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NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas

Kaohsiung Journal of Medical sciences 2024年第5期40卷 445-455页

作者： Lim, Lee-Moay Lee, Yi-Chen Lin, Ting-Wei Hong, Zi-Xuan Hsu, Wei-Chi Ke, Hung-Lung Hwang, Daw-Yang Chung, Wen-Yu Li, Wei-Ming Lin, Hui-Hui Kuo, Hung-Tien Huang, A-Mei Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Anatomy School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Urology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Urology Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Medical University Kaohsiung Taiwan National Institute of Cancer Research National Health Research Institute Tainan Taiwan Department of Computer Science and Information Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Urology Ministry of Health and Welfare Pingtung Hospital Pingtung Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Doctoral Degree Program in Toxicology College of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Department of Biochemistry School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Research Center for Environmental Medicine Kaohsiung Medical University Kaohsiung Taiwan

Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes in UTUC patients and validated the results in tests on UTUC cell lines. A total of 118 UTUC cancer tissue samples were examined to evaluate the expression of NTRK3. Survival curves were generated using Kaplan–Meier estimates, and Cox regression models were used for investigating survival outcomes. Higher NTRK3 expression was correlated with worse progression-free survival, cancer-specific survival, and overall survival. Moreover, the results of an Ingenuity Pathway Analysis suggested that NTRK3 may interact with the PI3K-AKT-mTOR signaling pathway to promote cancer. NTRK3 downregulation in BFTC909 cells through shRNA reduced cellular migration, invasion, and activity in the AKT-mTOR pathway. Furthermore, the overexpression of NTRK3 in UM-UC-14 cells promoted AKT-mTOR pathway activity, cellular migration, and cell invasion. From these observations, we concluded that NTRK3 may contribute to aggressive behaviors in UTUC by facilitating cell migration and invasion through its interaction with the AKT-mTOR pathway and the expression of NTRK3 is a potential predictor of clinical outcomes in cases of UTUC. © 2024 The Authors. The Kaohsiung Journal of Medical sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University.

关键词： AKT-mTOR pathway neurotrophic receptor tyrosine kinase 3 (NTRK3) prognosis tropomyosin-related kinase (TrK) upper tract urothelial carcinoma (UTUC)

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Realtime Vehicle Counting Method Using Haar Cascade Classifier Model

Realtime Vehicle Counting Method Using Haar Cascade Classifi...

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International Conference on Advanced Mechatronics, Intelligent Manufacture, and Industrial Automation (ICAMIMIA)

作者： Prasetyo Mimboro Yaya Heryadi Lukas Wayan Suparta Antoni Wibowo Doctor of Computer Science Graduate Program Faculty of Computer Science Bina Nusantara University Jakarta Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta Indonesia Cognitive Engineering Research Group (CERG) Atma Jaya University Jakarta Indonesia Computer Science Department Bina Nusantara University Jakarta Indonesia

ISBN: (纸本)9781665499705

The proliferation of digital camera technology has provided many digital images for object detection and counting in public places. This paper presents an experiment on the realtime vehicle counting method to be implemented in a single board computer. The proposed design's objective is to detect and count vehicles entering and exiting at entrances using haar cascade classifier algorithms and other automatic open and close door systems controlled by a single board computer (SBC). The proposed system was tested using raspberry pi 4 model B with a 4GB RAM platform. The empiric results using 3-minute video as input with a total of 113 passing vehicles the proposed method achieve of 91.2 % of average accuracy.

关键词： Mechatronics Automation Computational modeling Digital images Random access memory Object detection Logic gates

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DiffusionRet: Generative Text-Video Retrieval with Diffusion Model

DiffusionRet: Generative Text-Video Retrieval with Diffusion...

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International Conference on computer Vision (ICCV)

作者： Peng Jin Hao Li Zesen Cheng Kehan Li Xiangyang Ji Chang Liu Li Yuan Jie Chen School of Electronic and Computer Engineering Peking University Shenzhen China AI for Science (AI4S)-Preferred Program Peking University Shenzhen Graduate School Shenzhen China Department of Automation and BNRist Tsinghua University Beijing China Peng Cheng Laboratory Shenzhen China

Existing text-video retrieval solutions are, in essence, discriminant models focused on maximizing the conditional likelihood, i.e., p(candidates|query). While straightforward, this de facto paradigm overlooks the underlying data distribution p(query), which makes it challenging to identify out-of-distribution data. To address this limitation, we creatively tackle this task from a generative viewpoint and model the correlation between the text and the video as their joint probability p(candidates,query). This is accomplished through a diffusion-based text-video retrieval framework (Diffusion-Ret), which models the retrieval task as a process of gradually generating joint distribution from noise. During training, DiffusionRet is optimized from both the generation and discrimination perspectives, with the generator being optimized by generation loss and the feature extractor trained with contrastive loss. In this way, DiffusionRet cleverly leverages the strengths of both generative and discriminative methods. Extensive experiments on five commonly used text-video retrieval benchmarks, including MSRVTT, LSMDC, MSVD, ActivityNet Captions, and DiDeMo, with superior performances, justify the efficacy of our method. More encouragingly, without any modification, DiffusionRet even performs well in out-domain retrieval settings. We believe this work brings fundamental insights into the related fields. Code is available at https://***/jpthu17/DiffusionRet.

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Tunable Source of Quantum-Correlated Photons with Integrated Pump Rejection in a Silicon CMOS Platform

Tunable Source of Quantum-Correlated Photons with Integrated...

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Frontiers in Optics + Laser science 2021, FiO+LS 2021 - Part of Frontiers in Optics, FiO 2021

作者： Fargas Cabanillas, Josep M. Kramnik, Danielius Ramesh, Anirudh Gentry, Cale M. Stojanović, Vladimir Kumar, Prem Popović, Miloš A. Department of Electrical and Computer Engineering Photonics Center Boston University BostonMA02215 United States Department of Electrical Engineering and Computer Science UC Berkeley BerkeleyCA94720 United States Graduate Program in Applied Physics Northwestern University EvanstonIL60208 United States Department of Electrical Computer and Energy Engineering University of Colorado BoulderCO80309 United States Center for Photonic Communication and Computing Dept. of Electrical and Computer Eng. Northwestern University EvanstonIL60208 United States

ISBN: (纸本)9781557528209

A wavelength-tunable, silicon photon-pair source based on spontaneous four-wave mixing, integrated with a pump rejection filter in a single, flip-chip packaged CMOS chip, is demonstrated with a coincidence-to-accidentals ratio of 9.1 with no off-chip pump filtering. Frontiers in Optics / Laser science © Optica Publishing Group 2021.

关键词： CMOS integrated circuits

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Picosecond optical-to-x-ray (Cd,Mg)Te radiation detectors

Picosecond optical-to-x-ray (Cd,Mg)Te radiation detectors

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Conference on Lasers and Electro-Optics (CLEO)

作者： J. Cheng I. Komissarov G. Chen D. Chakraborty S. Kutcher H. Chen S. Trivedi Roman Sobolewski Materials Science Graduate Program University of Rochester Rochester New York USA Laboratory for Laser Energetics University of Rochester Rochester New York USA Department of Electrical and Computer Engineering University of Rochester Rochester New York USA Brimrose Technology Corp Sparks Maryland USA

We developed a dual optical/x-ray ultrafast photodetector based on in-house grown Cd 0.97 Mg 0.03 Te single crystals. The detector is characterized by ~200 ps full-width-at-half-maximum, readout-electronics limited p... 详细信息

ISBN: (纸本)9781957171258

关键词： Femtosecond lasers Photodetectors Photon counting Pump probe spectroscopy Radiation detectors Ti:sapphire lasers

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Statistical Analysis of Intrinsic High-Frequency Characteristic Fluctuation of Emerging Silicon Gate-All-Around Nanosheet (NS) MOSFETs at Sub-3-nm Nodes

Statistical Analysis of Intrinsic High-Frequency Characteris...

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IEEE Electron Devices Technology and Manufacturing Conference (EDTM)

作者： Sekhar Reddy Kola Yiming Li Min-Hui Chuang Kazuhiko Endo Seiji Samukawa Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Institute of Communications Engineering Department of Electronics and Electrical Engineering Institute of Biomedical Engineering Center for mm Wave Smart Radar System and Technologies National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Fluid Science Tohoku University 2-1-1 Katahira Aoba-ku Sendai Japan National Institute of Advanced Industrial Science and Technology Tsukuba Japan

In recent years, the GAA NS Si MOSFET has been explored as a leading technology. However, the intrinsic parameters of GAA NS Si MOSFETs are affected to varying degrees by various fluctuation sources, Statistically independent and identically distributed $(iid)$ assumptions on the aforementioned random variables overestimate the variability of high-frequency characteristics, compared with considering all fluctuation factors simultaneously. Notably, the random nanosized metal grains dominates the variations of voltage gain, cut-off frequency, and 3dB frequency because the random work functions strongly alter the channel surface potential.

关键词： MOSFET Fluctuations Statistical analysis Gallium arsenide Cutoff frequency Metals Logic gates

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New Frontiers for Wave engineering Using Metamaterials

New Frontiers for Wave Engineering Using Metamaterials

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2022年全国微波毫米波会议

作者： Andrea Alù Photonics Initiative Advanced Science Research Center City University of New York Physics Program Graduate Center City University of New York Department of Electrical and Computer Engineering City College of New York

Metamaterials are engineered materials with properties that go well beyond what offered by nature, providing unprecedented opportunities to tailor and enhance the control of waves. In this talk, I discuss our recent activity at microwaves and THz frequencies, showing how suitably tailored meta-atoms and their arrangements open exciting avenues for wave manipulation, including metasurfaces with enhanced wavefront manipulation, and magnet-free nonreciprocity and topological phenomena. Insights into the underlying physics and new devices based on these concepts will be presented.

关键词： New Frontiers for Wave engineering Using Metamaterials

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engineering the directionality of hot carrier tunneling in plasmonic tunneling structures

arXiv

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arXiv 2023年

作者： Abbasi, Mahdiyeh Liao, Shusen Zhu, Yunxuan Natelson, Douglas Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics and Astronomy Engineering Rice University HoustonTX77005 United States Department of Materials Science and Nanoengineering Rice University HoustonTX77005 United States

Tunneling metal-insulator-metal (MIM) junctions can exhibit an open-circuit photovoltage (OCPV) response under illumination that may be useful for photodetection. One mechanism for photovoltage generation is hot carrier tunneling, in which photoexcited carriers generate a net photocurrent that must be balanced by a drift current in the open-circuit configuration. We present experiments in electromigrated planar MIM structures, designed with asymmetric plasmonic properties using Au and Pt electrodes. Decay of optically excited local plasmonic modes preferentially creates hot carriers on the Au side of the junction, leading to a clear preferred directionality of the hot electron photocurrent and hence a preferred polarity of the resulting OCPV. In contrast, in an ensemble of symmetric devices constructed from only one Au, polarity of the OCPV has no preferred direction. Copyright © 2023, The Authors. All rights reserved.

关键词： Plasmonics

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Performance comparison of InGaN-based 40–80 μm micro-LEDs fabricated with and without plasma etching

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Materials Today Advances 2024年 22卷

作者： Lo, Yu-Yun Chen, Yi-Ho Hsu, Yun-Cheng Lee, Tzu-Yi Hung, Yu-Ying Kao, Yu-Cheng Zan, Hsiao-Wen Wuu, Dong- Sing Kuo, Hao-Chung Samukawa, Seiji Horng, Ray-Hua Institute of Electronics National Yang Ming Chiao Tung University 1001 University Road Hsinchu30010 Taiwan Department of Photonics College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Nantou54561 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan Institute of Communications Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan

The fabrication of InGaN-based blue 4✕4 array micro-LEDs (μLEDs) with 40 μm ✕40 μm chip size and 2✕2 array μLEDs with 80 μm ✕80 μm chip size etching by the inductive coupled plasma reactive ion etching (ICPRIE) and defect-free neutral beam etching (NBE) processes was studied in this work. In μLEDs of this size, the influence of defects formation in the sidewalls on EQE was evaluated. There was almost no difference in EQE between μLEDs array etched by the NBE process no matter 40 μm ✕40 μm and 80 μm ✕80 μm, but the dependence was observed in the ICPRIE. Even with this size, it was found that the size effect of EQE is smaller than that in case of using ICPRIE for defect-free neutral beam etching. This impact is substantial since μLED predominantly operated at low current density, around 1–5 A/cm2. Consequently, the reduction of defect density, encompassing both internal and sidewall defects, becomes imperative even in 40–80 μm InGaN-based μLEDs. This not only improves the overall efficiency of μLEDs but also fortifies the brightness stability of μLED displays if process etching by NBE. It was also found that the etching shape had an influence on EQE. It could be attributed to fact that the etching profile angle of NBE was more vertical than that of ICPRIE. Because the different angles of the mesa resulted in different light intensity. The μLEDs emitting with a wavelength of 450 nm, the light extraction efficiency and intensity at a mesa angle 58° of NBE etching μLEDs was about 8% lower than those of an angle (38°) of ICPRIE etching μLEDs by simulation. © The Authors

关键词： Light emitting diodes

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Pulsed Terahertz Time Domain Spectroscopy for Evaluating Treatment Efficacy: Initial Validation in Monitoring Pancreatic Ductal Adenocarcinoma

Pulsed Terahertz Time Domain Spectroscopy for Evaluating Tre...

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International Conference on Infrared and Millimeter Waves

作者： Debamitra Chakraborty Bradley N. Mills Jing Cheng Ivan Komissarov Scott A. Gerber Roman Sobolewski Materials Science Graduate Program University of Rochester Rochester New York USA Laboratory for Laser Energetics University of Rochester Rochester New York USA Department of Surgery University of Rochester Medical Center Rochester New York USA Department of Electrical and Computer Engineering University of Rochester Rochester New York USA

Pancreatic Ductal Adenocarcinoma (PDAC) is a highly invasive malignancy with limited curative effectiveness. Here, we report the viability of using pulsed Terahertz (THz) time domain spectroscopy (THz TDS) to monitor the efficacy of Stereotactic Body Radiation Therapy (SBRT) in treating PDAC in murine models. Our study shows that THz imaging can provide reliable and reproducible results to differentiate the changes in untreated and SBRT-treated PDAC tissue using THz refractive index and absorption coefficient as mapping parameters with statistical significance. Hence the study highlights that pulsed THz-TDS can be used as a technique to monitor tumor responses to immunotherapy, providing a comprehensive assessment of the tumor’s reaction to the treatment.

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