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Influence of Biomimetic Apatite Coating on the Biobehavior of TiO_(2)Scaffolds

Journal of Bionic engineering 2024年第4期21卷 1975-1986页

作者： Shima Mahtabian Seyed Mehdi Mirhadi Nahid Hassanzadeh Nemati Melika Sharifi Fariborz Tavangarian Department of Biomedical Engineering University of DelawareNewarkDE19716USA Department of Ceramic Engineering Islamic Azad University(Shahreza Branch)ShahrezaIsfahan86145-311Iran Department of Biomedical Engineering Islamic Azad University(Science and Research Branch)TehranIran Mechanical Engineering Program School of ScienceEngineering and TechnologyPennsylvania State UniversityHarrisburgMiddletownPA17057USA Department of Materials Science&Engineering Islamic Azad University(Najaf Abad Branch)Najaf AbadIsfahan***Iran Biomedical Engineering Department Pennsylvania State UniversityState CollegeUniversity ParkPennsylvania16802USA

Immersion of scaffolds in Simulated Body Fluid(10SBF)is a standardized method for evaluating their bioactivity,simulating in vivo conditions where apatite deposits can be formed on the surface of scaffold,facilitating bone integration and ensuring their suitability for bone implant purposes,ultimately contributing to long-term implant *** effect of apatite deposition on bioactivity and cell behavior of TiO_(2)scaffolds was *** were soaked in 10SBF for different durations to form HAP layer on their *** results proved the development of a hydroxyapatite film resembling the mineral composition of bone Extracellular Matrix(ECM)on the TiO_(2)*** XRD test findings showed the presence of hydroxyapatite layer similar to bone at the depth of 10 nm.A decrease in the specific surface area(18.913 m^(2)g^(−1)),the total pore volume(0.045172 cm^(3)g^(−1)(at p/p0=0.990)),and the mean pore diameter(9.5537 nm),were observed by BET analysis which confirmed the formation of the apatite *** was found that titania scaffolds with HAP coating promoted human osteosarcoma bone cell(MG63)cell attachment and *** seems that immersing the scaffolds in 10SBF to form HAP coating before utilizing them for bone tissue engineering applications might be a good strategy to promote bioactivity,cell attachment,and implant fixation.

关键词： Titania Hierarchical meso/macro porous 10SBF Biomimetic apatite Coating

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Assessing Hemodynamic Changes in Cerebral Aneurysms Post Coil Embolization: A Preliminary Investigation

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Journal of engineering and science in Medical Diagnostics and Therapy 2025年第3期8卷 031014页

作者： Monfared, Mohammadali Hollingsworth, Luke Gamage, Peshala Thibbotuwawa Taebi, Amirtaha Biomedical Engineering Program Mississippi State University Mississippi StateMS39762 United States Department of Biomedical Engineering and Science Florida Institute of Technology MelbourneFL32901 United States

A cerebral aneurysm is a weakened area in the wall of a blood vessel within the brain that causes the vessel to bulge outwards. The choice of treatment depends on various factors including the size and location of the aneurysm and the risk of rupture, and should be tailored to individual situations rather than following a universal approach due to their variability among individuals. This approach provides the possibility of choosing precise treatment plans that are proper for each patient's circumstances. The utilization of computational fluid dynamics (CFD) allows for the prediction of after-surgery hemodynamic changes before any surgical approach. The goal of this research was to investigate the flow characteristics and hemodynamic parameters in cerebral arteries before and after endovascular embolization treatments using CFD in three patient-specific geometries with at least one aneurysm at the middle cerebral artery's bifurcation. To model the coiling, the computational domain was divided into two fluid domains, a general fluid domain consisting of the parent arteries and a porous domain inside the aneurysm. CFD modeling was conducted to simulate blood flow in pre- and postcoiling scenarios. Results showed that the coiling model with different porosity values led to a redirection of blood flow away from the aneurysm sac. Additionally, changes in shear stress indicated potential alterations in susceptibility to vascular remodeling. In conclusion, these findings indicated that utilizing CFD modeling for simulating blood flow in patient-specific cerebral arteries could be utilized to predict hemodynamic parameters before any treatment. Copyright © 2025 by ASME.

关键词： Computational fluid dynamics

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Targeting glial metabolism in neurodegenerative diseases:detail matters

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Neural Regeneration Research 2023年第11期18卷 2393-2394页

作者： Ruqayya Afridi Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguSouth Korea Department of Biomedical Sciences BK21 PLUS KNU Biomedical Convergence ProgramSchool of MedicineKyungpook National UniversityDaeguSouth Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguSouth Korea

Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and *** decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of *** studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory ***,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).

关键词： degenerative metabolism diseases

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Enhancing waste sorting and recycling efficiency: robust deep learning-based approach for classification and detection

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Neural Computing and Applications 2025年第6期37卷 4567-4583页

作者： Sayem, Faizul Rakib Islam, Md. Sakib Bin Naznine, Mansura Nashbat, Mohammad Hasan-Zia, Mazhar Kunju, Ali K Ansaruddin Khandakar, Amith Ashraf, Azad Majid, Molla Ehsanul Kashem, Saad Bin Abul Chowdhury, Muhammad E. H. Department of Electrical and Electronic Engineering University of Dhaka Dhaka Bangladesh Department of Biomedical Engineering Military Institute of Science and Technology Dhaka Bangladesh Department of Computer Science & Engineering Rajshahi University of Engineering & Technology Rajshahi6204 Bangladesh Chemical Engineering Department University of Doha for Science and Technology Doha Qatar Department of Electrical Engineering Qatar University Doha2713 Qatar Computer Applications Department Academic Bridge Program Qatar Foundation Doha Qatar Department of Computing Science AFG College With the University of Aberdeen Doha Qatar

Given the severity of waste pollution as a major environmental concern, intelligent and sustainable waste management is becoming increasingly crucial in both developed and developing countries. The material composition and volume of urban solid waste are key considerations in processing, managing, and utilizing city waste. Deep learning technologies have emerged as viable solutions to address waste management issues by reducing labor costs and automating complex tasks. However, the limited number of trash image categories and the inadequacy of existing datasets have constrained the proper evaluation of machine learning model performance across a large number of waste classes. In this paper, we present robust waste image classification and object detection studies using deep learning models, utilizing 28 distinct recyclable categories of waste images comprising a total of 10,406 images. For the waste classification task, we proposed a novel dual-stream network that outperformed several state-of-the-art models, achieving an overall classification accuracy of 83.11%. Additionally, we introduced the GELAN-E (generalized efficient layer aggregation network) model for waste object detection tasks, obtaining a mean average precision (mAP50) of 63%, surpassing other state-of-the-art detection models. These advancements demonstrate significant progress in the field of intelligent waste management, paving the way for more efficient and effective solutions. © The Author(s) 2024.

关键词： Deep learning for waste management Intelligent waste management Object detection in waste management Sustainable waste processing Urban solid waste Waste image classification

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Variable Length Multi-Objective Whale Optimization for Trust Aware Data Gathering in Wireless Sensor Network

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IEEE Access 2025年 13卷 32100-32121页

作者： Saad, Mohammed Ayad Jaafar, Rosmina Chellappan, Kalaivani Faculty of Engineering and Built Environment Department of Electrical Electronics and System Engineering Selangor Bangi43600 Malaysia Al-Kitab University Department of Medical Instrumentations Technique Engineering Kirkuk36001 Iraq Universitas Airlangga Biomedical Engineering Study Program Faculty of Science and Technology Surabaya60115 Indonesia

Efficient data collection in wireless sensor networks (WSNs) is crucial. While traditional approaches rely on stationary data sinks, the use of mobile sinks, like unmanned aerial vehicles (UAVs), has shown promise in enhancing data-gathering capabilities. However, existing methods often overlook the importance of trust, leaving the network susceptible to malicious or faulty nodes. To address this issue, we propose a novel trust-aware data-gathering algorithm, Variable Length Multi-Objective Whale Optimization Data Gathering (VLMOWO-DG). Our algorithm simultaneously optimizes energy consumption, delay, and trust while employing mobile sinks to collect data from sensor nodes. By considering trust as a key performance metric, we improve data reliability and security. The VLMOWO-DG algorithm introduces flexibility through variable-length solution representation and application-oriented operators, allowing for efficient exploration of the solution space. Simulation results demonstrate that our proposed algorithm significantly outperforms established benchmarks, NSGA-II and NSGA-III, in terms of domination and hypervolume. This leads to a remarkable improvement of 200% in data gathering performance. © 2015 The Authors.

关键词： Data collection

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Antimalarial potency and cytotoxicity studies of secondary metabolites from fractions 38K, 38T, and 56 Streptomyces hygroscopicus subsp. hygroscopicus in vitro

Journal of Biotech Research

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Journal of Biotech Research 2024年 16卷 129-140页

作者： Fitri, Loeki Enggar Sulistomo, Hikmawan Wahyu Khotimah, Husnul Winarsih, Sri Istiapalja, Fadilah Afifah, Mutiara Nor ‘Azizah, Mahya Nailul Malaria Research Group Universitas Brawijaya Malang Indonesia Department of Parasitology Universitas Brawijaya Malang Indonesia Department of Pharmacology Universitas Brawijaya Malang Indonesia Department of Pharmacy Universitas Brawijaya Malang Indonesia Program in Biomedical Science Faculty of Medicine Universitas Brawijaya Malang Indonesia

Recent research has revealed that Plasmodium falciparum (P. falciparum) possesses an Artemisinin-based Combination Therapy (ACT) resistance mechanism. To address this issue, new antimalarial chemicals are required. In vitro, in vivo, and in silico tests have been conducted on metabolite extracts of Streptomyces hygroscopicus subsp. hygroscopicus (S. hygroscopicus) and showed antimalarial effects through various mechanisms. The aim of this research was to determine the effectiveness and cytotoxicity of active fractions 38K, 38T, and 56 of S. hygroscopicus secondary metabolites as antimalarial. Fractionation procedure was performed using flash column chromatography BUCHI Reveleris® PREP Purification System. Effectiveness test was conducted on Plasmodium berghei (P. berghei) culture by parasite inhibition counts. The cytotoxicity effect of S. hygroscopicus was observed utilizing the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide Assay (MTT Assay) on Michigan Cancer Foundation-7 (MCF-7) breast cancer cell culture. Inhibition Concentration 50% (IC50) and Cytotoxicity Concentration 50% (CC50) was obtained from probit analysis. S. hygroscopicus fractions 38K, 38T, and 56 showed antimalarial activity against P. berghei, with fraction 38T having the strongest activity as antimalarial from selectivity index. Fraction 38T had the IC50 with the value of 11.66 μg/mL which included in the promising activity classification of IC50. Almost all asexual stages of parasite morphology were damaged by the fractions. MCF-7, a cell line used to study antimalarial cytotoxicity, was unaffected by any of the three fractions due to its CC50 exceeding 50 μg/mL. S. hygroscopicus fractions 38K, 38T, and 56 of the metabolite extracts contain non-toxic compounds that can damage the morphology of intra-erythrocytic stage and inhibit the growth of P. berghei in vitro. © 2024, Bio Tech System. All rights reserved.

关键词： Metabolites

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Corrosion Inhibition Efficiency of Biosynthesized Silver Nanoparticles Using Citrus aurantium Peels Extract

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Journal of Bio- and Tribo-Corrosion 2024年第3期10卷 1-24页

作者： Hamze, Zeina K. Faraj, Marwa Mhanna, Rami Younes, Ghassan El-Dakdouki, Mohammad H. Department of Chemistry Faculty of Science Beirut Arab University Riad El Solh Beirut11072809 Lebanon Biomedical Engineering Program Maroun Semaan Faculty of Engineering and Architecture American University of Beirut Beirut1107 2020 Lebanon

Corrosion is a detrimental persistent industrial conundrum that can cause the failure of operating equipment and weakening of construction assemblies, thus threatening the lives of humans, and accelerating the consumption of the natural metals reservoirs. In this study, we deployed green silver nanoparticles (AgNPs) as corrosion inhibitors for mild steel. Citrus aurantium peels aqueous extract (CAPE) mediated the bio-reduction of silver ions (Ag+) into silver nanoparticles (AgNPs) under optimized experimental conditions. The prepared nanoparticles were comprehensively characterized by various techniques for size, morphology, optical properties, crystallinity, and elemental composition. Phytochemical analysis showed that the plant extract is rich in phenolic compounds that facilitated the formation of metallic silver from Ag+ ions. The anticorrosion properties of CAPE and CAPE-AgNPs for mild steel in 0.5 M HCl were investigated by potentiodynamic polarization and electrochemical impedance spectroscopy techniques. The biosynthesized CAPE-AgNPs were more efficient than CAPE in slowing down corrosion with inhibition efficiency of 70% attained at 1000 ppm of the inhibitor. CAPE and CAPE-AgNPs acted as mixed-type corrosion inhibitors with dominance over the cathodic reaction. Fitting the experimental data into different isotherms demonstrated that the corrosion inhibition was an endothermic process that took place through physical adsorption. CAPE-AgNPs significantly reduced pitting and localized damage on the metal surface. These findings highlighted the utility of CAPE-AgNPs as efficient corrosion inhibitors in different industrial settings. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

关键词： Silver nanoparticles

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Entropy-Based Analysis of Electromyography Signal Complexity During Flexion of the Flexor Carpi Radialis Muscle Under Varied Load Conditions 4th

Entropy-Based Analysis of Electromyography Signal Complexity...

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4th International Conference on Electronics, biomedical engineering, and Health Informatics, ICEBEHI 2023

作者： Katherine Putra, Alfian Pramudita Kurniawan, Angeline Shane Istiqomah, Dezy Zahrotul Sholihah, Nisa’ul Al-Salehi, Khalid Ali Salem Ain, Khusnul Sapuan, Imam Andarini, Esti Biomedical Engineering Master Program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya60115 Indonesia Biomedical Engineering Study program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia School of Nursing Southern Medical University Guangdong Guangzhou510515 China

ISBN: (纸本)9789819714629

The motor impairments that stroke patients experience as a primary contributor to death and disability also impact their quality of life. Due to its characteristics as complex muscle signals, the Electromyograph (EMG) signal may be one of the markers in rehabilitation and a substitute that may be used to judge the success of rehabilitation. This study aims to analyze the complexity of EMG signals originating from the flexion of the flexor carpi radialis muscle with various weights indicating the rehabilitation state. It is important to monitor the progress of rehabilitation, and it can be done by using complexity analysis. The complexity of the EMG is examined in this work utilizing entropy measurement, namely Approximate Entropy (ApEn), Sample Entropy (SampEn), and Fuzzy Approximate Entropy (fApEn). We concentrated on the flexor carpi radialis muscle using flexion–extension exercises and varying the weight load. This study’s results indicate differences in the complexity of the EMG signal in the flexor carpi radialis when performing flexion–extension movements. Three differences showed a correlation based on the value of ApEN, SampEn, and fApEn. Complexity Analysis using fApEn showed the best correlation at R = 0.9966, which can be used to evaluate the rehabilitation process. The increase in weight was followed by the increase of the fApEn value, indicating that the value can be used to evaluate the rehabilitation process. The use of complexity analysis of EMG signal from flexion movement in flexor carpi radialis with various weights can be used to indicate the progress in the rehabilitation process. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

关键词： Entropy

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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