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Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives

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Acta Pharmaceutica Sinica B 2018年第6期8卷 862-880页

作者： Gantumur Battogtokh Yeon Su Choi Dong Seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee Han Chang Kang Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciences and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy College of Pharmacy The Catholic University of Korea Division of Bioengineering Incheon National University Department of Polymer Science and Engineering Chungnam National University

mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.

关键词： Anticancer agents Antioxidants Direct conjugation Mitochondria-targeting Sensing agents

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Reversible hydrogels with tunable mechanical properties for optically controlling cell migration

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Nano Research 2018年第10期11卷 5556-5565页

作者： Xin Wu Wenmao Huang Wen-Hao Wu Bin Xue Dongfang Xiang Ying Li Meng Qin Fei Sun Wei Wang Wen-Bin Zhang Yi Cao Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructure and Department of Physics Nanjing University Nanjing 210093 China Key Laboratory of Polymer Chemistry & Physics of Ministry of Education Center for Soft Matter Science and Engineering College ot Chemistry and Molecular Engineering Peking University Beijing 100871 China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and Engineering Nanjing University olin formation Science & Technology Nanjing 210044 China Department of Chemical and Biomolecular Engineering Division of BioMedical Engineering and Center for Systems Biology & Human Health The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Synthetic hydrogels are widely used as biomimetic in vitro model systems to understand how cells respond to complex microenvironments. The mechanical properties of hydrogels are deterministic for many cellular behaviors, including cell migration, spreading, and differentiation. However, it remains a major challenge to engineer hydrogels that recapture the dynamic mechanical properties of native extracellular matrices. Here, we provide a new hydrogel platform with spatiotemporally tunable mechanical properties to assay and define cellular behaviors under light. The change in the mechanical properties of the hydrogel is effected by a photo-induced switch of the cross-linker fluorescent protein, Dronpa145N, between the tetrameric and monomeric states, which causes minimal changes to the chemical properties of the hydrogel. The mechanical properties can be rapidly and reversibly tuned for multiple cycles using visible light, as confirmed by rheological measurements and atomic force microscopy- based nano-indentation. We further demonstrated real-time and reversible modulation of cell migration behaviors on the hydrogels through photo-induced stiffness switching, with minimal invasion to the cultured cells. Hydrogels with a programmable mechanical history and a spatially defined mechanical hierarchy might serve as an ideal model system to better understand complex cellular functions.

关键词： Dronpa photo-responsive hydrogel mechanical properties cell migration artificial extracellular matrix

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Erratum to ‘Effect of soft segment molecular weight on the microcellular foaming behavior of TPU using supercritical CO 2 ’ [J. Supercrit. Fluids, 160, 2020, 104816]

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The Journal of Supercritical Fluids 2021年 171卷

作者： Mohammadreza Nofar Bige Batı Emine Büşra Küçük Amirjalal Jalali Metallurgical & Materials Engineering Department Faculty of Chemical and Metallurgical Engineering Istanbul Technical University Maslak Istanbul 34469 Turkey Polymer Science and Technology Program Istanbul Technical University Maslak Istanbul 34469 Turkey Microcellular Plastics Manufacturing Laboratory Department of Mechanical and Industrial Engineering University of Toronto Toronto Ontario M5S 3G8 Canada

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Unlocking Durable and Sustainable Zinc–Iodine Batteries via Molecularly Engineered Polyiodide Reservoirs

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Angewandte Chemie - International Edition 2025年 e202506822页

作者： Zhang, Leiqian Luo, Ke Gong, Jiaming Zhou, Yazhou Guo, Hele Yu, Yi He, Guanjie Gohy, Jean-François Parkin, Ivan P. Hofkens, Johan He, Qing Liu, Tianxi Müllen, Klaus Lai, Feili Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University Wuxi214122 China State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University Changsha410082 China State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai200240 China Nanotechnology Centre Centre for Energy and Environmental Technologies VŠB-Technical University of Ostrava 17. listopadu 2172/15 Ostrava-Poruba70800 Czech Republic Department of Chemistry KU Leuven Celestijnenlaan 200F Leuven3001 Belgium School of Chemical Engineering Zhengzhou University Zhengzhou450001 China Department of Chemistry University College London LondonWC1H 0AJ United Kingdom Université catholique de Louvain Place L. Pasteur 1 Louvain-la-Neuve1348 Belgium Department of Molecular Spectroscopy Max Planck Institute for Polymer Research Ackermannweg 10 Mainz55128 Germany

Zinc–iodine batteries (ZIBs) are promising candidates for safe and sustainable energy storage but are hindered by polyiodide shuttling, leading to rapid capacity decay and limited cyclability. In this work, we propose a "polyiodide reservoirs" concept, utilizing iodophilic covalent organic cages to confine polyiodide through multiple noncovalent interactions. By precisely engineering the nitrogen-active site densities around 3D cavities, these cages evolve from open to near-enclosed structure, achieving molecular-level polyiodide entrapment. The optimized superphane cage (18 N-active sites) enables a ZIB with 90.1% capacity retention after 4000 cycles at 5 C, even under extreme conditions (58.9 wt% iodine content within the cage and an iodine area loading of 3.7 mg cm−2 in the cathode). Importantly, the cage's solubility-driven regeneration capability retains 85.4% initial capacity over three reuse cycles. This work establishes covalent organic superphanes as a transformative platform for long-life ZIBs, offering a dual solution to shuttle suppression and electrode sustainability through structural confinement and dynamic recyclability. © 2025 Wiley-VCH GmbH.

关键词： Petroleum reservoir evaluation

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Nanostructured Polyelectrolyte-surfactant Complex Pervaporation Membranes for Ethanol Recovery:the Relationship between the Membrane Structure and Separation Performance

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Chinese Journal of polymer science 2018年第1期36卷 25-33页

作者： Pei-Yao Zheng Ping Zhang Zhi-Wei Sun Chen-Hui Zhu Quan-Fu An Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science&EngineeringZhejiang UniversityHangzhou 310027China Materials Science Division of Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Beijing Key Laboratory for Green Catalysis and Separation College of Environmental and Energy EngineeringBeijing University of TechnologyBeijing100124China

Polyelectrolyte-surfactant complexes（PESCs） were fabricated through the interaction of poly（acrylic acid） and four different cationic surfactants or their mixtures. PESC membranes were prepared by solution casting method and were applied in ethanol recovery from aqueous solution via pervaporation. Elemental analysis（EA）, Fourier transform infrared spectroscopy（FTIR）, water contact angle（CA） measurement, differential scanning calorimetry（DSC） and X-ray scattering were employed to characterize the composition, structure and properties of PESCs. The results reveal that the investigated PESCs are similar in hydrophobicity but different in hierarchical nanostructures. In separating 5 wt% ethanol/water mixture, PESC membranes with high crystallinity will have both low flux and ethanol selectivity because of the high packing density and low permeability of crystalline regions. Meanwhile, the hierarchical nanostructures of PESC membranes change under pervaporation environment as was revealed by in situ synchrotron radiation X-ray scattering measurement. That is, the crystalline region could melt at high temperature in swelling state, thus consequently enhancing the ethanol selectivity.

关键词： Polyelectrolyte-surfactant complex Pervaporation Ethanol recovery Crystallinity

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Ambient nanoparticles/nanominerals and hazardous elements from coal combustion activity:Implications on energy challenges and health hazards

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Geoscience Frontiers 2018年第3期9卷 863-875页

作者： Binoy K.Saikia Jyotilima Saikia Shahadev Rabha Luis F.O.Silva Robert Finkelman Polymer Petroleum and Coal Chemistry Group Materials Science and Technology DivisionCSIR-North East Institute of Science and TechnologyJorhat785006AssamIndia Academy of Scientific and Innovative Research CSIR-NEIST CampusJorhat785006India Research group in Environmental Management and Sustainability Department of Civil and Environmental EngineeringUniversidad de la CostaBarranquillaColombia University of Texas at Dallas RichardsonTXUSA

Coal is the most abundant fossil fuel in the world. Because of the growth of coal mining, coal-fired power plants and coal-burning industries, the increase of the emission of particulates(coarse, fine or ultrafine)is of great concern. There is a relationship between increasing human morbidity and mortality and progressive environmental air pollution caused by these types of particles. Thus, the knowledge of the physico-chemical composition and ambient concentrations of coal-derived nanoparticles will improve pollution control strategy. Given the current importance of this area of research, the advanced characterization of this coal combustion-derived nanoparticles/nanominerals as well as hazardous elements is likely to be one of the hottest research fields in coming days. In this review, we try to compile the existing knowledge on coal-derived nanoparticles/nanominerals and discuss the advanced level of characterization techniques for future research. This review also provides some of aspects of health risks associated with exposure to ambient nanoparticles. In addition, the presence of some of the hazardous elements in coal and coal combustion activities is also reviewed.

关键词： Coal combustion Nanoparticles Nanominerals Hazardous elements Human health Coal energy challenge

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Electromagnetized-Nanoparticle-Modulated Neural Plasticity and Recovery of Degenerative Dopaminergic Neurons in the Mid-Brain

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Advanced materials (Deerfield Beach, Fla.) 2020年第43期32卷 e2003800页

作者： Di Zhao Pei-Jian Feng Jia-Hao Liu Mei Dong Xiao-Quan Shen Ying-Xin Chen Qun-Dong Shen Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China. Key Laboratory of High-Performance Polymer Materials and Technology of MOE Nanjing University Nanjing 210023 China. College of Materials & Environmental Engineering Hangzhou Dianzi University Hangzhou 310018 China.

The degeneration of dopaminergic neurons is a major contributor to the pathogenesis of mid-brain disorders. Clinically, cell therapeutic solutions, by increasing the neurotransmitter dopamine levels in the patients, are hindered by low efficiency and/or side effects. Here, a strategy using electromagnetized nanoparticles to modulate neural plasticity and recover degenerative dopamine neurons in vivo is reported. Remarkably, electromagnetic fields generated by the nanoparticles under ultrasound stimulation modulate intracellular calcium signaling to influence synaptic plasticity and control neural behavior. Dopaminergic neuronal functions are reversed by upregulating the expression tyrosine hydroxylase, thus resulting in ameliorating the neural behavioral disorders in zebrafish. This wireless tool can serve as a viable and safe strategy for the regenerative therapy of the neurodegenerative disorders.

关键词： dopaminergic neurons electromagnetized nanoparticles neural plasticity regenerative therapy remote control

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Correction: Expanding plastics recycling technologies: chemical aspects, technology status and challenges

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Green Chemistry 2022年第23期24卷 9329-9329页

作者： Houqian Li Horacio A. Aguirre-Villegas Robert D. Allen Xianglan Bai Craig H. Benson Gregg T. Beckham Sabrina L. Bradshaw Jessica L. Brown Robert C. Brown Victor S. Cecon Julia B. Curley Greg W. Curtzwiler Son Dong Soumika Gaddameedi John E. Estela-García Ive Hermans Min Soo Kim Jiaze Ma Lesli O. Mark Manos Mavrikakis Olumide O. Olafasakin Tim A. Osswald Konstantinos G. Papanikolaou Harish Radhakrishnan Marco Antonio Sanchez Castillo Kevin L. Sánchez-Rivera Khairun N. Tumu Reid C. Van Lehn Keith L. Vorst Mark M. Wright Jiayang Wu Victor M. Zavala Panzheng Zhou George W. Huber Department of Chemical and Biological Engineering University of Wisconsin-Madison Madison WI USA Biological Systems Engineering University of Wisconsin-Madison Madison WI USA Renewable Resources and Enabling Sciences Center National Renewable Energy Laboratory Golden CO USA BOTTLE Consortium National Renewable Energy Laboratory Golden CO USA Department of Mechanical Engineering Iowa State University Ames IA USA Department of Civil and Environmental Engineering University of Wisconsin-Madison Madison WI USA Bioeconomy Institute Iowa State University Ames IA USA Polymer and Food Protection Consortium Department of Food Science and Human Nutrition Iowa State University Ames IA USA Department of Chemistry University of Wisconsin-Madison Madison WI USA Zoology and Environmental Studies University of Wisconsin-Madison Madison WI USA Department of Mechanical Engineering University of Wisconsin-Madison Madison WI USA Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí San Luis Potosí 78210 Mexico

Correction for ‘Expanding plastics recycling technologies: chemical aspects, technology status and challenges’ by Houqian Li et al., Green Chem., 2022, https://***/10.1039/d2gc02588d.

Correction for ‘Expanding plastics recycling technologies: chemical aspects, technology status and challenges’ by Houqian Li et al., Green Chem., 2022, https://***/10.1039/d2gc02588d.

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Biomimetic electroactive materials and devices for regenerative engineering

Nature Reviews Electrical Engineering

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Nature Reviews Electrical engineering 2025年 1-17页

作者： Yang Liu Boon Chin Heng Xuehui Zhang Xuliang Deng Yunyang Bai Yong Wang Thanh D. Nguyen Department of Dental Materials & Dental Medical Devices Testing Center Peking University School and Hospital of Stomatology Beijing PR China NMPA Key Laboratory for Dental Materials Peking University School and Hospital of Stomatology Beijing PR China Institute of Advanced Clinical Medicine Peking University Beijing China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing PR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Peking University School and Hospital of Stomatology Beijing PR China National Center for Stomatology Peking University School and Hospital of Stomatology Beijing PR China National Clinical Research Center for Oral Diseases Peking University School and Hospital of Stomatology Beijing PR China NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing PR China Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing PR China Center of Digital Dentistry Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing PR China Department of Mechanical Engineering University of Connecticut Storrs CT USA Department of Biomedical Engineering University of Connecticut Storrs CT USA Institute of Materials Science Polymer Program University of Connecticut Storrs CT USA

Electrical signalling cues have an important role in regulating human metabolism. Electrical stimulation is widely used to promote tissue regeneration and functional recovery. Electroactive biomaterials and devices, which convert various physical stimuli and energy sources to electrical signalling cues, have demonstrated much potential in repairing damaged tissues such as bone, cartilage, nerves, skin, muscle, tendons and ligaments, owing to their self-powering and biomimetic properties. In this Review, we examine the design and engineering of biomimetic electroactive devices for tissue repair. We highlight the conductive, piezoelectric and triboelectric properties of materials that can be applied for regenerative engineering as well as the engineering strategies used to develop effective devices with these materials. We also discuss how electroactive materials and devices can target specific tissues and clinical applications, and the mechanisms underlying the successful regeneration of tissue with these devices. Finally, we outline the need for further work on safety, effectiveness and regulation to aid the clinical translation of electroactive devices for regenerative medicine and tissue engineering.

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Retraction notice to "Resource recovery and biorefinery potential of apple orchard waste in the circular bioeconomy" [Bioresour. Technol. 321 (2021) 124496]

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Bioresource technology 2025年 421卷 132181页

作者： Shiyi Qin Balendu Shekher Giri Anil Kumar Patel Taner Sar Huimin Liu Hongyu Chen Ankita Juneja Deepak Kumar Zengqiang Zhang Mukesh Kumar Awasthi Mohammad J Taherzadeh College of Natural Resources and Environment Northwest A&F University Yangling Shaanxi Province 712100 China. Center for Excellence for Sustainable Polymer Department of Chemical Engineering Indian Institute of Technology Guwahati 781039 India. Centre for Energy and Environmental Sustainability Lucknow 226029 Uttar Pradesh India. Swedish Centre for Resource Recovery University of Borås 501 90 Borås Sweden Department of Molecular Biology and Genetics Gebze Technical University Gebze-Kocaeli 41400 Turkey. Institute of Biology Freie Universität Berlin Altensteinstr. 6 14195 Berlin Germany. Department of Agricultural and Biological Engineering University of Illinois at Urbana Champaign 1304 W. Pennsylvania Avenue Urbana IL 61801 USA. Department of Chemical Engineering SUNY College of Environmental Science and Forestry 402 Walters Hall 1 Forestry Drive Syracuse NY 13210 USA. College of Natural Resources and Environment Northwest A&F University Yangling Shaanxi Province 712100 China Swedish Centre for Resource Recovery University of Borås 501 90 Borås Sweden. Electronic address: mukesh_awasthi45@***. Swedish Centre for Resource Recovery University of Borås 501 90 Borås Sweden.

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