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Engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru-Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

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ACS Applied Materials and Interfaces 2024年第19期16卷 24172-24190页

作者： dirersa, Worku Batu Kan, Tzu-Chun Chang, Jungshan Getachew, Girum Ochirbat, Sonjid Kizhepat, Shamsa Wibrianto, Aswandi Rasal, Akash Chen, Hung-An Ghule, Anil Vithal Chou, Tzung-Han Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Green Nanotechnology Laboratory Department of Chemistry Shivaji University Kolhapur416004 India Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin64002 Taiwan

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemodynamic therapy (CdT), yet endogenous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we design RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-mediated synergistic therapy based on heterogeneous Ru-Cu peroxide nanodots (RuxCu1-xO2 Nds) and chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The Ru-Cu peroxide Nds (RCp Nds, x = 0.50) possess the highest oxygen vacancy (OV) density, which grants them the potential to form massive Lewis’s acid sites for peroxide adsorption, while the dispersibility and targetability of the Nds were improved via surface modification using hyaluronic acid (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, and Cu+/2+ ions, which cooperatively facilitate hydroxyl radical (•OH) formation and deactivate antioxidant GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined with laser treatment, RCpCCPT produces singlet oxygen (1O2) for PdT, which induces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is disrupted, releasing up to 92% of the CPT within 48 h. In vitro investigations showed that laser-treated RCpCCPT caused 81.5% cell death from PdT/CdT and chemotherapy (CT). RCpCCPT in cancer cells produces red-blue emission in images of cells taking them in, which allows for fluorescence image-guided Xdynamic treatment. The overall results show that RCp Nds and RCpCCPT are more biocompatible and have excellent Xdynamic the

关键词： Oxidation

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Integration of a Microfluidics System With a U-Shaped Optical Fiber Sensor for Sensing Various Concentrations of Glucose

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IEEE Sensors Journal 2024年第13期24卷 20617-20628页

作者： Hsiang-Cheng Hsu Tien-Bao Tran Thi Thuy-Vy Nguyen Hoang-dang Le Chia-Chin Chiang Department of Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Mechanical Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan College of Engineering Can Tho University Ninh Kieu Can Tho Vietnam

This study introduces a successfully manufactured U-shaped optical fiber sensor integrated with a microfluidics system to detect varying glucose concentrations. It outlines the fabrication process of the microfluidics system, accomplished using a CO2 laser on polymethyl methacrylate (PMMA) material. Through three cycles of experiments involving different glucose concentrations, the results indicate a consistent trend in both resonance wavelength and transmission loss, showing an increase as glucose concentration rises from 5% to 50%. The system demonstrates a high wavelength sensitivity coefficient of 0.114 nm/% with ${R}^{{2}} =0.95$ and a notable transmission loss sensitivity of 0.09 dB/% and ${R}^{{2}} =0.94$ . This advanced system proves to be effective in achieving rapid, sensitive, and cost-efficient glucose monitoring. Consequently, the microfluidics system is deemed suitable for its intended purpose.

关键词： Microfluidics Glucose Optical fiber sensors Sensors Sensitivity Claddings Viscosity

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Overcoming the Blood-Brain Tumor Barrier with docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (dTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and dTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, dTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free dTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by dTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate dTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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Students Learning Performance and Engagement in a Visual programming Environment

Students Learning Performance and Engagement in a Visual Pro...

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Proceedings of the 6th International Conference on Innovative Technologies and Learning, ICITL 2023

作者： Wen, Fu-Hsiang Wu, Tienhua Hsu, Wei-Chih Ph.D. Program in Engineering Science and Technology College of Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Management Air Force Institute of Technology Kaohsiung Taiwan Department of Computer and Communication Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan

ISBN: (纸本)9783031401121

This study employed a quasi-experimental method to explore differences in students’ learning performance and engagement between visual and textual language programming environments. Specifically, this study examined how strongly engagement dimensions affect participants’ learning achievement in a Scratch experimental setting. One hundred and thirty-two undergraduate students participated. The results revealed that participants with Scratch intervention outperformed those with text-based language instructions in terms of performance and behavioral, emotional, cognitive, and agentic engagement. The findings indicated that engagement significantly predicted student academic success in a visual learning environment. This study concluded that visual programming tools such as Scratch help novices engaged and effectively learn core aspects of programming concepts. Additionally, student engagement deepens an understanding of predictions of programmers’ behaviors and achievements and mechanisms behind the effectiveness of visualization intervention. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Students

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Faster Groebner bases for Lie derivatives of OdE systems via monomial orderings 49

Faster Groebner bases for Lie derivatives of ODE systems via...

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49th International Symposium on Symbolic and Algebraic Computation, ISSAC 2024

作者： Bessonov, Mariya Ilmer, Ilia Konstantinova, Tatiana Ovchinnikov, Alexey Pogudin, Gleb Soto, Pedro Department of Mathematics Cuny Nyc College of Technology New YorkNY United States Ph.D. Program in Computer Science Cuny Graduate Center New YorkNY United States Department of Mathematics Cuny Queens College New YorkNY United States Department of Mathematics Cuny Queens College United States Ph.D. Programs in Mathematics and Computer Science Cuny Graduate Center New YorkNY United States Lix Cnrs École Polytechnique Institute Polytechnique de Paris Paris France

ISBN: (纸本)9798400706967

Symbolic computation for systems of differential equations is often computationally expensive. Many practical differential models have a form of polynomial or rational OdE system with specified outputs. A basic symbolic approach to analyze these models is to compute and then symbolically process the polynomial system obtained by sufficiently many Lie derivatives of the output functions with respect to the vector field given by the OdE system. In this paper, we present a method for speeding up Gröbner basis computation for such a class of polynomial systems by using specific monomial ordering, including weights for the variables, coming from the structure of the OdE model. We provide empirical results that show improvement across different symbolic computing frameworks and apply the method to speed up structural identifiability analysis of OdE models. © 2024 ACM.

关键词： Polynomials

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Robust Audio Watermarking Based on Empirical Mode decomposition and Group differential Relations

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AES: Journal of the Audio Engineering Society 2023年第3期71卷 100-117页

作者： Lai, Wen-Hsing Chou, Tsung-Yuan Chou, Meng-Chen Schuller, Björn W. Department of Computer and Communication Engineering National Kaohsiung University of Science and Technology No. 1 University Rd. Yanchao Dist. Kaohsiung City82445 Taiwan ZD.B Chair of Embedded Intelligence for Health Care and Wellbeing University of Augsburg Germany Ph.D. Program in Engineering Science and Technology College of Engineering National Kaohsiung University of Science and Technology Taiwan GLAM – Group on Language Audio & Music Imperial College London United Kingdom

An audio watermarking technique using Complementary Ensemble Empirical Mode decomposition and group differential relations of average absolute amplitudes of the last Intrinsic Mode Function (IMF) is proposed. By using group differential relations, the relationship with neighboring samples in the last IMF is well preserved, and near-imperceptibility can be achieved. Placing a watermark on low-frequency components, the last IMF, which is perceptually significant, therefore makes the watermark difficult to be removed. The embedding watermark, which is a logo image in our experiment, is processed by Arnold transformation, secret key encryption, and Bose–Chaudhuri–Hocquenghem coding to enhance robustness and security. Experimental results of the signal-to-noise ratio fit the recommendations of imperceptibility of the International Federation of the phonographic Industry. The average Objective difference Grade (an objective measure that correlates very well with subjective assessment) and subjective quality assessment were performed to evaluate the imperceptibility. Furthermore, our method accomplishes robustness under 13 different categories of attacks, including noise corruption, amplitude scaling, echo addition, resampling, re-quantization, low-pass filtering, MPEG-1 Audio Layer III compression, digital-to-Analog/Analog-to-digital conversion, cropping, time shift, zero thresholding, jittering, and combined attacks. © 2023 Authors. All rights reserved.

关键词： Intrinsic mode functions

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deep Learning-Based Positioning Error Fault diagnosis of Wire Bonding Equipment and an Empirical Study for IC Packaging

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IEEE Transactions on Semiconductor Manufacturing 2023年第4期36卷 619-628页

作者： Kao, Sheng-Xiang Chien, Chen-Fu International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Intelligent Manufacturing and Circular Economy Research Center National Tsing Hua University Artificial Intelligence for Intelligent Manufacturing Systems Research Center National Science and Technology Council Department of Industrial Engineering and Engineering Management Hsinchu300044 Taiwan

Little research has been done for artificial intelligence applications of semiconductor backend. This study aims to develop a deep learning based fault diagnosis framework as prognostics and health management (phM) solutions with a comprehensive analytics process. A linear encoder sensor is employed to measure position, while data preparation is conducted to convert position information into a signal. Then, signal processing is used to extract the features, in which high pass filter is applied to normalize the signal and emphasize the features. High-dimensional features including time domain statistical features, time-frequency domain features obtained by continuous wavelet transform (CWT), and frequency domain features converted by fast Fourier transform (FFT) are extracted to prepare the dataset. An ensemble neural network model that integrates deep neural network (dNN) and convolutional neural network (CNN) is employed to recognize the pattern and diagnose the positioning errors. The accuracy and false alarm rate are considered to support maintenance decisions. An empirical study was conducted in a world leading IC assembly and testing company for validation. The results have shown that the proposed approach can effectively detect inappropriate installation of the bond head in wire bonding equipment for predictive maintenance and cost reduction. © 1988-2012 IEEE.

关键词： Failure analysis

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Fog and rain water chemistry in a tea plantation of northern Taiwan

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Environmental science and Pollution Research 2023年第42期30卷 96474-96485页

作者： Wang, Yi-Tzu Lin, Neng-Huei Chang, Chung-Te Huang, Jr-Chuan Lin, Teng-Chiu Department of Life Science National Taiwan Normal University Taipei11677 Taiwan Department of Atmospheric Sciences National Central University Taoyuan32001 Taiwan Center for Environmental Monitoring Technology National Central University Taoyuan32001 Taiwan –Ph.D. Program on Biodiversity Tunghai University Taichung407224 Taiwan Department of Life Science Tunghai University Taichung407224 Taiwan Department of Geography National Taiwan University Taipei10617 Taiwan

Tea plantations are expanding globally and many are in mountainous areas with frequent fog but few studies have examined fog chemistry in these areas. We examined chemical composition of fog and rain water at a tea plantation in northern Taiwan. Fog water was collected using a Kroneis passive cylindrical fog-water collector and rain water was collected using a 20-cm-diameter funnel. The most abundant ions were Cl− and Na+ in both fog and rain waters due to the proximity of the site to the coast. The order of abundance of other ions was NO3− > Mg2+ > SO42− > Ca2+ > NH4+ > K+ > H+ in fog water and SO42− > K+ > NO3− > NH4+ > Ca2+ > Mg2+ > H+ in rain water. The concentration enrichment ratio (fog to rain) ranged between 2.2 (K+) and 22 (Mg2+) lying between sites near major emission sources and sites in remote areas, possibly because the immediate surrounding landscape is covered with secondary forests although it is near large cities. Factor analysis highlights the influences of sea-salt aerosols on the variation of fog and rain water chemistry. Sea-salt corrections using Na+ as the sea salt tracer led to negative concentrations of Cl− and Mg2+ suggesting that assumptions involved in sea-salt corrections were not satisfied. Agriculture influence is identified as a unique factor for explaining variance of K+, NH4+, and dissolved organic nitrogen (dON) concentrations in fog water but not rain water. Ion concentrations in fog and rain water were generally higher in the weekly samples associated with air trajectories passing through the continental East Asia than those associated with oceanic trajectories pointing to the role of regional pollution sources in affecting local fog and rain water chemistry. Our study highlights greater effects of tea agriculture on fog than rain water chemistry. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Ions

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Cuisine Image Recognition and Recommender System using Convolutional Neural Network 5

Cuisine Image Recognition and Recommender System using Convo...

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5th IEEE Eurasia Conference on IOT, Communication and Engineering, ECICE 2023

作者： Chang, Chin-Chih Wei, Chi-Hung Wu, Kuan-Yun Kao, Hao-Xiang Hsiao, Sean Chung Hua University Department of Computer Science and Information Engineering Hsinchu Taiwan Chung Hua University Ph.D. Program in Engineering Science Hsinchu Taiwan National Kaohsiung University of Science and Technology Department of Computer Science and Information Engineering Kaohsiung Taiwan Chung Hua University Program of Applied Foreign Language and Smart Commerce Hsinchu Taiwan

ISBN: (纸本)9798350314694

The fusion of technology and culinary exploration has allowed for the emergence of advanced online customer service systems. We developed a novel approach to enhance the dining experience. We used a Cuisine Image Recognition and Recommender System (CIRRS) powered by Convolutional Neural Network (CNN) to identify and suggest diverse cuisines based on visual inputs. CIRRS swiftly identified diverse cuisines from user-captured images, offering information on origin, ingredients, and variations by crawling websites. The system enhanced dining experiences by suggesting personalized menus based on individual preferences and past selections. Extensively tested across various culinary genres, CIRRS consistently demonstrated accuracy and adaptability. User feedback validated its potential to simplify dining choices and elevate satisfaction. This innovative system enriched dining experiences as a valuable tool for culinary enthusiasts, chefs, and restaurateurs, bridging the gap between technology and gastronomy, It also offers a unique way to explore Taiwanese cuisines. © 2023 IEEE.

关键词： convolutional neural network (CNN) deep learning image recognition recommender system web crawler

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Effects of an automated programming assessment system on the learning performances of experienced and novice learners

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Interactive Learning Environments 2023年第8期31卷 5347-5363页

作者： Cheng, Li-Chen Li, Wei Tseng, Judy C. R. Department of Information and Finance Management National Taipei University of Technology Taipei Taiwan STEM Education Research Center Wenzhou University Zhejiang Province Wenzhou China Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan

programming ability is the core ability of this era and can be obtained and improved through practice. In this paper, an Automated programming Assessment system based on Mastery learning and Peer competition (APAMP) was proposed and developed. APAMP allows students to practice repeatedly by providing immediate feedback after their programs are submitted. It also presents an analytical dashboard as a competition mechanism for students to visualize their learning performance and compare their performance with peers. By incorporating APAMP into programming courses, students can master programming skills through repeated practice, and their enthusiasm for learning programming can also be encouraged by peer competition. To evaluate the effects of APAMP on the learning performance of students with programming language learning and novice students, a quasi-experiment was conducted in a high school. The experimental results showed that the learning achievement of the two groups of students improved significantly. Moreover, the learning attitude of students in the experienced group improved significantly, with the experienced students benefiting more from the system than the novice students. In fact, the novice students showed a significant decline in learning attitude and learning motivation, which was contrary to our intuition. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

关键词： automated programming assessment systems learning performance mastery learning peer competition programming instruction

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