This paper presents the design and fabrication of a highly-miniaturized system for continuous glucose monitoring which holds great promise for patients inflicted with diabetes mellitus. To achieve the realization of a...
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ISBN:
(纸本)9781479903313
This paper presents the design and fabrication of a highly-miniaturized system for continuous glucose monitoring which holds great promise for patients inflicted with diabetes mellitus. To achieve the realization of a truly implantable system, a variety of issues such as robust electrochemical sensor design, miniaturization of the electronic components and counteracting biofouling and negative tissue response need to be addressed. In this report, we present a highly-miniaturized transcutaneous continuous glucose monitoring system which holistically addresses the aforementioned tribulations associated with implantable devices. Specifically, a high performance amperometric electrochemical glucose sensor is integrated with custom designed complementary metal-oxide-semiconductor electronics. The fabricated electrochemical sensor is Clark-based, and employs stratification of five functional layers to achieve a linear response within the physiological range of glucose concentration (2–22 mM). Furthermore, the sensor is encased with a thick polyvinyl alcohol (PVA) hydrogel containing poly(lactic-co-glycolic acid) (PLGA) microspheres which provides continuous, localized delivery of dexamethasone utilized to combat inflammation and fibrosis. Such miniature size (0.665 mm 2 ) and low power operation (140 μW) of the electronic system render it ideal for continuous glucose monitoring devices and other metabolic sensing systems.
This article was originally published online on 29 September 2014 with an error in the journal title of Ref. 36. The corrected reference appears below:
This article was originally published online on 29 September 2014 with an error in the journal title of Ref. 36. The corrected reference appears below:
作者：
Shu ZhangYing LiGuanjie XuShuli LiYao LuOzan ToprackiXiangwu ZhangFiber and Polymer Science Program
Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC..
Li2MnSiO4 has an extremely high theoretical capacity of 332 mAh?g?1. However, only around half of this capacity has been realized in practice and the capacity retention during cycling is also low. In this study, Li2Mn...
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Li2MnSiO4 has an extremely high theoretical capacity of 332 mAh?g?1. However, only around half of this capacity has been realized in practice and the capacity retention during cycling is also low. In this study, Li2MnSiO4/carbon composite nanofibers were prepared by a combination of electrospinning and heat treatment. The one-dimensional continuous carbon nanofiber matrix serves as long-distance conductive pathways for both electrons and ions. The composite nanofiber structure avoids the aggregation of Li2MnSiO4 particles, which in turn enhances the electrode conductivity and promotes the reaction kinetics. The resultant Li2MnSiO4/carbon composite nanofibers were used as the cathode material for Li-ion batteries, and they delivered high charge and discharge capacities of 218 and 185 mAh?g?1, respectively, at the second cycle. In addition, the capacity retention of Li2MnSiO4 at the first 20th cycles increased from 37% to 54% in composite nanofibers.
Organic Transistor (OT) modeling, fabrication and applicability has undergone remarkable progress during last ten years. Organic Thin Film Transistors (OTFTs) have received significant attention recently because of th...
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Brilliant, iridescent colors found on the bodies and wings of many birds, butterflies and moths are produced by structural variations and have been the subject of study for centuries. Such brilliant colors have been d...
Brilliant, iridescent colors found on the bodies and wings of many birds, butterflies and moths are produced by structural variations and have been the subject of study for centuries. Such brilliant colors have been described as metallic colors due to the saturation or purity of the color produced and have attracted the attention of great scientists like Newton, Michelson and Lord Rayleigh. It was recognized early on that such colors arise from physical effects such as interference or diffraction as opposed to colors that are normally produced due to the presence of chromophores which absorb or emit light. Common examples of physical colors are some butterfly wings [1], color of Indigo snake skin [2], hummingbird feathers [3,4], arthropod cuticles [which are due to selective reflection of color from the solidified cholesteric phase of chitin crystallites] [5], gemstones like opal [6,7], and some crystals like potassium chlorate [8]. While the origins of such colors are well understood the properties of color and color specification have not received much attention.
Li2MnSiO4 has an extremely high theoretical capacity of 332 mAh?g?1. However, only around half of this capacity has been realized in practice and the capacity retention during cycling is also low. In this study, Li2Mn...
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Li2MnSiO4 has an extremely high theoretical capacity of 332 mAh?g?1. However, only around half of this capacity has been realized in practice and the capacity retention during cycling is also low. In this study, Li2MnSiO4/carbon composite nanofibers were prepared by a combination of electrospinning and heat treatment. The one-dimensional continuous carbon nanofiber matrix serves as long-distance conductive pathways for both electrons and ions. The composite nanofiber structure avoids the aggregation of Li2MnSiO4 particles, which in turn enhances the electrode conductivity and promotes the reaction kinetics. The resultant Li2MnSiO4/carbon composite nanofibers were used as the cathode material for Li-ion batteries, and they delivered high charge and discharge capacities of 218 and 185 mAh?g?1, respectively, at the second cycle. In addition, the capacity retention of Li2MnSiO4 at the first 20th cycles increased from 37% to 54% in composite nanofibers.
The influence of foam morphology on the release rate of Indomethacin (INM) from a solid solution prepared by hot melt extrusion was investigated. Closed cell foams were produced through a batch process, employing CO2 ...
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ISBN:
(纸本)9781622760831
The influence of foam morphology on the release rate of Indomethacin (INM) from a solid solution prepared by hot melt extrusion was investigated. Closed cell foams were produced through a batch process, employing CO2 as physical blowing agent. In all cases foamed disks showed faster INM's release than un-foamed disks. The time required for completing INM's release was reduced up to 75% mainly due to extensive and random breakage of the sample during dissolution test.
The helical and tubular structures self‐assembled from proteins have inspired scientists to design synthetic building blocks that can be"polymerized"into supramolecular polymers through coordinated no
The helical and tubular structures self‐assembled from proteins have inspired scientists to design synthetic building blocks that can be"polymerized"into supramolecular polymers through coordinated no
The grafting of hydroxyapatite/beta-tricalcium phosphate with β-cyclodextrin was achieved using a two step reaction with (β-glycidyloxypropyl)trimethoxysilane as a linker. Firstly, the silane group was brought to re...
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