Nakano, J. H. and Cole, J. T. (NCDC, Atlanta, Ga. 30333). Antigenic segregation of type 2 poliovirus isolants related and unrelated to Sabin's vaccine strain with Modifled-Wecker Technique. Amer. J. Epid., 1970, 9...
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Nakano, J. H. and Cole, J. T. (NCDC, Atlanta, Ga. 30333). Antigenic segregation of type 2 poliovirus isolants related and unrelated to Sabin's vaccine strain with Modifled-Wecker Technique. Amer. J. Epid., 1970, 97; 317–327.—One hundred and sixty-seven pedigreed vaccine-derived strains and 4 strains from 2 contacts of vaccinees were antigenically characterized. All were vaccine-like except 2 strains from 1 contact. Reciprocal test results suggested that the 2 strains were wild, and antigenically similar to 1 of the 4 wild strains isolated from the same area during the same year. Strains P712KP2 and P712KP5, 2 progenitors of Sabin 2 (P712, ch, 2ab), tested reciprocally with Sabin 2, were antigenically homologous. Antigenic characterization of 157 wild isoIants, obtained from clinical cases and asymptomatic individuals, revealed that 152 (96.9%) were nonvaccine-like, 4 (2.5%) were intermediate and 1 (0.6%) was vaccine-like. The vaccine-like strain was probably vaccine-derived since it was isolated after the initiation of oral polio vaccination. The data establish the stability of the antigenic character of Sabin 2 upon passage in human intestinal tracts and the rare occurrence of vaccine-like wild strains in nature. Reciprocal tests performed with antisera prepared against 9 selected strains showed the interrelationships of their antigenic characteristics. The formulation and use of antigenic and antibody profiles are discussed.
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