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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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Marine macro-litter sources and ecological impact: a review

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Environmental Chemistry Letters 2024年第3期22卷 1257-1273页

作者： Le, Van-Giang Nguyen, Hoang-Lam Nguyen, Minh-Ky Lin, Chitsan Hung, Nguyen T. Quang Khedulkar, Akhil P. Hue, Nguyen K. Trang, Phung T. Thu Mungray, Arvind Kumar Nguyen, D. Duc Central Institute for Natural Resources and Environmental Studies Vietnam National University Hanoi111000 Viet Nam Department of Civil Engineering McGill University MontrealQC Canada Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Biomedical Engineering and Environmental Science National Tsing Hua University Hsinchu30013 Taiwan Environmental Research Center Institute of Hydrology and Meteorology Science and Climate Change Hanoi111000 Viet Nam Department of Chemical Engineering Sardar Vallabhbhai National Institute of Technology Gujarat Surat395007 India Department of Civil and Energy System Engineering Kyonggi University Suwon16227 Korea Republic of Institute of Applied and Sustainable Technology Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam

Marine pollution by various debris is rising in the context of increasing urbanization, industrialization and worldwide trade. Here, we review marine macro-litter with focus on sources, abundance, distribution, and impact on aquatic wildlife, human health, and the economy. We observe that about 75–80% of marine litter originates from land-based sources, including poorly managed landfills and improper disposal. Macro-litter ingestion by marine life is of growing concern, in particular concerning the presence of plastics and associated pollutants, e.g., bisphenol A and phthalates, in fishes. These pollutants are accumulated and transferred to human via seafood. Marine plastic pollution induces a substantial rise of economic costs due to the decline of ecosystem services. Mitigation of marine plastic pollution should be done by following the ten Rs principles of refuse, rethink, reduce, re-use, repair, refurbish, remanufacture, repurpose, recycle, and recover. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

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Assessment of Simple Adhesive Substrates for Quantifying Microplastics

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SSRN 2022年

作者： Rieland, Julie M. Hu, Zeyuan Deese, Julian S. Love, Brian J. The University of Michigan United States Department of Materials Science and Engineering Department of Biomedical Engineering Macromolecular Science and Engineering Graduate Program

Microplastics are a growing environmental concern, with a large body of evidence documenting substantial distribution of plastic material in virtually all environmental compartments. Countermeasures that help to bind, aggregate, or coalesce these distributed particles might result in lower human and animal exposures. Pressure sensitive adhesives (PSAs) have been identified as a viable microplastic (MP) capture mechanism with a range of potential use conditions. As with any countermeasure, there is a need to evaluate potential solutions in terms of collection efficiency, cost, ease of installation, etc. Expanding on our previous work, spray-coated PSAs were investigated as submerged surfaces as tools to assess MP binding in aqueous dispersions. Resins containing two differing molecular weights of poly(2-ethylhexyl acrylate) PSA (92k and 950k), and a 50:50 by weight mixture of the two resins were applied as spray-coated substrates to compare the effect of resin composition on MP-adhesive binding. Thin films of PSA (92k 6 ± 1 μm, 950k 4 ± 2 μm, 50:50 BD 6.5 ± 1 μm) were sprayed on borosilicate glass slides using a commercial air brush. Polydisperse nylon-12 particles varying in size from 15-30 µm in diameter were dispersed in deionized water at concentrations between 0.01 and 5 mg mL -1 and agitated under ambient conditions to assess adhesive binding as quantitative comparisons of microparticle capture. Mixed assays were also performed comparing binding of common MP species including polyethylene (50, 200 µm), polystyrene (10 µm), and polyester fibers (1000 µm) to understand how varying composition, size, and form factor affect adsorption. The glass slide method showed increasing linear trends of particle binding with increased adhesive exposure time and MP concentration. The lower molecular weight 92K adhesive had lower viscosity, higher wettability for microplastics but also led to a less stable adhesive film complicating analysis. As a field-deployable scheme for mi

关键词： Aggregates

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Flexible organic solar cells for biomedical devices

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Nano Research 2021年第9期14卷 2891-2903页

作者： Bin Kan Faheem Ershad Zhoulyu Rao Cunjiang Yu Department of Mechanical Engineering University of HoustonHoustonTX 77204USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA Materials Science and Engineering Program University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204USA Texas Center for Superconductivity University of HoustonHoustonTX 77204USA

Organic solar cells(OSCs),particularly made based on solution processing methods,have made significant progress over the past decades through the concurrent evolution of organic photovoltaic materials and device ***,high power conversion efficiencies around 18%and over 16%have been demonstrated in both rigid and flexible OSCs,*** most of the OSC research has centered on efficiency and cost,their emerging and potential usages in many critical applications,particularly in biomedical fields have been *** this mini-review,we will briefly discuss the high-performance organic photovoltaic materials and the representative flexible OSCs to give a scope on the recent rapid development of ***,we will review some progress on the applications of OSCs in biomedical devices and integrated *** potential challenges associated with integrating OSCs for biomedical devices will be put forward.

关键词： organic solar cells photovoltaic flexible biomedical bioelectronics

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3D Image Generation from X-Ray Projections Using Generative Adversarial Networks

3D Image Generation from X-Ray Projections Using Generative ...

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IEEE Symposium on Bioinformatics and Bioengineering (BIBE)

作者： Mohammad AlShurbaji Salam Dhou Biomedical Engineering Graduate Program American University of Sharjah Sharjah UAE Department of Computer Science and Engineering American University of Sharjah Sharjah UAE

The human brain can effortlessly imagine a 3D image from only 2D images with a little expertise and imagination, but for machines, this is not a trivial task. Because of this, reconstructing 3D images from 2D ones is a hot topic and has many applications. In this paper, we propose a Generative Adversarial Network (GAN)-based approach that generates CT-like images using pairs of orthogonal X-ray projections taken from different angles. In this work, a variety of orthogonal pairs from different angles, ranging from 0°&90° to 60°&150°, were considered as input to the 3D image generation model. The effectiveness of the proposed method was assessed by measuring the Structural Similarity Index (SSIM) and Peak Signal-to-Noise Ratio (PSNR), which resulted in values of 0.641 and 29.21, respectively. Furthermore, the model's ability to capture the respiratory motion in the input projections and reflect it in the generated images was also assessed. This work demonstrated the feasibility of generating CT-like images from X-ray projections captured from different orthogonal angles taking into consideration the respiratory motion exhibited in these projections.

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Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

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Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

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Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic,histological,and urine analysis

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Nano Research 2022年第4期15卷 3356-3366页

作者： Liping Wang Wenqiong Su Khan Zara Ahmad Xin Wang Ting Zhang Youyi Yu Edward Kai-Hua Chow Dean Ho Xianting Ding State Key Laboratory of Oncogenes and Related Genes Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Cancer Science Institute of Singapore Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore The N.1 Institute for Health(N.1) National University of SingaporeSingapore 117456Singapore The Institute for Digital Medicine(WisDM) National University of SingaporeSingapore 117456Singapore Department of Pharmacology National University of SingaporeSingapore 117597Singapore Department of Biomedical Engineering National University of SingaporeSingapore 117583Singapore

While doxorubicin(DOX)is one of the most common chemotherapeutic drugs for treating cancer,use of DOX must be managed carefully due to dose-related ***(ND)drug delivery system conjugated with DOX(NDX)has been reported to enhance treatment efficacy and attenuate toxicity in murine cancer *** addition,extensive biocompatibility studies indicate that NDs seem to be well tolerated in non-human *** the clinical translation of NDX,it is necessary to verify the safety of ND in large *** of nanomedicine drug safety for large animal are not commonly reported,and this work represents a key milestone in bridging earlier advances towards clinical ***,NDs’safety as a drug-delivery platform was evaluated in Naïve Beagle *** study is performed with DOX,ND,and NDX in a dual-gender animal model using intravenous(IV)injection and hepatic portal vein(HPV)injection *** dogs are monitored for their health phenotype changes in continuous 5 *** and urine obtained are for clinical pathology *** results indicate that ND drug delivery platform significantly relieves DOX toxicity for Naïve Beagle dog *** study provides guidance for the pre-clinical safety assessment of NDX therapy at large animal level.

关键词： nanomedicine doxorubicin nanodiamonds safety biodistribution

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Modifying BiVO4 as a photocatalyst for water oxidation using constant-duration alkaline-etched post treatments

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New Journal of Chemistry 2023年第2期48卷 569-577页

作者： Hsu, Chuan-Chih Chuang, Kai-Jie Huang, Hsiao-Wen Pan, Bo-Jin Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. Ltd. Rm. 7 10F. No. 189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro Ouagadougou03 Burkina Faso International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

BiVO4 with suitable band edges and a small band gap is considered an efficient photocatalyst for the oxygen evolution reaction (OER), but short charge-transfer lengths limit its photocatalytic ability. Increasing active sites can essentially enhance oxidation reactions and photocatalytic ability. The alkaline etching technique can refine the surface properties of BiVO4 by introducing oxygen vacancies and possibly establishing a heterojunction, but suitable alkaline etching methods are rarely discussed. In this study, three alkaline etching methods, including hydrothermal, soaking, and electrodeposition processes, are first applied for a constant duration to tailor the surface properties of BiVO4 as a photocatalyst for the OER. Alkaline-etched BiVO4 prepared using hydrothermal and soaking processes shows better photocatalytic abilities due to the generation of additional oxygen vacancies, while poor photocatalytic ability is found for that fabricated using electrodeposition due to the formation of less photocatalytic VO2. The highest photocurrent density of 2.38 mA cm−2 is obtained at 1.23 V versus a reversible hydrogen electrode in an electrolyte without a hole scavenger for the BiVO4 etched in the hydrothermal process, while the untreated BiVO4 presents a photocurrent density of 0.58 mA cm−2. A photocurrent retention of 92.3% is achieved after 5000 seconds of continuous illumination. The study supplies blueprints for establishing effective alkaline etching methods for enhancing the photocatalytic ability of BiVO4, with the exception of time costs. © 2024 The Royal Society of Chemistry.

关键词： Charge transfer

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BAF45D regulates spinal cord neural stem/progenitor cell fate through the SMAD-PAX6 axis

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Genes & Diseases 2023年第2期10卷 366-369页

作者： Xueying Chen Xiujuan Hu Jing Jiang Jie Tao Lihua Liu Shengyun Fang Yuxian Shen Qingsong Hu Chao Liu School of Basic Medical Sciences Anhui Medical UniversityHefeiAnhui 230032China Department of Histology and Embryology Institute of Stem Cell and Tissue EngineeringAnhui Medical UniversityHefeiAnhui 230032China Division of Life Sciences and Medicine University of Science and Technology of ChinaThe First Affiliated Hospital of USTCHefeiAnhui 230001China Institute of Clinical Pharmacology Anhui Medical UniversityHefeiAnhui 230032China Center for Biomedical Engineering and Technology University of MarylandBaltimoreMD 21201USA

Mutations in BRG1-associated factor 45D (BAF45D, also known as double PHD fingers 2 (DPF2)) are linked to Coffin-Siris syndrome (CSS).1 However, the underlying molecular mechanisms remain ill-defined. Here, we identified that wild-type but not CSS-associated BAF45D mutants increased the expression of PAX6,2 a neural stem cell marker, and phosphorylated SMAD3 (p-SMAD3) in spinal cord neural stem cells (NSCs) derived from H9 human embryonic stem cells. Both BAF45D and SMAD3 are required for the induction of p-SMAD3 and PAX6 together with STAT3 and SMAD7 by retinoic acid (RA). In the presence of RA, BAF45D knockdown decreased the expression of genes that regulate stem cell pluripotency. Moreover, the same genes in the spinal cord NSCs had more binding sites with BAF45D than those in H9 cells. Furthermore, Gene Ontology (GO) assay results indicated that BAF45D targets more pathways responsible for stem cell maintenance in NSCs. Finally, BAF45D is associated with BRG1, p-SMAD3, and PAX6. Together, these findings suggest a role for BAF45D in modulating PAX6 expression through SMAD signaling, highlighting the importance of BAF45D in neural stem/progenitor cell fate commitment.

关键词： PAX6 progenitor SMAD

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Advances in transcription factor delivery: Target selection, engineering strategies, and delivery platforms

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Journal of Controlled Release 2025年 384卷 113885页

作者： Lee, Yeji Yoo, Seongkyeong Cho, Seongeon Kim, Iljin Kim, In-San KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Chemical and Biological Integrative Research Center Biomedical Research Institute Korea Institute Science and Technology Seoul02792 Korea Republic of Department of Pharmacology and Program in Biomedical Science and Engineering Inha University College of Medicine Incheon22212 Korea Republic of Research Center for Controlling Intercellular Communication Inha University College of Medicine Incheon22212 Korea Republic of

Recent advances in delivery systems for transcription factors (TFs) have opened new therapeutic opportunities in regenerative medicine, cancer therapy, and genetic disorders. However, effective TF delivery still faces substantial obstacles, including limited cellular uptake, inefficient nuclear translocation, low cargo stability, and insufficient target specificity. Furthermore, artificial TFs have enabled targeted modulation of gene expression, further expanding their therapeutic potential. This review comprehensively discusses current progress in TF delivery methodologies, including direct TF protein delivery using cell-penetrating peptides, and extracellular vesicles, as well as TF gene delivery approaches utilizing both lipid-based nanoparticles and viral strategies. Notably, engineered nanoparticles have emerged as promising platforms due to their precise control over TF delivery, improved specificity, and minimized off-target effects. Despite these significant advancements, major hurdles in delivery efficiency, cargo stability, and overall safety persist. Overcoming these obstacles will be essential to accelerate the clinical translation of TF-based therapeutics for a broad spectrum of diseases. © 2024

关键词： Transcription factors

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