检索结果-内蒙古大学图书馆

ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

引用

Journal of Cachexia, Sarcopenia and Muscle 2024年第3期15卷 949-962页

作者： Kung, Mei-Lang Yang, Tai-Hua Lin, Chia-Chi Ho, Jia-Yun Hung, Tzu-Chi Chang, Chih-Hsiang Huang, Kuan-Wen Chen, Chien-Chin Chen, Yun-Wen Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan Department of Biomedical Engineering College of Engineering National Cheng Kung University Tainan Taiwan Department of Orthopedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Department of Pharmacology College of Medicine National Cheng Kung University Tainan Taiwan Department of Pathology Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi Taiwan Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan Taiwan Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified. However, the functional role of ADAR2 in obesity-associated NAFLD and sarcopenia remains unclear. Methods: ADAR2^+/+/GluR-B^R/R mice (wild type [WT]) and ADAR2^−/−/GluR-B^R/R mice (ADAR2 knockout [KO]) were subjected to feeding with standard chow or high-fat diet (HFD) for 20 weeks at the age of 5 weeks. The metabolic parameters, hepatic lipid droplet, grip strength test, rotarod test, muscle weight, fibre cross-sectional area (CSA), fibre types and protein associated with protein degradation were examined. Systemic and local tissues serum amyloid A1 (SAA1) were measured. The effects of SAA1 on C2C12 myotube atrophy were investigated. Results: ADAR2 KO mice fed with HFD exhibited lower body weight (−7.7%, P < 0.05), lower liver tissue weight (−20%, P < 0.05), reduced liver lipid droplets in concert with a decrease in hepatic triglyceride content (−24%, P < 0.001) and liver injury (P < 0.01). ADAR2 KO mice displayed protection against HFD-induced glucose intolerance, insulin resistance and dyslipidaemia. Skeletal muscle mass (P < 0.01), muscle strength (P < 0.05), muscle endurance (P < 0.001) and fibre size (CSA;P < 0.0001) were improved in ADAR2 KO mice fed with HFD compared with WT mice fed with HFD. Muscle atrophy-associated transcripts, such as forkhead box protein O1, muscle atrophy F-box/atrogin-1 and muscle RING finger 1/tripartite motif-containing 63, were decreased in ADAR2 KO mice fed with HFD compare

关键词： ADAR2 diabetes inflammation muscle atrophy NAFLD SAA1

来源：评论

学校读者我要写书评

暂无评论

The Design of a Drone-Assisted System for Large Wildlife Vaccination Shooting Based on AI Image Identification Technology 20

The Design of a Drone-Assisted System for Large Wildlife Vac...

引用

20th IEEE International Conference on e-Business engineering, ICEBE 2024

作者： Tsai, Yao-Yu Tsai, Yao-Chuan Tai, Chang-Hsien Chen, Chen-Chih Hsu, Uzu-Kuei National Chung Hsing University National Pingtung University of Science and Technology Sustainable Circular Economy R&d Center Department of Bio-Industrial Mechatronics Engineering Pingtung Taichung Taiwan National Chung Hsing University Department of Bio-Industrial Mechatronics Engineering Taichung Taiwan College of Biomedical Engineering and Technology Tzu Chi University Hualien Taiwan Institute of Wildlife Conservation National Pingtung University of Science and Technology Pingtung Taiwan Program of Artificial Intelligence and Mechatronics National Pingtung University of Science and Technology Pingtung Taiwan

ISBN: (纸本)9798350365856

This study designs a UAV -assisted system integrated with AI image recognition technology to alleviate the difficulty for operators in stabilizing the UAV and accurately administering vaccines. The system uses thermal imaging modules and AI recognition systems to lock onto and track target animals in real-time. Utilizing MAVLink, the UAV adjusts its flight path based on the dynamic behavior of the animals, ensuring that the target remains within shooting range for precise vaccine administration. This technology not only improves the efficiency and accuracy of wildlife vaccination but also significantly reduces the workload on operators, providing a forward-looking solution for wildlife management. © 2024 IEEE.

关键词： Thermography (imaging)

来源：评论

学校读者我要写书评

暂无评论

Z-Laminating Assembly of Graphene Nanoflakes for Super-Strong Membranes and Functional Coatings

引用

ACS Applied Nano Materials 2024年第13期7卷 14957-14963页

作者： Santos, Ian Daniell Tjarks, Patrick Muthu, Jeyavelan Lin, You-Chen Yen, Zhi-Long Chand, Pradyumna Kumar Raman, Radha Nguyen, Dinh Tuan Rouhani, Mehdi Jeng, Yeau-Ren Hsieh, Ya-Ping Hofmann, Mario Department of Physics National Taiwan University Taipei 106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei 106 Taiwan J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences Prague 18200 Czech Republic Institute of Atomic and Molecular Sciences Academia Sinica Taipei 106 Taiwan Department of Chemistry National Taiwan University Taipei 106 Taiwan Department of Physics National Central University Taoyuan 320 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Central University Taipei 106 Taiwan Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan 70101 Taiwan Department of Materials Science and Engineering National Cheng Kung University Tainan 70101 Taiwan Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng-Kung University (NCKU) Tainan 70101 Taiwan

We demonstrate the strengthening of graphene, an atomically thin carbon allotrope, by out-of-plane folding. Through lateral confinement of graphene at the water-air interface, nanoscale buckling was induced in suspended flakes, leading to an unexpected folding transition beyond a critical surface pressure. The emergence of folding was confirmed by in situ Brewster angle reflectivity and ex situ microscopy, showing a unique “z-laminated” nanostructure. Molecular dynamics simulations indicate that z-lamination yields an enhanced adhesion between neighboring flakes compared to lateral sliding, which was confirmed by a surface pressure hysteresis during the folding process. Mechanical testing reveals superior Young’s modulus and yield strength when compared to conventional graphene assemblies and even compared to composites. We demonstrate the potential of the z-lamination approach for applications in graphene-based structural materials, tribological layers, and functional electrochemical coatings. Finally, the complete recyclability of z-laminated graphene opens up new routes toward sustainable nanostructured materials. © 2024 The Authors. Published by American Chemical Society

关键词： 2D materials composites laminated graphene membranes recyclable

来源：评论

学校读者我要写书评

暂无评论

Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress

IEEE Open Journal of Nanotechnology

引用

IEEE Open Journal of Nanotechnology 2024年 5卷 9-16页

作者： Aslam, Muhammad Chang, Shu-Wei Chuang, Min-Hui Chen, Yi-Ho Lee, Yao-Jen Li, Yiming Parallel and Scientific Computing Laboratory National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electrical Engineering National Cheng Kung University Tainan701401 Taiwan Institute of Communications Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan

Recently, a-IGZO has advanced toward the next-generation electronics system because of its compatibility with complementary metal oxide semiconductor (CMOS) and back-end-of-line (BOEL) based systems. A systematic electrical characterization of a-IGZO TFT related to reliability issues, such as positive bias temperature stress (PBTS) and negative bias temperature stress (NBTS), would entitle its integration into novel electronics systems. Unexpectedly, PBTS is characterized by the transition of positive Vth shift to negative Vth shift (ΔVth, the positive shift followed by the stress and temperature activated negative shift). This transition is attributed to charge trapping/trap-site generations and hydrogen migration to the active layer. The ΔVth shift mechanism depends on the temperature and voltage stress. On the other hand, a negative ΔVth shift has been observed during the NBTS operation and could be attributed to the hole trapping at the interface of GI/IGZO. An effective suppression of the gate leakage current has also been observed during reliability tests. Simulation results reveal a pronounced potential at the edges of source and drain regions, and considered the origin of hydrogen migration into the IGZO layer. Thermal image results also reveal the strong temperature/potential distribution at the edges of the source/drain regions, indorsing the simulation results. © 2020 IEEE.

关键词： Oxide semiconductors

来源：评论

学校读者我要写书评

暂无评论

Strategies to Reduce Long-Term Drug Resistance by Considering Effects of Differential Selective Treatments 3rd

Strategies to Reduce Long-Term Drug Resistance by Considerin...

引用

3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021

作者： Ghodsi Asnaashari, Tina Chang, Young Hwan Department of Biomedical Engineering and Computational Biology Program Oregon Health and Science University Portland United States

ISBN: (纸本)9783030912406

Despite great advances in modeling and cancer therapy using optimal control theory, tumor heterogeneity and drug resistance are major obstacles in cancer treatments. Since recent biological studies demonstrated the evidence of tumor heterogeneity and assessed potential biological and clinical implications, tumor heterogeneity should be taken into account in the optimal control problem to improve treatment strategies. Here, first we study the effects of two different treatment strategies (i.e., symmetric and asymmetric) in a minimal two-population model to examine the long-term effects of these treatment methods on the system. Second, by considering tumor adaptation to treatment as a factor of the cost function, the optimal treatment strategy is derived. Numerical examples show that optimal treatment decreases tumor burden for the long-term by decreasing rate of tumor adaptation over time. © 2021, Springer Nature Switzerland AG.

关键词： Tumors

来源：评论

学校读者我要写书评

暂无评论

Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

引用

biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

关键词：

来源：评论

学校读者我要写书评

暂无评论

Performance of learned pseudo-CT in transcranial ultrasound simulations using fluid and solid skulls

Performance of learned pseudo-CT in transcranial ultrasound ...

引用

2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Gao, Ya Lauber, Beatrice Werner, Beat Colacicco, Giovanni Razansky, Daniel Cheng, Qian Estrada, Héctor Tongji University Institute of Acoustics School of Physics Science and Engineering Shanghai China University of Zurich Institute of Pharmacology and Toxicology Faculty of Medicine Zurich Switzerland Eth Zurich Institute for Biomedical Engineering Department of Information Technology and Electrical Engineering Zurich Switzerland University of Zurich Institute of Anatomy Faculty of Medicine Zurich Switzerland Research Zurich Switzerland

ISBN: (纸本)9798350346459

Transcranial ultrasound (tUS) applications require accurate simulations to predict intracranial acoustic pressure. tUS simulations are usually performed neglecting shear wave propagation in the skull (fluid skull) due to its simplicity. Computed tomography (CT) head scans are the gold standard to extract geometrical and material properties needed in tUS simulations. To minimize ionizing-radiation in patients, pseudo-CT images obtained from magnetic resonance (MR) imaging by deep learning (DL) methods are an attractive alternative to CT. We built a U-net based neural network to map MR images to CT images and simulated the tUS field generated by a 0.5 MHz transducer focused on the cortex, propagating through a fluid- or solid skull. At normal incidence, the maximum error in the DL-simulated lies below 35% compared to the CT-simulation. However, at 40°of incidence the error in the predicted peak transcranial pressure increases up to 60% in DL-simulated solid skulls compared to CT-simulated solid skull. The smaller wavelength of shear waves is much more affected by the fine inner skull structure, which is missing in pseudo-CT images. Thus, our findings suggest that the DL-based pseudo-CT images are not suitable for predicting tUS fields in arbitrary conditions and should only be considered under strict normal incidence. © 2023 IEEE.

关键词： Shear waves

来源：评论

学校读者我要写书评

暂无评论

Correction: Materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

引用

MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA" to "Pritzker School of Molecular engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

The effect of cacao bean extracts on the prevention of periodontal tissue breakdown in diabetic rats with orthodontic tooth movements

引用

Journal of Oral Biology and Craniofacial Research 2024年第4期14卷 384-389页

作者： Hikmah, Nuzulul Hidayat, Mohamad Permatasari, Nur Rudijanto, Achmad Doctoral Program in Medical Science Faculty of Medicine Universitas Brawijaya Malang Indonesia Department of Dentistry-Biomedical Sciences Oral and Maxillofacial Pathology Faculty of Dentistry Universitas Jember Jember Indonesia Department of Orthopaedic Saiful Anwar General Hospital Faculty of Medicine Universitas Brawijaya Malang Indonesia Department of Pharmacology Faculty of Medicine Universitas Brawijaya Malang Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Brawijaya Malang Indonesia Department of Internal Medicine Saiful Anwar General Hospital Faculty of Medicine Universitas Brawijaya Malang Indonesia

Objective: Proper management of orthodontic treatment in diabetic patients is essential due to the heightened risk of periodontal tissue breakdown associated with hyperglycemia. Cacao bean extracts (CBE) are known to reduce the inflammatory response and increase synthesis and angiogenesis in periodontitis. Therefore, this study aims to examine the effect of CBE on preventing periodontal tissue breakdown in diabetes with orthodontic force. Methods: A total of 25 Wistar rats were divided randomly into 5 groups, including non-diabetes, diabetes, diabetes cacao 125, 250, and 500 mg/kg BW. Diabetic rats were induced with the stratified dose of Streptozotocin, and a 30-g-force from orthodontic device was applied in all groups. Diabetes cacao group was given CBE for 7 days using a gastric probe. GCF samples were used to analyze the eNOS level through the ELISA method. NFκB, Collagen-1, and FGF-2 expression were then assessed using the immunohistochemical method, while the number of fibroblasts and blood vessels was observed using hematoxylin-eosin stained tissue. The data obtained were analyzed with one-way ANOVA and post hoc tests, with p < 0.05. Results: CBE at a dose of 250 mg/kg BW significantly increased eNOS level, Collagen-1, and FGF-2 expression, and the number of fibroblasts and blood vessels in diabetes groups. Meanwhile, the treatment decreased NFκB expression in diabetes groups (p < 0.05). Conclusion: This study proved that CBE increased periodontal ligament synthesis and angiogenesis and decreased inflammatory response, thereby preventing periodontal tissue breakdown in diabetic rat models with tooth movement. © 2024 The Authors

关键词： Cacao extracts Diabetes Orthodontic tooth movements Periodontal tissue

来源：评论

学校读者我要写书评

暂无评论

PhageBox: An Open Source Digital Microfluidic Extension with Applications for Phage Discovery

TechRxiv

引用

TechRxiv 2023年

作者： Albin, Dreycey Buecherl, Lukas Kochavi, Eitan Niehaus, Elise Novack, Sasha Uragoda, Shenali Myers, Chris J. Alistar, Mirela Department of Computer Science CU Boulder BoulderCO United States Biomedical Engineering Program CU Boulder United States Department of Electrical Computer and Energy Engineering and Biomedical Engineering Program CU Boulder United States ATLAS Institute The Department of Computer Science CU Boulder BoulderCO United States

Objective: Recent advancements demonstrate the significant role of digital microfluidics in automating laboratory work with DNA and on-site viral testing. However, since commercially available instruments are limited to droplet manipulation, our work addresses the need for accelerated integration of other components, such as temperature control, that can expand the application domain. Methods: We developed PhageBox— an accessible device that can be used as a biochip extension. At hardware level, PhageBox integrates temperature and electromagnetic control modules. At software level, PhageBox is controlled by embedded software containing a unique model for bio-protocol programming, and a graphical user interface for visual device feedback and operation. Results: To evaluate PhageBox’s efficacy for biomedical applications, we performed functional testing. Similarly, we validated the temperature control using thermography, obtaining a range of ±0.2◦C. The electromagnets produced a magnetic force of 15 milliTesla, demonstrating precise immobilization of magnetic beads. We show the potential of PhageBox for bacteriophage research through three initial protocols: a universal framework for PCR, T7 bacteriophage restriction enzyme digestion, and concentrating X174 RF genomic DNA. Conclusion: Our work presents an open-source hardware and software extension for digital microfluidics devices. This extension integrates temperature and electromagnetic modules, demonstrating efficacy in biomedical applications and potential for bacteriophage research. Significance: We developed PhageBox to be accessible: the components are off-the-shelf at a low cost (≤$200), and the hardware designs and software code are open-source. With the long aim of ensuring reproducibility and accelerating collaboration, we also provide a DIY-build document. (GitHub: https://***/Dreycey/PhageBox) © 2023, CC BY-SA.

关键词： Digital microfluidics

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：