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Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis

Environmental Toxicology 2024年第6期39卷 3356-3366页

作者： Kuo, Min-Yung Dai, Wen-Chyi Chang, Jie-Li Chang, Jo-Shu Lee, Tse-Min Chang, Chia-Che Pediatric Surgery Division Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung Taiwan Doctoral Program in Biotechnology Industrial Innovation and Management National Chung Hsing University Taichung Taiwan Taichung Municipal Taichung First Senior High School Taichung Taiwan Department of Chemical and Materials Engineering Research Center for Smart Sustainable Circular Economy Tunghai University Taichung Taiwan Department of Life Sciences National Chung Hsing University Taichung Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung Taiwan Graduate Institute of Biomedical Sciences Master Program in Precision Health Doctoral Program in Translational Medicine Rong Hsing Research Center for Translational Medicine The iEGG and Animal Biotechnology Research Center National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan

Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising target in cancer therapy due to its persistent activation in various cancers, including melanoma. Herein, we revealed that Fucoxanthin is cytotoxic to human melanoma cell lines A2758 and A375 while showing limited cytotoxicity to normal human melanocytes. Apoptosis is a primary reason for Fucoxanthin's melanoma cytotoxicity, as the pan-caspase inhibitor z-VAD-fmk drastically abrogated Fucoxanthin-elicited clonogenicity blockage. Besides, Fucoxanthin downregulated tyrosine 705-phosphorylated STAT3 (p-STAT3 (Y705)), either inherently present in melanoma cells or inducible by interleukin 6 (IL-6) stimulation. Notably, ectopic expression of STAT3-C, a dominant-active STAT3 mutant, abolished Fucoxanthin-elicited melanoma cell apoptosis and clonogenicity inhibition, supporting the pivotal role of STAT3 blockage in Fucoxanthin's melanoma cytotoxicity. Moreover, Fucoxanthin lowered BCL-xL levels by blocking STAT3 activation, while ectopic BCL-xL expression rescued melanoma cells from Fucoxanthin-induced killing. Lastly, Fucoxanthin was found to diminish the levels of JAK2 with dual phosphorylation at tyrosine residues 1007 and 1008 in melanoma cells, suggesting that Fucoxanthin impairs STAT3 signaling by blocking JAK2 activation. Collectively, we present the first evidence that Fucoxanthin is cytotoxic selectively against human melanoma cells while sparing normal melanocytes. Mechanistically, Fucoxanthin targets the JAK2/STAT3/BCL-xL antiapoptotic axis to provoke melanoma cell death. This discovery implicates the potential application of Fucoxanthin as a chemopreventive or therapeutic strategy for melanoma management. © 2024 Wiley Periodicals LLC.

关键词： Carotenoids

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Reusable Hydrogen Storage Tank with Flange Design

Reusable Hydrogen Storage Tank with Flange Design

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International Conference on Applied System Innovation (ICASI)

作者： Yun-Qi Li Hsuan-Jung Chen Hsi-Wen Yang Chih-Yuan Chen Shao-Fu Chang Ssu-Ying Chen Chien-Chon Chen College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Department of Chemistry Michigan State University MI USA Department of Materials Engineering National United University Miaoli Taiwan Graduate Institute of Intellectual Property National Taipei University of Technology Taiwan Department of Energy Engineering National United University Miaoli Taiwan

ISBN: (数字)9798350394924

ISBN: (纸本)9798350394931

For how to store and transport hydrogen, the first thought is to store hydrogen directly in the cylinder. However, this method is not desirable, because generally at least 700 atm high pressure, the hydrogen contained in the cylinder to be useful. Therefore it is very unsafe at such high pressures. In This paper, we design and production of a new generation of solid-state hydrogen storage and discharge container. The goal of “development of solid-state hydrogen storage technology” is to break through the bottlenecks of hydrogen storage technology safety, hydrogen storage density, high-efficiency hydrogen absorption and release, transportation safety, and engineering practice.

关键词： Technological innovation Hydrogen storage Temperature Surface resistance Hydrogen Transportation Production

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Ultra Wide Dynamic Range High Power RF Rectifier

Ultra Wide Dynamic Range High Power RF Rectifier

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European Conference on Antennas and Propagation, EuCAP

作者： Xiaochen Yu Jinyao Zhang Minzhang Liu Yi Huang Ta-Jen Yen Jiafeng Zhou Department of Electrical Engineering and Electronics University of Liverpool Liverpool UK Department of Materials Science and Engineering National Tsing Hua University Hsinchu Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan

A high-power RF-to-DC rectifier applied to wireless power transfer (WPT) with ultra-wide input power dynamic range is proposed in this paper. A GaN (gallium nitride) HEMT (high electron mobility transistor) is utilized to realize rectification at high power up to 12 W and a Schottky diode is used for lower-power rectification. Excellent switching between the two circuits’ rectification modes is achieved by adding a circulator. The rectifier has a 30 dB dynamic range with an efficiency of over 50% at 2.4 GHz.

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Low voltage graphene interface engineered organic ferroelectric tunnel junction devices

arXiv

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arXiv 2025年

作者： Natani, S. Khajanji, P. Cheng, L. Eshraghi, K. Zhang, Z. Shipley, W. Tao, A. Bandaru, P.R. Department of Mechanical Engineering University of California San Diego La Jolla CA United States Program in Materials Science University of California San Diego La Jolla CA United States Applied Materials Santa ClaraCA United States

It has been indicated 1 that the path forward for the widespread usage of ferroelectric (FE) materials may be considerably facilitated through the reduction of programming voltages to on-chip logic compatible values o... 详细信息

关键词： Ferroelectric devices

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Pulsing-Induced Healing of a Surface Crack of a Nickel-Based Alloy

SSRN

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SSRN 2024年

作者： Wang, Qian Quan, Mingming Tan, Zhen Liu, Ming Wang, Dianlong Yang, Xiao Liu, Ying Mao, Yaning Liang, Zhimin Yang, Fuqian Wang, Liwei School of Material Science and Engineering Hebei University of Science and Technology Shijiazhuang050018 China Hebei Key Laboratory of Material Near-Net Forming Technology Shijiazhuang050018 China School of Mechanical Engineering and Automation Fuzhou University Fuzhou350108 China HBIS Group Materials Institute HBIS Group Hebei Shijiazhuang050023 China Materials Program Department of Chemical and Materials Engineering University of Kentucky LexingtonKY40506 United States School of Material Science and Engineering Australia

In this work, we demonstrate the feasibility of applying electric pulses to heal surface cracks on Ni-based GH4169 alloy under compressive load. There exists an incubation time for the onset of the healing of a crack, which is associated with local temperature at the crack tip. The crack size decreases with increasing the pulsing time at a constant healing rate prior to complete healing of the crack. Increasing compressive load accelerates the healing process. The electric pulsing leads to the formation of an influential zone surrounding the crack with the finest grain sizes in the healed crack and the coarsest grain sizes away from the influential zone. The indentation hardness increases with the increase the distance to the crack tip of the healed crack. A model of viscous flow in the crack channel is proposed for the crack healing. The resultant force on the crack faces due to the crack healing increases with the increase of the healing time and the decrease of the crack width. © 2024, The Authors. All rights reserved.

关键词： Crack tips

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Growth Mechanism and Photoresponses of Anodized WO3 Nanotubes Fabricated Using Aao Templates

SSRN

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SSRN 2024年

作者： Chang, Yung-Huang Liao, Yi-Ting Huang, Chien-Sheng Chen, Yuan-Tsung Bachelor Program in Industrial Technology National Yunlin University of Science and Technology Yunlin Taiwan Department of Electronic Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate School of Materials Science National Yunlin University of Science and Technology Yunlin Taiwan

For anodic aluminum oxide (AAO)-assisted anodization process, almost all metal oxide nanostructures are in the form of nanodots and nanorods, while tubular metal oxide nanostructures are rarely investigated. In this study, the anodized WO3 nanotubes with cap structures are successfully fabricated via AAO assistance in an anodization process. The height of the WO3 nanotubes is limited to ~180 nm by an electric field of 0.75 GV/m due to the dielectric breakdown effect, which is larger than the height of ~130 nm for the nanorods with 0.855 GV/m. The WO3 species is the dominant component at the top of the nanotubes, while the incomplete oxides such as W2O5, WOx, and even tungsten metal rule the elementss at the bottom. The bottom-up growth mechanism of the WO3 nanotubes is identified at the oxide/metal interface. The photoresponse of the WO3 nanotubes exhibits superiority under blue and UV light irradiation compared to the incompletely anodized WO3 nanorings, whereas opposite results are observed under red and green light irradiation. This result demonstrates that completely anodized structures facilitate exciton pumping, while incomplete oxides are conducive to low-energy excitons. The unique tubular metal oxide nanostructures are advantageous for designing various sensing devices, especially in optics. © 2024, The Authors. All rights reserved.

关键词： Excitons

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Transferable screened range-separated hybrid functionals for electronic and optical properties of van der Waals materials

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Physical Review materials 2023年第10期7卷 104001-104001页

作者： María Camarasa-Gómez Ashwin Ramasubramaniam Jeffrey B. Neaton Leeor Kronik Department of Molecular Chemistry and Materials Science Weizmann Institute of Science Rehovoth 7610001 Israel Department of Mechanical and Industrial Engineering University of Massachusetts Amherst Amherst Massachusetts 01003 USA Materials Science and Engineering Graduate Program University of Massachusetts Amherst Amherst Massachusetts 01003 USA Department of Physics University of California Berkeley California 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA Kavli Energy NanoSciences Institute at Berkeley University of California Berkeley California 94720 USA

The accurate description of electronic properties and optical absorption spectra is a long-standing challenge for density functional theory. Recently, the introduction of screened range-separated hybrid (SRSH) functionals for solid-state materials has allowed for the calculation of fundamental band gaps and optical absorption spectra that are in very good agreement with many-body perturbation theory. However, since solid-state SRSH functionals are typically tuned to reproduce the properties of bulk phases, their transferability to low-dimensional structures, which experience substantially different screening than in the bulk, remains an open question. In this work, we explore the transferability of SRSH functionals to several prototypical van der Waals materials, including transition-metal sulfides and selenides, indium selenide, black phosphorus, and hexagonal boron nitride. Considering the bulk and a monolayer of these materials as limiting cases, we show that the parameters of the SRSH functional can be determined systematically, using only the band-edge quasiparticle energies of these extremal structural phases as fitting targets. The resulting SRSH functionals can describe both electronic band structures and optical absorption spectra with accuracy comparable to more demanding ab initio many-body perturbation theory (GW and Bethe-Salpeter equation) approaches. Selected examples also demonstrate that the SRSH parameters, obtained from the bulk and monolayer reference structures, display good accuracy for band structures and optical spectra of bilayers, indicating a degree of transferability that is independent of the fitting procedure.

关键词： 2-dimensional systems Density functional theory First-principles calculations GW method

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The challenges of measuring spin Seebeck noise

arXiv

引用

arXiv 2023年

作者： Luo, Renjie Zhao, Xuanhan Legvold, Tanner J. Chen, Liyang Liu, Changjiang Hong, Deshun Bhattacharya, Anand Natelson, Douglas Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Program Smalley-Curl Institute Rice University HoustonTX77005 United States Materials Science Division Argonne National Laboratory LemontIL60439 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

Just as electronic shot noise in driven conductors results from the granularity of charge and the statistical variation in the arrival times of charge carriers, there are predictions for fundamental noise in magnon currents due to angular momentum being carried by discrete excitations. The inverse spin Hall effect as a transduction mechanism to convert spin current into charge current raises the prospect of experimental investigations of such magnon shot noise. Spin Seebeck effect measurements have demonstrated the electrical detection of thermally driven magnon currents and have been suggested as an avenue for accessing spin current fluctuations. Using spin Seebeck structures made from yttrium iron garnet on gadolinium gallium garnet, we demonstrate the technical challenges inherent in such noise measurements. While there is a small increase in voltage noise in the inverse spin Hall detector at low temperatures associated with adding a magnetic field, the dependence on field orientation implies that this is not due to magnon shot noise. We describe theoretical predictions for the expected magnitude of magnon shot noise, highlighting ambiguities that exist. Further, we show that magnon shot noise detection through the standard inverse spin Hall approach is likely impossible due to geometric factors. Implications for future attempts to measure magnon shot noise are discussed. Copyright © 2023, The Authors. All rights reserved.

关键词： Shot noise

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Optimizing cultivation strategies and scaling up for fucoxanthin production using Pavlova sp.

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Bioresource Technology 2024年 399卷 130609页

作者： Chen, Chun-Yen Liu, Ping-Yung Chang, Yu-Han Nagarajan, Dillirani Latagan, Mary Joy D. de Luna, Mark Daniel G. Chen, Jih-Heng Chang, Jo-Shu University Center for Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan701 Taiwan Department of Chemical Engineering National Cheng Kung University Tainan Taiwan Institute of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Nanzih Campus Kaohsiung City Taiwan Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City1101 Philippines Environmental Engineering Program National Graduate School of Engineering University of the Philippines Quezon City Diliman1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City1101 Philippines Department of Chemical and Materials Engineering National Kaohsiung University of Science and Technology Kaohsiung807 Taiwan Department of Chemical and Materials Engineering Tunghai University Taichung407 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung407 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taiwan

The microalgal-based production of fucoxanthin has emerged as an imperative research endeavor due to its antioxidant, and anticancer properties. In this study, three brown marine microalgae, namely Skeletonema costatum, Chaetoceros gracilis, and Pavlova sp., were screened for fucoxanthin production. All strains displayed promising results, with Pavlova sp. exhibiting the highest fucoxanthin content (27.91 mg/g) and productivity (1.16 mg/L·day). Moreover, the influence of various cultivation parameters, such as culture media, salinity, sodium nitrate concentration, inoculum size, light intensity, and iron concentration, were investigated and optimized, resulting in a maximum fucoxanthin productivity of 7.89 mg/L·day. The investigation was further expanded to large-scale outdoor cultivation using 50 L tubular photobioreactors, illustrating the potential of Pavlova sp. and the cultivation process for future commercialization. The biomass and fucoxanthin productivity for the large-scale cultivation were 70.7 mg/L·day and 4.78 mg/L·day, respectively. Overall, the findings demonstrated considerable opportunities for fucoxanthin synthesis via microalgae cultivation and processing. © 2024 Elsevier Ltd

关键词： Microalgae

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