammetry in 2 M ammonium sulfite. © The Electrochemical Society.

关键词： Nanoparticles

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SEM analysis of electrophoretically-deposited cobalt ferrite films 229

SEM analysis of electrophoretically-deposited cobalt ferrite...

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Symposium on Electrophoretic Deposition - 229th ECS Meeting

作者： Verma, N. Talbot, J.B. Chemical Engineering Program Department of NanoEngineering University of California San Diego San DiegoCA92093 United States

ISBN: (纸本)9781623323899

Cobalt ferrite nanoparticles were synthesized and electrophoretically deposited onto aluminum foil, graphite paper, and carbon felt. The resulting cobalt ferrite films were studied to determine their potential for use as an electrocatalyst for the oxidation of ammonium sulfite to ammonium sulfate for a proposed sulfur ammonia thermochemical cycle for hydrogen production. The effects of electrophoretic deposition conditions on deposit morphology and the effects of deposit morphology on electrochemical activity in 2M ammonium sulfite were investigated by SEM analysis. © The Electrochemical Society.

关键词： Sulfur compounds

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Electrophoretic deposition of nanoparticles as electrocatalysts for electrolysis in the solar sulfur ammonia hydrogen production 5th

Electrophoretic deposition of nanoparticles as electrocataly...

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5th International Conference on Electrophoretic Deposition: Fundamentals and Applications, EPD 2014

作者： Pacheco, Nicole S. Verma, Neil Haider, Komail Talbot, Jan B. Chemical Engineering Program Department of NanoEngineering University of California San DiegoCA92093 United States

ISBN: (纸本)9783038354970

Cobalt ferrite nanoparticles were deposited using electrophoretic deposition from two different bath chemistries, 90 vol.% water and 10 vol.% isopropanol with hexadecyltrimethlyammonium bromide (CTAB) and 100 % ethanol. The deposits were tested for electrocatalytic activity for the oxidation of ammonium sulfite to ammonium sulfate as part of a solar sulfur ammonia thermochemical cycle to produce hydrogen. © (2015) Trans Tech Publications, Switzerland.

关键词： Nanoparticles

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Bioprinting: Microfluidics‐Enabled Multimaterial Maskless Stereolithographic Bioprinting (Adv. Mater. 27/2018)

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Advanced Materials 2018年第27期30卷

作者： Amir K. Miri Daniel Nieto Luis Iglesias Hossein Goodarzi Hosseinabadi Sushila Maharjan Guillermo U. Ruiz‐Esparza Parastoo Khoshakhlagh Amir Manbachi Mehmet Remzi Dokmeci Shaochen Chen Su Ryon Shin Yu Shrike Zhang Ali Khademhosseini Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA Microoptics and GRIN Optics Group Applied Physics Department Faculty of Physics University of Santiago de Compostela Santiago de Compostela 15782 Spain Polymeric Materials Research Group Department of Materials Science and Engineering Sharif University of Technology Tehran *** Iran Department of Biomedical Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA Department of NanoEngineering University of California San Diego La Jolla CA 92093 USA Department of Bioengineering University of California San Diego La Jolla CA 92093 USA Materials Science and Engineering Program University of California San Diego La Jolla CA 92093 USA Center for Minimally Invasive Therapeutics (C‐MIT) University of California‐Los Angeles Los Angeles CA 90095 USA Department of Radiology David Geffen School of Medicine University of California‐Los Angeles Los Angeles CA 90095 USA Department of Bioengineering Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA California NanoSystems Institute (CNSI) University of California‐Los Angeles Los Angeles CA 90095 USA Department of Bioindustrial Technologies Konkuk University Seoul 143‐701 Republic of Korea

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Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

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Nature nanotechnology 2019年第8期14卷 811页

作者： Hon S Leong Kimberly S Butler C Jeffrey Brinker May Azzawi Steve Conlan Christine Dufès Andrew Owen Steve Rannard Chris Scott Chunying Chen Marina A Dobrovolskaia Serguei V Kozlov Adriele Prina-Mello Ruth Schmid Peter Wick Fanny Caputo Patrick Boisseau Rachael M Crist Scott E McNeil Bengt Fadeel Lang Tran Steffen Foss Hansen Nanna B Hartmann Lauge P W Clausen Lars M Skjolding Anders Baun Marlene Ågerstrand Zhen Gu Dimitrios A Lamprou Clare Hoskins Leaf Huang Wantong Song Huiliang Cao Xuanyong Liu Klaus D Jandt Wen Jiang Betty Y S Kim Korin E Wheeler Andrew J Chetwynd Iseult Lynch Sayed Moein Moghimi André Nel Tian Xia Paul S Weiss Bruno Sarmento José das Neves Hélder A Santos Luis Santos Samir Mitragotri Steve Little Dan Peer Mansoor M Amiji Maria José Alonso Alke Petri-Fink Sandor Balog Aaron Lee Barbara Drasler Barbara Rothen-Rutishauser Stefan Wilhelm Handan Acar Roger G Harrison Chuanbin Mao Priyabrata Mukherjee Rajagopal Ramesh Lacey R McNally Sara Busatto Joy Wolfram Paolo Bergese Mauro Ferrari Ronnie H Fang Liangfang Zhang Jie Zheng Chuanqi Peng Bujie Du Mengxiao Yu Danielle M Charron Gang Zheng Chiara Pastore Department of Urology Mayo Clinic Rochester MN USA. Department of Physiology and Biomedical Engineering Mayo Clinic Rochester MN USA. Department of Nanobiology Sandia National Laboratories Albuquerque NM USA. Center for Micro-Engineered Materials University of New Mexico Albuquerque Albuquerque NM USA. Departments of Chemical and Biological Engineering University of New Mexico Albuquerque NM USA. Department of Molecular Genetics and Microbiology University of New Mexico Albuquerque NM USA. UNM Comprehensive Cancer Center University of New Mexico Albuquerque NM USA. Cardiovascular Research Group School of Healthcare Science Manchester Metropolitan University Manchester UK. British Society for Nanomedicine Liverpool UK. Institute of Life Science Swansea University Medical School Swansea University Swansea UK. Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK. Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK. Department of Chemistry School of Physical Sciences University of Liverpool Liverpool UK. Centre for Cancer Research and Cell Biology Queen's University of Belfast Belfast UK. National Center for Nanoscience and Technology of China Beijing China. Cancer Research Technology Program Nanotechnology Characterization Laboratory Frederick National Laboratory for Cancer Research Frederick MD USA. Laboratory of Animal Sciences Program Center for Advanced Preclinical Research Frederick National Laboratory for Cancer Research Frederick National Laboratory for Cancer Research Frederick MD USA. Trinity Translational Medicine Institute Department of Clinical Medicine Trinity College Dublin Dublin Ireland. Laboratory for Biological Characterisation of Advanced Materials Trinity Translational Medicine Institute Trinity College Dublin Dublin Ireland. Nanomedicine Group Advanced Materials and Bioengineering Research (AMBER) centre Centre

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The AFLOW fleet for materials discovery

arXiv

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arXiv 2017年

作者： Toher, Cormac Oses, Corey Hicks, David Gossett, Eric Rose, Frisco Nath, Pinku Usanmaz, Demet Ford, Denise C. Perim, Eric Calderon, Camilo E. Plata, Jose J. Lederer, Yoav Jahnátek, Michal Setyawan, Wahyu Wang, Shidong Xue, Junkai Rasch, Kevin Chepulskii, Roman V. Taylor, Richard H. Gomez, Geena Shi, Harvey Supka, Andrew R. Al Orabi, Rabih Al Rahal Gopal, Priya Cerasoli, Frank T. Liyanage, Laalitha Wang, Haihang Siloi, Ilaria Agapito, Luis A. Nyshadham, Chandramouli Hart, Gus L.W. Carrete, Jesús Legrain, Fleur Mingo, Natalio Zurek, Eva Isayev, Olexandr Tropsha, Alexander Sanvito, Stefano Hanson, Robert M. Takeuchi, Ichiro Mehl, Michael J. Kolmogorov, Aleksey N. Yang, Kesong D'Amico, Pino Calzolari, Arrigo Costa, Marcio De Gennaro, Riccardo Nardelli, Marco Buongiorno Fornari, Marco Levy, Ohad Curtarolo, Stefano Department of Mechanical Engineering and Materials Science Duke University DurhamNC27708 United States Center for Materials Genomics Duke University DurhamNC27708 United States Departamento de Química Física Universidad de Sevilla Sevilla41012 Spain Department of Physics NRCN P.O. Box 9001 Beer-Sheva84190 Israel Department of Materials Science and Engineering Massachusetts Institute of Technology MA02139 United States Department of Physics and Science of Advanced Materials Program Central Michigan University Mount PleasantMI48859 United States Science of Advanced Materials Program Central Michigan University Mount PleasantMI United States Solvay Design and Development of Functional Materials Department AXEL'ONE Collaborative Platform - Innovative Materials Saint Fons Cedex69192 France Department of Physics Department of Chemistry University of North Texas DentonTX76203 United States Department of Physics and Astronomy Brigham Young University ProvoUT84602 United States Institute of Materials Chemistry TU Wien ViennaA-1060 Austria Universite e Grenoble Alpes Grenoble38000 France CEA LITEN 17 Rue des Martyrs Grenoble38054 France Department of Chemistry State University of New York at Buffalo BuffaloNY14260 United States Laboratory for Molecular Modeling Division of Chemical Biology and Medicinal Chemistry UNC Eshelman School of Pharmacy University of North Carolina Chapel HillNC27599 United States School of Physics AMBER and CRANN Institute Trinity College Dublin 2 Ireland Department of Chemistry St. Olaf College NorthfieldMN55057 United States Center for Nanophysics and Advanced Materials University of Maryland College ParkMD20742 United States Department of Materials Science and Engineering University of Maryland College ParkMD20742 United States United States Naval Academy AnnapolisMD21402 United States Department of Physics Binghamton University State University of New York BinghamtonNY13902 United States Depart

The traditional paradigm for materials discovery has been recently expanded to incorporate substantial data driven research. With the intent to accelerate the development and the deployment of new technologies, the AFLOW Fleet for computational materials design automates high-throughput first principles calculations, and provides tools for data verification and dissemination for a broad community of users. AFLOW incorporates different computational modules to robustly determine thermodynamic stability, electronic band structures, vibrational dispersions, thermo-mechanical properties and more. The AFLOW data repository is publicly accessible online at ***, with more than 1.7 million materials entries and a panoply of queryable computed properties. Tools to programmatically search and process the data, as well as to perform online machine learning predictions, are also available. Copyright © 2017, The Authors. All rights reserved.

关键词： Calculations

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New Applications of Electrophoretic Deposition (Solid State Lighting)

New Applications of Electrophoretic Deposition (Solid State ...

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Annual Meeting of the American Electrophoresis Society 2014, AES 2014 - Topical Conference at the 2014 AIChE Annual Meeting

作者： Talbot, Jan B. Chemical Engineering Program Department of NanoEngineering University of California San Diego San DiegoCA United States

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