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Potent T cell Responses Induced by Single DNA Vaccine Boosted with Recombinant Vaccinia Vaccine

Virologica Sinica 2013年第2期28卷 109-115页

作者： Lianxing Liu Chao Qiu Yang Huang Jianqing Xu Yiming Shao State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Science Research Department Shanghai Public Health Clinical Center Public Health Clinical Center affiliated to Fudan University

Plasmid DNA, an effective vaccine vector, can induce both cellular and humoral immune responses. However, plasmid DNA raises issues concerning potential genomic integration after injection. This issue should be considered in preclinical studies. Tiantan vaccinia virus (TV) has been most widely utilized in eradicating smallpox in China. This virus has also been considered as a successful vaccine vector against a few infectious diseases. Potent T cell responses through T-cell receptor (TCR) could be induced by three injections of the DNA prime vaccine followed by a single injection of recombinant vaccinia vaccine. To develop a safer immunization strategy, a single DNA prime followed by a single recombinant Tiantan vaccinia (rTV) aids vaccine was used to immunize mice. Our data demonstrated that one DNA prime/rTV boost regimen induced mature TCR activation with high functional avidity, preferential T cell Vβ receptor usage and high sensitivity to anti-CD3 antibody stimulation. No differences in T cell responses were observed among one, two or three DNA prime/rTV boost regimens. This study shows that one DNA prime/rTV boost regimen is sufficient to induce potent T cell responses against HIV.

关键词： HIV Vaccine T cell responses Prime-boost regimen

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HPV Infection among Uygur Women in a Rural Area of Hetian Prefecture,Xinjiang Uygur Autonomous Region, China

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Biomedical and Environmental Sciences 2013年第11期26卷 934-936页

作者： Sulaiya HUSAIYIN Mayinuer NIYAZI WANG Li hong WANG Jun Jie WANG Jian Bing Ayeti SIMAYI WANG Lin Zumurelaiti AINIWAER MA Chun Hua Jennifer S.SMITH Department of Gynecology Cancer Institute/Hospital Xinjiang People's Hospital Center for Reproductive Medicine Weifang People’s Hospital National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Department of Cancer Epidemiology Cancer Institute/Hospital Chinese Academy of Medical Sciences Gillings School of Global Public Health University of North Carolina

It is not clear how HPV infection is prevalent among Uygur women in Xinjiang Uygur Autonomous Region, China and whether the distribution of HPV infection is related with cervical intraepithelial neoplasia （CIN） incidence among them. A study including 883 Uygur women were conducted from 2006 to 2007 in Hetian Prefecture, Xinjiang Uygur Autonomous Region, China.

关键词： HPV Infection among Uygur Women in a Rural Area of Hetian Prefecture,Xinjiang Uygur Autonomous Region In China

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Prevalence and seroincidence of hepatitis B and hepatitis C infection in high risk people who inject drugs in china and Thailand

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Hepatitis research and treatment 2014年第1期2014卷 296958页

作者： J Brooks Jackson Liu Wei Fu Liping Apinun Aramrattana David D Celentano Louise Walshe Yi Xing Paul Richardson Ma Jun Geetha Beauchamp Deborah Donnell Yuhua Ruan Liying Ma David Metzger Yiming Shao Department of Pathology Johns Hopkins University Baltimore MD 21287 USA. Guangxi Center for Disease Control and Prevention Nanning 530028 China. Xinjiang Center for Disease Control and Prevention Urumqi 83001 China. Research Institute for Health Sciences Chiang Mai University Chiang Mai 50200 Thailand. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA. Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Beijing 102206 China. University of Pennsylvania Philadelphia PA 19104 USA.

We determined the prevalence and incidence of HBV and HCV infection in people who inject drugs (PWIDs) at high risk for HIV in China and Thailand and determined the association of HBV and HCV incidence with urine opiate test results and with short-term versus long-term buprenorphine-naloxone (B-N) treatment use in a randomized clinical trial (HPTN 058). 13.8% of 1049 PWIDs in China and 13.9% of 201 PWIDs in Thailand were HBsAg positive at baseline. Among HBsAg negative participants, the HBsAg incidence rate was 2.7/100 person years in China and 0/100 person years in Thailand. 81.9% of 1049 PWIDs in China and 59.7% of 201 in Thailand were HCV antibody positive at baseline. The HCV confirmed seroincidence rate among HCV antibody negative PWIDs was 22/100 person years in China and 4.6/100 person years in Thailand. Incident HBsAg was not significantly different in the short-term versus long-term B-N arm in China or Thailand. Participants with positive opiate results in at least 75% of their urines during the time period were at increased risk of incident HBsAg (HR = 5.22; 95% CI, 1.08 to 25.22; P = 0.04) in China, but not incident HCV conversion in China or Thailand.

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HIV infection among new synthetic drug abusers： a pilot study in Beijing

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Chinese Medical Journal 2013年第8期126卷 1517-1521页

作者： LI Ping CHEN Xiao XIE Pei-yan CHU Ping LI Dong-liang LI Qian-qian SHAO Yi-ming JIA Zhong-wei School of Public Health Guangxi Medical University NanningGuangxi 530021 China State Key Laboratory for Infectious Disease Prevention andControl National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention Beijing102206 China Zaozhuang Center for Disease Control and Prevention ZaozhuangShandong 277101 China College of Mathematical Science Ocean University of ChinaQingdao Shangdong 266003 China Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical University Beijing 100045 China Chaoyang District Center for Disease Control and Prevention Beijing 10021 China National Institution on Drug Dependence Peking UniversityBeijing 100191 China Takemi Program in International Health Department of GlobalHealth and Population Harvard School of Public Health BostonMA USA

Background Following the increased human immunodeficiency virus （HIV） notification （infection） rates via sexual transmission and increased abuse of new synthetic drugs instead of heroin in China, a study on HIV infections and risk factors among synthetic drugs and heroin users in Beijing was conducted to provide a cue for further development of targets and strategies of HIV/aids control and prevention for different drug populations. Methods A total of 428 subjects including 224 heroin users and 204 new synthetic drug users was recruited from communities in Beijing by convenience sampling. A X2 test was used to compare HIV and syphilis infections between the two subpopulations. Logistic regression models were used to evaluate factors related to HIV, syphilis infections and abuse of synthetic drugs. Results Unbalanced distributions of demographics were detected between the two subpopulations. Compared with heroin users, most users of synthetic drugs were migrants, single and of younger age （age 〈30 years）. Ten HIV infections and twenty-four syphilis infections were confirmed among 428 subjects. No significant difference in HIV infection was found between the two subpopulations （crude odds ratio （OR） =0.46, 95% confidence interval （CI）： 0.07-15.80 and adjusted odds ratio （AOR） =1.26, 95% Ch 0.09-18.28） while four times as many syphilis infections were identified among users of synthetics drugs （AOR=3.92, 95% CI： 1.06-14.56）. HIV and syphilis infections appeared to work *** migrants who were of Han ethnicity, single and who had stayed in Beijing for more than six months were more likely to abuse synthetics drugs. Conclusions The new synthetic drug users and heroin users are different subpopulations. We optimistically speculate that HIV has not yet been introduced into the former in Beijing, but considering higher syphilis infections in synthetic drug users and the role of syphilis in HIV infection, synthetic drug users, as a possible and important driver

关键词： human immunodeficiency virus syphilis new synthetic drugs heroin drug

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What we are watching-five top global infectious disease threats, 2012: A perspective from CDC's global disease detection operations center

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Emerging Health Threats Journal 2013年第1期6卷 103402/ehtjv6i020632-103402/ehtjv6i020632页

作者： Christian, Kira A. Ijaz, Kashef Dowell, Scott F. Chow, Catherine C. Chitale, Rohit A. Bresee, Joseph S. Mintz, Eric Pallansch, Mark A. Wassilak, Steven McCray, Eugene Arthur, Ray R. Division of Global Disease Detection and Emergency Response Center for Global Health Centers for Disease Control and Prevention Atlanta GA United States Influenza Division National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention Atlanta GA United States Division of Foodborne Waterborne and Enteric Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta GA United States Division of Viral Diseases National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention Atlanta GA United States Global Immunization Division Center for Global Health Centers for Disease Control and Prevention Atlanta GA United States Division of Tuberculosis Elimination National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA United States Division of Integrated Biosurveillance Armed Forces Health Surveillance Center US Department of Defense Silver Spring MD United States

Disease outbreaks of international public health importance continue to occur regularly;detecting and tracking significant new public health threats in countries that cannot or might not report such events to the global health community is a challenge. The Centers for Disease control and prevention's (CDC) Global Disease Detection (GDD) Operations Center, established in early 2007, monitors infectious and noninfectious public health events to identify new or unexplained global public health threats and better position CDC to respond, if public health assistance is requested or required. At any one time, the GDD Operations Center actively monitors approximately 30-40 such public health threats;here we provide our perspective on five of the top global infectious disease threats that we were watching in 2012: (1) avian influenza A (H5N1), (2) cholera, (3) wild poliovirus, (4) enterovirus-71, and (5) extensively drug-resistant tuberculosis. © 2013 Kira A. Christian et al.

关键词： CDC Disease detection Emergency response Epidemic intelligence Epidemiology Global health

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MODELING PRIMARY AND SECONDARY DRUG RESISTANCES UNDER CHINA^S ＂FOUR-FREE-ONE-CARE POLICY＂

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International Journal of Biomathematics 2012年第5期5卷 1-19页

作者： JIE LOU LINGCHEN BU ESTHER HAN YUHUA RUAN HUI XING YIMING SHAO Department of Mathematics Shanghai University99 Shangda Road Shanghai 200~ P. R. China Texas College of Osteopathic MedicineUniversity of North Texas Health Science Center Fort Worth TX USA State Key Laboratory for Infectious Disease Control and Prevention andNational Center for AIDS//STD Control and Prevention Chinese Center for Disease Control and Prevention 155 Changbai Road Changping District Beijing 102206 P. R. China

We propose a mathematical model to evaluate the effect of China＇s ＂Four-Free-One-Care Policy＂ in MSM population in Beijing. We divided the drug resistant H[V patients into two sub-populations： primary drug resistance and secondary drug resistance. Uncertainty and sensitivity analysis based on Latin Hypercube Sampling （LHS） were used for these thresholds of our model. We find that drug-resistant HIV will spread fast in MSM population under China＇s current treatment policy. Especially＇, primary-resistant strain is very likely to dominate the HIV positive MSM individuals after 10 years. The conclusions hint that, China＇s outlook on HIV infections is not optimistic if sufficient kinds free second-line drugs in China cannot be put into use in the near future.

关键词： HIV Latin Hypercube Sampling primary drug resistance secondary drugresistance.

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1474Genotypic Characterization ofpncAGene in Patients with Multidrug-resistant Tuberculosis from South Africa

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Open Forum Infectious Diseases 2014年第SUPPL_1期1卷 S389–S389页

作者： Allana, Salim Mathema, Barun Brust, James Mthiyane, Thuli Mlisana, Koleka Moodley, Pravi Shah, Sarita Gandhi, Neel Epidemiology Emory University Rollins School of Public Health Atlanta GA Epidemiology Columbia University Mailman School of Public Health New York NY Divisions of General Internal Medicine and Infectious Diseases Montefiore Medical Center and Albert Einstein College of Medicine Bronx NY Microbiology Virology Research University of KwaZulu Natal Durban South Africa MMedMicro Department of Medical Microbiology University of KwaZulu-Natal and National Health Laboratory Service Durban South Africa Department of Virology University of KwaZulu-Natal and National Health Laboratory Service Durban South Africa International Research and Program Branch Division of TB Elimination National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA Epidemiology and Global Health Emory University Rollins School of Public Health Atlanta GA

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Estimation of Population-Size Changes and HIV Prevalence among Female Sex Workers from 2006 to 2009 in Kaiyuan,Yunnan,China

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Biomedical and Environmental Sciences 2012年第4期25卷 489-494页

作者： WANG Jun Jie YANG Qian FAN Pan Ying REILLY Kathleen H. DING Guo Wei WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China Department of Public Health Peking Union Medical College Tsinghua University Beij'ing 100730 China Tulane University Health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA

Objective This study is to estimate the population size and prevalence of HIV and herpes simplex virus type 2 （HSV-2） infections among female sex workers （FSWs） in Kaiyuan, Yunnan Province, China. Methods Eight cross-sectional studies were conducted among FSWs in Kaiyuan from 2006 to 2009. Based on the data from two study time points each year, the total numbers of FSWs and HIV positive FSWs were estimated by using the capture-recapture technique （CR）. Results Estimated sizes of FSWs in Kaiyuan were 1 629, 1 672, 1 186, and 1 014 in the respective years from 2006 to 2009. Although the crude prevalence rates of HIV and HSV-2 varied over time, the adjusted prevalence among this population was relatively stable at 10%-12% and the adjusted HSV-2 prevalence ranged from 67% to72%. Conclusion The reason for the slight decrease of the size of the FSW population is unknown. The adjusted prevalence rates of HIV and HSV-2 among them were stable over the course of this study.

关键词： Population HIV FSWs Capture-recapture

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Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China

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Biomedical and Environmental Sciences 2011年第4期24卷 343-348页

作者： MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206 China Department of Public Health Nanjing Medical University Nanjing 210029 Jiangsu China

Objective The migrant population is a vulnerable group for HIV infection in *** potential epidemic trends among migrants is critical for developing HIV preventative measures in this *** The Estimation and Projection Package （EPP） model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in *** The prevalence of HIV among migrants in 2009 was estimated at 0.075% （95% CI：0.042%,0.108%） in *** HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% （95% CI：0.070%,0.150%） by *** Although the 2009 estimates for the HIV/aids epidemic in China indicate a slower rate of increase compared with the national HIV/aids epidemic,it is estimated to persistently increase among migrants over the next 5 *** will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population.

关键词： China Transients and migrants Estimation and projection package HIV/aids

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Correlation Analysis on Total Lymphocyte Count and CD4 Count in HIV-infected Patients: A Retrospective Evaluation

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第5期31卷 712-716页

作者：王宇明梁淑英于二曼郭金玲李自钊王哲杜玉开 Henan Provincial Medical Academy Department of Epidemiology and Biostatistics College of Public Health Zhengzhou University Center for AIDS/STD Control and Prevention Department of Health of Henan Province Institute for Infection Disease Control and Prevention Henan Provincial Center for Disease Control and Prevention Department of Maternal and Child Health Care and Adolescent Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology

CD4 count is the standard method for determining eligibility for highly active antiretroviral therapy （HAART） and monitoring HIV/aids disease progression, but it is not widely available in resource-limited settings. This study examined the correlation between total lymphocyte count （TLC） and CD4 count of HIV-infected patients before and after HAART, and assessed the thresholds of TLC for making decisions about the initiation and for monitoring HAART. A retrospective study was performed, and 665 HIV-infected patients with TLC and CD4 count from four counties （Shangcai, Queshan, Shenqiu and Weishi） were included in the study. Pearson correlation and receiver operating characteristic （ROC） were used. TLC and CD4 count after HAART was significantly increased as compared with pre-HAART （P〈0.01）. An overall positive correlation was noted between TLC and CD4 count （pre-HAART, r=0.73, P=0.0001; follow-up HAART, r=0.56, P=0.0001）. The ROC curve between TLC and CD4 count showed that TLC ≤ 1200 cells/mm3 could predict CD4 〈 200 cells/mm3 with a sensitivity of 71.12%, specificity of 66.35% at pre-HAART. After 12-month HAART, the optimum prediction for CD4 count 〈 200 cells/mm3 was a TLC ≤ 1300 cells/mm3, with a sensitivity of 63.27%, and a specificity of 74.84%. Further finding indicated that TLC change was positively correlated to CD4 change （r=0.77, P=0.0001） at the time point of 12-month treatment, and the best prediction point of TLC change for CD4 increasing was 135 cells/mm3. TLC and its change can be used as a surrogate marker for CD4 count and its change of HIV-infected individuals for making decisions about the initiation and for monitoring HAART in resource-limited settings.

关键词： HIV/aids CD4 count total lymphocyte count highly active antiretroviral therapy

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