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Trends in Incidence of hiv and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun Bai Long Li Jie Yang Fangning Zhao Jinyu Hou Maohe Yu Houlin Tang STD&AIDS Control and Prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&AIDS Control and Prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(hiv)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of hiv and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

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Study on the Technical Parameters for Estimating hiv-1 Incidence by Using a Recombinant Antigen-based Capture Enzyme Immunoassay—China

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China CDC weekly 2024年第48期6卷 1278-1282页

作者： Wenli Liang Jibao Wang Hongxia Yan Xinhui Zhang Dorjiwangmo Dongmin Li Xing Duan Hao Wu Yinyin Wang Li Bai Jian Sun Mengjie Han Yikui Wang Bin Su Min Wang Tashibazong Wenge Xing Cui Zhang Ruijuan Qiao Maofeng Qiu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of AIDS/STD Control and Prevention Dehong Center for Disease Control and PreventionMangshi CountyDehong Dai and Jingpo Autonomous PrefectureYunnan ProvinceChina Beijing Key Laboratory for HIV/AIDS Research Beijing Youan HospitalCapital Medical UniversityBeijingChina Institute of Infectious Diseases Prevention and Treatment Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina Department of AIDS Control and Prevention Xizang Autonomous Region Center for Disease Control and PreventionLhasa CityXizang Autonomous RegionChina Experimental Center Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina Department of AIDS Control and Prevention Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Laboratory Department Liupanshui Center for Disease Control and PreventionLiupanshui CityGuizhou ProvinceChina

Introduction:A novel recombinant antigen-based capture enzyme immunoassay(RAg-CEIA)was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1(hiv-1)incidence in ***:We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution *** assay was used to measure normalized optical density(ODn)values in 171 longitudinal plasma specimens from 51 hiv-1 seroconverting individuals,plotted against estimated days *** determined the optimal ODn threshold value for differentiating recent from long-term infections and calculated the mean duration of recent infection(MDRI)for incidence *** false recent rate(FRR)was determined using 481 hiv-1 antibody-positive specimens with infection durations exceeding twice the ***:Optimal RAg-CEIA parameters were established with a raw material dilution ratio of 1/12 for calibrator preparation and an enzyme conjugate titer of 1:*** values demonstrated consistent temporal increases across hiv-1 seroconverting individuals,though with notable kinetic heterogeneity in individual *** optimal ODn threshold value of 0.8 for distinguishing recent from long-term infections corresponded to an MDRI of 205 days and an FRR of 4.78%.Conclusions:The optimized RAg-CEIA effectively differentiates recent from long-term hiv-1 infections at the population level,enabling reliable hiv-1 incidence estimation in China.

关键词： Antigen exceeding false

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Geographic origins, transmission hotspots, and drug resistance mutations of hiv-1 CRF08_BC in Zhejiang Province, China

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Infection 2025年 1-13页

作者： Zhao, Hehe Jiang, Jun Chai, Chengliang Pan, Xiaohong Lyu, Fan Xing, Hui Feng, Yi Cheng, Wei Li, Guixia Mei, Jianhua Zhong, Ping Guo, Zhihong Zhou, Xin Fan, Qin Zhang, Jiafeng National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Department of HIV/AIDS and STDs Control and Prevention Zhejiang Provincial Center for Disease Control and Prevention Zhejiang Hangzhou 310051 China Zhejiang Key Laboratory of Vaccine Infectious Disease Prevention and Control Zhejiang Hangzhou 310051 China Microbiology Laboratory Taizhou Prefectural Center for Disease Control and Prevention Taizhou Center for Disease Control and Prevention Taizhou China Microbiology Laboratory Lishui Prefectural Center for Disease Control and Prevention Lishui Center for Disease Control and Prevention Lishui China Department of AIDS and STD Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336 China AIDS Testing Professional Committee Zhejiang Provincial Association of AIDS and STDs Control and Prevention Zhejiang Hangzhou 310051 China

Purpose: To understand the geographic origins, transmission hotspots, and drug resistance mutations (DRMs) of hiv-1 CRF08_BC in Zhejiang Province, China. Methods: This study analyzed hiv-1 CRF08_BC pol sequences collected between 2020 and 2023. Bayesian inference was employed to investigate temporal epidemic trends, while hiv-TRACE and MCODE were used to identify transmission clusters (TCs), key hotspots and super-spreaders. DRMs associated with CRF08_BC were also characterized. Additionally, demographic data were integrated with these findings, allowing for a description of the transmission dynamics. Results: This study revealed that CRF08_BC strains in Zhejiang likely originated from Guangxi, with significant transmission among individuals aged 50 and older, particularly those with low educational levels. Molecular transmission analysis showed that 58.9% of CRF08_BC sequences were in TCs, with geographic concentrations in Taizhou (TZ) and Lishui (LS). 14 large clusters maintained effective reproductive numbers (Re) above 1, representing considerable epidemic growth. Hangzhou (HZ) emerged as a key transmission hub, with 10 TCs showing active transmission. LS established strong epidemiological links with HZ, Ningbo (NB), Taizhou (TZ), and Wenzhou (WZ), creating a pattern of viral spread radiating from LS to surrounding areas. DRMs were identified in 76 cases (6.0%), with NNRTI and NRTI mutations exhibiting distinct geographic clustering. Conclusions: The CRF08_BC strains in Zhejiang likely originated from Guangxi and are mainly found in individuals aged 50 and older with low education. The current epidemic hotspots are in TZ and LS, where NNRTI and NRTI mutations are clustered, significantly impacting treatment efficacy. © Springer-Verlag GmbH Germany, part of Springer Nature 2025.

关键词： CRF08_BC DRM Geographic origins Phylodynamic Transmission cluster

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Identifying the Key Nodes of hiv Molecular Transmission Network Among Men Who Have Sex with Men—Guangzhou,Guangdong Province,China,2015–2017

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China CDC weekly 2021年第38期3卷 803-807,I0007,I0008页

作者： Juan Yang Zhigang Han Huifang Xu Hui Xing Peng Xu Weibin Cheng Yuzhou Gu Fan Lyu The National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of HIV/AIDS Control and Prevention Center for Disease Control and PreventionGuangzhouGuangdongChina.

Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(hiv)transmission networks is crucial for developing effective prevention *** is added by this report?This study identified key nodes of the hiv molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.

关键词： utilizing prevention network

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Exploration of an Efficient Simultaneous Molecular Detection Method of hiv,HCV,and Syphilis from a Single Dried Blood Spot

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Biomedical and Environmental Sciences 2021年第4期34卷 257-264页

作者： MA Jie Qiong XU Qing Qing HE Lin HE Xiao Xia CHEN Kai WANG Yue Hua XING Wen Ge JIANG Yan National HIV Reference Laboratory National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective The aim of the present study was to evaluate the performance of the simultaneous detection of hiv-1 RNA,hiv-1 DNA,and HCV RNA using one dried blood spot(DBS)as an alternative sample to *** A total of 571 paired DBS/plasma samples were collected from men who have sex with men(MSM)and injection drug users(IDUs),and serological and molecular assays were *** plasma results as the reference standard,the performance of DBS tests for hiv-1 RNA,hiv-1 DNA,and HCV RNA was ***’s correlation coefficients and Bland-Altman analysis were performed to assess the correlation and concordance between DBS and *** Among paired plasma/DBS samples with detectable hiv-1 RNA and HCV RNA,five samples(5/32)were not detectable in DBS,while measurable hiv-1 RNA levels were present in plasma(1.44 to3.99 log10 copies/m L).There were two samples(2/94)with undetectable HCV RNA in DBS,while measurable HCV RNA levels were present in plasma(-5 to 5.99 log10 copies/m L).The correlation between hiv-1 RNA light chain variable region(VL)values obtained from plasma and DBS showed that r=0.683(P<0.01),n=27 and r=0.612(P<0.01),n=89 in HCV ***-Altman analysis revealed that in hiv-1 RNA,the mean(±SD)difference between hiv-1 RNA in plasma and DBS was 1.00±1.01 log10 copies/m L,and all samples were within±1.96 SD(-0.97 to 2.97 log10 copies/m L)for *** mean difference(±SD)in HCV RNA was 0.15±1.08 log10 copies/m L,and 94.38%(84/89)were within±1.96 SD(-1.96 to 2.67 log10 copies/m L).Overall,hiv-1 RNA and HCV RNA levels obtained from a DBS were lower than those obtained from ***-1 DNA in a DBS showed concordant results with hiv-1 RNA in ***-1 DNA RT-PCR using a DBS showed acceptable *** The performance of the simultaneous detection of hiv-1 RNA,hiv-1 DNA,and HCV RNA using one DBS was ***,as an alternative sample to plasma,may be a viable option for the simultaneous detection of hiv-1 RNA,hiv-1 DNA,and HCV R

关键词： Dried blood spot(DBS) Correlation Bland-Altman hiv-1 RNA hiv-1 DNA HCV RNA

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Modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.Hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen Ian H.Spicknall Matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

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Spatial-temporal Analysis of Tuberculosis at the Community Level in the Baoshan District, Shanghai 2014–2019

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Biomedical and Environmental Sciences 2022年第5期35卷 458-462页

作者： MA Zhi Tao WANG Na HE Fan LIU Xiao Feng SHEN Xin Department of Tuberculosis and HIV/AIDS Prevention Baoshan Centers for Disease Control and PreventionBaoshan 201901ShanghaiChina Division of Tuberculosis and HIV/AIDS Prevention Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Institutes of Preventive Medicine Shanghai 200336China

Mycobacterium tuberculosis is the primary bacteria that leads to human tuberculosis(TB),which usually affects the pulmonary *** is one of the top 10 causes of death worldwide;however,China is one of eight countries th... 详细信息

关键词： organs tuberculosis death

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Economic Evaluation of the Comprehensive aids prevention and control Program—Tianjin Municipality,China,2011-2022

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China CDC weekly 2023年第48期5卷 1067-1072页

作者： Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou Zhuang Cui STD&AIDS Control and Prevention Section Tianjin Centers for Disease Control and PreventionTianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjinChina

What is already known about this topic?Acquired immunodeficiency syndrome(aids)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on *** is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(hiv)prevention strategies in *** 2011 and 2022,it is estimated that effective measures could prevent 2,965 new hiv infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese *** are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized hiv prevention and control strategies,as well as to guide public health policymaking.

关键词： prevention globally Tianjin

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Epidemiological Analysis of Tuberculosis Infection and Trend Changes-152 Belt and Road Partner Countries, 2013-2021

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China CDC weekly 2024年第49期6卷 1289-1293,I0001-I0003页

作者： Rong Du Xiao Xiao Jing Chen Xin Shen Qi Zhao Department of Epidemiology School of Public HealthFudan UniversityShanghaiChina NHC Key Laboratory of Health Technology Assessment Fudan UniversityShanghaiChina Division of Tuberculosis and HIV/AIDS Prevention Shanghai Municipal Center for Disease Control and PreventionShanghaiChina Department of Social Medicine School of Public HealthFudan UniversityShanghaiChina

What is already known about this topic?The Belt and Road Initiative promotes increased interactions among participating countries,which concurrently elevates the risk of infectious diseases such as tuberculosis(TB).Since TB infection can significantly contribute to the disease burden,it is crucial to delineate the epidemic status and identify the change trends in TB infection among the countries involved in the initiative.

关键词： diseases infection tuberculosis

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Trends in Mortality and Prevalence of Reported hiv/aids Cases——China,2002-2021

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China CDC weekly 2023年第42期5卷 943-947页

作者： Zhihui Dou Yanan Luo Yan Zhao Xiaoying Zheng Mengjie Han National Center for AIDS/STD Control and Prevention China Center for Disease Control and PreventionBeijingChina Department of Global Health School of Public HealthPeking UniversityBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?Annually,only the incidence and mortality for Acquired Immune Deficiency Syndrome(aids)patients are officially *** is added by this report?For the first time,information detailing the reported rate,mortality rate,and prevalence rate trends of hiv,aids,and hiv/aids in China’s entire population over the past two decades has been *** are the implications for public health practice?Our research overcomes the longstanding limitation of hiv/aids analysis as the sole ***,it incorporates a comprehensive examination of the overall population,utilizing indicators and analytic methods from chronic disease analyses.

关键词： mortality hiv/aids Immune

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