检索结果-内蒙古大学图书馆

Comparison of Advanced Sample Preparation Techniques for High-Resolution Imaging of Sponge Spicule Cross-Sections

Comparison of Advanced Sample Preparation Techniques for Hig...

Symposium on Natural Fibers and Biocomposites: A Sustainable Solution, 2025, held as part of the TMS Annual Meeting and Exhibition, TMS 2025

作者： Tavangarian, Fariborz Fani, Niloofar Monfared, Armaghan Hashemi Sadeghzade, Sorour Mechanical Engineering Program School of Science Engineering and Technology Pennsylvania State University Harrisburg MiddletownPA17057 United States Department of Biomedical Engineering Pennsylvania State University State College University ParkPA16802 United States School of Engineering Westlake University Hangzhou310024 China

ISBN: (纸本)9783031811890

This study comprehensively investigates the effectiveness of three advanced sample preparation techniques—ion milling, laser cuttingLaser-based techniques, and Focused Ion Beam (FIB) milling—for high-resolution imaging of Euplectella aspergillum sponge fibers called spicules. Primarily composed of silica layers with nanometer-scale organic interlayers, spicules possess complex hierarchical structures which are critical for their mechanical propertiesMechanical property. Accurate characterizationCharacterization of these structures requires advanced sample preparation to prevent artefacts and preserve structural integrity. Ion milling introduced significant surface degradation and uneven material removal in spicules. Despite its precision, laser cutting caused thermal damage and induced micro-cracks, compromising the microstructural integrity. In contrast, FIB milling provided superior results, producing smooth, artefact-free cross-sections with minimal thermal and mechanical stress. The real-time imaging capability of FIB milling further ensured optimal sample preparation, making it the most suitable technique for delicate biological materials like spicules. The findings of this study provide valuable insights into the preparation of biological samples for further research and analysis. © The Minerals, Metals & Materials Society 2025.

关键词： Milling (machining)

来源：评论

学校读者我要写书评

暂无评论

A Saliva Fern Recognition with Image Tone Equalization and Detection Method 18th

A Saliva Fern Recognition with Image Tone Equalization and D...

引用

18th International Conference on Intelligent Information Hiding and Multimedia Signal Processing, IIH-MSP 2022

作者： Chen, Jian-Yu Chuang, Hui-Yu Horng, Mong-Fong Shieh, Chin-Shiuh Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of BS/GYN Kaohsiung Medical University Hospital Kaohsiung Taiwan Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan

ISBN: (纸本)9789819901043

Pregnancy preparation has become the daily work of many young married couples. How to know the ovulation period easily and conveniently, the image of fern-like crystals in female saliva is a valuable feature. However, due to the low accuracy of image detection, it is difficult to popularize. This study proposes to use image processing technology to recognize fern-like crystals in female saliva. Different from the previous practice, the preprocessing method of tone equalization and edge detection is proposed to improve recognition quality, particularly recognition sensitivity. The experimental results show that the achieved sensitivity is 100% for test data and the preprocessing, including tone equalization, median filtering, and erosion operations, contributes an improvement in accuracy by 26%. Consequently, the proposed methods are indeed helpful. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Median filters

来源：评论

学校读者我要写书评

暂无评论

Super-Resolution Displacement Spectroscopic Sensing over a Surface“Rainbow”

引用

engineering 2022年第10期17卷 75-81页

作者： Lyu Zhou Nan Zhang Chang Chieh Hsu Matthew Singer Xie Zeng Yizheng Li Haomin Song Josep Jornet Yun Wu Qiaoqiang Gan Department of Electrical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Biomedical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA Material Science Engineering Program King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical *** these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral *** particular,for imaging-based spectroscopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution ***,we report a unique"rainbow"trapping metasurface for on-chip spectrometers and *** with super-resolution image processing,the low-setting 4×optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as0.002 *** unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength *** this low-setting 4×microscope imaging system,we demonstrate a biosensing resolution of 1.92×109exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.

关键词： Rainbow trapping Metasurface Surface plasmon polaritons Super-resolution displacement On-chip biosensing

来源：评论

学校读者我要写书评

暂无评论

The use of combined remote electronic monitoring and blood concentrations of antipsychotics for assessment of therapeutic adherence in patients with schizophrenia: results of a prospective study

引用

BMC Psychiatry 2025年第1期25卷 1-11页

作者： Šilhán, Petr Hýža, Martin Ambroš, Samuel Dostálek, Petr Schwarzová, Jana Skřont, Tomáš Perničková, Denisa Baarová, Pavla Augustynek, Martin Kacířová, Ivana Uřinovská, Romana Department of Psychiatry University Hospital Ostrava 17. listopadu 1790 Ostrava Poruba 708 52 Czech Republic Department of Clinical Neurosciences Faculty of Medicine University of Ostrava Ostrava Czech Republic Department of Cybernetics and Biomedical Engineering Faculty of Electrical Engineering and Computer Science VSB-Technical University Ostrava Ostrava Czech Republic Department of Clinical Pharmacology Institute of Laboratory Medicine University Hospital Ostrava Ostrava Czech Republic Institute of Clinical Pharmacology Faculty of Medicine University of Ostrava Ostrava Czech Republic

Background: Schizophrenia is a serious mental illness, the pharmacological treatment of which comprises primarily the use of antipsychotics. However, non-adherence to their use and its reliable determination present a serious clinical and economic problem. This study aimed to determine therapeutic adherence in outpatients with schizophrenia spectrum disorders by combining short-term electronic monitoring of dispenser opening with the measurement of antipsychotic blood concentrations. Methods: A total of 55 patients underwent a week-long electronic monitoring of dispenser opening and measurement of blood concentrations before and after monitoring. Patients who correctly opened the dispenser at least in 80% of scheduled time points during the weekly interval and, at the same time, did not show a change in blood concentration of the antipsychotic by more than 30% in any direction, were considered adherent. Results: 69.1% of the patients met the adherence criteria, which was less than that determined by the Drug Attitude Inventory (DAI-10), the Visual Analogue Scale (VAS), and the Clinician Rating Scale (CRS). 7.3% of the patients took less than 80% of the prescribed doses and a change in blood concentrations of the antipsychotic by more than 30% was detected in 25.4% of the patients. In 70.9% of patients, the detected concentrations were within the recommended therapeutic reference interval. The groups of adherent and non-adherent patients did not differ statistically significantly in the severity of their illness as determined by the Clinical Global Impression (CGI), the Personal and Social Performance scale (PSP), and the Positive and Negative Syndrome Scale (PANSS). Conclusions: The combined method of evaluating adherence in schizophrenia patients confirmed the results determined by other methods. The benefits of this approach are described in the paper. © The Author(s) 2025.

关键词： Antipsychotics Schizophrenia Telehealth Therapeutic adherence Therapeutic drug monitoring

来源：评论

学校读者我要写书评

暂无评论

Ultra-transparent nanostructured coatings via flow-induced one-step coassembly

引用

Nano Materials science 2022年第2期4卷 97-103页

作者： Jingjing Liu Sonia E.Chavez Hao Ding Maria M.Farooqui Zaili Hou Sharon Lin Thomas D.D'Auria Julia M.Kennedy Anna Marie LaChance Luyi Sun Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsConnecticut06269United States Department of Chemical&Biomolecular Engineering University of ConnecticutStorrsConnecticut06269United States Department of Biomedical Engineering University of ConnecticutStorrsConnecticut06269United States

Polyvinyl alcohol(PVA)/laponite(LP)nanocomposite coatings were fabricated via a facile one-step coassembly *** formed nanocoatings contain a high concentration of LP nanosheets,which can be well aligned along the substrate surface during the coassembly *** to the highly orientated structure,the flexible nanocoatings exhibit ultra-high transparency and superior mechanical properties,and can also act as excellent gas *** nanocoatings can be exceptional candidates for a variety of applications,such as food packaging.

关键词： Nanocoating Coassembly Polyvinyl alcohol Laponite

来源：评论

学校读者我要写书评

暂无评论

Single-sequence protein structure prediction using a language model and deep learning (Oct, 10.1038/s41587-022-01432-w, 2022)

引用

NATURE BIOTECHNOLOGY 2022年第11期40卷 1692-1692页

作者： Chowdhury, Ratul Bouatta, Nazim Biswas, Surojit Floristean, Christina Kharkar, Anant Roy, Koushik Rochereau, Charlotte Ahdritz, Gustaf Zhang, Joanna Church, George M. Sorger, Peter K. AlQuraishi, Mohammed Laboratory of Systems Pharmacology Program in Therapeutic Science Harvard Medical School Boston MA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Nabla Bio Inc. Boston MA USA Department of Computer Science Columbia University New York NY USA Integrated Program in Cellular Molecular and Biomedical Studies Columbia University New York NY USA Department of Systems Biology Columbia University New York NY USA Department of Systems Biology Harvard Medical School Boston MA USA

AlphaFold2 and related computational systems predict protein structure using deep learning and co-evolutionary relationships encoded in multiple sequence alignments (MSAs). Despite high prediction accuracy achieved by these systems, challenges remain in (1) prediction of orphan and rapidly evolving proteins for which an MSA cannot be generated; (2) rapid exploration of designed structures; and (3) understanding the rules governing spontaneous polypeptide folding in solution. Here we report development of an end-to-end differentiable recurrent geometric network (RGN) that uses a protein language model (AminoBERT) to learn latent structural information from unaligned proteins. A linked geometric module compactly represents Cα backbone geometry in a translationally and rotationally invariant way. On average, RGN2 outperforms AlphaFold2 and RoseTTAFold on orphan proteins and classes of designed proteins while achieving up to a 106-fold reduction in compute time. These findings demonstrate the practical and theoretical strengths of protein language models relative to MSAs in structure prediction.

关键词： Computational biophysics Machine learning Protein structure predictions

来源：评论

学校读者我要写书评

暂无评论

Spectral Learning of Shared Dynamics Between Generalized-Linear Processes 38

Spectral Learning of Shared Dynamics Between Generalized-Lin...

引用

38th Conference on Neural Information Processing Systems, NeurIPS 2024

作者： Oganesian, Lucine L. Sani, Omid G. Shanechi, Maryam M. Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA United States Ming Hsieh Department of Electrical and Computer Engineering Thomas Lord Department of Computer Science Alfred E. Mann Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los AngelesCA United States

Generalized-linear dynamical models (GLDMs) remain a widely-used framework within neuroscience for modeling time-series data, such as neural spiking activity or categorical decision outcomes. Whereas the standard usage of GLDMs is to model a single data source, certain applications require jointly modeling two generalized-linear time-series sources while also dissociating their shared and private dynamics. Most existing GLDM variants and their associated learning algorithms do not support this capability. Here we address this challenge by developing a multi-step analytical subspace identification algorithm for learning a GLDM that explicitly models shared vs. private dynamics within two generalized-linear time-series. In simulations, we demonstrate our algorithm's ability to dissociate and model the dynamics within two time-series sources while being agnostic to their respective observation distributions. In neural data, we consider two specific applications of our algorithm for modeling discrete population spiking activity with respect to a secondary time-series. In both synthetic and real data, GLDMs learned with our algorithm more accurately decoded one time-series from the other using lower-dimensional latent states, as compared to models identified using existing GLDM learning algorithms. © 2024 Neural information processing systems foundation. All rights reserved.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

引用

Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

来源：评论

学校读者我要写书评

暂无评论

THE EFFECTS OF PRE-COATING LAYERS ON BARRIER LAYER PERFORMANCE

THE EFFECTS OF PRE-COATING LAYERS ON BARRIER LAYER PERFORMAN...

引用

TAPPICon 2023 - Rock the Roll: Unleashing the Harmonies of the Paper Industry

作者： Pokharel, Kritee Wang, Jinwu Bousfield, Douglas Paper Surface Science Program Department of Chemical and Biomedical Engineering University of Maine OronoME04469 United States Forest Products Laboratory MadisonWI United States

CNF (cellulose nanofibrils) layers on paper are an effective barrier against oxygen and grease and improve dispersion-based barrier coatings. The potential to produce paper grades with good oxygen, grease, and moisture barrier properties is clear, but synergies between CNF, other coating layers, and water-borne barrier coatings (WBBC) are not. Different WBBC weights were applied to papers with different CNF films that varied in quality and amounts. WBBC were also applied to pigmented coating layers with different pigment types and pigment to volume concentrations (PVC). Samples are tested for oil and grease resistance (OGR), water vapor transmission rate (WVTR), and oxygen transmission rate (OTR). WVTR reduces by more than ten times when WBBC is applied to a CNF film compared to no layer at the same coat weight. WVTR is reduced when WBBC is applied to pigment coating layers as well. The folding of the samples reduces moisture barrier performance to some degree but not grease resistance when a CNF film is used. WBBC coatings on CNF film have good oxygen barrier properties. © 2023 TAPPICon 2023 - "Rock the Roll: Unleashing the Harmonies of the Paper Industry". All rights reserved.

关键词： Oxygen

来源：评论

学校读者我要写书评

暂无评论

Beyond the Scroll: Eye-Tracking Evaluations on the National Gallery of Indonesia’s Instagram 26th

Beyond the Scroll: Eye-Tracking Evaluations on the National ...

引用

26th International Conference on Asia-Pacific Digital Libraries, ICADL 2024

作者： Sari, Desy Novita Prameswari, Clarissa Rahmi Anshori, Isa Master’s Program in Library Science Universitas Indonesia Kota Depok Indonesia Department of Library and Information Sciences Universitas Indonesia Kota Depok Indonesia Biomedical Engineering Department School of Electrical Engineering and Informatics Bandung Institute of Technology Bandung Indonesia National Gallery of Indonesia Central Jakarta Indonesia

ISBN: (纸本)9789819608676

Eye-tracking studies focused on art galleries and museums within the realm of Instagram, especially in the Indonesian context, are notably scant. This investigation elucidates the user interaction and experience of the art gallery’s Instagram account, @galerinasional. Employing a quantitative approach, we implemented eye-tracking experiments using the well-known online eye-tracking software RealEye. The study participants were followers of the National Gallery of Indonesia’s (Galnas) Instagram profile, seven women and three men, in two age brackets: 18–24 years (n = 5) and 25–34 years (n = 5). The experimental protocol required participants to execute five tasks centered on locating exhibition details and artwork on the Galnas Instagram platform, with a duration of 100 s allocated to each task. The Participant Quality Grade (PQG), examination duration, optimal browser dimensionality, K-factor mean, gaze and fixation frequencies, and heat maps were determined for the participants. The key findings are as follows. (1) The participants’ PQG scores were predominantly between 4 and 6. (2) Investigative browsing typically exceeded the 100-s limit. (3) The consensus on the ideal browser dimensions hovered around 1,368.6 × 814.8 px. (4) The K-factor mean across participants tended toward K > 0. (5) The average gaze occurrence was 27 items per second for most participants. (6) A noticeable disparity in fixation counts was observed between the two age groups, with individuals aged 25–34 demonstrating prolonged engagement with Galnas’ content. (7) Heat maps accentuated a pronounced concentration on visual content, encompassing photographs, videos, and their associated captions. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Economic and social effects

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：