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Percutaneous Coronary Intervention With a Drug-Eluting Stent Versus Coronary Artery Bypass Grafting in Patients Receiving Dialysis: A National Study From Taiwan

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Kidney medicine 2024年第2期6卷 100768页

作者： Szu-Yu Pan Ju-Yeh Yang Nai-Chi Teng Yun-Yi Chen Shi-Heng Wang Chien-Lin Lee Kang-Lung Chen Yen-Ling Chiu Shih-Ping Hsu Yu-Sen Peng Yung-Ming Chen Shuei-Liong Lin Likwang Chen Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Institute of Health Policy and Management College of Public Health National Taiwan University Taipei Taiwan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Research Shin-Kong Wu Ho-Su Memorial Hospital Taipei Taiwan. Institute of Hospital and Health Care Administration National Yang Ming Chiao Tung University Taipei Taiwan. National Center for Geriatrics and Welfare Research National Health Research Institutes Yunlin Taiwan. Department of Cardiology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Cardiovascular Surgery Far Eastern Memorial Hospital New Taipei City Taiwan. Graduate Program in Biomedical Informatics Department of Computer Science and Engineering College of Informatics Yuan Ze University Taoyuan Taiwan. Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan.

Rationale & Objective:We aimed to study the comparative effectiveness of percutaneous coronary intervention with drug-eluting stent and coronary artery bypass grafting in patients receiving dialysis. Study Design:This was a retrospective observational cohort study. Setting & Participants:This population-based study identified patients receiving dialysis hospitalized for coronary revascularization between January 1, 2009 and December 31, 2015, in the Taiwan National Health Insurance Research Database. Exposures:Patients received percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting. Outcomes:The study outcomes were all-cause mortality, in-hospital mortality, and repeat revascularization. Analytical Approach:Propensity scores were used to match patients. Cox proportional hazards models and logistic regression models were constructed to examine associations between revascularization strategies and mortality. Interval Cox models were fitted to estimate time-varying hazards during different periods. Results:A total of 1,840 propensity score-matched patients receiving dialysis were analyzed. Coronary artery bypass grafting was associated with higher in-hospital mortality (coronary artery bypass grafting vs percutaneous coronary intervention with drug-eluting stent; crude mortality rate 12.5% vs 3.3%; adjusted OR, 5.22; 95% CI, 3.42-7.97; < 0.001) and longer hospitalization duration (median [IQR], 20 [14-30] days vs 3 [2-8] days; < 0.001). After discharge, repeat revascularization, acute coronary syndrome, and repeat hospitalization all occurred more frequently in the percutaneous coronary intervention with drug-eluting stent group. Importantly, with a median follow-up of 2.8 years, coronary artery bypass grafting was significantly associated with a higher risk of all-cause overall mortality (adjusted HR, 1.19; 95% CI, 1.05-1.35; = 0.006) in the multivariable Cox proportional hazard model. Sensitivity and subgroup analyses yie

关键词： Coronary artery bypass grafting coronary revascularization dialysis drug-eluting stent end-stage kidney disease mortality percutaneous coronary intervention survival

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Genomic Surveillance of SARS-CoV-2 in Taiwan: A Perspective on Evolutionary Data Interpretation and Sequencing Issues

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Biomedical journal 2024年 100820页

作者： Yu-Nong Gong Nai-Yu Kuo Ting-Syuan Yeh Shin-Ru Shih Guang-Wu Chen Research Center for Emerging Viral Infections College of Medicine Chang Gung University Taoyuan Taiwan International Master Degree Program for Molecular Medicine in Emerging Viral Infections College of Medicine Chang Gung University Taoyuan Taiwan Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital Taoyuan Taiwan. Medical Education Department Linkou Chang Gung Memorial Hospital Taoyuan Taiwan. National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Taiwan. Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science College of Medicine Chang Gung University Taoyuan Taiwan Research Center for Chinese Herbal Medicine Research Center for Food and Cosmetic Safety and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan Taiwan. Department of Computer Science and Information Engineering College of Engineering Chang Gung University Taoyuan Taiwan. Electronic address: gwchen@mail.cgu.edu.tw.

This review presents a comprehensive perspective on the genomic surveillance of SARS-CoV-2 in Taiwan, with a focus on next-generation sequencing and phylogenetic interpretation. This article aimed to explore how Taiwan has utilized genomic sequencing technologies and surveillance to monitor and mitigate the spread of COVID-19. We examined databases and sources of genomic sequences and highlighted the role of data science methodologies in the explanation and analyses of evolutionary data. This review addressed the challenges and limitations inherent in genomic surveillance, such as concerns regarding data quality and the necessity for interdisciplinary expertise for accurate data interpretation. Special attention was given to the unique challenges faced by Taiwan, including its high population density and major transit destination for international travelers. We underscored the far-reaching implications of genomic surveillance data for public health policy, particularly in influencing decisions regarding travel restrictions, vaccine administration, and public health decision-making. Studies were examined to demonstrate the effectiveness of using genomic data to implement public health measures. Future research should prioritize the integration of methodologies and technologies in evolutionary data science, particularly focusing on phylodynamic analytics. This integration is crucial to enhance the precision and applicability of genomic data. Overall, we have provided an overview of the significance of genomic surveillance in tracking SARS-CoV-2 variants globally and the pivotal role of data science methodologies in interpreting these data for effective public health interventions.

关键词： SARS-CoV-2 data science genomic surveillance next-generation sequencing phylodynamics

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Erratum: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

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Nature communications 2017年第1期8卷 1298页

作者： Song Li Chwee Tat Koe Su Ting Tay Angie Lay Keng Tan Shenli Zhang Yingjie Zhang Patrick Tan Wing-Kin Sung Hongyan Wang Neuroscience and Behavioural Disorders Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore. Cellular and Molecular Research National Cancer Centre Singapore 169610 Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore 119074 Singapore. Genome Institute of Singapore 60 Biopolis Street Genome 02-01 Singapore 138672 Singapore. Department of Computer Science National University of Singapore Singapore 117417 Singapore. Neuroscience and Behavioural Disorders Program Duke-NUS Medical School 8 College Road Singapore 169857 Singapore. hongyan.wang@duke-nus.edu.sg. NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive Singapore 117456 Singapore. hongyan.wang@duke-nus.edu.sg. Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore. hongyan.wang@duke-nus.edu.sg.

A correction to this article has been published and is linked from the HTML version of this article.

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The implementation of computer based instruction model on Gost Algorithm Cryptography Learning

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IOP Conference Series: Materials science and Engineering 2018年第1期420卷

作者： Tonni Limbong Janner Simarmata ARS Tambunan Parulian Siagian Joel Panjaitan Lestina Siagian Erbin Sitorus Marvin Frans Sakti Hutabarat Abba Suganda Girsang Katen Lumbanbatu Universitas Katolik Santo Thomas Jalan Setia Budi No. 479 F Tanjung Sari Tj. Sari Medan Selayang 20132 Medan - Indonesia Universitas Negeri Medan Jalan Willem Iskandar Pasar V Medan 20221 Medan - Indonesia Universitas HKBP Nommensen Jalan Sutomo No.4A Perintis Medan Timur 20235 Medan - Indonesia Akademi Teknik Deli Serdang Jl. Sultan Hasanuddin Tj. Garbus Satu Lubuk Pakam 20518 Deli Serdang – Indonesia Institut Sains dan Teknologi TD Pardede Jl. Dokter TD Pardede No. 21 Medan Baru 20152 Medan – Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta Indonesia STMIK Kaputama Jl. Veteran No. 4A - 9A Tangsi 20714 Binjai - Indonesia

The objective of this study is to develop learning media by using the computer Based Instruction (CBI) model for GOST algorithm cryptographic material (Gosudarstvennyi Standard). Besides, the study serves to present learning using computer media, especially in the Informatics Engineering study program. The method used in this study uses the Research and Development (R & D) method. The results of this development research are learning media products in the form of tutorial CDs with the contents of the material: GOST Cryptographic Theory, Encryption Process and Decryption process using alphabet text data. Based on the results of the application and testing of the program, it can be concluded that this application is easy to use. Learning the Gost algorithm in the encoding method utilizing the computer Based Instructions (CBI) method helps to understand the material and facilitate the learning process.

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THE STRUCTURAL SYNTHESIS DESIGN program - ITS IMPACT ON THE FLEET

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NAVAL ENGINEERS JOURNAL 1983年第3期95卷 87-99页

作者： WIERNICKI, CJ GOODING, TG NAPPI, NS Mr. Christopher J. Wiernicki:graduated from Vanderbilt University in 1980 with a B.E. degree in Structural Engineering. Upon graduation he began his professional career at the David Taylor Naval Ship Research and Development Center. As a structural engineer in the Surface Ship Structures Division Mr. Wiernicki was responsible for developing improved methods and procedures for designing and evaluating structural systems for surf ace combatants. Specific projects included design for producibility development and evaluation of automated ship structural design methods and participation in the structural design of the CG 49 Cruiser and the current DDG 51 Destroyer. In 1982 Mr. Wiernicki received his M.S. degree in Ocean Engineering from George Washington University. Mr. Wiernicki is a recipient of the SNAME 1982-82 Graduate Scholarship and is currently doing post graduate work in Naval Architecture at Massachusetts Institute of Technology he is a member of ASNE SNAME ASCE and Chi Epsilon. Mr. Thomas G. Gooding:graduated in 1975 from the University of Michigan with B.S. degrees in Oceanography and Naval Architecture. After graduation he began his professional career at the Naval Ship Engineering Center (NA VSEC) as a structural engineer. From 1975 till 1978 Mr. Gooding worked in the area of ship dry docking and was the structural task leader on the complex overhaul ofUSS Long Beach (CGN-9). Mr. Gooding returned to the University of Michigan to receive a M.S. in Naval Architecture in 1979. Currently Mr. Gooding is the structural task leader on the DDGX/DDG 51 program at the Naval Sea Systems Command (NAVSEA). Mr. Gooding is a member of SNAME and the Naval Institute. Mr. Natale S. Nappi:graduated from City College of New York in 1954 with a Bachelor of Civil Engineering and received his M.S. in Civil Engineering from Polytechnic Institute of Brooklyn in 1959. He began his professional career in 1964 at the New York Naval Shipyard as a Naval Architect (Structure) performing detail structural design and fabrication s

The structural design of a ship's section is a complicated, repetitive and time consuming task. With the advent of new technology, high speed computers have enabled the ship designer to accomplish in a matter of seconds what would formerly take days to accomplish by hand. The Structural Synthesis Design program (SSDP) is a N avy developed computer-aided design tool which is used to design (or to analyze) the longitudinal scantlings for a variety of ship cross sections, consisting of any practical combinations of decks, platforms, bulkheads and materials, i.e., various steel and aluminum alloys. The final hull section design will have the lowest practical weight for the chosen geometric configuration, structural arrangements, and imposed loadings. The scantling developed by the program will satisfy all U.S. N avy ship structural design criteria. An explanation of the objective and design elements of N avy ship structures is included. The rationale behind the SSDP design philosophy is developed along with the significant program capabilities. In an attempt to highlight the influence of automated design procedures on the current naval ship design process, the effect of the SSDP on the DDG 51 destroyer structural development is addressed.

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Neural signature of tDCS, tPCS and their combination

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Brain Stimulation 2017年第4期10卷 e41-e41页

作者： Aurore Thibaut Cristina Russo Leon Morales-Quezada Aura Hurtado-Puerto Alícia Deitos Steven Freedman Sandra Carvalho Felipe Fregni Spaulding-Labuschagne Neuromodulation Center Spaulding Rehabilitation Hospital Department of Physical Medicine and Rehabilitation Harvard Medical School Boston MA USA Coma Science Group GIGA-Research University and University Hospital of Liege Liege Belgium Department of Psychology and Milan Center for Neuroscience-NeuroMi University of Milano-Bicocca Milano Italy Laboratory for Neuropsychiatry and Neuromodulation Transcranial Magnetic Stimulation Clinical Service Department of Psychiatry Massachusetts General Hospital Boston USA Post-graduate Program in Medical Sciences School of Medicine Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Laboratory of Pain and Neuromodulation at UFRGS Porto Alegre Brazil Division of Translational Research Beth Israel Deaconess Medical Center Boston MA USA Neuropsychophysiology Laboratory CIPsi School of Psychology (EPsi) University of Minho Campus de Gualtar 4710-057 Braga Portugal

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Erratum to 'Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)': The American Journal of Cardiology 2019 Nov 15;124(10):1590-1593./ doi: 10.1016/***.2019.08.010

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The American journal of cardiology 2021年 142卷 161页

作者： Shiu-Dong Chung Ju-Chi Liu Tsai-Ning Lou Ben-Chang Shia Herng-Ching Lin Li-Ting Kao Division of Urology Department of Surgery Far Eastern Memorial Hospital Taipei Taiwan Department of Computer Science and Engineering and Graduate Program in Biomedical Informatics College of Informatics Yuan-Ze University Chung-Li Taiwan Sleep Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Cardiovascular Medicine Department of Medicine Medical University Hospital-Shuang Ho Hospital TaipeiTaiwan. School of Health Care Administration Taipei Medical University Taipei Taiwan. Big Data Research Center Taipei Medical University Taipei Taiwan. Sleep Research Center Taipei Medical University Hospital Taipei Taiwan School of Health Care Administration Taipei Medical University Taipei Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Department of Pharmacy Practice Tri-Service General Hospital Taipei Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan.. Electronic address: kaoliting@***.

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