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Human immunodeficiency virus prevention strategies in China

Chinese Medical Journal 2020年第3期133卷 318-325页

作者： Zun-You Wu Sarah Robbins Scott Division of HIV Prevention National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos AngelesCAUnited States.

This paper reviews the current epidemics of human immunodeficiency virus(HIV)infection in China,particularly the globally available prevention strategies developed and *** review focuses on HIV prevention measures in general,such as education,testing,and counseling and in specific responses to transmission modes,such as blood safety,harm reduction for people who inject drugs,and condom promotion to reduce sexual *** also assess newly developed prevention measures,such as prevention treatment,pre-exposure prophylaxis,post-exposure prophylaxis,male circumcision,and promising potential future preventions,including microbicides and *** on this assessment,we provide recommendations for their implementation in *** conclude that there is no magic bullet for HIV prevention,particularly sexual transmission of the disease,but only a combination of these prevention strategies can control the HIV epidemic.

关键词： Human immunodeficiency virus infection Epidemic prevention strategies China

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Prevalence and Influencing factors of Hyperlipidemia among HIV/aids patients with second-line antiretroviral therapy in Center Area of China

Prevalence and Influencing factors of Hyperlipidemia among H...

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中华中医药学会防治艾滋病分会2021年学术年会

作者： Chunling Yang Suna Ma Yanmin Ma Huijun Guo Pengyu Li Dongli Wang Zhibin Liu Qianlei Xu Yantao Jin The First Clinical Medical School Henan University of Traditional Chinese Medicine Department of AIDS Treatment and Research Center the First Affiliated Hospital of Henan University of Chinese Medicine Center for AIDS/STD Control and Prevention Center for Disease Control and Prevention of Henan Province Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine (Henan University of Chinese Medicine)

OBJECTIVE:To investigate the prevalence and influencing factors of hyperlipidemia among HIV/aids patients with second-line antiretroviral therapy(ART) in the high incidence area of aids in Henan province of ***:The standard medical record registers in Henan Province was used as the data source to collect the information of HIV/aids patients with second-line ART in *** was hyperlipidemia was defined according to the 2016 Chinese guidelines for the management of dyslipidemia in *** regression for univariate and multivariate analysis to explore the influencing factors of hyperlipidemia among HIV/aids patients with second-line *** results showed as odds ratio(OR) and 95% confidence interval(CI).RESULTS:A total of 2886 HIV/aids patients with second-line ART were included in this study,of which 978 patients were hyperlipidemia(33.9%).Patients with female,hyperglycemia,and CD4 cell count greater than 500 cells/μL had a higher prevalence of hyperlipidemia,which were 37.0%,49.0% and 41.3%,*** analysis showed that CD4 cell count of 350-500 cells/μL(OR=1.72,95%CI :1.26,2.38),CD4 cell count of more than 500 cells/μL(OR=2.49,95%CI :1.85,3.38) and glucose > of 6.2mmol/L(OR=2.08,95%CI :1.64,2.65) were all related risk factors for hyperlipidemia,with statistical significance(P<0.05).Male(OR=0.72,95%CI :0.61,0.85) and Hb<110g/L(OR=0.59,95%CI :0.45,0.76) were protective factors for the occurrence of hyperlipidemia,and the difference was statistically significant(P<0.05) CONCLUSION:Our study showed that HIV/aids patients with second-line ART had a higher prevalence of ***,CD4 cell count,glucose > 6.2mmol/L and hemoglobin < 110g/L were the influencing factors of ***,due to the limitations of the retrospective study,the results may be biased,so it is necessary to conduct a prospective study to confirm.

关键词： HIV/aids Second-line antiretroviral therapy Hyperlipidemia Prevalence Influencing factors

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Corrigendum to - "Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques" [eBioMedicine 58(2020) 102894]

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EBioMedicine 2024年 101卷 105014页

作者： Ivana Massud Susan Ruone Maria Zlotorzynska Richard Haaland Patrick Mills Mian-Er Cong Kristen Kelley Ryan Johnson Angela Holder Chuong Dinh George Khalil Yi Pan Colleen F Kelley Travis Sanchez Walid Heneine J Gerardo García-Lerma Division of HIV/AIDS Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA United States. Rollins School of Public Health Emory University Atlanta GA United States. Division of Scientific Resources National Center for Emerging and Zoonotic Infectious Disease Centers for Disease Control and Prevention Atlanta GA United States. Division of Infectious Diseases Department of Medicine Emory University Atlanta GA United States. Division of HIV/AIDS Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA United States. Electronic address: jng5@cdc.gov.

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Biosafety and immunology:An interdisciplinary field for health priority

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Biosafety and Health 2024年第5期6卷 310-318页

作者： Jun Liu Gary Wong Hui Li Yan Yang Yuxi Cao Yongfeng Li Yan Wu Zijie Zhang Cong Jin Xi Wang Yongwen Chen Bin Su Zhongfang Wang Qihui Wang Yunlong Cao Guobing Chen Zhaohui Qian Jincun Zhao Guizhen Wu NHC Key Laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID)Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Virology Unit Institut Pasteur du CambodgePasteur NetworkPhnom Penh 12000Cambodia Department of Pulmonary and Critical Care Medicine Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150040China Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciencesand School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China State Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences Yunnan UniversityKunming 650091China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Immunology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Institute of Immunology PLAThird Military Medical UniversityChongqing 200025China Beijing Key Laboratory for HIV/AIDS Research Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Guangzhou Laboratory Guangzhou 510005China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Changping Laboratory Beijing 102200China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationDepartment of Microbiology and ImmunologyInstitute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biolog

Biosafety hazards can trigger a host immune response after infection,invasion,or contact with the *** infection with a microorganism results in disease or biosafety concerns depends to a large extent on the immune status of the ***,it is essential to investigate the immunological character-istics of the host and the mechanisms of biological threats and agents to protect the host more *** and re-emerging infectious diseases,such as the current coronavirus disease 2019(COVID-19)pan-demic,have raised concerns regarding both biosafety and immunology *** studies involved in biosafety and immunology are relevant in many fields,including the development of vaccines and other immune interventions such as monoclonal antibodies and T-cells,herd immunity(or population-level barrier immunity),immunopathology,and multispecies immunity,i.e.,animals and even ***,advances in immunological science and technology are occurring rapidly,resulting in important research achievements that may contribute to the recognition of emerging biosafety hazards,as well as early warning,prevention,and defense *** review provides an overview of the interdisciplinary field of biosafety and *** collaboration and innovative application of immunology in the field of bio-safety is becoming essential for human health.

关键词： Immunology Biosafety Diagnosis Prophylaxis Therapy

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Synthetic Characteristics Associated with HIV Diagnosis through Voluntary HIV Testing among HIV-positive People with Non-marital and Non-commercial Heterosexual Transmission in China

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Biomedical and Environmental Sciences 2019年第6期32卷 459-464页

作者： YU Qiu Yan YU Shi Cheng XU Peng YANG Juan LI Xiao Yu LU Fan National Center for STD/AIDS Prevention and Control Chinese Center for Disease Control and Prevention Beijing 102206 China Office of Epidemiology Chinese Center for Disease Control and Prevention Beijing 102206 China Department of Cadre Health Care Beijing Jishuitan Hospital The Fourth Medical College of Peking University Beijing 100035 China

The Joint United Nations program on HIV/aids reported that 53% of new infections globally in 2017 were beyond key populations and their sexual *** this report, although only 16% in Asia and the Pacific were people living with HIV (PLHIV) who did not report any HIV-risk behaviors (mainly including injective drug use, men who have sex with men, sexual workers, and their dients), increasing diag no sed cases who reported their own transmission as non-marital and non-commercial heterosexual con tact (non-M&C sex, defi ned as those heterosexuals who have unpaid sex with any other sexual partners whom they have never married) in China have indicated that the HIV epidemic is spreading to the general population by the bridge of key populations.

关键词： Synthetic Characteristics HIV

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Corrigendum to "The influence of the COVID-19 pandemic on identifying HIV/aids cases in China: an interrupted time series study" [The Lancet Regional Health - Western Pacific 36 (2023) 100755]

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The Lancet regional health. Western Pacific 2024年 44卷 100995页

作者： Tianming Zhao Haixia Liu Gabriella Bulloch Zhen Jiang Zhaobing Cao Zunyou Wu Department of Epidemiology and Health Statistics School of Public Health Anhui Medical University Hefei China. National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing China. Faculty of Medicine Dentistry and Health Sciences University of Melbourne Melbourne Australia.

[This corrects the article DOI: 10.1016/***.2023.100755.].

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A community-based comprehensive intervention to reduce syphilis infection—among low-fee female sex workers in China:a matched-pair,community-based randomized study

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Infectious Diseases of Poverty 2019年第6期8卷 51-60页

作者： Wei Dong Chu Zhou Ke-Ming Rou Zun-You Wu Jun Chen Sarah Robbins Scott Man-Hong Jia Yue-Jiao Zhou Xi Chen Division of HIV Prevention National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention155 Changbai RoadBeijing 102206China Department of Epidemiology UCLA Fielding School of Public HealthLos AngelesUSA Institute of AIDS/STD Control and Prevention Yunnan Provincial Center for Disease Control and PreventionKunmingChina Institute of AIDS Control and Prevention Guangxi Zhuang Autonom ous Region for Disease Control and PreventionNanningChina Division of AIDS/STD Control and Prevention Hunan Provincial Center for Disease Control and PreventionChangshaChina

Background:Low-fee female sex workers(FSWs)are at high risk of acquiring and spreading human immunodeficiency virus(HIV)/sexually transmitted diseases(stds)in *** is an urgent need to develop comprehensive intervention measures targeted towards low-fee FSWs to reduce HIV/std ***,this study aimed to reduce HIV/std infections among low-fee FSW through a matched-pair,comiDunity-based randomized intervention trial carried out in 12 cities in three provinces in ***:Four cities from Guangxi Zhuang Autonomous Region,four from Yunnan Province,and four from Hunan Province were paired and participants received either the intervention package(including condom promotion,HIV and syphilis testing,reimbursement for syphilis treatment costs,and free anti-retroviral therapy or the current standard of ***-based,convenience sampling was used to recruit FSWs.A face-to-face interview and HIV and syphilis blood testing was conducted at baseline and follow-up intervals of 24 *** linear mixed models(GLMM)were used to evaluate the effect of the intervention package on reducing HIV/std infection in the ***:A total of 1024 eligible FSWs were enrolled in the baseline survey and 843 in the *** results showed that syphilis infeaion was reduced by 49%in the intervention group compared to the current standard of care group(P=0.0378,OR=0.51;95%CI:0.27-0.96).FSWs aged 35 years or older were 2.38 times more likely to get syphilis infection compared to those younger than 35 years old(P<0.0001,OR=2.38,95%CI:1.55-3.65).The risk of syphilis infection among more educated FSWs was 0.43 times less than those with lower levels of education(P<0.05,OR=0.43,95%CI:0.63-0.93).Conclusions:This study demonstrates that comprehensive interventions can lead to significant declines in syphilis infection amongst low-tier *** both behavioral and biomedical intervention measures should be considered when developing programs for low-fee FS

关键词： China Female sex workers Human immunodeficiency virus Syphilis

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control of HIV/aids can be achieved with multi-strategies

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Global Health Journal 2019年第2期3卷 29-32页

作者： Roger Detels Jing Wu Zunyou Wu Department of Epidemiology Fielding School of Public HealthUniversity of California at Los AngelesCA 90095USA Department of Epidemiology School of Public HealthAnhui Medical UniversityHefei 230032China Division of HIV Prevention National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Over past three decades,many prevention strategies have been proven effective in reducing human immunodeficiency virus (HIV) ***,none of these strategies alone are effective to stop the spread of *** review discusses a few key prevention strategies,including testing,harm reduction,prevention,prophylaxis,and modern communication *** argue that although there are great challenges remaining to stop HIV transmission via sexual contact and injecting drug use routes,the combination of these effective strategies,control HIV epidemic can be achieved.

关键词： HIV prevention strategy control Epidemic

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Correction: Behavior Change Among HIV-Negative Men Who Have Sex with Men Not Using PrEP in the United States

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aids and behavior 2024年第5期28卷 1781页

作者： Steven M Goodreau Michael P Barry Deven T Hamilton Austin M Williams Li Yan Wang Travis H Sanchez David A Katz Kevin P Delaney Department of Anthropology University of Washington Campus Box 353100 Seattle WA 98122 USA. goodreau@uw.edu. Center for Studies in Demography and Ecology University of Washington Seattle WA USA. goodreau@uw.edu. Department of Epidemiology University of Washington Seattle WA USA. Center for AIDS & STD University of Washington Seattle WA USA. Center for Studies in Demography and Ecology University of Washington Seattle WA USA. Division of STD Prevention Centers for Disease Control and Prevention Atlanta GA USA. Division of Adolescent and School Health Centers for Disease Control and Prevention Atlanta GA USA. Department of Epidemiology Emory University Atlanta GA USA. Department of Global Health University of Washington Seattle WA USA. Division of HIV Prevention Centers for Disease Control and Prevention Atlanta GA USA.

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Factors associated with unprotected anal intercourse among male students who have sex with men in three Northern regions of China

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Chinese Medical Journal 2019年第14期132卷 1639-1644页

作者： De-Chuan Zhang Zun-You Wu Sarah Robbins Scott Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhui 230032China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Background:Unprotected anal intercourse (UAI) has previously been associated with human immunodeficiency virus (HIV) *** students who have sex with men (SMSM) are at increased exposure to experience *** aim of this study was to investigate the status of UAI and related factors among SMSM in three northern regions of ***:From November 2018 to January 2019,SMSM,18 years or older,studying or living in Beijing,Tianjin,or Shijiazhuang,who had anal sex in the past 6 months were recruited by community-based organizations to participate in an unmatched,casecontrol *** demographic and behavioral information were collected via self-administrated electronic questionnaires and factors related to UAI were assessed using uni-and multivariate logistic regression ***:Among the 511 SMSM included in the study,210 (41.1%) reported UAI in the past 6 *** who had sexual partners at least 10 years older than themselves (odds ratio [OR]=2.277,95% confidence interval [CI]:1.380-3.756),used vacant capsules before sexual activity (OR =3.858,95 % CI:1.472-10.106),had a self-perceived moderate-HIV risk (OR =2.128,95 %CI:1.403-3.227),and unprotected,first anal intercourse (OR =2.236,95 % CI:1.506-3.320) had increased odds of ***:Factors associated with increased odds of engaging in UAI in the past 6 months among SMSM included having older sexual partners,using vacant capsules,having a self-perceived moderate risk of HIV,and unprotected,first anal *** education on risk reduction,including improving condom decision making in age-discordant relationships could help address the sexual risk behaviors among SMSM.

关键词： Students Men who have sex with men Unsafe Sex China

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