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Trends in Incidence of HIV and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun Bai Long Li Jie Yang Fangning Zhao Jinyu Hou Maohe Yu Houlin Tang STD&AIDS Control and Prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&AIDS Control and Prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(HIV)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of HIV and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

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Study on the Technical Parameters for Estimating HIV-1 Incidence by Using a Recombinant Antigen-based Capture Enzyme Immunoassay—China

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China CDC weekly 2024年第48期6卷 1278-1282页

作者： Wenli Liang Jibao Wang Hongxia Yan Xinhui Zhang Dorjiwangmo Dongmin Li Xing Duan Hao Wu Yinyin Wang Li Bai Jian Sun Mengjie Han Yikui Wang Bin Su Min Wang Tashibazong Wenge Xing Cui Zhang Ruijuan Qiao Maofeng Qiu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of AIDS/STD Control and Prevention Dehong Center for Disease Control and PreventionMangshi CountyDehong Dai and Jingpo Autonomous PrefectureYunnan ProvinceChina Beijing Key Laboratory for HIV/AIDS Research Beijing Youan HospitalCapital Medical UniversityBeijingChina Institute of Infectious Diseases Prevention and Treatment Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina Department of AIDS Control and Prevention Xizang Autonomous Region Center for Disease Control and PreventionLhasa CityXizang Autonomous RegionChina Experimental Center Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina Department of AIDS Control and Prevention Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Laboratory Department Liupanshui Center for Disease Control and PreventionLiupanshui CityGuizhou ProvinceChina

Introduction:A novel recombinant antigen-based capture enzyme immunoassay(RAg-CEIA)was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1(HIV-1)incidence in ***:We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution *** assay was used to measure normalized optical density(ODn)values in 171 longitudinal plasma specimens from 51 HIV-1 seroconverting individuals,plotted against estimated days *** determined the optimal ODn threshold value for differentiating recent from long-term infections and calculated the mean duration of recent infection(MDRI)for incidence *** false recent rate(FRR)was determined using 481 HIV-1 antibody-positive specimens with infection durations exceeding twice the ***:Optimal RAg-CEIA parameters were established with a raw material dilution ratio of 1/12 for calibrator preparation and an enzyme conjugate titer of 1:*** values demonstrated consistent temporal increases across HIV-1 seroconverting individuals,though with notable kinetic heterogeneity in individual *** optimal ODn threshold value of 0.8 for distinguishing recent from long-term infections corresponded to an MDRI of 205 days and an FRR of 4.78%.Conclusions:The optimized RAg-CEIA effectively differentiates recent from long-term HIV-1 infections at the population level,enabling reliable HIV-1 incidence estimation in China.

关键词： Antigen exceeding false

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Geographic origins, transmission hotspots, and drug resistance mutations of HIV-1 CRF08_BC in Zhejiang Province, China

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Infection 2025年 1-13页

作者： Zhao, Hehe Jiang, Jun Chai, Chengliang Pan, Xiaohong Lyu, Fan Xing, Hui Feng, Yi Cheng, Wei Li, Guixia Mei, Jianhua Zhong, Ping Guo, Zhihong Zhou, Xin Fan, Qin Zhang, Jiafeng National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Department of HIV/AIDS and STDs Control and Prevention Zhejiang Provincial Center for Disease Control and Prevention Zhejiang Hangzhou 310051 China Zhejiang Key Laboratory of Vaccine Infectious Disease Prevention and Control Zhejiang Hangzhou 310051 China Microbiology Laboratory Taizhou Prefectural Center for Disease Control and Prevention Taizhou Center for Disease Control and Prevention Taizhou China Microbiology Laboratory Lishui Prefectural Center for Disease Control and Prevention Lishui Center for Disease Control and Prevention Lishui China Department of AIDS and STD Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336 China AIDS Testing Professional Committee Zhejiang Provincial Association of AIDS and STDs Control and Prevention Zhejiang Hangzhou 310051 China

Purpose: To understand the geographic origins, transmission hotspots, and drug resistance mutations (DRMs) of HIV-1 CRF08_BC in Zhejiang Province, China. Methods: This study analyzed HIV-1 CRF08_BC pol sequences collected between 2020 and 2023. Bayesian inference was employed to investigate temporal epidemic trends, while HIV-TRACE and MCODE were used to identify transmission clusters (TCs), key hotspots and super-spreaders. DRMs associated with CRF08_BC were also characterized. Additionally, demographic data were integrated with these findings, allowing for a description of the transmission dynamics. Results: This study revealed that CRF08_BC strains in Zhejiang likely originated from Guangxi, with significant transmission among individuals aged 50 and older, particularly those with low educational levels. Molecular transmission analysis showed that 58.9% of CRF08_BC sequences were in TCs, with geographic concentrations in Taizhou (TZ) and Lishui (LS). 14 large clusters maintained effective reproductive numbers (Re) above 1, representing considerable epidemic growth. Hangzhou (HZ) emerged as a key transmission hub, with 10 TCs showing active transmission. LS established strong epidemiological links with HZ, Ningbo (NB), Taizhou (TZ), and Wenzhou (WZ), creating a pattern of viral spread radiating from LS to surrounding areas. DRMs were identified in 76 cases (6.0%), with NNRTI and NRTI mutations exhibiting distinct geographic clustering. Conclusions: The CRF08_BC strains in Zhejiang likely originated from Guangxi and are mainly found in individuals aged 50 and older with low education. The current epidemic hotspots are in TZ and LS, where NNRTI and NRTI mutations are clustered, significantly impacting treatment efficacy. © Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： CRF08_BC DRM Geographic origins Phylodynamic Transmission cluster

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Economic Evaluation of the Comprehensive aids prevention and control Program—Tianjin Municipality,China,2011-2022

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China CDC weekly 2023年第48期5卷 1067-1072页

作者： Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou Zhuang Cui STD&AIDS Control and Prevention Section Tianjin Centers for Disease Control and PreventionTianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjinChina

What is already known about this topic?Acquired immunodeficiency syndrome(aids)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on *** is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in *** 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese *** are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking.

关键词： prevention globally Tianjin

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Trends in Mortality and Prevalence of Reported HIV/aids Cases——China,2002-2021

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China CDC weekly 2023年第42期5卷 943-947页

作者： Zhihui Dou Yanan Luo Yan Zhao Xiaoying Zheng Mengjie Han National Center for AIDS/STD Control and Prevention China Center for Disease Control and PreventionBeijingChina Department of Global Health School of Public HealthPeking UniversityBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?Annually,only the incidence and mortality for Acquired Immune Deficiency Syndrome(aids)patients are officially *** is added by this report?For the first time,information detailing the reported rate,mortality rate,and prevalence rate trends of HIV,aids,and HIV/aids in China’s entire population over the past two decades has been *** are the implications for public health practice?Our research overcomes the longstanding limitation of HIV/aids analysis as the sole ***,it incorporates a comprehensive examination of the overall population,utilizing indicators and analytic methods from chronic disease analyses.

关键词： mortality HIV/aids Immune

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Identifying the Key Nodes of HIV Molecular Transmission Network Among Men Who Have Sex with Men—Guangzhou,Guangdong Province,China,2015–2017

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China CDC weekly 2021年第38期3卷 803-807,I0007,I0008页

作者： Juan Yang Zhigang Han Huifang Xu Hui Xing Peng Xu Weibin Cheng Yuzhou Gu Fan Lyu The National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of HIV/AIDS Control and Prevention Center for Disease Control and PreventionGuangzhouGuangdongChina.

Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention *** is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.

关键词： utilizing prevention network

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Modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.Hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen Ian H.Spicknall Matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

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Effectiveness of onsite and online education in enhancing knowledge and use of human immunodeficiency virus pre-and postexposure prophylaxis

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World Journal of Clinical Cases 2024年第22期12卷 5042-5050页

作者： Ying Shao Mei Zhang Li-Jun Sun Hong-Wei Zhang An Liu Xi Wang Ruo-Lei Xin Jian-Wei Li Jiang-Zhu Ye Yue Gao Zhang-Li Wang Zai-Cun Li Tong Zhang Clinic of Center for Infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases and Medical Immunology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and AIDS Prevention and Control Beijing 100050China Institute of STD/AIDS Prevention and Control Beijing Center for Disease Prevention and ControlBeijing 100013China

BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)***-risk behaviors prevalent among sexually transmitted infection clinic outpatients underscore the need for increased PrEP/PEP education in this *** To investigate the effects of both onsite and online health education on the knowledge of,and willingness to use,PrEP and PEP among individuals receiving PEP *** Participants were drawn from a cohort study on PEP service intervention at an std/aids outpatient clinic in designated HIV/aids hospitals in Beijing,conducted from January 1 to June 30,*** education was provided both onsite and online during *** assessing knowledge of,and willingness to use,PrEP/PEP were administered at baseline and again at 24 wk *** A total of 112 participants were enrolled in the study;105 completed the follow-up at week *** percentage of participants with adequate knowledge of,and willingness to use,PrEP significantly increased from 65.2%and 69.6%at baseline to 83.8%and 82.9%at the end of the intervention(both P<0.05).Similarly,those with adequate knowledge of,and willingness to use,PEP increased from 74.1%and 77.7%at baseline to 92.4%and 89.5%at week 24(P<0.05).Being between 31 years and 40 years of age,having a postgraduate degree or higher,and reporting a monthly expenditure of RMB 5000 or more were found to be significantly associated with knowledge of PrEP and PEP(both P<0.05).CONCLUSION The findings show that both onsite and online health education significantly improved the knowledge of,and increased willingness to use,PrEP and PEP in individuals utilizing PEP services.

关键词： Human immunodeficiency virus Pre-exposure prophylaxis Post-exposure prophylaxis Health education Intervention

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Correlates of Sexual Lifestyles Among Older Adults Living With HIV in China: Findings From the Sexual Well-being (SWELL) Study

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Infectious Microbes & Diseases 2023年第3期5卷 145-151页

作者： Bingyi Wang Xin Peng Leiwen Fu Xinyi Li Tongxin Shi Bowen Liang Tian Tian Thomas Fitzpatrick Zhen Lu Weijie Zhang JunyeBian Xin Xiao YingWang Yunlong Ao Lin Ouyang YongCai Maohe Yu Guohui Wu Linghua Li Xiaojun Meng Huachun Zou School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenChina Tianjin Hexi District Center for Disease Control and Prevention TianjinChina Division of Allergy and Infectious Diseases Department ofMedicineUniversity ofWashingtonSeattleWashingtonUSA Department of Scientific Research The People's Hospital of Guangxi Zhuang Autonomous RegionNanningChina Hongqiao International Institute of Medicine Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina School of Public Health Shanghai Jiao Tong University School ofMedicineShanghaiChina Guangzhou Eighth People’s Hospital GuangzhouMedical UniversityGuangzhouChina Department of AIDS/STD Control and Prevention Chongqing Center for Disease Control and PreventionChongqingChina Department of AIDS/STD Control and Prevention Tianjin Center for Disease Control and PreventionTianjinChina WuxiMunicipal Center for Disease Control and Prevention WuxiChina School of Public Health Fudan UniversityShanghaiChina School of Public Health Southwest Medical UniversityLuzhouChina Kirby Institute University of New South WalesSydneyAustralia

Sexual lifestyles are closely related to overall human health and *** studies have focused on sexual lifestyles among older adults living with HIV(OALHIV),especially in low-and middle-income *** study is a part of the sexual well-being among older adults in China(SWELL)study,which is a multicenter cross-sectional study focused on sexual health among older adults aged 50 years and *** were 680 OALHIV(≥50 years old)from the SWELL study conducted from June 2020 to December *** were collected through one-on-one *** used logistic regression to assess the correlates of sexual activity and sexual *** all participants,37.1%were sexually *** older,male,in a steady relationship and employed were associated with being sexually *** prevalence of sexual satisfaction was 69.8%among sexually active *** homosexual and reporting a better general health status were associated with sexual *** OALHIV who have depressive symptoms were less likely to report sexual *** support holistic healthy aging among OALHIV,it is important for healthcare providers to be educated about the importance of enquiring about sexual activity,satisfaction and problems and addressing concerns while conveying sex-positive attitudes during clinical reviews,as these are still critical aspects of their health and well-being.

关键词： aging older adults HIV intimacy sexuality China

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Association between the triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular diseases in people living with human immunodeficiency virus:Evidence from a retrospectively cohort study 2005-2022

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Chinese Medical Journal 2024年第22期137卷 2712-2719页

作者： Liqin Sun Yinsong Luo Xinyun Jia Hui Wang Fang Zhao Lukun Zhang Bin Ju Haiyan Wang Duo Shan Yun He Hongzhou Lu Jiaye Liu Department of Infectious Diseases National Clinical Research Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518010China School of Public Health Shenzhen University Medical SchoolShenzhenGuangdong 518060China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Introduction:The triglyceride to high-density lipoprotein cholesterol(TG/HDL-C)ratio,a novel biomarker for metabolic syndrome(MetS),has been validated in the general population as being significantly correlated with cardiovascular disease(CVD)***,its capabilities to predict CVD in people living with human immunodeficiency virus(HIV;PLWH)remain ***:We conducted a retrospective cohort study of 16,081 PLWH who initiated antiretroviral therapy(ART)at the Third People’s Hospital of Shenzhen(China)from 2005 to *** baseline TG/HDL-C ratio was calculated as TG(mmol/L)divided by HDL-C(mmol/L).We employed a multivariate Cox proportional hazards model to assess the association between the TG/HDL-C ratio and CVD occurrence,using Kaplan-Meier curves and log-rank tests to compare survival *** increase in prediction risk upon the addition of the biomarker to the conventional risk model was examined through the assessment of changes in net reclassification improvement(NRI)and integrated discrimination improvement(IDI).Nonlinear relationships were investigated using a restricted cubic spline plot,complemented by a two-piecewise Cox proportional hazards model to analyze threshold ***:At the median follow-up of 70 months,213 PLWH developed ***-Meier curves demonstrated a significant association between the increased risk of CVD and a higher TG/HDL-C ratio(log-rank P<0.001).The multivariate-adjusted Cox proportional hazards regression model indicated that the CVD hazard ratios(HR)(95%confidence intervals[95%CIs])for Q2,Q3,and Q4 versus Q1 of the TG/HDL-C ratio were 2.07(1.24,3.45),2.17(1.32,3.57),and 2.20(1.35,3.58),respectively(P<0.05).The consideration of the TG/HDL-C ratio in the model,which included all significant factors for CVD incidence,improved the predictive risk,as indicated by the reclassification metrics(NRI 16.43%,95%CI 3.35%-29.52%,P=0.014).The restriction cubic spline plot demonstrated an upward trend betw

关键词： Triglycerides Cholesterol,HDL Human immunodeficiency virus HIV Cardiovascular disease Incidence

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