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Open letter from Chinese hiv professionals on human genome editing (vol 393, pg 26, 2018)

LANCET 2019年第10166期393卷 30-30页

作者： Zhang, L. Zhong, P. Zhai, X. Comprehensive AIDS Research Center Global Health and Infectious Diseases School of Medicine Tsinghua University Beijing 100084 China Shanghai Municipal Institutes for Preventive Medicine Shanghai China Center for Bioethics Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department of Medicine University of Massachusetts Medical School Worcester MA USA

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Time from hiv diagnosis to viral suppression: Survival analysis of statewide surveillance data in Alabama, 2012 to 2014

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JMIR Public Health and Surveillance 2020年第2期6卷 e17217页

作者： Scott Batey, D. Dong, Xueyuan Rogers, Richard P. Merriweather, Anthony Elopre, Latesha Rana, Aadia I. Irene Hall, H. Mugavero, Michael J. Department of Social Work University of Alabama at Birmingham Birmingham AL United States ICF International Fairfax VA United States Division of STD Prevention and Control Alabama Department of Public Health Montgomery AL United States Department of Medicine University of Alabama at Birmingham Birmingham AL United States Division of HIV/AIDS Prevention Centers for Disease Control and Prevention Atlanta GA United States

Background: Evaluation of the time from hiv diagnosis to viral suppression (VS) captures the collective effectiveness of hiv prevention and treatment activities in a given locale and provides a more global estimate of how effectively the larger hiv care system is working in a given geographic area or jurisdiction. Objective: This study aimed to evaluate temporal and geographic variability in VS among persons with newly diagnosed hiv infection in Alabama between 2012 and 2014. Methods: With data from the National hiv Surveillance System, we evaluated median time from hiv diagnosis to VS (<200 c/mL) overall and stratified by Alabama public health area (PHA) among persons with hiv diagnosed during 2012 to 2014 using the Kaplan-Meier approach. Results: Among 1979 newly diagnosed persons, 1181 (59.67%) achieved VS within 12 months of diagnosis;52.6% (353/671) in 2012, 59.5% (377/634) in 2013, and 66.9% (451/674) in 2014. Median time from hiv diagnosis to VS was 8 months: 10 months in 2012, 8 months in 2013, and 6 months in 2014. Across 11 PHAs in Alabama, 12-month VS ranged from 45.8% (130/284) to 84% (26/31), and median time from diagnosis to VS ranged from 5 to 13 months. Conclusions: Temporal improvement in persons achieving VS following hiv diagnosis statewide in Alabama is encouraging. However, considerable geographic variability warrants further evaluation to inform public health action. Time from hiv diagnosis to VS represents a meaningful indicator that can be incorporated into public health surveillance and programming. © D Scott Batey, Xueyuan Dong.

关键词： hiv Public health surveillance Sustained viral suppression

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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal Shiv infection

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Nature communications 2024年第1期15卷 1054页

作者： Isabella C Young Ivana Massud Mackenzie L Cottrell Roopali Shrivastava Panita Maturavongsadit Alka Prasher Andres Wong-Sam Chuong Dinh Tiancheng Edwards Victoria Mrotz James Mitchell Josilene Nascimento Seixas Aryani Pallerla Allison Thorson Amanda Schauer Craig Sykes Gabriela De la Cruz Stephanie A Montgomery Angela D M Kashuba Walid Heneine Charles W Dobard Martina Kovarova J Victor Garcia J Gerardo Garcίa-Lerma S Rahima Benhabbour Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. Laboratory Branch Division of HIV Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA USA. Division of Pharmacotherapy and Experimental Therapeutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. Joint Department of Biomedical Engineering North Carolina State University and The University of North Carolina at Chapel Hill Chapel Hill NC USA. Comparative Medicine Branch Division of Scientific Resources National Center for Emerging and Zoonotic Infection Diseases Centers for Disease Control and Prevention Atlanta GA USA. Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology National Center for Emerging and Zoonotic Infection Diseases Centers for Disease Control and Prevention Atlanta GA USA. Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill NC USA. Pathology Services Core Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill NC USA. International Center for the Advancement of Translational Science Division of Infectious Diseases Center for AIDS Research University of North Carolina at Chapel Hill Chapel Hill NC USA. Laboratory Branch Division of HIV Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA USA. jng5@cdc.gov. Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA. benhabs@email.unc.edu. Joint Department of Biomedical Engineering North Carolina State University and The University of North Carolina at Chapel Hill Chapel Hill NC USA. benhabs@email.unc.edu.

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Benefits of early ART initiation on mortality among people with hiv

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The lancet. hiv 2022年第6期9卷 e377页

作者： Yihong Xie Jinhui Zhu Guanghua Lan Yuhua Ruan Department of Epidemiology and Biostatistics Guangxi Medical University Nanning Guangxi China. Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response Guangxi Center for Disease Control and Prevention Nanning Guangxi China. Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response Guangxi Center for Disease Control and Prevention Nanning Guangxi China State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Beijing China. Electronic address: ruanyuhua92@***.

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1520. Mind the Clap: Reported Disseminated Gonococcal Infections in the United States, 2020–2022

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Open Forum Infectious Diseases 2022年第SUPPLEMENT_2期9卷

作者： Laura A Quilter Eric C Tang Kelly A Johnson Kathleen Jacobson Alison Ridpath Stephanie Cohen Shobita Rajagopalan Monica D Munoz Justin L Holderman James B Kent Laura H Bachmann Kyle Bernstein Centers for Disease Control and Prevention Atlanta GA Sexually Transmitted Diseases Control Branch Richmond California California Department of Public Health &amp University of California San Francisco San Francisco California CDPH Richmond California San Francisco Department of Public Health San Francisco California Division of HIV and STD Programs Los Angeles California Division of HIV &amp STD Programs(DHSP) Los Angeles California Michigan Department Health and Human Services Lansing Michigan CDC Atlanta Georgia

Background Disseminated gonococcal infections (DGI) are estimated to occur in 0.5% to 3% of untreated Neisseria gonorrhoeae (GC) infections; however, surveillance and population-based studies to estimate DGI burden and describe recent DGI epidemiology and clinical manifestations are limited. In response to increased reports of DGI cases and clusters in the U.S., the Centers for Disease control and prevention (CDC) developed a surveillance system in 2020. We analyzed data captured by the initial two years of surveillance.

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Correction: A Peer-to-Peer Collaborative Learning Approach for the Implementation of Evidence-Informed Interventions to Improve hiv-Related Health Outcomes

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aids and behavior 2024年 2024 Mar 4页

作者： Alex S Keuroghlian Linda Marc Hilary Goldhammer Massah Massaquoi Alicia Downes Joseph Stango Hannah Bryant Sean Cahill Jessica Yen Antonia C Perez Jennifer M Head Kenneth H Mayer Janet Myers Gregory M Rebchook Beth Bourdeau Demetrios Psihopaidas Nicole S Chavis Stacy M Cohen The Fenway Institute Fenway Health 1340 Boylston Street Boston MA 02215 USA. akeuroghlian@***. Department of Psychiatry Massachusetts General Hospital Boston MA USA. akeuroghlian@***. Department of Psychiatry Harvard Medical School Boston MA USA. akeuroghlian@***. The Fenway Institute Fenway Health 1340 Boylston Street Boston MA 02215 USA. Department of Biostatistics The Harvard T.H. Chan School of Public Health Boston MA USA. AIDS United Washington DC USA. Department of Health Sciences Bouvé College of Health Northeastern University Boston MA USA. Kansas City Free Health Clinic Kansas City MO USA. Synergy Scientifics LLC Port Orford OR USA. Harvard T.H. Chan School of Public Health Boston MA USA. Harvard Medical School Beth Israel Deaconess Medical Center Boston MA USA. Division of Prevention Science University of California San Francisco San Francisco CA USA. US Department of Health and Human Services Health Resources and Services Administration HIV/AIDS Bureau Rockville MD USA. Division of HIV Prevention National Center for HIV Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA USA.

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2007-17年美国儿童和青少年结核病流行病学:国家监测数据分析

2007-17年美国儿童和青少年结核病流行病学:国家监测数据分析

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作者： Tori L Cowger Jonathan M Wortham Deron C Burton 许磊 Division of Tuberculosis Elimination National Center for HIV/AIDSViral HepatitisSTDand TB PreventionUS Centers for Disease Control and Prevention Department of Epidemiology Harvard T H Chan School of Public Health

背景:在2018年期间,全球15岁以下的儿童中约有100万例结核病病例和233000例与结核相关的死亡。儿童和青少年的结核病在临床和流行病学上存在差异,给护理和预防带来了挑战。对儿童和青少年结核病流行病学的了解有助于治疗和预防工作,以... 详细信息

背景:在2018年期间,全球15岁以下的儿童中约有100万例结核病病例和233000例与结核相关的死亡。儿童和青少年的结核病在临床和流行病学上存在差异,给护理和预防带来了挑战。对儿童和青少年结核病流行病学的了解有助于治疗和预防工作,以及消除结核病发病率和死亡率差异。目的:我们试图描述美国患有结核病的儿童和青少年的流行病学,包括按父母出生国和美国领土及自由联系的州分列的结核病发病率,这些情况以前没有描述过。方法:我们分析了2007-17年期间向国家结核病监测系统报告的15岁以下儿童和15-17岁青少年的数据,并使用美国人口普查局的人口估计数计算了结核病发病率。结果:在2010至2017年间,有6072例肺结核病例发生在儿童和青少年中,其中5175例(85%)发生在美国50个州或哥伦比亚特区,6072例中有897例(15%)发生在美国附属岛屿。在美国各州,5175例中有3520例(68%)发生在美国出生的人群中,包括3896名儿童中的2977名(76%)和1279名青少年中的543名(42%)。2007-2017年儿童和青少年发病率为1.0/10万人,同期下降47.8%(95%CI-51.4～44.1)。我们观察到,在所有非白人种族或族裔群体的儿童和青少年中,生活在美国附属岛屿的人,以及出生在结核病流行国家或与其父母一起出生的儿童中,结核病发病率过高。讨论:在对国家监测数据的审查中,我们观察到所有非白种人种族或族裔群体的儿童和青少年、生活在美国附属岛屿的儿童和青少年、出生在结核病流行国家或其父母来自于结核病流行国家的儿童和青少年中结核病发病率过高。此外,我们观察到,与美国各州相比,美国附属岛屿的儿童和青少年患结核病的死亡率高得不成比例。这些广泛和普遍的差距可能反映了结构性的不平等,造成了不成比例的接触、感染和疾病的脆弱性以及不平等的迅速诊断和治疗机会。我们的研究结果表明,美国的结核病护理和预防策略正在成功地降低儿童和青少年的总体结核病负担,但需要更多的关注和可能的新方法来解决这些年龄组结核病发病率和死亡率的差异。我们观察到儿童和青少年的结核病发病率和死亡率存在普遍的种族或民族和地理差异。与非西班牙裔白人儿童和青少年相比,每一个被调查的种族或族裔群体的结核病发病率都显著增加,这表明健康的结构性和社会决定因素可能具有广泛的影响,导致历史上边缘化的儿童和青少年接触结核病、感染或疾病进展的风险增加。尽管我们强调了结核病的差异可能会被种族,民族,地理位置和出生地等影响,但我们注意到这种异质性可能归因于基本的社会,政策和环境条件。此外,通过对各种健康结果的研究确定了有助于人口水平的其他因素健康差距,这些因素可能包括粮食安全和营养,获得经济和营养物质资源,住宅隔离,接触二手烟,室内外空气质量,持久历史创伤的影响(例如奴隶制,殖民,流离失所),医疗政策,获取和基础设施。所以除了努力预防和治疗高危儿童和青少年中的结核病外,还应努力阐明和改善风险增加的潜在社会和结构驱动因素。结论:总体而言,美国儿童和青少年中的结核病发病率较低,而且稳步下降,但仍需作出更多努力,以消除发病率和死亡率方面的差异。

关键词：肺结核儿童青少年流行病学

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Assessment of trends in cervical cancer screening rates using healthcare claims data: United States, 2003–2014

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Preventive Medicine Reports 2018年 9卷 124-130页

作者： Watson, Meg Benard, Vicki Flagg, Elaine W. Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Atlanta GA United States Division of Sexually Transmitted Disease Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta GA United States

Improved understanding of the natural history of cervical cancer has led to changes in screening recommendations, including the addition of the human papillomavirus (HPV) testing as an option in routine screening. Most studies of screening trends have used national self-reported survey data. To better understand recent trends in cervical cancer screening, including cytology (Papanicolaou, or Pap, tests) and human papillomavirus co-tests (HPV + Pap test), we used healthcare claims data to examine screening practices and trends. We analyzed screening among commercially-insured females ages 18–65 during 2005–2014 who were continuously enrolled during three or more contiguous calendar years, to identify those who received cervical cancer screening with a Pap test or co-test. We examined screening prevalence by age group and year. During the latter years of our study period, screening prevalence (regardless of screening method) declined significantly for women in all age groups examined. Despite declines in overall screening, the prevalence of co-testing increased in all age groups except those aged 18–20. In 2014, women aged 30–39 had the highest overall screening uptake (77.5%) and the highest use of co-testing (44.4%);this group also had the lowest overall declines in screening over the time period (−4.5%). These screening measures from healthcare claims were lower than self-reported screening from national surveys of the general population. More research to explore the reasons for these differences is needed to ensure that women are receiving appropriate screening, and to better understand why screening prevalence is declining among this population of commercially insured women. © 2018

关键词： Cervical cancer Cervical cancer screening Claims data HPV test

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Author Correction: Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial

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Nature medicine 2025年 2025 Apr 9页

作者： Ye Zhang Jianjun Li Yewei Xie Dan Wu Jason Ong Gifty Marley Adeeba Kamarulzaman Haidong Lu Fei Zou Jennifer S Smith Joseph D Tucker Gengfeng Fu Weiming Tang Kirby Institute UNSW Sydney Sydney New South Wales Australia. School of Public Health Nanjing Medical University Nanjing China. Department of HIV/STI Prevention and Control Jiangsu Provincial Center for Diseases Prevention and Control Nanjing China. University of North Carolina Project-China Guangzhou China. Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London UK. Central Clinical School Monash University Melbourne Victoria Australia. Melbourne Sexual Health Centre Alfred Health Carlton Victoria Australia. University of Malaysia Kuala Lumpur Malaysia. International AIDS Society Geneva Switzerland. Department of Epidemiology of Microbial Diseases Yale School of Public Health Yale University New Haven CT USA. Department of Biostatistics Gillings School of Global Public Health University of North Carolina Chapel Hill NC USA. Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill NC USA. Department of HIV/STI Prevention and Control Jiangsu Provincial Center for Diseases Prevention and Control Nanjing China. fugf@***. Guangdong Second Provincial General Hospital Guangzhou China. Weiming_tang@med.unc.edu.

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Trends in care and treatment for persons aged ≥13 years with hiv infection 17 U.S. jurisdictions, 2012-2015

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Open aids Journal 2018年第1期12卷 90-105页

作者： Karch, Debra L. Dong, Xueyuan Shi, Jing Hall, H.I. HIV Incidence and Case Surveillance Branch Division of HIV Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention 1600 Clifton Road NE MS E-47 Atlanta 30329 GA United States ICF International Inc Atlanta GA United States

Background: Care and viral suppression national goals for hiv infection are not being met for many at-risk groups. Assessment of the trends in national outcomes for linkage to care, receipt of care, and viral suppression among these groups is necessary to reduce transmission. Methods: Data reported to the National hiv Surveillance System by December 2016 were used to identify cases of hiv infection among persons aged 13 years and older in one of 17 identified jurisdictions with complete laboratory reporting. We estimated national trends in hiv-related linkage to care, receipt of care and viral suppression using estimated annual percent change from 2012-2015 for various characteristics of interest, overall and stratified by sex and race/ethnicity. Results: Overall, trends in linkage to and receipt of care and viral suppression increased from 2012-2015. Generally, linkage to and receipt of care increased among young black and Hispanic/Latino males, those with infection attributed to male-to-male sexual contact, and those not in stage 3 [aids] at hiv diagnosis. All sub-groups showed improvement in viral suppression. Within years, there remains a substantial disparity in receipt of care and viral suppression among racial/ethnic groups. Conclusion: While trends are encouraging, scientifically proven prevention programs targeted to high-risk populations are the foundation for stopping transmission of hiv infection. Frequent testing to support early diagnosis and prompt linkage to medical care, particularly among young men who have male to male sexual contact, black and Hispanic/Latino populations, are key to reducing transmission at all stages of disease. © 2018 Karch et al.

关键词： CD4 hiv infection Linkage Treatment Trend Viral suppression

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