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Patient-Facing, Semi-Automated, Solutions to Enhance Patient Participation in Measurement-Based Care Practice Standards in a Tele-Mental Health Specialty Clinic for Populations at Higher Risk for Self-Harm

SSRN

引用

SSRN 2023年

作者： Price, Matthew S. Christensen, Hande Urquhart, Joy Butte, Sarly Acierno, Ron Little, Deborah M. Department of Integrative Biology and Pharmacology University of Texas Health Science Center Houston United States Neuroscience Program University of Texas M.D. Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences United States Trauma and Resilience Center Louis A. Faillace MD Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center Houston United States

Purpose: Collecting validated measures during evidence-based psychotherapy is crucial to allow a therapist to tailor the speed and intensity of treatment. COVID clinic closure mandated we create a flexible, remote system to conduct measurement-based care, which was accomplished via ***: RedCap was used to create a semi-automated system allowing all clinically-indicated evidence-based measures to be delivered via email to patients;with results automatically sent to their provider. Importantly, indications of suicidal ideation were automatically escalated to the provider and center ***: Measure completion improved, while provider burden for collecting measures was greatly reduced;however, depending largely upon initial provider-patient ‘training’, overall compliance could still be significantly ***: This workflow gave providers information compared to the typical telemedicine environment, and in fact, improved data collection rates over our in-person environment. However, when patients were not 100% compliant with measures, the burden on providers increased. © 2023, The Authors. All rights reserved.

关键词： Automation

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LoraMap: Harnessing the Power of LoRA Connections

arXiv

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arXiv 2024年

作者： Park, Hyeryun Kwak, Jeongwon Jang, Dongsuk Park, Sumin Choi, Jinwook Interdisciplinary Program for Bioengineering Graduate School Seoul National University Korea Republic of Integrated Major in Innovative Medical Science Graduate School Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of Medical Research Center Institute of Medical and Biological Engineering Seoul National University Korea Republic of

Fact-checking techniques can mitigate hallucinations in Large Language Models (LLMs), a prominent issue in specialized domains. As parameter-efficient techniques such as Low-Rank Adaptation (LoRA) can overcome substantial computational overhead, some studies have explored the integration of multiple LoRAs. While previous studies focus on parallel integration, this paper investigates methods to establish connections among multiple LoRAs. We create three reasoning datasets tailored to fact-checking and fine-tune individual LoRAs, allowing them to view and reason from diverse perspectives. Then, we explore strategies for allocating these reasoning LoRAs and introduce LoraMap, an approach to map connections between them. The results of the fact-checking task demonstrate that the performance of LoraMap is superior to LoraHub, an existing method for integrating LoRAs. LoraMap also outperforms with significantly fewer trainable parameters than LoraConcat, which concatenates LoRAs and further fine-tunes them. Copyright © 2024, The Authors. All rights reserved.

关键词： Problem oriented languages

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Design of sonochemical assisted synthesis of Zr-MOF/g-C3N4-modified electrode for ultrasensitive detection of antipsychotic drug chlorpromazine from biological samples

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Microchimica Acta 2024年第4期191卷 182-182页

作者： Ashkar, M.A. Kutti Rani, S. Vasimalai, N. Kuo, Chih-Yu Yusuf, Kareem Govindasamy, Mani Department of Chemistry B.S. Abdur Rahman Crescent Institute of Science and Technology Vandalur Chennai600 048 India Department of Chemical Engineering & amp Biotechnology National Taipei University of Technology Taipei10608 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai6021055 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The rapid fabrication is described of binary electrocatalyst based on a highly porous metal–organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-C3N4) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsychotic drug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2D Zr-MOF@g-C3N4 was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies. The crystalline and porous nature of the composite was characterized by XRD and SEM analysis. The functional groups and surface characteristics were investigated by FT-IR, Raman and XPS. The major electrochemical properties of the Zr-MOF@g-C3N4 composite towards CLP detection were analyzed by CV, chronocoulometric (CC), chronoamperometric (CA) and differential pulse voltammetry (DPV) techniques. The composite exhibits a low detection limit (LOD) of 2.45 nM with a linear range of 0.02 to 2.99 µM and attractive sensitivity for CLP. The sensor system shows higher selectivity towards the possible interferences of CLP drug and exhibits better repeatability and stability. Finally, the fabricated sensor system shows a high recovery range varying from 96.2 to 98.9% towards the real samples. The proposed electrochemical probe might be a promising alternative to the prevailing diagnostic tools for the detection of CLP. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024.

关键词： Cyclic voltammetry

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Ultrasound-guided drug delivery system utilizing piezocatalytic MoS2 nanomaterials for anti-inflammatory therapy

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Nano Energy 2024年 127卷

作者： Lin, Ssu-Chi Joshi, Ravindra Ganguly, Anindita Barman, Snigdha Roy Pal, Arnab Kaswan, Kuldeep Liu, Kuei-Lin Nain, Amit Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Engineering Indian Institute of Science Karnataka Bangalore560012 India Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan

Traditional drug delivery systems lack the potential of controlled drug release, thereby decreasing drug utilization and release efficiency. Herein, a next generation of stimuli-responsive drug delivery platform is designed based on piezocatalytic molybdenum disulfide nanoflowers (MoS2 NFs) which can be triggered by ultrasound (US) stimulation for effective acute inflammation therapy. Under US irradiation, MoS2 NFs undergoes piezocatalysis to generate reactive oxygen species (ROS) owing to piezoelectric polarization, thus releasing loaded anti-inflammatory drug Indomethacin (IND) to the targeted inflammation site. The cumulative release of IND elevated significantly with the increase in the duration for US exposure due to the amplified ROS generation, which displayed a highly controllable nature of the as-designed drug delivery platform. For convenient applications, the IND loaded MoS2 NFs (IND@MoS2 NFs) was functionalized onto commercial dressings and their tunable in-vivo drug release performance was demonstrated in paw edema model. IND@MoS2 NFs upon US irradiation, controllably released IND into the site-specific inflamed paw which significantly inhibited 56 % of paw swelling in 6 h by suppressing the infiltration of neutrophils and expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α). The highly controllable drug delivery system holds great potential in facilitating personalized, user-friendly theranostic applications with improved patient outcomes. © 2024 Elsevier Ltd

关键词： Ultrasonics

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Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease

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European Polymer Journal 2024年 214卷

作者： Yang, I-Hsuan Kuan, Che-Yung Zhang, Sheng-Long Chen, Zhi-Yu Li, Chi-Han Liang, Ya-Jyun Kuo, Wei-Ting Chang, Chia-Ting Lin, Jason Hsieh, Hsing-Pang Chang, Jang-Yang Lin, Feng-Huei Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County Taiwan Department of Materials Science and Engineering National United University Miaoli County Taiwan Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan PhD Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli County Taiwan Taipei Cancer Center Taipei Medical University Hospital Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan

The cause of Alzheimer's disease (AD) remains unknown;however, studies have indicated the increased expression of cathepsin S (CTSS) in AD brains. Cathepsin S acts as a β-secretase, prompting the release of amyloid-β peptides and stimulating microglial cell activation, causing microglial migration, and contributing to neuroinflammation and disease progression. In this study, CT001, an inhibitor of the cysteine protease CTSS, was encapsulated in poly(lactic-co-glycolic acid)-polyethylene glycol microspheres combined with hydroxyapatite microspheres (CPPMs/HAMs) to achieve a constant and long-term drug release for AD. The results showed that CPPMs/HAMs had a uniform diameter of approximately 1 μm, enabling macrophage endocytosis and facilitating sustained CT001 release into the bloodstream, ultimately reaching the brain for AD treatment. The developed CPPMs/HAMs demonstrated excellent anti-inflammatory properties and mitigated CTSS expression in an in vitro inflammation microglial model. Intramuscular administration of CPPMs/HAMs improved learning and memory in AD mice during behavioral assessments. Furthermore, CPPMs/HAMs reduced CTSS expression, amyloid-beta accumulation, and deposition in vivo. This study demonstrated the potential of CT001 delivered via CPPMs/HAMs as a promising approach for managing AD in patients. © 2024

关键词： Peptides

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Characteristics Fluctuation of Sub-3-nm Bulk FinFET Devices Induced by Random Interface Traps

Characteristics Fluctuation of Sub-3-nm Bulk FinFET Devices ...

引用

IEEE Conference on Nanotechnology

作者： Sekhar Reddy Kola Min-Hui Chuang Yiming Li Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Electronics and Electrical Engineering Institute of Communications Engineering Institute of Biomedical Engineering Institute of Pioneer Semiconductor Innovation Institute of Artificial Intelligence Innovation National Yang Ming Chiao Tung University Hsinchu Taiwan

Three-dimensional (3D) bulk fin-typed field effect transistors (FinFETs) have emerged as key devices that can scale down the technology node beyond 22-nm. However, the scaled devices have created new sources of fluctuation inherent in 3D geometry. The interface trap is one such fluctuation that is caused by the trapping and de-trapping of charge carriers and has an adverse effect on device characteristics and variability. In this work, we study impacts of random interface traps (RITs) on electrical characteristic of bulk FinFETs by using a 3D quantum-mechanically corrected device simulation. RIT position effects on short channel effects (SCEs) are examined with physical governed influence to show the major fluctuations. More than 50% reductions of the RITs-induced characteristic fluctuation of the germanium (Ge) devices are observed, compared with Si devices. The Ge ones can reduce SCE variations and exhibit high immunity to RITs.

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A call to action to address escalating global threats to academic research

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The Innovation 2025年第4期6卷 17-19页

作者： Gaelle Piret Fun Man Fung Josie Fullerton Giuseppe Fico Dmitriy Ponkratov Wenxin Chen Daniela Latorre Kirsty Y.Wan Nima Aghaeepour Jules Welgryn Adeel Razi Patricia Silveyra Ahmet Altun Renata Z.Jurkowska Alice C.Hughes Joy Wolfram INSERM U1205 UGA38400 Saint Martin d’HèresFrance School of Chemistry University College DublinD04 C1P1 BelfieldIreland UCD Geary Institute for Public Policy University College DublinD04 N9Y1 DublinIreland School of Cardiovascular&Metabolic Health University of GlasgowG128TA GlasgowUK European Alliance for Medical and Biological Engineering and Science 3001 LeuvenBelgium Life Supporting Technologies Universidad Politécnica de Madrid28040 MadridSpain Siemens Digital Industries Software B908BG SolihullUK Department of Philosophy of Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Microbiology ETH Zurich8093 ZurichSwitzerland Living Systems Institute&Department of Mathematics and Statistics University of ExeterEX44QD ExeterUK Department of Anesthesiology Painand Perioperative MedicineDepartment of PediatricsDepartment of Biomedical Data ScienceStanford University School of MedicineStanfordCA 94305USA UniversitéParis Nanterre 92000 NanterreFrance Turner Institute for Brain and Mental Health School of Psychological Sciencesand Monash Biomedical ImagingMonash UniversityClaytonVIC 3800Australia Wellcome Centre for Human Neuroimaging University College LondonWC1N 3AR LondonUK CIFAR Azrieli Global Scholars Program TorontoON M5G 1M1Canada Department of Environmental and Occupational Health Indiana University School of Public Health BloomingtonBloomingtonIN 47408USA Department of Pharmacology Sivas Cumhuriyet UniversitySivas 58140Turkey Division of Biomedicine School of BiosciencesCardiff UniversityCF103AX CardiffUK School of Biological Sciences University of Hong KongHong Kong SAR 999077China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia School of Chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia

This article is a call to action to address escalating threats to scientific progress that affect academic researchers across the *** threats include public mistrust of science,challenges in translating academic research to end-user applications,a disconnect between academics and policymakers,emerging barriers to international collaboration,and a reliance on conventional metrics to evaluate academic *** article presents various calls to action informed by exemplary approaches across the globe that serve as frameworks to drive beneficial transformation for researchers,academic institutions,and society.

关键词： academic research calls action global threats public mistrust sciencechallenges translating academic research disconnect academics policymakers call action translation research

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Statistical Analysis of Intrinsic High-Frequency Characteristic Fluctuation of Emerging Silicon Gate-All-Around Nanosheet (NS) MOSFETs at Sub-3-nm Nodes

Statistical Analysis of Intrinsic High-Frequency Characteris...

引用

IEEE Electron Devices Technology and Manufacturing Conference (EDTM)

作者： Sekhar Reddy Kola Yiming Li Min-Hui Chuang Kazuhiko Endo Seiji Samukawa Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Institute of Communications Engineering Department of Electronics and Electrical Engineering Institute of Biomedical Engineering Center for mm Wave Smart Radar System and Technologies National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Fluid Science Tohoku University 2-1-1 Katahira Aoba-ku Sendai Japan National Institute of Advanced Industrial Science and Technology Tsukuba Japan

In recent years, the GAA NS Si MOSFET has been explored as a leading technology. However, the intrinsic parameters of GAA NS Si MOSFETs are affected to varying degrees by various fluctuation sources, Statistically independent and identically distributed $(iid)$ assumptions on the aforementioned random variables overestimate the variability of high-frequency characteristics, compared with considering all fluctuation factors simultaneously. Notably, the random nanosized metal grains dominates the variations of voltage gain, cut-off frequency, and 3dB frequency because the random work functions strongly alter the channel surface potential.

关键词： MOSFET Fluctuations Statistical analysis Gallium arsenide Cutoff frequency Metals Logic gates

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Improving quantitation accuracy in isobaric-labeling mass spectrometry experiments with spectral library searching and feature-based peptide-spectrum match filter

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Scientific Reports 2023年第1期13卷 1-10页

作者： Kuo, Tzu-Yun Wang, Jen-Hung Huang, Yung-Wen Sung, Ting-Yi Chen, Ching-Tai Department of Biochemical Science and Technology National Taiwan University Taipei 10617 Taiwan Bioinformatics Program Taiwan International Graduate Program Institute of Statistical Science Academia Sinica Taipei 11529 Taiwan Institute of Information Science Academia Sinica Taipei 11529 Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei 11221 Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan Department of Bioinformatics and Biomedical Engineering Asia University Taichung 41354 Taiwan Center for Precision Health Research Asia University Taichung 41354 Taiwan

Isobaric labeling relative quantitation is one of the dominating proteomic quantitation technologies. Traditional quantitation pipelines for isobaric-labeled mass spectrometry data are based on sequence database searching. In this study, we present a novel quantitation pipeline that integrates sequence database searching, spectral library searching, and a feature-based peptide-spectrum-match (PSM) filter using various spectral features for filtering. The combined database and spectral library searching results in larger quantitation coverage, and the filter removes PSMs with larger quantitation errors, retaining those with higher quantitation accuracy. Quantitation results show that the proposed pipeline can improve the overall quantitation accuracy at the PSM and protein levels. To our knowledge, this is the first study that utilizes spectral library searching to improve isobaric labeling-based quantitation. For users to conveniently perform the proposed pipeline, we have implemented the feature-based filter being executable on both Windows and Linux platforms;its executable files, user manual, and sample data sets are freely available at https://***/comics/Software_*** . Furthermore, with the developed filter, the proposed pipeline is fully compatible with the Trans-Proteomic Pipeline. © 2023, Springer Nature Limited.

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Piezoelectric and triboelectric nanogenerators: Promising technologies for self-powered implantable biomedical devices

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Nano Energy 2024年 119卷

作者： Khan, Arshad Joshi, Ravindra Sharma, Manish Kumar Ganguly, Anindita Parashar, Parag Wang, Ting-Wei Lee, Sangmin Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Chemical Engineering National Taiwan University Taipei10167 Taiwan

Implantable biomedical devices (IBDs) have garnered wide-scale attention in recent years due to their enormous contribution to the biomedical sector. However, an uninterrupted and reliable power source has consistently been the primary barrier for IBDs, which is greatly alleviated by batteries. The widespread application of battery-powered IBDs is hindered by several limitations, including bulkiness, limited capacity and shelf-life, and expenditure associated with surgery-based battery recharge/replacement. To address these challenges, state-of-the-art self-powering technologies have emerged, including implantable piezoelectric nanogenerators (iPENGs) and implantable triboelectric nanogenerators (iTENGs). These technologies enable IBDs to operate autonomously by harnessing the minute mechanical movements of internal organs, such as heartbeat, respiration, blood circulation, muscle contraction/relaxation, and lung vibration. This review focuses on the recent advancements in iTENGs and iPENGs for the development of self-powered IBDs with a wide range of applications, including energy harvesting from biomechanical and ultrasound sources and energy storage using batteries and capacitors. This study also explores the extensive sensing applications of IBDs in various areas including cardiac, gastrointestinal, bladder, and ligament-strain monitoring. Finally, therapeutic applications of IBDs, such as nerve stimulation, bone stimulation, cartilage therapy, tissue regeneration, muscle stimulation, drug delivery, and diabetes management are discussed. © 2023 Elsevier Ltd

关键词： Nanogenerators

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